Gene: MT3

4504
GIF|GIFB|GRIF|ZnMT3
metallothionein 3
protein-coding
16q13
Ensembl:ENSG00000087250 MIM:139255 Vega:OTTHUMG00000133282 UniprotKB:P25713
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.928e-1 (AD)  7.171e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCXR0.953
VEGFB0.917
ALDH20.909
POLR2J0.906
FXYD10.905
RAMP10.899
CST30.898
PMVK0.893
ECH10.893
PHPT10.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.797
OR4F29-0.794
IGSF10-0.254
TDRD1-0.254
ACTA2-AS1-0.253
FER1L6-0.249
TXK-0.243
CCDC68-0.231
GADL1-0.23
ZC3H11B-0.229

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of MT3 mRNA"18281256
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT3 protein results in decreased susceptibility to Doxorubicin]19767621
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT3 protein results in decreased susceptibility to Hydrogen Peroxide]19767621
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to MT3 protein19767621
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of MT3 mRNA"27567155
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MT3 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MT3 protein]26598702
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of MT3 mRNA17011747
C0248298-hydroxyguanineMT3 protein results in decreased abundance of 8-hydroxyguanine15190073
C000188alachloralachlor results in increased expression of MT3 mRNA12419858
D0151206-Aminonicotinamide6-Aminonicotinamide results in increased expression of MT3 protein10785446
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MT3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MT3 mRNA24449571
D001149ArsenatesArsenates results in increased expression of MT3 mRNA12773770
D001151ArsenicArsenic results in increased expression of MT3 mRNA23794209
D001151ArsenicArsenic results in increased expression of MT3 protein16854967|2379420
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MT3 protein]26598702
C006632arsenic trioxidearsenic trioxide results in decreased expression of MT3 mRNA22555517
D001205Ascorbic Acid[[MT3 protein binds to Zinc] which co-treated with Ascorbic Acid] inhibits the reaction [Copper results in increased chemical synthesis of Hydroxyl Radical]17389590
D001205Ascorbic AcidAscorbic Acid results in increased expression of MT3 mRNA15372504
C547126AZM551248AZM551248 results in decreased expression of MT3 mRNA22323515
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of MT3 mRNA21632023
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MT3 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MT3 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MT3 mRNA]25566086
C038328BEP protocolBEP protocol results in increased expression of MT3 mRNA18987330
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of MT3 mRNA26496021
C099952bifenthrinbifenthrin results in increased expression of MT3 mRNA26071804
C006780bisphenol Abisphenol A affects the expression of MT3 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of MT3 mRNA26496021
D002104CadmiumCadmium binds to MT3 protein11087412|1199401
D002104CadmiumCadmium results in increased expression of MT321783819
D002104CadmiumCadmium results in increased expression of MT3 mRNA11738272|2379420
D002104CadmiumCadmium results in increased expression of MT3 protein11738272|1685496
D002104CadmiumMT3 protein results in decreased susceptibility to Cadmium12908821
D002104CadmiumMT3 protein results in increased susceptibility to Cadmium15129022
D002104CadmiumSB 203580 inhibits the reaction [Cadmium results in increased expression of MT3]21783819
D002104CadmiumCadmium results in increased expression of MT3 mRNA8917669
D002104CadmiumMT3 results in increased susceptibility to Cadmium20851133
D002104CadmiumMT3 protein results in increased susceptibility to Cadmium20371971
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MT3 mRNA24113165
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MT3 protein28422390
D019256Cadmium Chloridenaringin inhibits the reaction [Cadmium Chloride results in increased expression of MT3 protein]28422390
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT3 mRNA12634122
