Gene: COX2

4513
COII|MTCO2
cytochrome c oxidase subunit II
protein-coding
-
Ensembl:ENSG00000198712 MIM:516040 UniprotKB:P00403
NC_011137.1
PubMed
0   ANCO-SNPs
ND
18   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB05412TalmapimodSmall Molecule309913-83-5InvestigationalTarget
ID Drug Name Action PubMed
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of COX2 mRNA"23958786
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of COX2 mRNA"21856379
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of COX2 protein"16603574
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased methylation of COX2 gene"25533936
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in increased expression of COX2 mRNA"26318274
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of COX2 mRNA]"11179685
C0415944-nonylphenol4-nonylphenol results in increased expression of COX2 mRNA16835292|1791269
C0415944-nonylphenol4-nonylphenol affects the expression of COX2 mRNA15792627
C027696acipimoxacipimox results in increased expression of COX2 mRNA25352640
D001151ArsenicArsenic results in increased expression of COX2 protein21514422
D001280AtrazineAtrazine results in decreased expression of COX2 mRNA22378314|2711463
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of COX2 mRNA16532367
D001280AtrazineAtrazine results in decreased expression of COX2 mRNA27114639
D004958Estradiol"3,3'-diindolylmethane inhibits the reaction [Estradiol results in decreased expression of COX2 mRNA]"11179685
D004958EstradiolEstradiol results in decreased expression of COX2 mRNA11179685
D004958EstradiolTetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of COX2 mRNA]11179685
D001622BetaineBetaine inhibits the reaction [Copper deficiency results in decreased expression of COX2 protein]25150618
C095105bexarotenebexarotene results in decreased expression of COX2 mRNA17178900
C095105bexarotenebexarotene results in decreased expression of COX2 protein17178900
C095105bexarotenebexarotene results in decreased expression of COX2 mRNA17178900
C006780bisphenol Abisphenol A results in decreased expression of COX2 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of COX2 protein26139607
C006780bisphenol A[Fructose co-treated with bisphenol A] results in decreased expression of COX2 protein26930160
D002083Butylated HydroxyanisoleButylated Hydroxyanisole inhibits the reaction [TNF protein results in decreased expression of COX2 protein]12470298
D002083Butylated HydroxyanisoleButylated Hydroxyanisole inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein]12470298
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein]12470298
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein]12470298
D002104CadmiumCadmium results in decreased activity of COX2 protein23741317
D002104CadmiumCadmium results in increased abundance of COX2 gene25388156
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of COX2 protein22886373
D003300CopperBetaine inhibits the reaction [Copper deficiency results in decreased expression of COX2 protein]25150618
D003300CopperCopper deficiency results in decreased expression of COX2 protein25150618
D003300Copper[AP1S1 gene mutant form affects the metabolism of Copper] which results in decreased expression of COX2 protein23423674
D003300CopperCopper deficiency results in decreased expression of COX2 protein24708542
D003300CopperCopper deficiency affects the activity of COX2 protein19845829
C029892cupric chloridecupric chloride results in increased expression of COX2 mRNA21641295
C029892cupric chloridecupric chloride results in increased expression of COX2 protein22699969
C029892cupric chloridecupric chloride results in increased expression of COX2 mRNA19616320
C029892cupric chloridecupric chloride results in increased expression of COX2 protein19616320
C057862cyanoginosin LRcyanoginosin LR affects the expression of COX2 mRNA20957730
C057862cyanoginosin LRcyanoginosin LR results in increased expression of COX2 mRNA23342045
C009160cyclonitecyclonite results in increased expression of COX2 mRNA20965580
D016047ZalcitabineZalcitabine results in decreased expression of COX2 mRNA19781600
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of COX2 mRNA29288687
D003907DexamethasoneDexamethasone results in increased expression of COX2 mRNA7491922
C049098diallyl phthalatediallyl phthalate results in decreased expression of COX2 protein16603574
D002945CisplatinCisplatin results in increased expression of COX2 protein22023808
D016049DidanosineDidanosine results in decreased expression of COX2 mRNA16940060
D016049DidanosineTenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA]16940060
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of COX2 mRNA18313992
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of COX2 mRNA28611668
D004041Dietary FatsINT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of COX2 mRNA]28611668
D004041Dietary Fatsrosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of COX2 mRNA]28611668
D000073417Dietary Sugars[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of COX2 mRNA28611668
D000073417Dietary SugarsINT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of COX2 mRNA]28611668
D000073417Dietary Sugarsrosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of COX2 mRNA]28611668
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of COX2 mRNA16532367
D004317DoxorubicinDoxorubicin affects the expression of COX2 protein29385562
D004317DoxorubicinDoxorubicin results in decreased activity of COX2 protein16278810
