Gene: MTF1

4520
MTF-1|ZRF
metal regulatory transcription factor 1
protein-coding
1p34.3
Ensembl:ENSG00000188786 MIM:600172 Vega:OTTHUMG00000004439 UniprotKB:Q14872
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.804e-1 (AD)  1.892e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPEN0.854
CRTC30.838
NIPBL0.831
MGA0.83
PCF110.828
BTBD70.825
BAZ1B0.822
ATP11A0.819
PHF80.819
KMT2C0.816

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.477
OR4F5-0.462
CRH-0.246
PRSS56-0.214
OR4F16-0.204
CACNG1-0.203
SPRR2B-0.193
SULT2B1-0.189
PAGE4-0.181
AVP-0.18

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MTF1 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MTF1 mRNA"21346803
C0188552-tert-butylhydroquinoneMTF1 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]14998373
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MTF1 mRNA"18648102
D020106AcrylamideAcrylamide results in increased expression of MTF1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MTF1 gene27153756
D000450AldosteroneAldosterone results in increased expression of MTF1 mRNA19333130
D000450AldosteroneAldosterone results in increased expression of MTF1 protein19333130
D000450AldosteroneAmlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]19333130
D000450AldosteroneAmlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]19333130
D000450AldosteroneSpironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]19333130
D000450AldosteroneSpironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]19333130
D000487AllethrinAllethrin results in increased activity of MTF1 protein20143881
C041524aluminum sulfatealuminum sulfate results in decreased expression of MTF1 mRNA15961160
D017311AmlodipineAmlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]19333130
D017311AmlodipineAmlodipine inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]19333130
C050510arsenic trichloridearsenic trichloride promotes the reaction [MTF1 protein binds to MT1 protein]19276070
C050510arsenic trichlorideMTF1 protein affects the reaction [arsenic trichloride results in increased expression of MT1 mRNA]19276070
C050510arsenic trichlorideMTF1 protein affects the reaction [Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]]19276070
C050510arsenic trichlorideMTF1 protein affects the susceptibility to arsenic trichloride19276070
C050510arsenic trichlorideMTF1 protein results in decreased susceptibility to arsenic trichloride19276070
C028559bathocuproine sulfonatebathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]11213479
C028559bathocuproine sulfonatebathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]11213479
C028559bathocuproine sulfonatebathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]11213479
D004958EstradiolEstradiol results in increased expression of MTF1 mRNA25210133
C583563bis(cysteinato)zincate(lI)MTF1 gene mutant form inhibits the reaction [bis(cysteinato)zincate(lI) results in increased expression of MT1 mRNA]23085594
C583563bis(cysteinato)zincate(lI)MTF1 gene mutant form promotes the reaction [bis(cysteinato)zincate(lI) results in increased expression of HMOX1 mRNA]23085594
C583563bis(cysteinato)zincate(lI)MTF1 results in increased susceptibility to bis(cysteinato)zincate(lI)23085594
C067982bis(N,N-diethyldithiocarbamate)Cu (II) complex"MTF1 protein affects the reaction [bis(N,N-diethyldithiocarbamate)Cu (II) complex results in increased expression of MT1A mRNA]"26961606
C067982bis(N,N-diethyldithiocarbamate)Cu (II) complex"MTF1 protein affects the reaction [bis(N,N-diethyldithiocarbamate)Cu (II) complex results in increased expression of MT1E mRNA]"26961606
C067982bis(N,N-diethyldithiocarbamate)Cu (II) complex"MTF1 protein affects the reaction [bis(N,N-diethyldithiocarbamate)Cu (II) complex results in increased expression of MT2A mRNA]"26961606
C006780bisphenol Abisphenol A results in decreased expression of MTF1 mRNA26063408
C006780bisphenol Abisphenol A results in decreased methylation of MTF1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of MTF1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MTF1 mRNA25181051
D019328Buthionine SulfoximineMTF1 results in decreased susceptibility to Buthionine Sulfoximine16221973
D019328Buthionine SulfoximineMTF1 results in decreased susceptibility to [Buthionine Sulfoximine co-treated with cadmium sulfate]16221973
D020122tert-ButylhydroperoxideMTF1 gene mutant form results in increased susceptibility to tert-Butylhydroperoxide15378601
D002104CadmiumCadmium affects the localization of and results in increased activity of MTF1 protein17269467
D002104CadmiumCadmium affects the localization of MTF1 protein17269467
D002104CadmiumCadmium promotes the reaction [MTF1 protein binds to MT1 promoter]17269467
D002104CadmiumCadmium results in increased expression of MTF1 mRNA17269467
D002104CadmiumCadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]9507026
D002104CadmiumCadmium results in increased expression of MTF1 mRNA14568174
D002104CadmiumGlutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]]9507026
D002104CadmiumMTF1 gene SNP affects the metabolism of Cadmium26529669
D002104CadmiumMTF1 protein results in decreased susceptibility to Cadmium12716893
D002104CadmiumCadmium affects the localization of and affects the activity of MTF1 protein10734081