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of ADGRV1 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of AGFG2 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of ALDOB mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of CLDN3 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of COQ10B mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of CRELD2 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of CTGF mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of CYP2C38 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of DAPK2 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of DDIT3 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of GMFB mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of HJURP mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of IFI202B mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of IFRD1 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of IMPACT mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of JUND mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of KEG1 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of LCE1M mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of MOSPD3 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of NACC2 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of NLE1 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of NREP mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of PLS3 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of POU3F1 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of PPP1R14B mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of PRPF4B mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of RHBDF1 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of S100A8 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of SAA1 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of SAA2 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of SFSWAP mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of TAGLN2 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of TOP3B mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of UTP6 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of VDAC1 mRNA]20371981
D019256Cadmium ChlorideMT3 affects the reaction [Cadmium Chloride affects the expression of VPS33B mRNA]20371981
D019256Cadmium ChlorideMT3 gene affects the susceptibility to Cadmium Chloride20371981
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MT3 mRNA22293419
C037123cadmium sulfatecadmium sulfate results in increased expression of MT3 mRNA12064557|1467641
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of MT3 mRNA24763279
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT3 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT3 mRNA12634122
D002994ClofibrateClofibrate results in decreased expression of MT3 mRNA17585979
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of MT3 mRNA18078969
C018021cobaltous chloridecobaltous chloride deficiency results in increased expression of MT3 mRNA17706837
C018021cobaltous chloridecobaltous chloride promotes the reaction [Oxygen deficiency results in increased expression of MT3 mRNA]17706837
C018021cobaltous chloridecobaltous chloride results in increased expression of MT3 mRNA19278353
C018021cobaltous chloride[Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of MT3 mRNA19278353
D003300CopperCopper results in increased expression of MT311803044
D003300CopperMT3 protein binds to and affects the abundance of Copper11803044
D003300CopperCopper binds to MT3 protein12072966|1291132
D003300CopperCopper binds to [MT3 protein binds to Zinc]17389590
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of MT3 mRNA24690739
D003300Copper[[MT3 protein binds to Zinc] which co-treated with Ascorbic Acid] inhibits the reaction [Copper results in increased chemical synthesis of Hydroxyl Radical]17389590
D003300Copper[MT3 protein binds to Zinc] which results in increased reduction of Copper17389590
D003300Copper[[MT3 protein binds to Zinc] which results in increased reduction of Copper] promotes the reaction [Copper binds to [MT3 protein binds to Zinc]]17389590
D003300CopperCopper deficiency results in increased expression of MT3 mRNA26033743
C029892cupric chloridecupric chloride results in decreased expression of MT3 mRNA24113165
C014347decitabinedecitabine results in increased expression of MT3 mRNA21170156
C014347decitabineZinc promotes the reaction [decitabine results in increased expression of MT3 mRNA]21170156
D003671DEET[fipronil co-treated with DEET] results in increased expression of MT3 mRNA27091632
D003907DexamethasoneDexamethasone results in increased expression of MT3 mRNA25047013
D003907DexamethasoneDexamethasone results in increased expression of MT3 mRNA8917669
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MT3 mRNA21266533
