Gene: MTHFR

4524
-
methylenetetrahydrofolate reductase
protein-coding
1p36.22
Ensembl:ENSG00000177000 MIM:607093 Vega:OTTHUMG00000002277 UniprotKB:P42898
NG_013351.1
PubMed
CD|ND|AD
326   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.253e-1 (AD)  5.825e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SUGP20.916
GGA20.908
MBD10.908
MAP3K120.905
QRICH10.903
SEC16A0.901
CMTR10.899
ZMYM30.897
POM121C0.897
TMEM1310.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.56
OR4F29-0.509
CTNNA3-0.323
SH2D1A-0.316
KLRC2-0.307
ANXA13-0.293
ZNF114-0.291
MTRNR2L10-0.291
SGMS2-0.287
SNHG18-0.286

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00115CyanocobalaminSmall Molecule68-19-9Approved|NutraceuticalTarget
DB00116Tetrahydrofolic acidSmall Molecule135-16-0NutraceuticalTarget
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalEnzyme
DB00140RiboflavinSmall Molecule83-88-5Approved|Investigational|NutraceuticalEnzyme
DB00158Folic AcidSmall Molecule59-30-3Approved|NutraceuticalEnzyme
DB00170MenadioneSmall Molecule58-27-5Approved|NutraceuticalEnzyme
DB00542BenazeprilSmall Molecule86541-75-5Approved|InvestigationalEnzyme
DB00544FluorouracilSmall Molecule51-21-8ApprovedEnzyme
DB00563MethotrexateSmall Molecule59-05-2ApprovedEnzyme
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of MTHFR mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MTHFR mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MTHFR mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MTHFR mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MTHFR mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MTHFR mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MTHFR mRNA"25510870
C0131235,10-methylenetetrahydrofolic acid"MTHFR protein results in increased metabolism of 5,10-methylenetetrahydrofolic acid"16187112
C0131235,10-methylenetetrahydrofolic acid"MTHFR protein results in increased reduction of 5,10-methylenetetrahydrofolic acid"7647779
C0131235,10-methylenetetrahydrofolic acid"MTHFR protein results in increased reduction of 5,10-methylenetetrahydrofolic acid"17387702
C0059845-methyltetrahydrofolateMTHFR protein results in increased chemical synthesis of 5-methyltetrahydrofolate7647779|9719624
C0118647-hydroxymethotrexateMTHFR mRNA results in decreased susceptibility to 7-hydroxymethotrexate19426680
D000082AcetaminophenAcetaminophen results in decreased expression of MTHFR mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of MTHFR mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MTHFR gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MTHFR mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of MTHFR mRNA28522335
D006710HomocysteineHomocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]18540024
D006710HomocysteineHomocysteine results in increased expression of MTHFR protein18540024
D006710HomocysteineMTHFR gene polymorphism results in increased abundance of Homocysteine19646848
D006710HomocysteineMTHFR protein affects the metabolism of Homocysteine20547447
D006710HomocysteineMTHFR protein mutant form results in increased abundance of Homocysteine7647779
D006710HomocysteineMTHFR protein SNP results in decreased methylation of Homocysteine17387702
D006710HomocysteineSimvastatin promotes the reaction [Homocysteine results in increased expression of MTHFR protein]18540024
D006710HomocysteineHomocysteine results in increased expression of MTHFR protein18540024
D006710Homocysteine[MTHFR gene mutant form co-treated with Methotrexate] results in increased abundance of Homocysteine19593106
D006710HomocysteineMTHFR protein affects the abundance of Homocysteine metabolite19204075
D006710Homocysteine[MTHFR protein results in increased methylation of Homocysteine] which results in increased chemical synthesis of Methionine18234410
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MTHFR mRNA16483693
D003504AncitabineMTHFR protein affects the susceptibility to Ancitabine18202788
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MTHFR mRNA24449571
D001151ArsenicMTHFR gene polymorphism affects the metabolism of and affects the susceptibility to Arsenic17365577|1754869
D001151ArsenicMTHFR gene polymorphism affects the metabolism of Arsenic17637926
D001151ArsenicMTHFR gene SNP results in increased susceptibility to Arsenic22747749
D001151ArsenicMTHFR polymorphism affects the metabolism of Arsenic17365577
D001151ArsenicMTHFR polymorphism affects the methylation of Arsenic17440589
C044946benazeprilMTHFR gene polymorphism affects the susceptibility to benazepril16081343
C044946benazeprilMTHFR gene SNP affects the susceptibility to benazepril20445573
C044946benazeprilMTHFR gene polymorphism affects the susceptibility to benazepril15226090
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of MTHFR mRNA26377693
D001622Betaine[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA28445388
C099952bifenthrinbifenthrin results in increased expression of MTHFR mRNA26071804
C006780bisphenol Abisphenol A results in increased expression of MTHFR mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of MTHFR mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MTHFR mRNA26079696
D002794Choline[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of MTHFR mRNA23439872
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFR mRNA20938992
D002794Choline[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA28445388
D003024ClozapineMTHFR gene polymorphism affects the susceptibility to Clozapine20547447
D003024ClozapineMTHFR protein affects the susceptibility to Clozapine20547447
D060729Coal AshMTHFR polymorphism affects the susceptibility to Coal Ash21334974
D003300CopperMTHFR protein polymorphism affects the abundance of Copper24583748
C093628cyproconazolecyproconazole results in increased expression of MTHFR mRNA25182419
D003561CytarabineMTHFR protein affects the susceptibility to Cytarabine18202788
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MTHFR mRNA]27941970
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MTHFR mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of MTHFR mRNA25016146
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of MTHFR mRNA22129741
D002117CalcitriolCalcitriol results in increased expression of MTHFR mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MTHFR mRNA21592394
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of MTHFR mRNA26924002
C109476epoxiconazoleepoxiconazole results in increased expression of MTHFR mRNA25182419
D005467FloxuridineMTHFR protein affects the susceptibility to Floxuridine18202788
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of MTHFR mRNA22213190
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased methylation of MTHFR promoter22213190
D005472FluorouracilMTHFR gene polymorphism affects the susceptibility to Fluorouracil16399440|1678547
D005472FluorouracilMTHFR gene polymorphism results in increased susceptibility to Fluorouracil15735113|1803462
D005472FluorouracilMTHFR gene polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin]18633250
D005472FluorouracilMTHFR protein affects the susceptibility to Fluorouracil15735113|1803462
D005472FluorouracilMTHFR protein affects the susceptibility to Fluorouracil analog15608557
D005472FluorouracilMTHFR protein results in increased metabolism of Fluorouracil18034621
D005492Folic AcidFolic Acid affects the expression of MTHFR mRNA17311948
D005492Folic Acid[Folic Acid co-treated with MTHFR gene SNP] affects the methylation of MGMT promoter17301267
D005492Folic AcidFolic Acid inhibits the reaction [MTHFR gene polymorphism results in increased activity of ACHE protein]16375580
D005492Folic AcidMTHFR gene mutant form results in decreased abundance of Folic Acid17115185
D005492Folic AcidMTHFR gene polymorphism affects the abundance of Folic Acid16621645|1669073
D005492Folic AcidMTHFR gene polymorphism affects the metabolism of Folic Acid20532609