D004317DoxorubicinDoxorubicin results in decreased expression of COX2 mRNA9952311
D004317DoxorubicinDoxorubicin results in decreased expression of COX2 protein17519947
D004317DoxorubicinDoxorubicin results in decreased expression of COX2 protein19217856
D004317Doxorubicinmitoquinone inhibits the reaction [Doxorubicin results in decreased expression of COX2 protein]19217856
C062669epicatechin gallateARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]29061316
C062669epicatechin gallate[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]29061316
C045651epigallocatechin gallateARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]29061316
C045651epigallocatechin gallate[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]29061316
D004996EthidiumEthidium results in decreased expression of COX2 mRNA22712077
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of COX2 mRNA17215170
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of COX2 mRNA12857939
C007738fluoranthenefluoranthene results in decreased expression of COX2 mRNA18522720
D005485FlutamideFlutamide results in decreased expression of COX2 mRNA19442681
D005632Fructose[Fructose co-treated with bisphenol A] results in decreased expression of COX2 protein26930160
D005707Gallic AcidARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]29061316
D005707Gallic Acid[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]29061316
C057580gallocatecholARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]29061316
C057580gallocatechol[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]29061316
D005947GlucoseGlucose deficiency results in increased expression of COX2 mRNA26811028
C010974glyphosateglyphosate results in increased expression of COX2 mRNA16532367
D006854HydrocortisoneHydrocortisone results in increased expression of COX2 mRNA16835292
D006861Hydrogen PeroxideARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]29061316
D006861Hydrogen Peroxide[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]29061316
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of COX2 protein29061316
C071541hydroxycobalamin(c-lactam)hydroxycobalamin(c-lactam) results in decreased expression of COX2 mRNA7508436
C541917INT 131INT 131 inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of COX2 mRNA]28611668
C553340INX 08189INX 08189 results in decreased expression of COX2 protein27466212
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of COX2 mRNA29288687
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of COX2 mRNA16532367
C017461lead nitratelead nitrate results in decreased expression of COX2 mRNA23315276
C017461lead nitratepuerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA]23315276
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of COX2 mRNA29288687
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of COX2 mRNA"24972896
D008727MethotrexateCOX2 protein affects the susceptibility to Methotrexate10699469
D008727MethotrexateMethotrexate results in increased expression of COX2 mRNA10699469
D008727MethotrexateSodium Azide inhibits the reaction [COX2 protein affects the susceptibility to Methotrexate]10699469
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of COX2 mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of COX2 protein24806433
C429014mitoquinonemitoquinone inhibits the reaction [Doxorubicin results in decreased expression of COX2 protein]19217856
D019810Sodium AzideSodium Azide inhibits the reaction [COX2 protein affects the susceptibility to Methotrexate]10699469
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of COX2 mRNA"25554681
D009532NickelNickel results in decreased expression of COX2 mRNA24084258
D019319Okadaic AcidOkadaic Acid affects the expression of COX2 mRNA22788371
D008939MitotaneMitotane results in decreased expression of COX2 mRNA23696597
D062907Oxaloacetic AcidOxaloacetic Acid results in increased expression of COX2 mRNA26811028
D062907Oxaloacetic AcidOxaloacetic Acid results in increased expression of COX2 protein26811028
D010269ParaquatParaquat results in increased expression of COX2 protein24521700
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of COX2 protein19616056
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of COX2 mRNA19616056
C006253pirinixic acidpirinixic acid results in decreased expression of COX2 mRNA16940010|1936038
C015586propiverinepropiverine binds to COX2 protein29273565
C033607puerarinpuerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA]23315276
D011794QuercetinQuercetin results in decreased expression of COX2 protein19207037
D017382Reactive Oxygen SpeciesButylated Hydroxyanisole inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein]12470298
D017382Reactive Oxygen SpeciesButylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein]12470298
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in decreased expression of COX2 protein12470298
C059514resveratrolresveratrol results in increased expression of COX2 protein24365713
C059514resveratrolresveratrol results in increased expression of COX2 mRNA21109418
C059514resveratrolresveratrol results in increased expression of COX223790948
C089730rosiglitazonerosiglitazone inhibits the reaction [[Dietary Fats co-treated with Dietary Sugars] results in decreased expression of COX2 mRNA]28611668
C089730rosiglitazonerosiglitazone results in increased expression of COX2 mRNA16513826|2208724
C017947sodium arsenitesodium arsenite affects the expression of COX2 mRNA20451245
C017947sodium arsenitesodium arsenite results in increased expression of COX2 protein27908234