D002945CisplatinCisplatin results in increased expression of MT3 mRNA16061661
D002945CisplatinFolic Acid affects the reaction [Cisplatin affects the expression of MT3 mRNA]16898872
D019422Dietary SucroseDietary Sucrose results in increased expression of MT3 mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MT3 mRNA17011747|2165843
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of MT3 mRNA24690739
D004228Dithionitrobenzoic AcidMT3 protein polymorphism affects the metabolism of Dithionitrobenzoic Acid14983064
D007980LevodopaLevodopa results in increased expression of MT3 mRNA11065139
D004317Doxorubicin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT3 protein results in decreased susceptibility to Doxorubicin]19767621
D004317DoxorubicinMT3 protein inhibits the reaction [Doxorubicin affects the localization of CYCS protein]19767621
D004317DoxorubicinMT3 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]19767621
D004317DoxorubicinMT3 protein inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]19767621
D004317DoxorubicinMT3 protein results in decreased susceptibility to Doxorubicin19767621
D004492Edetic AcidEdetic Acid results in increased alkylation of MT3 protein12383939
D004492Edetic AcidMT3 protein polymorphism affects the metabolism of Edetic Acid14983064
C118739entinostatentinostat results in increased expression of MT3 mRNA21170156|2130355
C118739entinostatZinc promotes the reaction [entinostat results in increased expression of MT3 mRNA]21170156
D000431EthanolEthanol results in increased expression of MT3 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MT3 mRNA12075121|1735126
D005033EthylmaleimideEthylmaleimide results in increased alkylation of MT3 protein12383939
D005054EugenolEugenol results in increased expression of MT3 mRNA15157811
C020326ferric nitrilotriacetateMT3 protein results in decreased susceptibility to ferric nitrilotriacetate12383939
C082360fipronil[fipronil co-treated with DEET] results in increased expression of MT3 mRNA27091632
C082360fipronilfipronil results in increased expression of MT3 mRNA27091632
D005492Folic AcidFolic Acid affects the reaction [Cisplatin affects the expression of MT3 mRNA]16898872
D004397FonofosFonofos results in increased methylation of MT3 promoter22847954
C027235gallium nitrategallium nitrate results in increased expression of MT3 mRNA18586083
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of MT3 mRNA24763279
D017313FenretinideFenretinide results in increased expression of MT3 mRNA28973697
D006861Hydrogen Peroxide2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT3 protein results in decreased susceptibility to Hydrogen Peroxide]19767621
D006861Hydrogen PeroxideMT3 protein results in decreased susceptibility to Hydrogen Peroxide12067712|1238393
D006861Hydrogen PeroxideRELA protein promotes the reaction [MT3 protein results in decreased susceptibility to Hydrogen Peroxide]19767621
D006861Hydrogen Peroxidestaurosporine aglycone inhibits the reaction [MT3 protein results in decreased susceptibility to Hydrogen Peroxide]19767621
D017665Hydroxyl Radical[[MT3 protein binds to Zinc] which co-treated with Ascorbic Acid] inhibits the reaction [Copper results in increased chemical synthesis of Hydroxyl Radical]17389590
D017665Hydroxyl RadicalMT3 protein binds to and affects the metabolism of Hydroxyl Radical12680700
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of MT3 mRNA17085751
D007608Kainic AcidKainic Acid results in decreased expression of MT3 mRNA12692462
D007608Kainic AcidKainic Acid results in increased expression of MT3 mRNA12692462
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT3 mRNA12634122
D015122MercaptopurineMercaptopurine results in increased expression of MT3 mRNA23358152
D008627Mercuric ChlorideMercuric Chloride results in increased expression of MT3 mRNA21628964
D008628MercuryMercury binds to MT3 protein15782327
D008628MercuryMercury results in increased expression of MT3 mRNA17018868|8917669
D008628MercuryMercury results in increased expression of MT3 protein15138662
D008628MercuryMercury results in increased expression of MT315138662
D008628MercuryMercury results in increased expression of MT3 protein12491035
D008628MercuryMercury results in increased expression of MT3 mRNA9587011
D019216Metals, Heavy"Metals, Heavy results in increased expression of MT3 mRNA"12773770
D008694MethamphetamineMT3 protein results in decreased susceptibility to Methamphetamine20801194
