Gene: MTIF2

4528
-
mitochondrial translational initiation factor 2
protein-coding
2p16.1
Ensembl:ENSG00000085760 MIM:603766 Vega:OTTHUMG00000129338 UniprotKB:P46199
NG_047062.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.669e-1 (AD)  5.859e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02877657chr2:55493212MTIF2Promoter6.877e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF140.906
ARMCX30.904
PAFAH1B20.899
ZFP900.896
BNIP3L0.894
STX70.893
API50.892
VAPB0.891
RNF1460.891
SERINC10.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.652
OR4F5-0.638
MTRNR2L10-0.274
MTRNR2L6-0.269
C8orf74-0.259
MTRNR2L9-0.253
C6orf223-0.25
ZBTB20-0.248
WNT7B-0.233
SOD3-0.23

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MTIF2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MTIF2 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of MTIF2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of MTIF2 mRNA17562736
D001151ArsenicArsenic affects the methylation of MTIF2 gene25304211
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of MTIF2 mRNA25412620
C044887beta-methylcholinebeta-methylcholine affects the expression of MTIF2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MTIF2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MTIF2 mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of MTIF2 mRNA25181051
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MTIF2 mRNA23650126
D002994ClofibrateClofibrate results in increased expression of MTIF2 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of MTIF2 mRNA19549813
C000944dicrotophosdicrotophos results in decreased expression of MTIF2 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of MTIF2 mRNA25016146
D018120FinasterideFinasteride results in increased expression of MTIF2 mRNA24136188
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of MTIF2 mRNA25412620
D005485FlutamideFlutamide results in increased expression of MTIF2 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MTIF2 mRNA20044591
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MTIF2 mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MTIF2 mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of MTIF2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MTIF2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MTIF2 mRNA"25554681
D009538NicotineNicotine results in increased expression of MTIF2 mRNA16949557
D010634PhenobarbitalPhenobarbital affects the expression of MTIF2 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of MTIF2 mRNA18445702
D011794QuercetinQuercetin results in decreased expression of MTIF2 mRNA21632981
D012715Sesame OilSesame Oil results in increased expression of MTIF2 mRNA29191790
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MTIF2 mRNA21354282
C012589trichostatin Atrichostatin A affects the expression of MTIF2 mRNA28542535

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003743translation initiation factor activity-IEA-  
GO:0003924GTPase activity-IEA-  
GO:0005525GTP binding-IEA-  
GO:0008135translation factor activity, RNA binding-ISS-  
GO:0043024ribosomal small subunit binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006446regulation of translational initiation-TAS7829522  
GO:0032790ribosome disassembly-ISS-  
GO:0070124mitochondrial translational initiation-IBA21873635  
GO:0070124mitochondrial translational initiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrion-TAS12095986  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5368286Mitochondrial translation initiationIEA
R-HSA-5368287Mitochondrial translationIEA
R-HSA-72766TranslationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24166409Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. (2014 Jan)Gelernter JMol Psychiatry