D005492Folic AcidMTHFR gene polymorphism affects the reaction [Folic Acid affects the methylation of CDKN2A promoter]16646054
D005492Folic AcidMTHFR gene SNP affects the abundance of Folic Acid21869730
D005492Folic AcidMTHFR protein affects the metabolism of Folic Acid20547447
D005492Folic Acid[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of MTHFR mRNA23439872
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFR mRNA20938992
D005492Folic Acid[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA28445388
D002955LeucovorinMTHFR gene polymorphism results in increased susceptibility to [Fluorouracil co-treated with Leucovorin]18633250
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of MTHFR mRNA19695318
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of MTHFR mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MTHFR mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MTHFR mRNA24231268
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MTHFR mRNA24796395
D048628KetolidesKetolides analog results in decreased expression of MTHFR mRNA24967691
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of MTHFR mRNA18386188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MTHFR mRNA20938992
D008715Methionine[MTHFR protein results in increased methylation of Homocysteine] which results in increased chemical synthesis of Methionine18234410
D008727MethotrexateMethotrexate results in decreased expression of MTHFR mRNA24449571
D008727MethotrexateMethotrexate results in increased expression of MTHFR mRNA23838799
D008727MethotrexateMTHFR gene polymorphism affects the abundance of Methotrexate24241962
D008727MethotrexateMTHFR gene polymorphism affects the metabolism of Methotrexate15753437
D008727MethotrexateMTHFR gene polymorphism affects the susceptibility to Methotrexate19821069|2106413
D008727MethotrexateMTHFR gene SNP affects the susceptibility to Methotrexate17488658|1838179
D008727MethotrexateMTHFR gene SNP results in decreased metabolism of Methotrexate19391036
D008727MethotrexateMTHFR mRNA results in decreased susceptibility to Methotrexate19426680
D008727MethotrexateMTHFR polymorphism results in increased susceptibility to Methotrexate21887680
D008727MethotrexateMTHFR protein affects the susceptibility to Methotrexate17502830
D008727MethotrexateMethotrexate affects the expression of MTHFR mRNA18502557
D008727Methotrexate[MTHFR gene mutant form co-treated with Methotrexate] results in increased abundance of Homocysteine19593106
D008727MethotrexateMTHFR gene mutant form results in increased susceptibility to Methotrexate19593106
D008727MethotrexateMTHFR protein affects the susceptibility to Methotrexate18551038
D008727MethotrexateMTHFR protein results in increased metabolism of Methotrexate19391036
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MTHFR mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of MTHFR mRNA22776087
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MTHFR mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of MTHFR mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MTHFR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MTHFR mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in increased expression of MTHFR mRNA19812364
D009532NickelNickel results in increased expression of MTHFR mRNA24768652|2558310
C076029olanzapineMTHFR gene polymorphism affects the susceptibility to olanzapine20547447
C076029olanzapineMTHFR protein affects the susceptibility to olanzapine20547447
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of MTHFR mRNA18386188
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MTHFR mRNA"25510870
C046012pentanalpentanal results in decreased expression of MTHFR mRNA26079696
C006253pirinixic acidpirinixic acid results in increased expression of MTHFR mRNA18301758|2081375
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of MTHFR mRNA19695318
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of MTHFR mRNA15849065
D012312RitodrineRitodrine results in decreased expression of MTHFR mRNA23370008
C089730rosiglitazoneMTHFR affects the susceptibility to rosiglitazone19951259
D012834SilverSilver results in decreased expression of MTHFR mRNA27131904
D019821SimvastatinHomocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]18540024
D019821SimvastatinSimvastatin promotes the reaction [Homocysteine results in increased expression of MTHFR protein]18540024
D019821SimvastatinSimvastatin results in increased expression of MTHFR protein modified form18540024
D019821SimvastatinMTHFR affects the susceptibility to Simvastatin18540024
D019821SimvastatinMTHFR gene mutant form inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]18540024
D019821SimvastatinMTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 mRNA]18540024
D019821SimvastatinMTHFR inhibits the reaction [Simvastatin results in increased expression of NOS2 protein]18540024
D019821SimvastatinSimvastatin results in increased expression of MTHFR protein modified form18540024
C009277sodium arsenateMTHFR gene mutant form results in increased susceptibility to sodium arsenate24384392
C017947sodium arsenitesodium arsenite results in decreased expression of MTHFR protein19766132
D012460SulfasalazineMTHFR gene polymorphism results in increased susceptibility to Sulfasalazine19578646
D012460SulfasalazineMTHFR protein results in increased susceptibility to Sulfasalazine19578646
D013629TamoxifenTamoxifen results in decreased expression of MTHFR mRNA15849065
D013629TamoxifenTamoxifen results in increased expression of MTHFR mRNA25123088
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MTHFR mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MTHFR mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTHFR mRNA28922406
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MTHFR mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of MTHFR promoter25214829
D014212TretinoinTretinoin results in decreased expression of MTHFR mRNA23724009
D014212TretinoinTretinoin results in increased expression of MTHFR mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MTHFR mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of MTHFR mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of MTHFR mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of MTHFR gene29154799
D014635Valproic AcidValproic Acid affects the expression of MTHFR mRNA9188671
D020888VigabatrinMTHFR results in increased susceptibility to Vigabatrin21490592
D012256RiboflavinMTHFR gene polymorphism affects the susceptibility to Riboflavin17303386
D014805Vitamin B 12[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA28445388

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004489methylenetetrahydrofolate reductase (NAD(P)H) activity-IBA21873635  
GO:0004489methylenetetrahydrofolate reductase (NAD(P)H) activity-IDA12673793  24769206  
GO:0004489methylenetetrahydrofolate reductase (NAD(P)H) activity-IGI10551815  
GO:0004489methylenetetrahydrofolate reductase (NAD(P)H) activity-IMP12673793  25736335  
GO:0004489methylenetetrahydrofolate reductase (NAD(P)H) activity-TAS-  
GO:0044877protein-containing complex binding-IPI24769206  
GO:0050660flavin adenine dinucleotide binding-IDA12673793  
GO:0050661NADP binding-IEA-  
GO:0071949FAD binding-IBA21873635  
GO:0072341modified amino acid binding-IDA20031578  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0006520cellular amino acid metabolic process-TAS7647779  
GO:0006555methionine metabolic process-IGI10551815  
GO:0006730one-carbon metabolic process-IBA21873635  
GO:0008015blood circulation-TAS7647779  
GO:0009086methionine biosynthetic process-IBA21873635  
GO:0031060regulation of histone methylation-IDA24769206  
GO:0033274response to vitamin B2-IEA-  
GO:0035999tetrahydrofolate interconversion-IBA21873635  
GO:0035999tetrahydrofolate interconversion-IDA12673793  
