Gene: ND3

4537
MTND3
NADH dehydrogenase, subunit 3 (complex I)
protein-coding
-
Ensembl:ENSG00000198840 MIM:516002 UniprotKB:P03897
NC_011137.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of ND3 mRNA"21856379
C104223aluminum lactatealuminum lactate results in decreased expression of ND3 mRNA24084166|2649315
C104223aluminum lactateQuercetin inhibits the reaction [aluminum lactate results in decreased expression of ND3 mRNA]26493151
D001280AtrazineAtrazine results in decreased expression of ND3 mRNA22378314|2711463
D001280AtrazineAtrazine results in increased expression of ND3 mRNA27114639
C004456beauvericinbeauvericin results in decreased expression of ND3 mRNA29203277
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ND3 mRNA28651000
C006780bisphenol Abisphenol A affects the expression of ND3 mRNA21786754
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ND3 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ND3 mRNA18804290
D019327Copper SulfateCopper Sulfate results in increased expression of ND3 mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in increased expression of ND3 mRNA23342045
D003634DDTND3 protein results in increased susceptibility to DDT25742511
C017180decamethrinND3 protein results in increased susceptibility to decamethrin25742511
D004237DiuronDiuron results in decreased expression of ND3 mRNA21551480
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of ND3 mRNA24534155
C010974glyphosateglyphosate results in increased expression of ND3 mRNA26302742
C410337K 7174K 7174 results in decreased expression of ND3 mRNA24086573
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ND3 mRNA18804290
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ND3 mRNA20039754
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ND3 mRNA24810058
C047806monomethylpropionmonomethylpropion results in increased expression of ND3 mRNA22303338
D009151Mustard GasMustard Gas results in increased expression of ND3 mRNA12884408
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ND3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ND3 mRNA"25554681|2724847
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of ND3 mRNA"21673326
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ND3 mRNA23948077
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ND3 mRNA28511854
D011794QuercetinQuercetin inhibits the reaction [aluminum lactate results in decreased expression of ND3 mRNA]26493151
D012969Sodium FluorideSodium Fluoride results in increased expression of ND3 protein28918527
D019284ThapsigarginThapsigargin results in decreased expression of ND3 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ND3 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ND3 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of ND3 mRNA22378314

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16384638  
GO:0008137NADH dehydrogenase (ubiquinone) activity-IBA21873635  
GO:0008137NADH dehydrogenase (ubiquinone) activity-NAS3921850  
GO ID GO Term Qualifier Evidence PubMed
GO:0006120mitochondrial electron transport, NADH to ubiquinone-NAS3921850  
GO:0006979response to oxidative stress-IEA-  
GO:0009642response to light intensity-IEA-  
GO:0032981mitochondrial respiratory chain complex I assembly-TAS-  
GO:0071385cellular response to glucocorticoid stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005747mitochondrial respiratory chain complex I-IBA21873635  
GO:0005747mitochondrial respiratory chain complex I-IDA12611891  
GO:0005747mitochondrial respiratory chain complex I-NAS3921850  
GO:0016021integral component of membrane-IEA-  
GO:0030964NADH dehydrogenase complex-IBA21873635  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-6799198Complex I biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19494790Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. (2009 Jul)Sapag APharmacogenet Genomics