C009279sodium bisulfitesodium bisulfite results in decreased expression of COX2 mRNA26980303
D012969Sodium FluorideSodium Fluoride results in decreased expression of COX2 protein27548804
D012969Sodium FluorideSodium Fluoride results in increased expression of COX2 protein28918527
D013458Sulfur DioxideSulfur Dioxide results in decreased expression of COX2 mRNA26980303
D000068698TenofovirTenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA]16940060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of COX2 mRNA]11179685
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of COX2 mRNA18172213
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COX2 mRNA16267337
D019284ThapsigarginThapsigargin results in decreased expression of COX2 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of COX2 mRNA28065790
D014212Tretinoin[IFNB1 protein co-treated with Tretinoin] results in increased expression of COX2 protein16826196
D014212TretinoinTretinoin results in increased expression of COX2 mRNA16840543
D014415TunicamycinTunicamycin results in decreased expression of COX2 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased methylation of COX2 gene28853863
D014635Valproic AcidValproic Acid results in increased expression of COX2 mRNA23179753|2718838
D015215ZidovudineZidovudine results in decreased expression of COX2 protein10912924|7807166
D015215ZidovudineZidovudine results in increased expression of COX2 mRNA16894629
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of COX2 mRNA18313992

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004129cytochrome-c oxidase activityCONTRIBUTES_TOIBA21873635  
GO:0004129cytochrome-c oxidase activitycontributes_toIMP10486321  
GO:0004129cytochrome-c oxidase activity-NAS2550900  
GO:0005507copper ion binding-IEA-  
GO:0005515protein binding-IPI23125284  24403053  24448823  25464930  25959673  28330871  
29154948  29355485  29381136  
GO ID GO Term Qualifier Evidence PubMed
GO:0006123mitochondrial electron transport, cytochrome c to oxygen-NAS2550900  
GO:0007595lactation-IEA-  
GO:0009409response to cold-IEA-  
GO:0010729positive regulation of hydrogen peroxide biosynthetic process-IEA-  
GO:0010940positive regulation of necrotic cell death-IEA-  
GO:0042773ATP synthesis coupled electron transport-IBA21873635  
GO:1902600proton transmembrane transport-IEA-  
GO:2001171positive regulation of ATP biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA16826196  22802641  
GO:0005743mitochondrial inner membrane-IDA19393246  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005751mitochondrial respiratory chain complex IV-IBA21873635  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0045277respiratory chain complex IV-IDA1651240  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa04260Cardiac muscle contraction
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5628897TP53 Regulates Metabolic GenesTAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17509026Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication. (2007 Jul)Perri FAm J Gastroenterol
28944930Protective effect of catalpol on nicotineinduced injury of alveolar bone and associated underlying mechanisms. (2017 Dec)Li YMol Med Rep
21750557Exposure to cyclooxygenase-2 inhibitors and risk of cancer: nested case-control studies. (2011 Jul 26)Vinogradova YBr J Cancer
20386472Cancer and inflammation: promise for biologic therapy. (2010 May)Demaria SJ Immunother
26980433The lack of aspirin resistance in patients with coronary artery disease. (2016 Mar 15)Homorodi NJ Transl Med
18676844RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. (2008 Aug 1)Wolff EMCancer Res
19748095Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome. (2010 Mar)Vogel UAtherosclerosis
16959787Peroxisome proliferator-activated [corrected] receptor-gamma2 [corrected] Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes. (2007 Feb)Vogel UCarcinogenesis
24203817Cyclooxygenase 2 genotypes influence prostate cancer susceptibility in Japanese Men. (2014 Mar)Sugie STumour Biol
18164040Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study. (2008 Mar 1)Vogel UMutat Res
28901402Carbon monoxide-releasing molecule suppresses inflammatory and osteoclastogenic cytokines in nicotine- and lipopolysaccharide-stimulated human periodontal ligament cells via the heme oxygenase-1 pathway. (2017 Nov)Song LInt J Mol Med
15613941Adjusting for unmeasured confounders in pharmacoepidemiologic claims data using external information: the example of COX2 inhibitors and myocardial infarction. (2005 Jan)Schneeweiss SEpidemiology
26617606Cigarette Smoke Amplifies Inflammatory Response and Atherosclerosis Progression Through Activation of the H1R-TLR2/4-COX2 Axis. (2015)Barua RSFront Immunol
17727719Effect of active smoking on the human bronchial epithelium transcriptome. (2007 Aug 29)Chari RBMC Genomics
20210241DNA/RNA markers for colorectal cancer risk in preserved stool specimens: a pilot study. (2009 Nov-Dec)Kato ITumori
22100366Cyclooxygenase-2 -765G>C polymorphism is associated with C-reactive protein levels in resistant smokers but not in chronic obstructive pulmonary disease patients. (2012 Jan 15)Lopez-Campos JLRespir Physiol Neurobiol
27913448Targeting Inflammation in Cancer Prevention and Therapy. (2016 Dec)Todoric JCancer Prev Res (Phila)
28713991Pien Tze Huang Gan Bao attenuates carbon tetrachlorideinduced hepatocyte apoptosis in rats, associated with suppression of p53 activation and oxidative stress. (2017 Sep)Zhao JMol Med Rep