GO:0035999tetrahydrofolate interconversion-IEA-  
GO:0035999tetrahydrofolate interconversion-IGI10551815  
GO:0035999tetrahydrofolate interconversion-IMP12673793  25736335  
GO:0043200response to amino acid-IEA-  
GO:0046500S-adenosylmethionine metabolic process-IEA-  
GO:0046655folic acid metabolic process-TAS-  
GO:0050667homocysteine metabolic process-IDA20031578  
GO:0051593response to folic acid-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0070555response to interleukin-1-IEA-  
GO:0070829heterochromatin maintenance-IDA24769206  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
hsa00670One carbon pool by folate
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196757Metabolism of folate and pterinesTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19742390From mild cognitive impairment to Alzheimer's disease - influence of homocysteine, vitamin B12 and folate on cognition over time: results from one-year follow-up. (2009 Jul-Aug)Siuda JNeurol Neurochir Pol
28397463Colorectal Cancer Carcinogenesis: a Multivariate Genetic Model in a Cohort of Romanian Population. (2017 Apr 1)Procopciuc LMClin Lab
24368279Dietary folate and related micronutrients, folate-metabolising genes, and ovarian cancer survival. (2014 Mar)Dixon SCGynecol Oncol
17117960Methylenetetrahydrofolate reductase C677T-polymorphism and its association with alcohol withdrawal seizure. (2006 Dec)Lutz UCAlcohol Clin Exp Res
29299150Methylenetetrahydrofolate reductase tagging polymorphisms are associated with risk of non-small cell lung cancer in eastern Chinese Han population. (2017 Dec 15)Ding HOncotarget
10397694Inherited prothrombotic conditions and premature ischemic stroke: sex difference in the association with factor V Leiden. (1999 Jul)Margaglione MArterioscler Thromb Vasc Biol
28689750Characteristics and Long-Term Prognosis of Patients Rallidis LSAm J Cardiol
23631288The TT genotype of the MTHFR 677C > T polymorphism increases susceptibility to premature coronary artery disease in interaction with some of the traditional risk factors. (2012)Sarecka-Hujar BActa Medica (Hradec Kralove)
23273201Association of 5, 10- methylenetetrahydrofolate reductase C677T polymorphism in susceptibility to tropical chronic pancreatitis in north Indian population. (2012 Dec 22)Singh SCell Mol Biol (Noisy-le-grand)
11303694Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction. (2001 Apr)Gulec SClin Cardiol
10376845Homocysteine, hypertension and stroke. (1999 May)Perry IJJ Hum Hypertens
22296361MTHFR gene polymorphisms and bladder cancer susceptibility: a meta-analysis including race, smoking status and tumour stage. (2011)Kouidhi SAsian Pac J Cancer Prev
20637366C677T polymorphism of the 5,10 MTHFR gene in young Mexican subjects with ST-elevation myocardial infarction. (2010 May)Isordia-Salas IArch Med Res
15219943Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina. (2004 Aug 10)Moore LECancer Lett
28086795Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study. (2017 Jan 13)Fawzy MSBMC Cardiovasc Disord
16351505Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. (2005)Otani TNutr Cancer
15530908Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults. (2004 Dec)Woodside JVAtherosclerosis
27774577Retrospective case-control study of correlation between MTHFR gene and OSCC risk in North India. (2017 Jul)Naqvi HClin Oral Investig
26770518Genetic variations in MTHFR and gastric cardia adenocarcinoma susceptibility in the Chinese Han population. (2015)Wang YInt J Clin Exp Med
28225483Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism. (2017 Feb)Xu BMedicine (Baltimore)
27430300Association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and susceptibility to Graves' ophthalmopathy. (2016 Sep)Lee JYMol Med Rep
11806787Genetics University of Toronto Thrombophilia Study in Women (GUTTSI): genetic and other risk factors for venous thromboembolism in women. (2001)Ray JGCurr Control Trials Cardiovasc Med
11204591Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men. (2001 Jan)Dekou VThromb Haemost
11424140Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum. (2001 Jul 1)Ulvik AAm J Med Genet
26770360Association of MTHFR genetic polymorphisms with venous thromboembolism in Uyghur population in Xinjiang, China. (2015)Li ZInt J Clin Exp Med
22524840Folate intake, methylenetetrahydrofolate reductase polymorphisms in association with the prognosis of esophageal squamous cell carcinoma. (2012)Jing CAsian Pac J Cancer Prev
23681825Heme-related gene expression signatures of meat intakes in lung cancer tissues. (2014 Jul)Lam TKMol Carcinog
19588544Combined effect of NAT2, MTR and MTHFR genotypes and tobacco on bladder cancer susceptibility in Tunisian population. (2009)Ouerhani SCancer Detect Prev
21737671Methylenetetrahydrofolate reductase (MTHFR) genotype, smoking habit, metastasis and oral cancer in Taiwan. (2011 Jun)Tsai CWAnticancer Res
23807201MTHFR C677T polymorphism, folate status and colon cancer risk in acromegalic patients. (2014 Jun)Torre MLPituitary
26317030A Study on MTHFR C677T Gene Polymorphism and Alcohol Dependence among Meiteis of Manipur, India. (2014)Singh HSJ Biomark
22024018Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population. (2011 Oct 25)Kiyohara CBMC Cancer
15231206[A case-control study on the polymorphisms of methylenetetrahydrofolate reductase 1298A-->C and susceptibility of esophageal cancer]. (2004 Apr)Gao CMZhonghua Liu Xing Bing Xue Za Zhi
27603386Association between MTHFR C677T polymorphism and abdominal aortic aneurysm risk: A comprehensive meta-analysis with 10,123 participants involved. (2016 Sep)Liu JMedicine (Baltimore)
18328637Protective effect against alcohol dependence of the thermolabile variant of MTHFR. (2008 Jul 1)Saffroy RDrug Alcohol Depend
21339095Smoking and polymorphisms in folate metabolizing genes and their effects on the histological stage and grade for bladder tumors. (2011 Feb)Rouissi KBull Cancer
15002923Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors. (2004 Winter)Tavares EFEthn Dis
25882505Women who deliver twins are more likely to smoke and have high frequencies of specific SNPs: Results from a sample of African-American women who delivered preterm, low birth weight babies. (2015 Sep-Oct)Huang HAm J Hum Biol
11575217[APOC3, CETP, beta-fibrinogen and MTHFR are genetic determinants of carotid intim-media thickness (Stanislas cohort)]. (2001 Aug)Pallaud CArch Mal Coeur Vaiss
17372834Folate status and risk of colorectal polyps in African Americans. (2007 Jun)Ashktorab HDig Dis Sci
21104445Mutations in methylenetetrahydrofolate reductase and in cysthationine beta synthase: is there a link to homocysteine levels in peripheral arterial disease? (2011 Jun)Santos MEMol Biol Rep
22880024Prevalence and associated factors of diabetes and impaired fasting glucose in Chinese hypertensive adults aged 45 to 75 years. (2012)Qin XPLoS One
26865327Hyperhomocysteinaemia is an independent risk factor of abdominal aortic aneurysm in a Chinese Han population. (2016 Feb 11)Liu JSci Rep
27473058Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects. (2016 Jul 29)Nakao HBMC Gastroenterol
16690736Predictors of vitamin B6 and folate concentrations in older persons: the InCHIANTI study. (2006 Jul)Gori AMClin Chem
24498831An MTHFR variant, plasma homocysteine levels and late-onset coronary artery disease in subjects from southern Iran. (2013 Aug 15)Saffari BPak J Biol Sci
17497026Thermolabile methylenetetrahydrofolate reductase C677T polymorphism and homocysteine are risk factors for coronary artery disease in Moroccan population. (2007)Bennouar NJ Biomed Biotechnol
22649255Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. (2012 Jul)Wernimont SMJ Nutr