D002104CadmiumCadmium affects the localization of MTF1 protein20688958
D002104CadmiumCadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]9507026
D002104CadmiumCadmium promotes the reaction [MTF1 protein binds to EP300 protein]18458062
D002104CadmiumCadmium promotes the reaction [MTF1 protein binds to SLC40A1 promoter]20688958
D002104CadmiumCadmium promotes the reaction [MTF1 protein binds to SP1 protein]18458062
D002104CadmiumGlutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]]9507026
D002104CadmiumMTF1 protein affects the reaction [Cadmium results in increased expression of MT1 mRNA]18458062
D002104CadmiumMTF1 protein affects the reaction [Cadmium results in increased expression of SLC40A1 mRNA]20688958
D002104CadmiumMTF1 results in decreased susceptibility to Cadmium16508004
D002104CadmiumCadmium results in increased activity of MTF1 protein19040355
D019256Cadmium ChlorideCadmium Chloride affects the phosphorylation of and affects the localization of MTF1 protein24962574
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [MTF1 protein binds to PPP2CA protein]24962574
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MTF1 mRNA27647474|2834114
D019256Cadmium ChloridePPP2CA protein affects the reaction [Cadmium Chloride affects the localization of MTF1 protein]24962574
D019256Cadmium ChlorideMTF1 gene mutant form promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]23085594
C037123cadmium sulfatecadmium sulfate results in increased expression of MTF1 mRNA23912858
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of ACSF2 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of AIDA mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of ARMCX2 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of ARRDC3 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of CEP68 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of COTL1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of CSRP1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of CTSE mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of CYB561 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of CYP2B9 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of CYP39A1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of DCK mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of FAM181B mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of FCGR1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of FGL2 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of FMN2 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of GADD45A mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of GSTO1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of GZMA mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of GZMB mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of H2AFV mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of HIP1R mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of ID3 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of IER3 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of IFT140 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of IL33 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of IL7 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of LPL mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of MCM2 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of MCM5 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of MPP7 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of MT1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of MT2 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of MTF1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of MYOM2 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of NCALD mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of NCF4 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of NDRG1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PAQR7 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PAXIP1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PDGFA mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PDXK mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PKM mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PLA2G4A mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PLK3 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PLPP3 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PPARG mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PRKAA2 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PRSS23 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of RAB29 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of RAP2B mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of RXRG mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of SELENOW mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of SERPINH1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of SGPP2 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of SLC25A25 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of SLC39A10 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of SMAD7 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of SULT5A1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of TIMP1 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of TMEM42 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of TTC4 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of UBC mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of UBE3A mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of UPP2 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of USP24 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of ZFP617 mRNA]16221973
