Gene info: ID 4508

Gene: ATP6

GENE ID: 4508

Synonyms: ATPase6|MTATP6

Description: ATP synthase F0 subunit 6

Gene type: protein-coding

Location: -

dbXrefs: Ensembl:ENSG00000198899 MIM:516060 UniprotKB:P00846

RefSeq: NC_011137.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00783	Estradiol	Small Molecule	50-28-2	Approved\|Investigational	Target
DB13952	Estradiol acetate	Small Molecule	4245-41-4	Approved\|Investigational	Target
DB13953	Estradiol benzoate	Small Molecule	50-50-0	Approved\|Investigational	Target
DB13954	Estradiol cypionate	Small Molecule	313-06-4	Approved\|Investigational	Target
DB13955	Estradiol dienanthate	Small Molecule	7732-97-0	Approved\|Investigational	Target
DB13956	Estradiol valerate	Small Molecule	979-32-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of ATP6 mRNA"	21856379
C001390	2-hydroxyestradiol	2-hydroxyestradiol results in increased expression of ATP6 mRNA	9886577
C014036	4-hydroxyestradiol	4-hydroxyestradiol results in increased expression of ATP6 mRNA	9886577
D000255	Adenosine Triphosphate	ATP6 protein affects the abundance of Adenosine Triphosphate	18273840
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of ATP6 mRNA	27732882
C104223	aluminum lactate	aluminum lactate results in decreased expression of ATP6 mRNA	24084166\|2649315
C104223	aluminum lactate	Quercetin inhibits the reaction [aluminum lactate results in decreased expression of ATP6 mRNA]	26493151
C506540	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Herbicides results in decreased expression of ATP6 mRNA]"	21318024
C506540	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of ATP6 mRNA]"	21318024
C506540	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [triclopyr results in decreased expression of ATP6 mRNA]"	21318024
C506540	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide results in increased expression of ATP6 mRNA"	21318024
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ATP6 mRNA	15949261
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ATP6 mRNA	14703492
D001280	Atrazine	Atrazine results in decreased expression of ATP6 mRNA	22378314\|2711463
D001280	Atrazine	[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of ATP6 mRNA	16532367
D001280	Atrazine	Atrazine results in increased expression of ATP6 mRNA	27114639
C004456	beauvericin	beauvericin results in decreased expression of ATP6 mRNA	29203277
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ATP6 protein	24211336
D004958	Estradiol	Estradiol binds to ATP6 protein	21034808
C006780	bisphenol A	bisphenol A results in decreased expression of ATP6 mRNA	25047013
C006780	bisphenol A	bisphenol A results in decreased expression of ATP6 mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of ATP6 mRNA	18804290
D002104	Cadmium	Cadmium results in increased expression of ATP6 mRNA	24084258
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of ATP6 mRNA	18409656
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ATP6 mRNA	19031917
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ATP6 mRNA	15963578
D002392	Catechin	Catechin affects the expression of ATP6 mRNA	26363153
D002392	Catechin	Catechin affects the reaction [Quercetin affects the expression of ATP6 mRNA]	26363153
D002392	Catechin	Quercetin affects the reaction [Catechin affects the expression of ATP6 mRNA]	26363153
C057862	cyanoginosin LR	cyanoginosin LR affects the expression of ATP6 mRNA	20957730
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of ATP6 mRNA	23342045
C017160	cypermethrin	cypermethrin results in increased expression of ATP6 mRNA	20965546
D004026	Dieldrin	Dieldrin results in increased expression of ATP6 mRNA	23041725
D004237	Diuron	[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of ATP6 mRNA	16532367
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ATP6 mRNA	9886577
D005054	Eugenol	Eugenol results in increased expression of ATP6 mRNA	21531020
D005472	Fluorouracil	[Fluorouracil co-treated with irinotecan] results in increased expression of ATP6 mRNA	16391804
D005485	Flutamide	Flutamide results in decreased expression of ATP6 mRNA	19442681
D005632	Fructose	Fructose results in increased expression of ATP6 protein	11934685
D005947	Glucose	ATP6 protein affects the susceptibility to Glucose	18273840
C010974	glyphosate	glyphosate results in increased expression of ATP6 mRNA	16532367
D006540	Herbicides	"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Herbicides results in decreased expression of ATP6 mRNA]"	21318024
D006540	Herbicides	Herbicides results in decreased expression of ATP6 mRNA	21318024
C051890	irinotecan	[Fluorouracil co-treated with irinotecan] results in increased expression of ATP6 mRNA	16391804
C028904	isoproturon	[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of ATP6 mRNA	16532367
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of ATP6 mRNA	24694518
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of ATP6 mRNA	21035857
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ATP6 mRNA"	26251327
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of ATP6 mRNA	24810058
D015741	Metribolone	Metribolone results in increased expression of ATP6 mRNA	17010196
D009840	Oligomycins	ATP6 gene mutant form affects the susceptibility to Oligomycins	27129022
D010846	Picloram	"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Picloram results in decreased expression of ATP6 mRNA]"	21318024
D010846	Picloram	Picloram results in decreased expression of ATP6 mRNA	21318024
C030984	pyrene	pyrene results in increased expression of ATP6 mRNA	15963578
D011794	Quercetin	Catechin affects the reaction [Quercetin affects the expression of ATP6 mRNA]	26363153
D011794	Quercetin	Quercetin affects the expression of ATP6 mRNA	26363153
D011794	Quercetin	Quercetin affects the reaction [Catechin affects the expression of ATP6 mRNA]	26363153
D011794	Quercetin	Quercetin inhibits the reaction [aluminum lactate results in decreased expression of ATP6 mRNA]	26493151
D017382	Reactive Oxygen Species	ATP6 protein affects the abundance of Reactive Oxygen Species	18273840
D017382	Reactive Oxygen Species	ATP6 protein affects the reaction [NOS2 protein affects the abundance of Reactive Oxygen Species]	18273840
D017382	Reactive Oxygen Species	ATP6 protein affects the reaction [PDX1 protein affects the abundance of Reactive Oxygen Species]	18273840
D017382	Reactive Oxygen Species	ATP6 protein affects the reaction [SOD2 protein affects the abundance of Reactive Oxygen Species]	18273840
C009279	sodium bisulfite	sodium bisulfite results in decreased expression of ATP6 mRNA	26980303
D013458	Sulfur Dioxide	Sulfur Dioxide results in decreased expression of ATP6 mRNA	26980303
D013458	Sulfur Dioxide	Sulfur Dioxide results in increased expression of ATP6 mRNA	22677886
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ATP6 mRNA	15716485
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ATP6 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ATP6 mRNA	28922406
D019284	Thapsigargin	Thapsigargin results in decreased expression of ATP6 mRNA	22378314
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ATP6 mRNA	28065790
C011559	tributyltin	ATP6 gene mutant form results in increased susceptibility to tributyltin	27129022
C032742	triclopyr	"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [triclopyr results in decreased expression of ATP6 mRNA]"	21318024
C032742	triclopyr	triclopyr results in decreased expression of ATP6 mRNA	21318024
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in decreased expression of ATP6 mRNA	25855008
D014415	Tunicamycin	Tunicamycin results in decreased expression of ATP6 mRNA	22378314
D014520	Urethane	Urethane results in increased expression of ATP6 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of ATP6 mRNA	23179753
D015215	Zidovudine	Zidovudine results in increased expression of ATP6 mRNA	16894629