16389035Congenital heart defects, maternal homocysteine, smoking, and the 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene: evaluating gene-environment interactions. (2006 Jan)Hobbs CAAm J Obstet Gynecol
25219684Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development. (2015 Apr)Bezerra JFOral Dis
15313378Cigarette smoke increases intimal hyperplasia and homocysteine in a rat carotid endarterectomy. (2004 Sep)Davis JAJ Surg Res
10090925Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males. (1999 Apr 1)Inbal ABlood
17496311Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers. (2007 Jul)Vineis PAnn Oncol
15054427Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR(C677T) genotype. Inter99 (7). (2004 Aug)Husemoen LLEur J Clin Nutr
27803768Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma. (2016 Oct 18)Peres NPWorld J Hepatol
11319182Polymorphisms of methylene-tetrahydrofolate reductase and risk of lung cancer: a case-control study. (2001 Apr)Shen HCancer Epidemiol Biomarkers Prev
22770603Elevated homocysteine is associated with poorer self-perceived physical health in older men: the Health in Men Study. (2012 Oct)Wong YYMaturitas
22277790Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C Polymorphisms and tobacco smoking on infant birth weight in a Japanese population. (2012)Yila TAJ Epidemiol
23391848OLR1, PON1 and MTHFR gene polymorphisms, conventional risk factors and the severity of coronary atherosclerosis in a Chinese Han population. (2013)Gu YCell Physiol Biochem
24080236Variation of types of alcoholism: review and subtypes identified in Han Chinese. (2014 Jan 3)Lee SYProg Neuropsychopharmacol Biol Psychiatry
12189485Major gene evidence after MTHFR-segregation analysis of serum homocysteine in families of patients undergoing coronary arteriography. (2002 Aug)Jee SHHum Genet
11207634Determinants of changes in plasma homocysteine in hyperthyroidism and hypothyroidism. (2001 Feb)Diekman MJClin Endocrinol (Oxf)
17220338Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. (2007 Jan)Hsiung DTCancer Epidemiol Biomarkers Prev
25587456The drop that spilled the cup: acute myocardial infarction in a young woman with underlying thrombophilic polymorphisms and oral contraceptive use. (2014)Russo NCase Rep Cardiol
23188888Associations of MTHFR and MTRR polymorphisms with serum lipid levels in Chinese hypertensive patients. (2014 May)Jiang SClin Appl Thromb Hemost
21187870Polymorphisms of methylenetetrahydrofolate reductase gene as the genetic predispositions of coronary artery diseases in eastern India. (2010 Jul)Dhar SJ Cardiovasc Dis Res
21746721High folate intake is related to better academic achievement in Swedish adolescents. (2011 Aug)Nilsson TKPediatrics
17999084Relationship between two sequence variations in the gene for peroxisome proliferator-activated receptor-gamma and plasma homocysteine concentration. Health in men study. (2008 Feb)Golledge JHum Genet
16169307MTHFR c.677C>T polymorphism as an independent predictor of peak bone mass in Danish men--results from the Odense Androgen Study. (2006 Feb)Abrahamsen BBone
14638877Evaluation of the modifying effects of unfavourable genotypes on classical clinical risk factors for ischaemic stroke. (2003 Dec)Szolnoki ZJ Neurol Neurosurg Psychiatry
21334974Ex vivo study for the assessment of behavioral factor and gene polymorphisms in individual susceptibility to oxidative DNA damage metals-induced. (2011 Jun)Di Pietro AInt J Hyg Environ Health
18336674Alcohol, cofactors and the genetics of hepatocellular carcinoma. (2008 Mar)Yu MCJ Gastroenterol Hepatol
23670871Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis. (2013 Aug)Butali ABirth Defects Res A Clin Mol Teratol
20940365Interaction between the MTHFR C677T polymorphism and alcohol--impact on oral cancer risk and multiple DNA methylation of tumor-related genes. (2011 Jan)Supic GJ Dent Res
21338559Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population. (2011 Oct)Huang TPublic Health Nutr
22252719Systematic review and meta-analysis of the risk factors for sudden sensorineural hearing loss in adults. (2012 Mar)Lin RJLaryngoscope
25155498Genetic polymorphisms, Biochemical Factors, and Conventional Risk Factors in Young and Elderly North Indian Patients With Acute Myocardial Infarction. (2016 Mar)Kaur RClin Appl Thromb Hemost
19557016MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women. (2009 Jul)Gao CMJ Hum Genet
22752805Prevalence of myocardial infarction polymorphisms in Afyonkarahisar, Western Turkey. (2012 Sep)Onrat STMol Biol Rep
15969978Genetic, dietary, and other lifestyle determinants of serum homocysteine levels in young adults in Costa Rica. (2005 Apr)Holst-Schumacher IRev Panam Salud Publica
11747974High prevalence of hyperhomocysteinemia in chronic alcoholism: the importance of the thermolabile form of the enzyme methylenetetrahydrofolate reductase (MTHFR). (2001 Oct)de la Vega MJAlcohol
22067726Is genetic screening necessary for determining the possibility of venous thromboembolism in cancer patients? (2012)Onur EMed Princ Pract
18712959Genetic polymorphisms of methylenetetrahydrofolate reductase and susceptibility to colorectal cancer. (2008 Apr-Jun)Cao HXAsian Pac J Cancer Prev
11170083Smoking behavior and the C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene. (2001 Feb 1)Johnson WAm J Med Genet
18840514Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer. (2009 Jan 30)Langevin SMToxicol Lett
29501539Contribution of MTHFR gene variants in lupus related subclinical atherosclerosis. (2018 Mar 6)Giannelou MClin Immunol
22219102Impact of MTHFR C677T gene polymorphism and vitamins intake on homocysteine concentration in the Polish adult population. (2011)Waskiewicz AKardiol Pol
18457979Severe atherosclerosis in rheumatoid arthritis and hyperhomocysteinemia: is there a link? (2008 Jul)El Bouchti IJoint Bone Spine
22022143Genetic interactions between MTHFR (C677T), methionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid determine susceptibility to premature coronary artery disease in Indian population. (2011 Jul)Kanth VVJ Cardiovasc Dis Res
20661822Evaluation of MTHFR677C>T polymorphism in prediction and prognosis of esophageal squamous cell carcinoma: a case-control study in a northern Indian population. (2010)Umar MNutr Cancer
11257267The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart study. (2001 Feb 15)Dekou VAtherosclerosis
11287760Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis. (2001 Mar)Lim PSNephron
17141597The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women. (2007 Mar)Baines MBone
21046286Genetic susceptibility of methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C, and G1793A polymorphisms with risk for bladder transitional cell carcinoma in men. (2011 Dec)Safarinejad MRMed Oncol
19326344Thiol and cardiovascular risk factor status in a male northern Irish population. (2008 Jul-Sep)Edgar KSInt J Vitam Nutr Res
11157318Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. (2001 Feb)Saw SMAm J Clin Nutr
21966393No effect of folic acid supplementation on global DNA methylation in men and women with moderately elevated homocysteine. (2011)Jung AYPLoS One
20471108Plasma homocysteine in schizophrenia: determinants and clinical correlations in Tunisian patients free from antipsychotics. (2010 Aug 30)Bouaziz NPsychiatry Res
15794259[The normotensive carriers of the MTHFR 677T allele, displaying the increased risk of development of the abdominal aortic aneurysm (AAA), occur at the highest frequency among the smoking patients]. (2004)Strauss EPrzegl Lek
15503105Plasma homocysteine, MTHFR C677T, CBS 844ins68bp, and MTHFD1 G1958A polymorphisms in spontaneous cervical artery dissections. (2004 Oct)Konrad CJ Neurol
27065203Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein thrombosis complicating liver cirrhosis. (2016 May)Ventura PThromb Res
