Gene: ND4

4538
MTND4
NADH dehydrogenase, subunit 4 (complex I)
protein-coding
-
Ensembl:ENSG00000198886 MIM:516003 UniprotKB:P03905
NC_011137.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of ND4 mRNA"21856379
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ND4 mRNA"19561079
D001151ArsenicArsenic results in increased expression of ND4 protein21514422
C006632arsenic trioxidearsenic trioxide results in increased expression of ND4 mRNA14703492
D001280AtrazineAtrazine results in decreased expression of ND4 mRNA22378314|2711463
D001280AtrazineAtrazine results in decreased expression of ND4 mRNA27114639
C004456beauvericinbeauvericin results in decreased expression of ND4 mRNA29203277
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ND4 mRNA28651000
D004958EstradiolEstradiol results in increased expression of ND4 mRNA28159858
C006780bisphenol Abisphenol A results in increased expression of ND4 mRNA27104808
C006780bisphenol Abisphenol A results in decreased expression of ND4 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ND4 mRNA23212613
D002235Carbofuran[Lindane co-treated with metolachlor co-treated with Carbofuran] affects the expression of ND4 mRNA21075942
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ND4 mRNA15963578
D003042CocaineCocaine results in increased expression of ND4 protein25100957
D003907Dexamethasone[Dexamethasone co-treated with INS protein] results in increased expression of ND4 mRNA11916924
D004996EthidiumEthidium results in decreased expression of ND4 mRNA22712077
D005047EtoposideEtoposide results in increased expression of ND4 mRNA26259609
C007738fluoranthenefluoranthene results in decreased expression of ND4 mRNA18522720
D005690GalactoseND4 protein affects the metabolism of Galactose8662757
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ND4 mRNA25613284
D001556Lindane[Lindane co-treated with metolachlor co-treated with Carbofuran] affects the expression of ND4 mRNA21075942
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ND4 mRNA21035857
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ND4 mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ND4 mRNA22776087
C051786metolachlor[Lindane co-treated with metolachlor co-treated with Carbofuran] affects the expression of ND4 mRNA21075942
D015741MetriboloneMetribolone affects the splicing of ND4 mRNA17010196
D015741MetriboloneMetribolone results in increased expression of ND4 mRNA17010196
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ND4 mRNA"25554681
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of ND4 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ND4 mRNA28511854
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ND4 mRNA26272509
C030984pyrenepyrene results in increased expression of ND4 mRNA15963578
C089730rosiglitazonerosiglitazone results in increased expression of ND4 mRNA11916924
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ND4 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of ND4 mRNA22378314
C009495titanium dioxidetitanium dioxide results in increased expression of ND4 mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ND4 mRNA28065790
D014415TunicamycinTunicamycin results in decreased expression of ND4 mRNA22378314
D014520UrethaneUrethane results in increased expression of ND4 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ND4 mRNA28001369
D002762CholecalciferolCholecalciferol results in decreased expression of ND4 mRNA10491287
D015215ZidovudineZidovudine affects the expression of ND4 mRNA20032539
D015215ZidovudineZidovudine results in increased expression of ND4 mRNA16894629

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003954NADH dehydrogenase activityCONTRIBUTES_TOIBA21873635  
GO:0008137NADH dehydrogenase (ubiquinone) activity-NAS3921850  
GO:0048039ubiquinone binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0006120mitochondrial electron transport, NADH to ubiquinone-NAS3921850  
GO:0007568aging-IEA-  
GO:0009060aerobic respiration-IBA21873635  
GO:0015990electron transport coupled proton transport-IBA21873635  
GO:0021549cerebellum development-IEA-  
GO:0032981mitochondrial respiratory chain complex I assembly-TAS-  
GO:0035094response to nicotine-IEA-  
GO:0045471response to ethanol-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005747mitochondrial respiratory chain complex I-IBA21873635  
GO:0005747mitochondrial respiratory chain complex I-IDA12611891  
GO:0005747mitochondrial respiratory chain complex I-NAS3921850  
GO:0016021integral component of membrane-IEA-  
GO:0045271respiratory chain complex I-IBA21873635  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-6799198Complex I biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25592585Mitochondrial variation and the risk of age-related macular degeneration across diverse populations. (2015)Restrepo NAPac Symp Biocomput
19494790Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. (2009 Jul)Sapag APharmacogenet Genomics