Gene: NUDT1

4521
MTH1
nudix hydrolase 1
protein-coding
7p22.3
Ensembl:ENSG00000106268 MIM:600312 Vega:OTTHUMG00000023072 UniprotKB:P36639
NC_000007.14
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.998e-2 (AD)  8.632e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NELFE0.765
NENF0.764
SWI50.76
TMEM2580.759
EEF1D0.757
FBXO70.755
DBNDD20.755
FBL0.748
ATOX10.745
CUEDC10.742

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.44
OR4F29-0.437
CUX2-0.282
PRKG2-0.272
C4orf45-0.26
SP8-0.257
CNGB1-0.252
CHRNA6-0.248
HS6ST3-0.246
HCN4-0.244

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NUDT1 mRNA"25270620
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NUDT1 mRNA"19167446
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NUDT1 mRNA"18648102
C0782068-oxodeoxyguanosine triphosphate8-oxodeoxyguanosine triphosphate results in increased hydrolysis of NUDT1 protein11314867
D000082AcetaminophenAcetaminophen results in increased expression of NUDT1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of NUDT1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NUDT1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NUDT1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NUDT1 protein20106945
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NUDT1 mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NUDT1 mRNA"11181447
D001554BenzeneNUDT1 gene SNP results in increased susceptibility to Benzene16600130
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NUDT1 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of NUDT1 mRNA19167446
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NUDT1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of NUDT1 mRNA25181051
D002104CadmiumCadmium results in decreased expression of NUDT1 mRNA24376830
D002104CadmiumCadmium results in decreased activity of NUDT1 protein16677676
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in decreased expression of NUDT1 mRNA28954213
C026690cerous chloridecerous chloride results in decreased expression of NUDT1 mRNA28954213
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of NUDT1 mRNA25270620
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NUDT1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of NUDT1 mRNA25270620
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NUDT1 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of NUDT1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NUDT1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of NUDT1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of NUDT1 mRNA19167446
D016572CyclosporineCyclosporine affects the expression of NUDT1 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of NUDT1 mRNA20106945
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of NUDT1 mRNA28659758
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NUDT1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NUDT1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of NUDT1 protein16803524
C000944dicrotophosdicrotophos results in decreased expression of NUDT1 mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of NUDT1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of NUDT1 mRNA21592394
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of NUDT1 mRNA24834073
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NUDT1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NUDT1 mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of NUDT1 mRNA18035473
D006861Hydrogen PeroxideNUDT1 mutant form results in increased susceptibility to Hydrogen Peroxide25127756
D006861Hydrogen Peroxide[NUDT1 mutant form results in increased susceptibility to Hydrogen Peroxide] which results in increased expression of OGG1 mRNA25127756
D006861Hydrogen Peroxide[OGG1 mutant form results in increased susceptibility to Hydrogen Peroxide] which results in increased expression of NUDT1 mRNA25127756
C056493imiquimodimiquimod results in decreased expression of NUDT1 mRNA21878529
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NUDT1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NUDT1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NUDT1 mRNA28628672
C544151jinfukangjinfukang results in increased expression of NUDT1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NUDT1 mRNA23086925
C410337K 7174K 7174 results in decreased expression of NUDT1 mRNA24086573
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in decreased expression of NUDT1 mRNA28954213
C052901lemongrass oillemongrass oil affects the expression of NUDT1 mRNA25976427
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NUDT1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NUDT1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NUDT1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NUDT1 mRNA"25554681
C119536nickel acetatenickel acetate results in increased activity of NUDT1 promoter11314867
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of NUDT1 mRNA27206323
D010100OxygenOxygen deficiency results in decreased expression of NUDT1 protein25030372
C016030pantogabpantogab results in decreased expression of NUDT1 mRNA17379144
D010269ParaquatNUDT1 protein results in decreased susceptibility to Paraquat24928220
D010269ParaquatParaquat results in decreased expression of NUDT1 mRNA23315990
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of NUDT1 mRNA28659758
D010634PhenobarbitalPhenobarbital affects the expression of NUDT1 mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of NUDT1 mRNA17426115|1830175
C045950propiconazolepropiconazole results in decreased expression of NUDT1 mRNA21278054
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of NUDT1 mRNA28659758
D011794QuercetinQuercetin results in increased expression of NUDT1 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of NUDT1 mRNA19167446
C547185riccardin Driccardin D results in decreased expression of NUDT1 mRNA24069304
D012402RotenoneRotenone results in increased expression of NUDT1 mRNA18191903
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of NUDT1 mRNA21427059
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of NUDT1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of NUDT1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NUDT1 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NUDT1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NUDT1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NUDT1 mRNA25270620
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of NUDT1 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NUDT1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NUDT1 mRNA25447457
D014212TretinoinTretinoin results in decreased expression of NUDT1 mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NUDT1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NUDT1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of NUDT1 mRNA19140230
C057693troglitazonetroglitazone results in increased expression of NUDT1 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of NUDT1 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of NUDT1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of NUDT1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of NUDT1 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of NUDT1 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IDA11139615  
GO:0005515protein binding-IPI25416956  
GO:00084138-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity-IDA10373420  22556419  
GO:0030515snoRNA binding-ISS-  
GO:00355398-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity-EXP8226881  15133035  
GO:00355398-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity-IDA10608900  22556419  
GO:0036219GTP diphosphatase activity-IDA11139615  
GO:00447132-hydroxy-adenosine triphosphate pyrophosphatase activity-EXP10373420  11756418  
GO:00447142-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity-EXP10373420  11756418  
GO:0046872metal ion binding-IEA-  
GO:0047693ATP diphosphatase activity-IDA10373420  11139615  
GO:0050072m7G(5')pppN diphosphatase activityNOTISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006195purine nucleotide catabolic process-IDA10608900  
GO:0006203dGTP catabolic process-IDA10373420  22556419  
GO:0006281DNA repair-IC10373420  
GO:0006979response to oxidative stress-TAS8226881  
GO:0007568aging-IEA-  
GO:0008584male gonad development-IEA-  
GO:0034656nucleobase-containing small molecule catabolic process-TAS-  
GO:0042262DNA protection-IDA10608900  
GO:0046061dATP catabolic process-IDA10373420  
GO:0046686response to cadmium ion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0005615extracellular space-IEA-  
GO:0005634nucleus-IDA12857738  
GO:0005737cytoplasm-IDA7782328  
GO:0005739mitochondrion-IDA12857738  
GO:0005759mitochondrial matrix-IDA7782328  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0031965nuclear membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-2393930Phosphate bond hydrolysis by NUDT proteinsTAS
R-HSA-74259Purine catabolismTAS
R-HSA-8956319Nucleobase catabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18155253OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study. (2008 Mar 1)Hatt LMutat Res
25447457Tobacco smoking-response genes in blood and buccal cells. (2015 Jan 22)Na HKToxicol Lett
15654505Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (2005)Liu YJ Hum Genet