17719079MTHFR C677T mutation in central retinal vein occlusion: a case-control study in Chinese population. (2008)Gao WThromb Res
19885596Gene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case-control study. (2009 Dec)Henriquez-Hernandez LAOncol Rep
22606049Interactions of several lipid-related gene polymorphisms and cigarette smoking on blood pressure levels. (2012)Yin RXInt J Biol Sci
11863127Hyperhomocysteinemia, low folate status, homozygous C677T mutation of the methylene tetrahydrofolate reductase and renal arterial thrombosis. (2002 Feb)Queffeulou GClin Nephrol
11558898An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis. (2001)Kawamoto RJ Hum Genet
10229729Plasma homocyst(e)ine concentration, but not MTHFR genotype, is associated with variation in carotid plaque area. (1999 May)Spence JDStroke
21441790Polymorphisms and pancreatic cancer risk: a meta-analysis. (2011 May)Mazaki TEur J Cancer Prev
12482561Hyperhomocysteinemia and vitamin B-12 deficiency are more striking in Syrians than in Germans--causes and implications. (2003 Jan)Herrmann WAtherosclerosis
23244112Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas. (2012)Cheng HAsian Pac J Cancer Prev
28171870Methylene Tetrahydrofolate Reductase (MTHFR) rs868014 Polymorphism Regulated by miR-1203 Associates with Risk and Short Term Outcome of Ischemic Stroke. (2017)He WCell Physiol Biochem
20065319Interaction of methylenetetrahydrofolate reductase genotype and smoking habit in Taiwanese lung cancer patients. (2009 Nov-Dec)Liu CSCancer Genomics Proteomics
28192769Disorganization at the stage of schizophrenia clinical outcome: Clinical-biological study. (2017 May)Nestsiarovich AEur Psychiatry
24189452The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals. (2014 Mar)Supanc VJ Stroke Cerebrovasc Dis
16936384Methylenetetrahydrofolate reductase gene polymorphism in Indian stroke patients. (2006 Sep)Kalita JNeurol India
15151261The Diamant Alpin Dialysis cohort study: clinico-biological characteristics and cardiovascular genetic risk profile of incident patients. (2004 Jan-Feb)Pernod GJ Nephrol
22664498Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians. (2012 Apr)Gupta SKIndian J Med Res
20203488The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with idiopathic ischemic stroke in the young Mexican-Mestizo population. (2010)Isordia-Salas ICerebrovasc Dis
22528331High prevalence of three prothrombotic polymorphisms among Palestinians: factor V G1691A, factor II G20210A and methylenetetrahydrofolate reductase C677T. (2012 Oct)Hussein ASJ Thromb Thrombolysis
25102261Maternal folate, alcohol and energy metabolism-related gene polymorphisms and the risk of recurrent pregnancy loss. (2012 Oct)Sata FJ Dev Orig Health Dis
9194768The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. (1997 Jun)Malinow MRArterioscler Thromb Vasc Biol
22533155[Role of the polymorphisms within genes encoding proteins related to endothelial dysfunction in coronary artery disease]. (2011)Sarecka-Hujar BWiad Lek
19172696The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. (2008)Eklof VScand J Clin Lab Invest
22535530Prothrombotic gene polymorphisms and plasma factors in young North Indian survivors of acute myocardial infarction. (2012 Aug)Dogra RKJ Thromb Thrombolysis
12630544Homocysteine, endothelial dysfunction, and coronary artery disease: emerging strategy for secondary prevention. (2002 Sep-Oct)Woo KSJ Card Surg
24014284The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism. (2013 Dec)Mehlig KHeart
20842733Variants in folate pathway genes as modulators of genetic instability and lung cancer risk. (2011 Jan)Piskac-Collier ALGenes Chromosomes Cancer
27996298Genetic Interactions in Nonsyndromic Orofacial Clefts in Europe-EUROCRAN Study. (2017 Nov)Mossey PACleft Palate Craniofac J
21342495Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population. (2011 Feb 22)Cui LHBMC Med Genet
19332210Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: data from the Women's Genome Health Study. (2009 Apr)Albert MAAm Heart J
12844196Risk factors and methylenetetrahydrofolate reductase gene polymorphisms in a young South African Indian-based population with acute myocardial infarction. (2003 May-Jun)Ranjith NCardiovasc J S Afr
24197804Hyperhomocysteinemia is an independent predictor of sub-clinical carotid vascular damage in subjects with grade-1 hypertension. (2014 Jun)Mazza AEndocrine
20106900International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. (2010 Apr)Truong TCarcinogenesis
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet
11714857Genetic influences on lipid metabolism trait variability within the Stanislas Cohort. (2001 Nov)Pallaud CJ Lipid Res
17590289Impact of air pollution and genotype variability on DNA damage in Prague policemen. (2007 Jul 30)Novotna BToxicol Lett
17972183Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population. (2007 Nov-Dec)Boccia SBiomarkers
25550183Elevation in Total Homocysteine Levels in Chinese Patients With Essential Hypertension Treated With Antihypertensive Benazepril. (2016 Mar)Jiang SClin Appl Thromb Hemost
19424840Physical activity is inversely associated with total homocysteine levels, independent of C677T MTHFR genotype and plasma B vitamins. (2007 Dec)Dankner RAge (Dordr)
26986182Associations Between Methylenetetrahydrofolate Reductase Polymorphisms, Serum Homocysteine Levels, and Incident Cortical Cataract. (2016 Mar 17)Tan AGJAMA Ophthalmol
12602921Breast cancer risk and methylenetetrahydrofolate reductase polymorphism. (2003 Feb)Semenza JCBreast Cancer Res Treat
113361845,10-Methylenetetrahydrofolate reductase polymorphism and early organ damage in primary hypertension. (2001 Apr)Ravera MAm J Hypertens
11359462APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort). (2001 May)Pallaud CClin Genet
20564317Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C, and G1793A) gene and risk of prostate cancer: a case-control study. (2010 Nov 1)Safarinejad MRProstate
29461227[THE DIFFERENTIATED APPROACH TO PREVENTION OF NEURAL TUBE DEFECTS IN CHILDREN]. (2018 Jan)Kotova NGeorgian Med News
22676332Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City. (2013)Fridman OClin Exp Hypertens
23554734MTHFR C677T polymorphisms are associated with aberrant methylation of the IGF-2 gene in transitional cell carcinoma of the bladder. (2012 Mar)Cheng HJ Biomed Res
11870335Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke: sex difference in Japanese. (2001 Dec)Wu YKobe J Med Sci
16340945Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study. (2006 May)Husemoen LLEur J Clin Nutr
19394322Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians. (2009 Jul)Vinukonda GClin Chim Acta
18180190Evidence for sex differences in the determinants of homocysteine concentrations. (2008 Apr)Stanislawska-Sachadyn AMol Genet Metab
19846566Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review. (2009 Nov 15)Taioli EAm J Epidemiol
17243563Association of methylenetetrahydrofolate (MTHFR) and apolipoprotein E (apo E) genotypes with homocysteine, vitamin and lipid levels in carotid stenosis. (2006 Dec)Zuntar IColl Antropol
15244514Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking. (2004 Apr-Jun)Gao CMAsian Pac J Cancer Prev
16580699A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers. (2006 Jul 25)Ishikawa HMutat Res
12119198Homocysteine levels in men and women of different ethnic and cultural background living in England. (2002 Sep)Cappuccio FPAtherosclerosis
21666966Association of uricemia with biochemical and dietary factors in human adults with metabolic syndrome genotyped to C677T polymorphism in the methylenetetrahydrofolate reductase gene. (2011 Mar-Apr)Kimi Uehara SNutr Hosp
25104092Heterozygote advantage of methylenetetrahydrofolate reductase polymorphisms on clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. (2014 Nov)Li XTumour Biol