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein]"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein]"23933227
D015741MetriboloneMetribolone results in increased expression of MT3 mRNA23794209
D015741MetriboloneMetribolone results in increased expression of MT3 protein23794209
D009151Mustard GasMustard Gas results in decreased expression of MT3 mRNA18988085
C006389N-acetylserotoninN-acetylserotonin binds to MT3 protein20519847
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MT3 mRNA"21624382
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MT3 mRNA"24911292
C005274naringinnaringin inhibits the reaction [Cadmium Chloride results in increased expression of MT3 protein]28422390
D009498NeurotoxinsMT3 protein results in decreased susceptibility to Neurotoxins19453299
D009498NeurotoxinsMT3 protein results in decreased susceptibility to [Neurotoxins results in increased abundance of Zinc]19453299
D009538Nicotine"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein]"23933227
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein]"23933227
D009569Nitric OxideMT3 protein results in decreased susceptibility to Nitric Oxide10854270
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of MT3 mRNA27206323
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of MT3 mRNA17616710
D026403S-NitrosothiolsS-Nitrosothiols results in increased nitrosation of MT3 protein12081484
D010100OxygenMT3 protein affects the susceptibility to Oxygen12763630
D010100OxygenMT3 protein results in decreased susceptibility to Oxygen12058024
D010100OxygenOxygen deficiency results in increased expression of MT3 mRNA12763630
D010100Oxygencobaltous chloride promotes the reaction [Oxygen deficiency results in increased expression of MT3 mRNA]17706837
D010100Oxygen[Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of MT3 mRNA19278353
D010100OxygenOxygen deficiency results in increased expression of MT3 mRNA17706837|1927835
D010100OxygenOxygen results in increased expression of MT3 mRNA15680347|2291145
D010269ParaquatParaquat results in increased expression of MT3 mRNA24060684
D010269ParaquatParaquat results in increased expression of MT3 protein24060684
D010278ParathionParathion results in increased methylation of MT3 promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of MT3 mRNA27341501
D052638Particulate MatterParticulate Matter results in increased expression of MT3 mRNA24216475
D010406PenicillinsPenicillins results in increased expression of MT3 mRNA23266720
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of MT3 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MT3 mRNA18281256
D010936Plant ExtractsPlant Extracts results in decreased expression of MT3 mRNA23557933
D010984PlatinumPlatinum results in increased expression of MT3 mRNA28465190
D010984PlatinumPlatinum results in increased expression of MT3 protein28465190
C043435polylactic acid-polyglycolic acid copolymer"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein]"23933227
D011192Potassium DichromatePotassium Dichromate results in increased expression of MT3 mRNA19167472
D011441PropylthiouracilPropylthiouracil results in decreased expression of MT3 mRNA24780913
D011794QuercetinQuercetin results in increased expression of MT3 mRNA22996356
D012402RotenoneRotenone results in increased expression of MT3 mRNA23186747
C093642SB 203580SB 203580 inhibits the reaction [Cadmium results in increased expression of MT3]21783819
D012643Selenium[Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of MT3 mRNA11444866
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MT3 mRNA23806026
D012834SilverSilver results in increased expression of MT3 mRNA27131904
D012835Silver NitrateSilver Nitrate analog results in increased expression of MT3 mRNA22831968
D012906SmokeSmoke affects the expression of MT3 mRNA23693141
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT3 mRNA12634122
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of MT3 mRNA21632023
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [MT3 protein results in decreased susceptibility to Hydrogen Peroxide]19767621
D013481SuperoxidesMT3 protein results in decreased susceptibility to Superoxides12383939
D013481SuperoxidesMT3 protein binds to and affects the metabolism of Superoxides12680700
C061133tamibarotenetamibarotene affects the expression of MT3 mRNA15498508
C012568terbufosterbufos results in increased methylation of MT3 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MT3 mRNA24680724