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of ZKSCAN6 mRNA]16221973
C037123cadmium sulfateMTF1 affects the reaction [cadmium sulfate results in increased expression of CSRP1 mRNA]16221973
C037123cadmium sulfateMTF1 affects the reaction [cadmium sulfate results in increased expression of NDRG1 mRNA]16221973
C037123cadmium sulfateMTF1 results in decreased susceptibility to [Buthionine Sulfoximine co-treated with cadmium sulfate]16221973
C037123cadmium sulfateMTF1 results in decreased susceptibility to cadmium sulfate16221973
C074702chromium hexavalent ionchromium hexavalent ion inhibits the reaction [MTF1 protein binds to MT1A promoter]12716893
C074702chromium hexavalent ionchromium hexavalent ion results in decreased activity of MTF1 protein12716893
C074702chromium hexavalent ionMTF1 protein results in decreased susceptibility to chromium hexavalent ion12716893
C074702chromium hexavalent ionchromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]]18605988
C074702chromium hexavalent ionMTF1 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]]21467744
C074702chromium hexavalent ionchromium hexavalent ion inhibits the reaction [MTF1 protein binds to EP300 protein]21467744
C007095cobaltiprotoporphyrinbathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]11213479
C007095cobaltiprotoporphyrinbathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]11213479
C007095cobaltiprotoporphyrin[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein11213479
C007095cobaltiprotoporphyrin[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA11213479
D003300CopperMTF1 protein affects the susceptibility to Copper17290228
D003300CopperMTF1 results in decreased susceptibility to Copper15318808
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of MTF1 mRNA24690739
D003300CopperMTF1 results in decreased susceptibility to Copper15318808
D003300CopperMTF1 protein affects the reaction [Copper results in increased activity of MT1 promoter]14576086
D003300CopperCopper results in increased activity of MTF1 protein19040355
D019327Copper SulfateCopper Sulfate results in decreased expression of MTF1 mRNA20599845
D019327Copper SulfateCopper Sulfate results in increased expression of MTF1 mRNA19549813|2059984
C030973cupric oxidecupric oxide results in increased expression of MTF1 mRNA22077320
D003513CycloheximideMTF1 protein affects the reaction [Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]]19276070
D003513CycloheximideMTF1 protein affects the reaction [Cycloheximide results in increased expression of MT1 mRNA]19276070
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MTF1 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of MTF1 mRNA28302478
D004147DioxinsDioxins affects the expression of MTF1 mRNA20463971
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of MTF1 mRNA24690739
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MTF1 mRNA17606305
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MTF1 mRNA17942748
D005485FlutamideFlutamide results in increased expression of MTF1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of MTF1 mRNA20655997
C027235gallium nitrategallium nitrate results in increased expression of MTF1 mRNA18586083
D005978GlutathioneGlutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]]9507026
D005978GlutathioneGlutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]]9507026
D006418Hemebathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]11213479
D006418Heme[Heme co-treated with HPX protein] affects the localization of MTF1 protein11213479
D006861Hydrogen PeroxideMTF1 protein affects the reaction [Hydrogen Peroxide results in increased expression of MT1 mRNA]14998373
D006861Hydrogen PeroxideMTF1 results in decreased susceptibility to Hydrogen Peroxide16508004
D007461IodoacetatesMTF1 protein affects the reaction [Iodoacetates results in increased expression of MT1 mRNA]14998373
D007501IronIron affects the localization of MTF1 protein17269467
D007501IronIron results in increased expression of MTF1 mRNA17269467
C008261lead acetatelead acetate affects the phosphorylation of MTF1 protein24962574
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MTF1 mRNA19339665
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MTF1 mRNA]19339665
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MTF1 mRNA26378955
D008628MercuryMercury results in increased expression of MTF1 mRNA16823088
D008628MercuryMercury results in increased activity of MTF1 protein19040355
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MTF1 mRNA]19339665
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MTF1 mRNA28001369
D009532NickelNickel affects the localization of and results in increased activity of MTF1 protein19097988
C029938nickel sulfatenickel sulfate affects the phosphorylation of MTF1 protein24962574
C029938nickel sulfatenickel sulfate results in increased activity of MTF1 protein19131640