16627623Different allele-distribution of mthfr 677 C -> T and mthfr -393 C -> a in patients classified according to subtypes of Lesch's typology. (2006 Jul-Aug)Bonsch DAlcohol Alcohol
27770044Methotrexate impact on radiographic progression in biologic-treated rheumatoid arthritis under clinical remission: A case report on monozygotic Caucasian twins. (2016 Dec)Soukup TInt J Immunopathol Pharmacol
15138617The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study. (2004 Jun)Strandhagen EInt J Mol Med
29566195Lifestyle, metabolite, and genetic determinants of formate concentrations in a cross-sectional study in young, healthy adults. (2018 Mar 1)Brosnan JTAm J Clin Nutr
23935293Prevalence of thrombophilic mutations in patients with unprovoked thromboembolic disease. A comparative analysis regarding arterial and venous disease. (2012 Jul)Mandala EHippokratia
23414319Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight. (2013 Feb)Haworth KEEpigenomics
12001978Nutritional advice to increase soluble fibre intake does not change plasma folate or homocysteine in men with angina: a randomised controlled trial. (2002 Feb)Ashfield-Watt PAPublic Health Nutr
12033523Are the associations between life-style related factors and plasma total homocysteine concentration different according to polymorphism of 5,10-methylenetetrahydrofolate reductase gene (C677T MTHFR)? A cross-sectional study in a Japanese rural population. (2002 Mar)Lwin HJ Epidemiol
18037339Genetic polymorphisms and micronucleus formation: a review of the literature. (2008 Mar-Apr)Iarmarcovai GMutat Res
18937353Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor. (2008 Oct)Lu ZYBirth Defects Res A Clin Mol Teratol
17493640Biomarkers of air pollution exposure--a study of policemen in Prague. (2007 Nov 1)Topinka JMutat Res
14569745The prevalence of MTHFR 677C-->T missense mutation, total plasma homocysteine levels and associated risk factors in Malay subjects. (2003 Jun)Ling KHMed J Malaysia
11075868Associations between family history of cancer and genes coding for metabolizing enzymes (United States). (2000 Oct)Slattery MLCancer Causes Control
22541966Incorporating single-nucleotide polymorphisms into the Lyman model to improve prediction of radiation pneumonitis. (2013 Jan 1)Tucker SLInt J Radiat Oncol Biol Phys
24122328No association between hyperhomocysteinemia and vascular access thrombosis in chronic hemodialysis. (2003 Jan-Mar)Lvesque RJ Vasc Access
18704761Molecular genetics of myocardial infarction. (2008 Jan)Yamada YGenomic Med
16737574[Study on the relations between genetic polymorphisms in methylenetetrahydrofolate reductase, methionine synthase and the risk of pancreatic cancer]. (2006 Jan)Wang LZhonghua Liu Xing Bing Xue Za Zhi
15117811Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study. (2004 Sep)Lin JCarcinogenesis
27759072Interactions between lifestyle and MTHFR polymorphisms on homocysteine concentrations in young adults belonging to the 1982 Pelotas Birth Cohort. (2017 Feb)Oliveira IOEur J Clin Nutr
22065928Analysis of candidate genes for age-related macular degeneration subtypes in the Japanese population. (2011)Tanaka KMol Vis
12891167Case report: Acute myocardial infarction in a 32-year-old white male found to have antiphospholipid antibody syndrome and MTHFR mutation homozygosity. (2003 Jul-Aug)Stoupakis GHeart Lung
23335901The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency. (2012)Spellicy CJFront Psychiatry
19630705Alterations in homocysteine metabolism among alcohol dependent patients--clinical, pathobiochemical and genetic aspects. (2008 Jan)Lutz UCCurr Drug Abuse Rev
11398138Factors explaining the difference of total homocysteine between men and women in the European Investigation Into Cancer and Nutrition Potsdam study. (2001 Jun)Dierkes JMetabolism
12439143Genetic risk factors in young adults with 'cryptogenic' ischemic cerebrovascular disease. (2002 Oct)Grossmann RBlood Coagul Fibrinolysis
16191433Possible genetic damage in the Czech nuclear power plant workers. (2006 Jan 29)Sram RJMutat Res
19211287Coagulopathies frequency in aseptic osteonecrosis patients. (2009 Mar)Mehsen NJoint Bone Spine
19968891Lifestyle and genetic determinants of folate and vitamin B12 levels in a general adult population. (2010 Apr)Thuesen BHBr J Nutr
16234002Genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and risk of pancreatic cancer. (2005 Aug)Wang LClin Gastroenterol Hepatol
22707612Genetic risk factors for thrombosis in systemic lupus erythematosus. (2012 Aug)Kaiser RJ Rheumatol
21254359Folate pathway and nonsyndromic cleft lip and palate. (2011 Jan)Blanton SHBirth Defects Res A Clin Mol Teratol
21360915[Smoking enhances the decrease of adiponectin level in patients with coronary artery disease, carriers of MTHFR 677T and PON1 55M alleles]. (2010)Strauss EPrzegl Lek
18545917Cerebrovascular risk factors and MRI abnormalities in migraine. (2008 May)Rao RNeurol Sci
18662591Association of the polymorphisms of MTHFR C677T, VDR C352T, and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma. (2008 Aug)Li DArch Med Res
23183616Impact of methylenetetrahydrofolate reductase C677T polymorphism on the risk of gastric cancer and its interaction with Helicobacter pylori infection. (2012)Saberi SIran Biomed J
25634595Prevalence of hyperhomocysteinaemia and some of its major determinants in Shaanxi Province, China: a cross-sectional study. (2015 Feb 28)Liu XDBr J Nutr
26315791Risk Factors for Thrombosis Development in Mexican Patients. (2015 Nov)Zavala-Hernandez CAnn Vasc Surg
9543106C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. EARS group. (1998 Feb)Gudnason VAtherosclerosis
11953142[Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke]. (2002 Jan 25)Huang YZhonghua Yi Xue Za Zhi
15181872[Hyperhomocysteinemia and pregnancy complications]. (2004 Apr)Sztenc SGinekol Pol
12411076[Polymorphisms of methylenetetrahydrofolate reductase C677T and the risk of stomach cancer]. (2002 Aug)Gao CZhonghua Liu Xing Bing Xue Za Zhi
17687709The role of one-carbon metabolism in schizophrenia and depression. (2007 Jul-Aug)Frankenburg FRHarv Rev Psychiatry
22853296Association between gene expression of metabolizing enzymes and esophageal squamous cell carcinomas in China. (2012 Oct)Liu RGenet Test Mol Biomarkers
19650814Association between MTHFR 677C-T polymorphism and alcohol dependence according to Lesch and Babor typology. (2009 Sep)Benyamina AAddict Biol
15226189Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study. (2004 Nov 15)Frederiksen JBlood
16100725Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes. (2005 Sep 15)Shaw GMAm J Med Genet A
21790336Low-molecular-weight heparin in women with repeated implantation failure. (2011 Jul)Lodigiani CWomens Health (Lond)
20721969Polymorphisms of methylenetetrahydrofolate reductase are associated with a high risk of nasopharyngeal carcinoma in a smoking population from Southern China. (2010 Nov)Cao YMol Carcinog
20213658Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with sudden sensorineural hearing loss. (2010 Apr)Uchida YLaryngoscope
19634497Gene-gene interaction affects coronary artery disease risk. (2009 Apr)Mendonca MIRev Port Cardiol
28436623MTHFR methylation moderates the impact of smoking on DNA methylation at AHRR for African American young adults. (2017 Sep)Beach SRHAm J Med Genet B Neuropsychiatr Genet
12364720Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. (2002 Oct)McIlroy SPStroke
23337712Retinal vein occlusion: genetic predisposition and systemic risk factors. (2013 Apr)Giannaki KBlood Coagul Fibrinolysis
29526315Identification of genetic risk factors associated with ischaemic stroke in young Mexican patients. (2018 Mar 8)Jimenez-Gonzalez MCNeurologia
17146542[Stroke: epidemiology, risk factors, and genetics]. (2006 Nov)Khaw AVHamostaseologie