D013849ThimerosalThimerosal results in increased expression of MT3 mRNA19357975
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MT3 mRNA28065790
D014212TretinoinTretinoin affects the expression of MT3 mRNA15498508
C495433tris(1,10-phenanthroline)chromium(III) chloride"tris(1,10-phenanthroline)chromium(III) chloride results in increased activity of MT3 protein"20043934
C495433tris(1,10-phenanthroline)chromium(III) chloride"tris(1,10-phenanthroline)chromium(III) chloride results in increased expression of MT3 mRNA"20043934
C495433tris(1,10-phenanthroline)chromium(III) chloride"Zinc inhibits the reaction [tris(1,10-phenanthroline)chromium(III) chloride results in increased activity of MT3 protein]"20043934
C495433tris(1,10-phenanthroline)chromium(III) chloride"Zinc inhibits the reaction [tris(1,10-phenanthroline)chromium(III) chloride results in increased expression of MT3 mRNA]"20043934
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of MT3 mRNA18078969
D014635Valproic AcidValproic Acid results in increased expression of MT3 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MT3 gene25560391
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of MT3 mRNA15541757
D001335Vehicle EmissionsVehicle Emissions results in increased expression of MT3 mRNA24216475
D014810Vitamin E[Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of MT3 mRNA11444866
C009687wortmanninwortmannin results in decreased susceptibility to MT3 protein19767621
D015032ZincCopper binds to [MT3 protein binds to Zinc]17389590
D015032ZincMT3 protein binds to and affects the abundance of Zinc12081484
D015032ZincMT3 protein binds to and affects the transport of Zinc15736926
D015032Zinc[[MT3 protein binds to Zinc] which co-treated with Ascorbic Acid] inhibits the reaction [Copper results in increased chemical synthesis of Hydroxyl Radical]17389590
D015032Zinc[MT3 protein binds to Zinc] which results in increased reduction of Copper17389590
D015032Zinc[[MT3 protein binds to Zinc] which results in increased reduction of Copper] promotes the reaction [Copper binds to [MT3 protein binds to Zinc]]17389590
D015032ZincZinc binds to MT3 protein11087412|1199401
D015032Zinc"Zinc inhibits the reaction [tris(1,10-phenanthroline)chromium(III) chloride results in increased activity of MT3 protein]"20043934
D015032Zinc"Zinc inhibits the reaction [tris(1,10-phenanthroline)chromium(III) chloride results in increased expression of MT3 mRNA]"20043934
D015032ZincZinc promotes the reaction [decitabine results in increased expression of MT3 mRNA]21170156
D015032ZincZinc promotes the reaction [entinostat results in increased expression of MT3 mRNA]21170156
D015032ZincZinc results in increased expression of MT3 mRNA18208603
D015032ZincZinc results in increased expression of MT3 protein18208603
D015032ZincMT3 protein affects the abundance of Zinc12714242|1463710
D015032ZincMT3 protein affects the susceptibility to Zinc14637104
D015032ZincMT3 protein binds to and affects the activity of Zinc14637104
D015032ZincZinc results in increased expression of MT3 mRNA8917669
D015032ZincZinc binds to MT3 protein15130702
D015032ZincZinc results in increased expression of MT3 mRNA15612480
D015032Zinc[MT3 protein binds to RAB3A protein] which results in decreased susceptibility to Zinc15039103
D015032ZincMT3 protein results in decreased susceptibility to [Neurotoxins results in increased abundance of Zinc]19453299
D015032ZincZinc results in increased expression of MT3 mRNA15952664|1701888
D015032ZincMT3 protein binds to and affects the abundance of Zinc12405537
C016837zinc chloridezinc chloride results in increased expression of MT3 mRNA18947441

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005507copper ion binding-IDA21320589  
GO:0005507copper ion binding-TAS8751715  
GO:0005515protein binding-IPI20646067  21044950  21320589  
GO:0008144drug binding-IDA19536566  
GO:0008270zinc ion binding-IDA17712581  19536566  21320589  
GO:0016209antioxidant activity-NAS12383939  
GO:0030295protein kinase activator activity-IDA18295594  
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process-IDA16387743  
GO:0046870cadmium ion binding-IDA16601975  17712581  18157556  
GO:0046872metal ion binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000060protein import into nucleus, translocation-IDA18554677  
GO:0001666response to hypoxia-IDA12763630  
GO:0001934positive regulation of protein phosphorylation-IDA18295594  
GO:0006112energy reserve metabolic process-ISS-  