D009599NitroprussideNitroprusside promotes the reaction [Zinc Sulfate results in increased expression of MTF1 mRNA]17018880
D009599NitroprussideNitroprusside results in increased expression of MTF1 mRNA17018880
D009599Nitroprusside"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MTF1 mRNA]"17018880
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine affects the localization of MTF1 protein16423564
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MTF1 mRNA]"17018880
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MTF1 mRNA"12756304|1288863
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [MTF1 protein binds to SLC39A10 promoter]"21738690
C029341oxophenylarsineoxophenylarsine binds to MTF1 protein19276070
D010100OxygenOxygen deficiency promotes the reaction [HIF1A protein binds to MTF1 promoter]22087877
D010100OxygenOxygen deficiency results in increased expression of MTF1 mRNA22087877
C006253pirinixic acidpirinixic acid results in decreased expression of MTF1 mRNA23811191
D011192Potassium DichromatePotassium Dichromate affects the phosphorylation of MTF1 protein24962574
D011192Potassium DichromatePotassium Dichromate results in increased expression of MTF1 mRNA11678601
C010423pyrithione zincMTF1 gene mutant form promotes the reaction [pyrithione zinc results in increased expression of HMOX1 mRNA]23085594
C059514resveratrolresveratrol results in increased expression of MTF1 mRNA12002526
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of MTF1 mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of MTF1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MTF1 mRNA23623845
D012835Silver NitrateMTF1 mutant form inhibits the reaction [Silver Nitrate results in increased expression of MT1A mRNA]19733233
D012835Silver NitrateMTF1 mutant form inhibits the reaction [Silver Nitrate results in increased expression of SLC30A1 mRNA]19733233
D012835Silver NitrateSilver Nitrate results in increased activity of MTF1 protein19733233
C009277sodium arsenatesodium arsenate results in increased expression of MTF1 protein11353140
C017947sodium arsenitesodium arsenite affects the phosphorylation of MTF1 protein24962574
C017947sodium arseniteMT1 gene mutant form affects the reaction [sodium arsenite results in increased expression of MTF1 mRNA]25485709
C017947sodium arseniteMT2 gene mutant form affects the reaction [sodium arsenite results in increased expression of MTF1 mRNA]25485709
C017947sodium arsenitesodium arsenite results in increased expression of MTF1 mRNA25485709
C017947sodium arsenitesodium arsenite results in increased expression of MTF1 protein11353140
D017693Sodium BicarbonateSodium Bicarbonate promotes the reaction [MTF1 protein binds to MT2 promoter]15965962
C016104sodium bichromatesodium bichromate results in increased expression of MTF1 mRNA22155349
D013148SpironolactoneSpironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]19333130
D013148SpironolactoneSpironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]19333130
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MTF1 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTF1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MTF1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MTF1 mRNA24058054|2821309
D014520UrethaneUrethane results in increased expression of MTF1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MTF1 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of MTF1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MTF1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of MTF1 mRNA23034163
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of MTF1 mRNA19244175
D015032ZincZinc promotes the reaction [MTF1 protein binds to MT2A promoter]21883094
D015032ZincZinc promotes the reaction [PTEN protein binds to MTF1 protein]21883094
D015032ZincZinc affects the localization of and results in increased activity of MTF1 protein17269467
D015032ZincZinc promotes the reaction [MTF1 protein binds to MT1 promoter]17269467
D015032ZincCadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]9507026
D015032ZincCEBPA protein promotes the reaction [MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]]17363595
D015032ZincGlutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]]9507026
D015032ZincMTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]17363595
D015032ZincMTF1 protein results in decreased susceptibility to Zinc12716893
D015032ZincZinc deficiency results in increased expression of MTF1 mRNA22171008
D015032ZincZinc promotes the reaction [MTF1 protein binds to HSF1 protein]16460681
D015032ZincZinc promotes the reaction [MTF1 protein binds to MT2A enhancer]16460681
D015032ZincZinc promotes the reaction [MTF1 protein binds to MT2A promoter]1459136
D015032ZincZinc results in increased activity of MTF1 protein1459136|16460681
D015032ZincZinc results in increased expression of MTF1 mRNA14568174
D015032ZincZinc results in increased expression of MTF1 protein16719502
D015032ZincCadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]9507026
D015032Zincchromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]]18605988
D015032ZincGlutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]]9507026
D015032ZincMTF1 mutant form inhibits the reaction [Zinc results in decreased expression of SLC39A10 mRNA]21738690