28381531Ratios of One-Carbon Metabolites Are Functional Markers of B-Vitamin Status in a Norwegian Coronary Angiography Screening Cohort. (2017 Jun)Ulvik AJ Nutr
21597034The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. (2011 Jun)Ye XPsychosom Med
19837268Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population. (2009 Nov)Rouissi KCancer Genet Cytogenet
10359544Colorectal cancer: molecules and populations. (1999 Jun 2)Potter JDJ Natl Cancer Inst
11279635Racial variation in fasting and random homocysteine levels. (2001 Apr)Estrada DAAm J Hematol
10323785Determinants of fasting and post-methionine homocysteine levels in families predisposed to hyperhomocysteinemia and premature vascular disease. (1999 May)de Jong SCArterioscler Thromb Vasc Biol
20447924Plasma folate, related genetic variants, and colorectal cancer risk in EPIC. (2010 May)Eussen SJCancer Epidemiol Biomarkers Prev
15790587Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan. (2005 Jul)Yang CXCarcinogenesis
25702197Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: results from the German Investigation on Neurobiology in Alcoholism (GINA). (2015 Mar)Semmler AAlcohol
15581963The effect of methylenetetrahydrofolate reductase polymorphism C677T on cervical cancer in Korean women. (2004 Dec)Sull JWGynecol Oncol
15136061The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine. (2004 Jun)Brown KSAtherosclerosis
11309278Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population. (2001 Apr 15)Song CCancer Res
29444504The SNP Rs915014 in MTHFR Regulated by MiRNA Associates with Atherosclerosis. (2018)Liu XCell Physiol Biochem
15950563Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes. (2005 Jun 15)Mager AAm J Cardiol
9067278Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. (1997 Mar 15)Ma JCancer Res
19917450Significant association between methylenetetrahydrofolate reductase 677T allele and hyperuricemia among adult Japanese subjects. (2009 Oct)Itou SNutr Res
20944139Significant association of methylenetetrahydrofolate reductase single nucleotide polymorphisms with prostate cancer susceptibility in taiwan. (2010 Sep)Wu HCAnticancer Res
20977771Association of methylenetetrahydrofolate reductase C677T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. (2010 Oct 27)Zhang LLipids Health Dis
20003837The effect of MTHFR c.677C>T on plasma homocysteine levels depends on health, age and smoking. (2009 Dec 1)Semmler AClin Invest Med
16521945[The different genotypes of MTHFR 1298A>C and PON1 -108C>T polymorphisms confer the increased risk of the abdominal aortic aneurysm in the smoking and nonsmoking persons]. (2005)Strauss EPrzegl Lek
16274479Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes. (2005 Nov 7)Pollex RLCardiovasc Diabetol
15886801Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage. Results of a multicentre case-control study. (2005 May)Krause MThromb Haemost
17174622Association of the methylenetetrahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women. (2007 Mar)Hong XBone
16700986[Relationship between methylenetrahydrofolate reductase gene and ischemic stroke]. (2006 May)Li CMZhongguo Wei Zhong Bing Ji Jiu Yi Xue
24278388One-carbon metabolism pathway gene variants and risk of clear cell renal cell carcinoma in a Chinese population. (2013)Zhang LPLoS One
22103680Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. (2011 Nov 21)Wernimont SMBMC Med Genet
15380460Associations of plasma homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism with carotid intima media thickness among South Asian, Chinese and European Canadians. (2004 Oct)Kelemen LEAtherosclerosis
10739378Inherited thrombophilia as a risk factor for the development of ischemic stroke in young adults. (2000 Feb)Voetsch BThromb Haemost
15905312Endothelial nitric oxide synthase -786T>C, but not 894G>T and 4a4b, polymorphism influences plasma homocysteine concentrations in persons with normal vitamin status. (2005 Jul)Fatini CClin Chem
24419225Folate deficiency is not associated with increased mitochondrial genomic instability: results from dietary intake and lymphocytic mtDNA 4977-bp deletion in healthy young women in Italy. (2014 Mar)Agodi AMutagenesis
16894468Assessment of genetic risk for myocardial infarction. (2006 Aug)Yamada YThromb Haemost
29722849An evidence-based approach to globally assess the covariate-dependent effect of the MTHFR single nucleotide polymorphism rs1801133 on blood homocysteine: a systematic review and meta-analysis. (2018 May 1)Jin HAm J Clin Nutr
25909872Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson's disease. (2015)Garcia SFolia Neuropathol
15688408Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis. (2005 May 20)Neumann ASInt J Cancer
17492607[Factors determining hyperhomocysteinemia in the chronic phase of strokes]. (2007 May 1-15)Carod-Artal FJRev Neurol
11520404Socio-economic disparities in preterm birth: causal pathways and mechanisms. (2001 Jul)Kramer MSPaediatr Perinat Epidemiol
21097530Influence of GSTM1, GSTT1, GSTP1, NAT1, NAT2, EPHX1, MTR and MTHFR polymorphism on chromosomal aberration frequencies in human lymphocytes. (2011 Mar)Skjelbred CFCarcinogenesis
11925474Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico. (2002 Apr)Weinstein SJJ Nutr
17683517The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics. (2008 Jan)Lao OAnn Hum Genet
26035704MTHFR C677T polymorphism interaction with heavy alcohol consumption increases head and neck carcinoma risk. (2015 Jun 2)Zhuo XSci Rep
12429870Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. (2002 Dec)De Bree APharmacol Rev
23285280A possible genetic link between MTHFR genotype and smoking behavior. (2012)Linnebank MPLoS One
19280995Human paraoxonase gene polymorphisms and coronary artery disease risk. (2008 Dec)Mendonca MIRev Port Cardiol
14727014Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin study. (2004 Aug)Bathum LOsteoporos Int
19565010Lack of association of methylenetetrahydrofolate reductase 677C>T mutation with coronary artery disease in a Pakistani population. (2005 Jul 28)Iqbal MPJ Mol Genet Med
11680544Prevalence of the methylenetetrahydrofolate reductase 677C > T mutation in the Mediterranean Spanish population. Association with cardiovascular risk factors. (2001)Guillen MEur J Epidemiol
12775885Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population. (2003 Jul)Inamoto NStroke
27087411Serum and red-blood-cell folate demonstrate differential associations with BMI in pregnant women. (2016 Oct)Shen MPublic Health Nutr
21597397Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification. (2011 Jul)Nagele PPharmacogenet Genomics
28765644Lipid levels and new-onset diabetes in a hypertensive population: the China Stroke Primary Prevention Trial. (2017 Aug 1)Li LSci Rep
21637473Association of homocysteine and methylene tetrahydrofolate reductase (MTHFR C677T) gene polymorphism with coronary artery disease (CAD) in the population of North India. (2010 Apr)Tripathi RGenet Mol Biol
16374229Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer: a nested case-control study. (2006 Feb)Van Guelpen BREur J Cancer Prev
18457169Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica. (2006 Mar)Salazar-Sanchez LRev Biol Trop
11059519Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer. (2000 Sep)Kiyohara CJ Epidemiol
15682292A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations. (2005 Apr)Kealey CHum Genet
23858518Association between MTHFR gene polymorphisms, smoking, and the incidence of vascular dementia. (2013 Jul)Jin PAsia Pac J Public Health
16217917Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: a population-based case-control study. (2005)Karagas MRInt J Hyg Environ Health
12975018[Interactions between lifestyle, methylanetetrahydrofolate reductase gene and polymorphisms in thymidylate synthase gene with risk of stomach cancer]. (2003 Jul)Gao CMZhonghua Liu Xing Bing Xue Za Zhi