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0015078	proton transmembrane transporter activity	-	IEA	-
GO:0016887	ATPase activity	contributes_to	IDA	12110673
GO:0022857	transmembrane transporter activity	-	IC	12110673

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006754	ATP biosynthetic process	-	TAS	-
GO:0007568	aging	-	IEA	-
GO:0042407	cristae formation	-	TAS	-
GO:0042776	mitochondrial ATP synthesis coupled proton transport	-	IC	12110673
GO:0055093	response to hyperoxia	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005743	mitochondrial inner membrane	-	TAS	-
GO:0005753	mitochondrial proton-transporting ATP synthase complex	-	IDA	12110673
GO:0016021	integral component of membrane	-	IEA	-
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	-	IEA	-

KEGG ID	KEGG Term
hsa00190	Oxidative phosphorylation
hsa01100	Metabolic pathways
hsa05010	Alzheimer's disease
hsa05012	Parkinson's disease
hsa05016	Huntington's disease

Reactome ID	Reactome Term	Evidence
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1592230	Mitochondrial biogenesis	TAS
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	TAS
R-HSA-163210	Formation of ATP by chemiosmotic coupling	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-8949613	Cristae formation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21789102	Atypical early onset of diabetes, deafness and lung cancer in a male patient with mitochondrial mutations in peripheral mononuclear cells. (2009)	Suzuki S	BMJ Case Rep