Gene: ND2

4536
MTND2
MTND2
protein-coding
-
Ensembl:ENSG00000198763 MIM:516001 UniprotKB:P03891
NC_011137.1
PubMed
0   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of ND2 mRNA"21856379
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in decreased expression of ND2 mRNA]"11756511
C0059753,4-dihydroxyphenylethanol"3,4-dihydroxyphenylethanol inhibits the reaction [sodium arsenite results in decreased expression of ND2 mRNA]"28225195
C104223aluminum lactatealuminum lactate results in decreased expression of ND2 mRNA24084166|2649315
C104223aluminum lactateQuercetin inhibits the reaction [aluminum lactate results in decreased expression of ND2 mRNA]26493151
D001280AtrazineAtrazine results in decreased expression of ND2 mRNA22378314|2711463
D001280AtrazineAtrazine results in decreased expression of ND2 mRNA27114639
C004456beauvericinbeauvericin results in decreased expression of ND2 mRNA29203277
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ND2 mRNA28651000
C006780bisphenol Abisphenol A affects the expression of ND2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ND2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ND2 mRNA28628672
D002104CadmiumCadmium affects the expression of ND2 mRNA18522720
D019256Cadmium ChlorideCadmium Chloride affects the expression of ND2 mRNA18409656
D002235Carbofuran[Lindane co-treated with metolachlor co-treated with Carbofuran] results in decreased expression of ND2 mRNA21075942
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ND2 mRNA15963578
D002392CatechinCatechin affects the expression of ND2 mRNA26363153
D002392CatechinCatechin affects the reaction [Quercetin affects the expression of ND2 mRNA]26363153
D002392CatechinQuercetin affects the reaction [Catechin affects the expression of ND2 mRNA]26363153
D019327Copper SulfateCopper Sulfate results in increased expression of ND2 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of ND2 mRNA19406218
C057862cyanoginosin LRcyanoginosin LR affects the expression of ND2 mRNA20957730
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ND2 mRNA28628672
D064730DexrazoxaneDexrazoxane results in increased expression of ND2 mRNA26873546
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of ND2 mRNA18313992
D004026DieldrinDieldrin results in decreased expression of ND2 mRNA23041725
D000069462Dimethyl FumarateDimethyl Fumarate results in increased expression of ND2 mRNA27277809
D000069462Dimethyl FumarateNFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA]27277809
C007738fluoranthenefluoranthene results in decreased expression of ND2 mRNA18522720
D005485FlutamideFlutamide results in decreased expression of ND2 mRNA19442681
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ND2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ND2 mRNA28628672
D001556Lindane[Lindane co-treated with metolachlor co-treated with Carbofuran] results in decreased expression of ND2 mRNA21075942
D008694Methamphetamine"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in decreased expression of ND2 mRNA]"11756511
D008694MethamphetamineMethamphetamine results in decreased expression of ND2 mRNA11756511
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of ND2 mRNA27544571
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ND2 mRNA24810058
C051786metolachlor[Lindane co-treated with metolachlor co-treated with Carbofuran] results in decreased expression of ND2 mRNA21075942
D015741MetriboloneMetribolone results in increased expression of ND2 mRNA17010196
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ND2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ND2 mRNA"27248475
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ND2 mRNA19616056|2851185
D010578PetroleumPetroleum affects the expression of ND2 mRNA25208076
C030984pyrenepyrene results in increased expression of ND2 mRNA15963578
D011794QuercetinCatechin affects the reaction [Quercetin affects the expression of ND2 mRNA]26363153
D011794QuercetinQuercetin affects the expression of ND2 mRNA26363153
D011794QuercetinQuercetin affects the reaction [Catechin affects the expression of ND2 mRNA]26363153
D011794QuercetinQuercetin inhibits the reaction [aluminum lactate results in decreased expression of ND2 mRNA]26493151
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ND2 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased mutagenesis of ND2 gene27908234
C017947sodium arsenite"3,4-dihydroxyphenylethanol inhibits the reaction [sodium arsenite results in decreased expression of ND2 mRNA]"28225195
C017947sodium arsenitesodium arsenite results in decreased expression of ND2 mRNA27425645|2822519
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ND2 mRNA15716485
D019284ThapsigarginThapsigargin results in decreased expression of ND2 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ND2 mRNA28065790
D014415TunicamycinTunicamycin results in decreased expression of ND2 mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of ND2 mRNA23179753|2800136
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of ND2 mRNA"25208076
D015215ZidovudineZidovudine results in increased expression of ND2 mRNA16894629
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of ND2 mRNA18313992
D015034Zinc OxideZinc Oxide analog results in decreased expression of ND2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008137NADH dehydrogenase (ubiquinone) activity-NAS3921850  9475751  
GO:0019901protein kinase binding-IEA-  
GO:0035255ionotropic glutamate receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006120mitochondrial electron transport, NADH to ubiquinone-NAS3921850  9475751  
GO:0032981mitochondrial respiratory chain complex I assembly-TAS-  
GO:0072593reactive oxygen species metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005747mitochondrial respiratory chain complex I-IDA12611891  
GO:0005747mitochondrial respiratory chain complex I-NAS3921850  9475751  
GO:0014069postsynaptic density-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-6799198Complex I biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16407369Mitochondrial DNA mutations in oral squamous cell carcinoma. (2006 May)Prior SLCarcinogenesis
29424826How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? (2018 Mar)McCarty CAOptom Vis Sci
15262184Association of a 5178C-->A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals. (2004 Aug)Takagi KAtherosclerosis
25031572NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study. (2014)Kokaze ATob Induc Dis
19494790Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. (2009 Jul)Sapag APharmacogenet Genomics