D015032ZincMTF1 mutant form inhibits the reaction [Zinc results in increased expression of SLC40A1 mRNA]20688958
D015032ZincMTF1 protein affects the reaction [Zinc results in increased expression of MT1 mRNA]18458062
D015032ZincMTF1 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]]21467744
D015032ZincMTF1 protein results in increased susceptibility to Zinc16847313
D015032ZincZinc affects the localization of and results in increased activity of MTF1 protein10734081
D015032ZincZinc affects the localization of MTF1 protein15142038|2068895
D015032Zinc[Zinc affects the localization of MTF1 protein] promotes the reaction [MTF1 protein binds to SLC39A13 promoter]22228435
D015032Zinc[[Zinc affects the localization of MTF1 protein] promotes the reaction [MTF1 protein binds to SLC39A13 promoter]] which results in increased expression of SLC39A13 mRNA22228435
D015032ZincZinc binds to MTF1 protein10734081
D015032Zinc[Zinc binds to MTF1 protein] affects the reaction [MTF1 protein binds to MT1 promoter]10734081
D015032ZincZinc promotes the reaction [MTF1 protein binds to EP300 protein]18458062|1860598
D015032ZincZinc promotes the reaction [MTF1 protein binds to EP300 protein binds to CREBBP protein]18458062
D015032Zinc[Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] which results in increased expression of MT1 mRNA21035574
D015032ZincZinc promotes the reaction [MTF1 protein binds to MT1 promoter]18605988|2103557
D015032ZincZinc promotes the reaction [MTF1 protein binds to SLC39A10 promoter]21738690
D015032ZincZinc promotes the reaction [MTF1 protein binds to SP1 protein]18458062
D015032ZincZinc promotes the reaction [MTF1 protein promotes the reaction [EP300 protein binds to SP1 protein]]18458062
D015032ZincZinc promotes the reaction [MTF1 protein results in increased expression of SLC30A2 mRNA]20133611
D015032ZincZinc results in increased activity of MTF1 protein10605938|2208787
D015032ZincZinc results in increased expression of MTF1 mRNA22228435
D015032ZincZinc results in increased expression of MTF1 protein22228435
D015032ZincZinc affects the localization of MTF1 protein21738690
D015032Zinc[Zinc affects the localization of MTF1 protein] promotes the reaction [MTF1 protein binds to SLC30A1 promoter]21738690
D015032Zinc[[Zinc affects the localization of MTF1 protein] promotes the reaction [MTF1 protein binds to SLC30A1 promoter]] which results in increased expression of SLC30A1 mRNA21738690
D015032ZincZinc binds to MTF1 protein19097988
D015032ZincZinc results in increased activity of MTF1 protein19040355
C088059zinc bis(histidinate)MTF1 gene mutant form promotes the reaction [zinc bis(histidinate) results in increased expression of MT1 mRNA]23085594
C016837zinc chloridezinc chloride results in decreased expression of MTF1 mRNA18947441
C016837zinc chloridezinc chloride affects the localization of MTF1 protein11551972|1642356
C016837zinc chloridezinc chloride results in increased phosphorylation of and results in increased activity of MTF1 protein11551972
D019287Zinc SulfateZinc Sulfate affects the localization of MTF1 protein21883094
D019287Zinc SulfateMTF1 mutant form inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA]21883094
D019287Zinc SulfateNitroprusside promotes the reaction [Zinc Sulfate results in increased expression of MTF1 mRNA]17018880
D019287Zinc SulfateZinc Sulfate affects the phosphorylation of and affects the localization of MTF1 protein24962574
D019287Zinc SulfateZinc Sulfate promotes the reaction [MTF1 protein binds to HSF1 protein]16460681
D019287Zinc SulfateZinc Sulfate promotes the reaction [MTF1 protein binds to MT2A enhancer]16460681
D019287Zinc SulfateZinc Sulfate results in increased activity of MTF1 protein16460681
D019287Zinc SulfateZinc Sulfate results in increased expression of MTF1 mRNA17018880
D019287Zinc SulfateZinc Sulfate results in increased expression of MTF1 protein25162517
D019287Zinc SulfateZinc Sulfate results in increased expression of MTF1 protein11213479
D019287Zinc SulfateZinc Sulfate promotes the reaction [PTEN protein binds to MTF1 protein]21883094

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA9582278  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000987proximal promoter sequence-specific DNA binding-IDA15735762  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA9582278  
GO:0003677DNA binding-TAS8065932  
GO:0003700DNA-binding transcription factor activity-TAS3208749  
GO:0003713transcription coactivator activity-TAS3208749  
GO:0005515protein binding-IPI16189514  19060904  
GO:0035035histone acetyltransferase binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-TAS3208749  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006979response to oxidative stress-IEA-  
GO:0010038response to metal ion-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9582278  
GO:0046686response to cadmium ion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS3208749  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5660489MTF1 activates gene expressionIEA
R-HSA-5660489MTF1 activates gene expressionTAS
R-HSA-5660526Response to metal ionsIEA
R-HSA-5660526Response to metal ionsTAS
R-HSA-8953897Cellular responses to external stimuliIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26529669Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc. (2015 Dec 15)Adams SVToxicol Appl Pharmacol