26728177Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents. (2016 Apr)Nilsson TKFASEB J
24535271Polymorphisms of methylenetetrahydrofolate reductase and glutathione S-transferase are not associated with the risk of papillary thyroid cancer in Korean population. (2014 Jun)Kweon SSMol Biol Rep
16760910Renal vascular sclerosis is associated with inherited thrombophilias. (2006 Aug)Goforth RLKidney Int
11302003Plasma homocysteine and microvascular complications in type 1 diabetes. (2000 Dec)Vaccaro ONutr Metab Cardiovasc Dis
23032828Thrombophilic molecular markers in young patients (<40 years) with coronary artery disease. (2012 Jul-Sep)Sherpa MIndian J Pathol Microbiol
9051203A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction. (1997 Jan 3)Brugada RAtherosclerosis
21812773Migraine with binocular blindness: a clinic-based study. (2011 Nov-Dec)Rozen TDHeadache
17934972Associations of methylenetetrahydrofolate reductase C677T polymorphism with markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study. (2008)Collings AScand J Clin Lab Invest
15025678Correlates of total homocysteine plasma concentration in type 2 diabetes. (2004 Mar)Russo GTEur J Clin Invest
17468511Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study. (2007 Aug)Suzuki TCarcinogenesis
26650456Hyperhomocysteinemia-induced upper extremity deep vein thrombosis and pulmonary embolism in a patient with methyltetrahydrofolate reductase mutation: a case report and literature review. (2016 Sep)Gao LBlood Coagul Fibrinolysis
19654594Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study. (2009 Oct)Husemoen LLEur J Clin Nutr
17418242Chromosomal aberrations in environmentally exposed population in relation to metabolic and DNA repair genes polymorphisms. (2007 Jul 1)Sram RJMutat Res
16702348The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. (2006 Jun)Refsum HJ Nutr
12747593Genetic variations observed in arterial and venous thromboembolism--relevance for therapy, risk prevention and prognosis. (2003 Apr)Harrington DJClin Chem Lab Med
29678854The Relationship of Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Ischemic Stroke in Chinese Han Population. (2018 Mar)Mao XAnn Clin Lab Sci
23363719[Association between gene polymorphisms of methylenetetrahydrofolate reductase and plasma homocysteine in Uygur patients with venous thromboembolism]. (2012 Dec)Abudureheman KZhonghua Xin Xue Guan Bing Za Zhi
17283302Cardiovascular fitness is negatively associated with homocysteine levels in female adolescents. (2007 Feb)Ruiz JRArch Pediatr Adolesc Med
14639706Cleft palate, transforming growth factor alpha gene variants, and maternal exposures: assessing gene-environment interactions in case-parent triads. (2003 Dec)Jugessur AGenet Epidemiol
12716294Methionine Synthase Reductase Gene A66G Polymorphism is Associated with Risk of Colorectal Cancer. (2002)Matsuo KAsian Pac J Cancer Prev
15093278Cytogenetic biomarkers and genetic polymorphisms. (2004 Apr 1)Norppa HToxicol Lett
19079989[Correlation of aberrant methylation of MGMT gene to MTHFR C677T genetic polymorphisms in esophageal squamous cell carcinoma]. (2008 Dec)Xue HCAi Zheng
29745998MTHFR regulatory effects on methylation of CG05575921 in response to smoking: Effects are also discernable using MTHFR expression. (2018 May 10)Beach SRHAm J Med Genet B Neuropsychiatr Genet
159419585,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer. (2005 Jun)Li DCancer Epidemiol Biomarkers Prev
15941959Sex differences in risk of lung cancer associated with methylene-tetrahydrofolate reductase polymorphisms. (2005 Jun)Shi QCancer Epidemiol Biomarkers Prev
14734201Methylenetetrahydrofolate reductase (MTHFR) c677t gene variant modulates the homocysteine folate correlation in a mild folate-deficient population. (2004 Feb)Pereira ACClin Chim Acta
15671130Treatment of depression: time to consider folic acid and vitamin B12. (2005 Jan)Coppen AJ Psychopharmacol
18176672Thrombophilia in young patients with acute myocardial infarction. (2008 Jan)Celik MSaudi Med J
19403988Smoking confers a MTHFR 677C>T genotype-dependent risk for systemic atherosclerosis: results from a large number of elderly autopsy cases that died in a community-based general geriatric hospital. (2009 Apr)Sawabe MJ Atheroscler Thromb
10928104Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia. (2000 May-Jun)Piyathilake CJAnticancer Res
18826096[Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of laryngeal squamous cell carcinoma]. (2008 Jun)Ni XZhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
15952646[Study on the relationship between methylene tetrahydrofolate reductase gene (677C-->T) mutation and skin lesions in endemic arsenic poisoning]. (2005 Mar)Chen LWei Sheng Yan Jiu
22578003Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort. (2012 Jul)Lykke JAJ Thromb Haemost
12690011Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas. (2003 Feb)Marugame TInt J Epidemiol
12774202Emerging risk factors for ischemic stroke. (2003 May)Abbate RNeurol Sci
17505678Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease. (2007 Jan 4)Guerzoni ARSao Paulo Med J
28004270Determinants of folate and vitamin B12 plasma levels in the French E3N-EPIC cohort. (2018 Mar)de Batlle JEur J Nutr
19083485Association of homocysteinemia with high concentrations of serum insulin and uric acid in Brazilian subjects with metabolic syndrome genotyped for C677T polymorphism in the methylenetetrahydrofolate reductase gene. (2008 Nov)Uehara SKNutr Res
15726099Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer. (2005 Mar 14)Pufulete MBr J Cancer
27322299Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility. (2016 Jun 17)Fan SInt J Environ Res Public Health
16968465Homocysteine, traditional risk factors and impaired renal function in coronary artery disease. (2006 Oct)Pizzolo FEur J Clin Invest
17596206One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study. (2007 Sep)Suzuki TCancer Sci
20544798Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. (2010 Aug)Summers CMBirth Defects Res A Clin Mol Teratol
23372658Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer. (2013)Swartz MDPLoS One
25007516[Analysis of the effect of N5, N10-methylenetetrahydrofolate reductase gene C(677)-->T polymorphism on the ischemic stroke development in persons with various risk factors]. (2014)Harbuzova VIuFiziol Zh
20065615Association of C677T polymorphism in MTHFR gene, high homocysteine and low HDL cholesterol plasma values in heterozygous familial hypercholesterolemia. (2009)Real JTJ Atheroscler Thromb
24613192Association between seven single nucleotide polymorphisms involved in inflammation and proteolysis and abdominal aortic aneurysm. (2015 May)Saratzis AJ Vasc Surg
24648965Meta-analysis on MTHFR polymorphism and lung cancer susceptibility in East Asian populations. (2013 May)Zhang XDBiomed Rep
22479380Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. (2012)McKay JAPLoS One
15179108Fibrate treatment and prevalence risk of mild hyperhomocysteinaemia in clinical coronary heart disease patients. (2004 Jun)Mayer O JrEur J Cardiovasc Prev Rehabil
22399526High circulating folate and vitamin B-12 concentrations in women during pregnancy are associated with increased prevalence of atopic dermatitis in their offspring. (2012 Apr)Kiefte-de Jong JCJ Nutr
22370993Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics. (2012 Apr)Ellingrod VLJ Clin Psychopharmacol
20504332Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population. (2010 May 26)Cui LHBMC Cancer
26670299Genetic risk factors for spontaneous intracerebral haemorrhage. (2016 Jan)Carpenter AMNat Rev Neurol
22292644Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer. (2011)Zhao PAsian Pac J Cancer Prev