GO:0006707cholesterol catabolic process-ISS-  
GO:0006829zinc ion transport-ISS-  
GO:0006875cellular metal ion homeostasis-NAS12383939  
GO:0006875cellular metal ion homeostasis-TAS21818286  
GO:0006882cellular zinc ion homeostasis-IBA21873635  
GO:0006882cellular zinc ion homeostasis-ISS-  
GO:0006915apoptotic process-IEA-  
GO:0007420brain development-IEA-  
GO:0008283cell proliferation-TAS1873033  
GO:0010038response to metal ion-TAS-  
GO:0010273detoxification of copper ion-IBA21873635  
GO:0010507negative regulation of autophagy-ISS-  
GO:0010628positive regulation of gene expression-IDA18295594  
GO:0010628positive regulation of gene expression-ISS-  
GO:0010940positive regulation of necrotic cell death-IDA15129022  16387743  
GO:0010942positive regulation of cell death-IDA16387743  
GO:0010942positive regulation of cell death-ISS-  
GO:0014002astrocyte development-ISS-  
GO:0016570histone modification-IMP21818286  
GO:0019430removal of superoxide radicals-IDA12383939  
GO:0030308negative regulation of cell growth-IDA16601975  17712581  
GO:0030308negative regulation of cell growth-IMP16945328  
GO:0030308negative regulation of cell growth-TAS18157556  
GO:0030517negative regulation of axon extension-IDA16601975  17712581  
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway-IDA18295594  
GO:0032095regulation of response to food-ISS-  
GO:0032148activation of protein kinase B activity-IDA18295594  
GO:0033210leptin-mediated signaling pathway-ISS-  
GO:0034599cellular response to oxidative stress-IEP20039155  
GO:0035690cellular response to drug-IDA19536566  
GO:0036091positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress-IDA18554677  
GO:0043066negative regulation of apoptotic process-IDA15129022  18554677  
GO:0043085positive regulation of catalytic activity-ISS-  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA16387743  
GO:0043491protein kinase B signaling-IDA18554677  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0044242cellular lipid catabolic process-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA18295594  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0050794regulation of cellular process-IBA21873635  
GO:0050821protein stabilization-IDA18295594  
GO:0051354negative regulation of oxidoreductase activity-IDA21320589  
GO:0055069zinc ion homeostasis-IDA18157556  
GO:0055073cadmium ion homeostasis-IDA18157556  
GO:0060049regulation of protein glycosylation-ISS-  
GO:0060547negative regulation of necrotic cell death-IDA18554677  
GO:0060547negative regulation of necrotic cell death-ISS-  
GO:0070371ERK1 and ERK2 cascade-IDA18554677  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA18295594  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:0071276cellular response to cadmium ion-IBA21873635  
GO:0071276cellular response to cadmium ion-IDA16387743  
GO:0071280cellular response to copper ion-IBA21873635  
GO:0071294cellular response to zinc ion-IBA21873635  
GO:0071456cellular response to hypoxia-IEP18206644  
GO:0071732cellular response to nitric oxide-IDA18157556  
GO:0097214positive regulation of lysosomal membrane permeability-ISS-  
GO:2000117negative regulation of cysteine-type endopeptidase activity-IDA18554677  
GO:2000296negative regulation of hydrogen peroxide catabolic process-IEA-  
GO:2000376positive regulation of oxygen metabolic process-ISS-  
GO:2000378negative regulation of reactive oxygen species metabolic process-IDA18554677  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005622intracellular-IDA21818286  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA10355541  
GO:0005741mitochondrial outer membrane-IEA-  
GO:0005791rough endoplasmic reticulum-IEA-  
GO:0005829cytosol-TAS-  
GO:0005840ribosome-IEA-  
GO:0005874microtubule-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0008021synaptic vesicle-ISS-  
GO:0014069postsynaptic density-IEA-  
GO:0016234inclusion body-IDA20039155  
GO:0030424axon-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA20039155  
GO:0097450astrocyte end-foot-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5660526Response to metal ionsTAS
R-HSA-5660526Response to metal ionsIEA
R-HSA-5661231Metallothioneins bind metalsTAS
R-HSA-5661231Metallothioneins bind metalsIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16351731Metallothionien 3 expression is frequently down-regulated in oesophageal squamous cell carcinoma by DNA methylation. (2005 Dec 13)Smith EMol Cancer