Gene: MTAP

4507
BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus
methylthioadenosine phosphorylase
protein-coding
9p21.3
Ensembl:ENSG00000099810 MIM:156540 Vega:OTTHUMG00000019690 UniprotKB:Q13126
NG_032650.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.973e-1 (AD)  3.198e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25162921chr9:21801897MTAP1.740e-8Maternal smoking in pregnancy27040690
cg25162921chr9:21801897MTAP2.770e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STAM20.848
FAM208A0.843
TRIP110.843
USP80.84
SYNRG0.839
SMCHD10.837
PBRM10.837
SMARCAD10.837
YIPF60.835
SREK10.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.538
OR4F29-0.494
NANOGNB-0.237
HMHB1-0.204
OR6C74-0.185
OR4F16-0.173
SLURP1-0.17
MTRNR2L6-0.165
TNP2-0.16
OR51A2-0.157

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00173AdenineSmall Molecule73-24-5Approved|NutraceuticalTarget
DB02158(1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-RibitolSmall MoleculeExperimentalTarget
DB02281FormycinSmall Molecule6742-12-7ExperimentalTarget
DB022825'-Deoxy-5'-MethylthioadenosineSmall MoleculeExperimentalTarget
DB029335'-Deoxy-5'-(Methylthio)-TubercidinSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of MTAP mRNA"23829299
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTAP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTAP mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MTAP protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MTAP protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTAP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTAP mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MTAP mRNA21420995
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MTAP protein]26598702
C006632arsenic trioxidearsenic trioxide results in decreased expression of MTAP protein19364129
C006632arsenic trioxidearsenic trioxide results in increased expression of MTAP mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MTAP mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MTAP mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MTAP mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of MTAP mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MTAP mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MTAP mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MTAP gene28505145
C584509C646 compoundC646 compound results in decreased expression of MTAP mRNA26191083
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MTAP mRNA25270620
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MTAP gene20938992
D002994ClofibrateClofibrate results in increased expression of MTAP mRNA23811191
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MTAP mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of MTAP mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of MTAP mRNA25270620
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MTAP mRNA]27941970
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of MTAP mRNA28962523
D004041Dietary FatsDietary Fats results in decreased expression of MTAP mRNA18042831
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MTAP protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MTAP mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MTAP mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTAP mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MTAP mRNA23649840
D005472FluorouracilFluorouracil results in decreased expression of MTAP mRNA16510598
D005485FlutamideFlutamide results in increased expression of MTAP mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MTAP gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of MTAP mRNA23649840
D017313FenretinideFenretinide results in decreased expression of MTAP mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of MTAP mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MTAP mRNA25613284
C544151jinfukangjinfukang results in increased expression of MTAP mRNA27392435
C410337K 7174K 7174 results in decreased expression of MTAP mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MTAP mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MTAP gene20938992
D008727MethotrexateMethotrexate results in increased expression of MTAP mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MTAP mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MTAP mRNA23649840
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MTAP mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MTAP mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of MTAP mRNA18042831
C006253pirinixic acidpirinixic acid results in increased expression of MTAP mRNA18301758|1844570
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MTAP mRNA23221170
D013629TamoxifenTamoxifen affects the expression of MTAP mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTAP mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTAP mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MTAP mRNA17942748|2015994
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MTAP mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of MTAP mRNA23411599
C066340tolcaponetolcapone binds to MTAP protein19783845
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MTAP mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTAP mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of MTAP mRNA24935251|2627250
D014520UrethaneUrethane results in decreased expression of MTAP mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTAP mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of MTAP mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of MTAP gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MTAP mRNA23179753|2627250
C111237vorinostatvorinostat results in decreased expression of MTAP mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004645phosphorylase activity-TAS8687427  
GO:0004731purine-nucleoside phosphorylase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0017061S-methyl-5-thioadenosine phosphorylase activity-IBA21873635  
GO:0017061S-methyl-5-thioadenosine phosphorylase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS8687427  
GO:0006166purine ribonucleoside salvage-IEA-  
GO:0006738nicotinamide riboside catabolic processNOTIDA19001417  
GO:0019509L-methionine salvage from methylthioadenosine-IBA21873635  
GO:0019509L-methionine salvage from methylthioadenosine-IEA-  
GO:0019509L-methionine salvage from methylthioadenosine-TAS-  
GO:0032259methylation-IEA-  
GO:0033574response to testosterone-IEA-  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1237112Methionine salvage pathwayTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1430728MetabolismTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-168256Immune SystemTAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-9020591Interleukin-12 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19427650MTAP gene is associated with ischemic stroke in Chinese Hans. (2009 Sep 15)Li SJJ Neurol Sci
21342647[Detection of MTAP protein and gene expression in non-small cell lung cancer]. (2011 Feb)Li SZhongguo Fei Ai Za Zhi
23462334Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans. (2013 Sep 10)Lv XGene