Gene: ND4L

4539
MTND4L
NADH dehydrogenase, subunit 4L (complex I)
protein-coding
-
Ensembl:ENSG00000212907 MIM:516004 UniprotKB:P03901
NC_011137.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of ND4L mRNA"21856379
D001280AtrazineAtrazine results in decreased expression of ND4L mRNA22378314|2711463
D001280AtrazineAtrazine results in increased expression of ND4L mRNA27114639
C004456beauvericinbeauvericin results in decreased expression of ND4L mRNA29203277
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ND4L mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ND4L mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of ND4L mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ND4L mRNA27858113
C006780bisphenol Abisphenol A results in decreased expression of ND4L mRNA25181051
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ND4L mRNA27858113
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ND4L mRNA26102036
D0156551-Methyl-4-phenylpyridiniumMTERF4 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of ND4L mRNA]26102036
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ND4L mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ND4L mRNA"25554681
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ND4L mRNA28511854
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ND4L mRNA15716485
D019284ThapsigarginThapsigargin results in decreased expression of ND4L mRNA22378314
D014415TunicamycinTunicamycin results in decreased expression of ND4L mRNA22378314
D014520UrethaneUrethane results in increased expression of ND4L mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008137NADH dehydrogenase (ubiquinone) activity-IBA21873635  
GO:0008137NADH dehydrogenase (ubiquinone) activity-NAS3921850  
GO ID GO Term Qualifier Evidence PubMed
GO:0006120mitochondrial electron transport, NADH to ubiquinone-NAS3921850  
GO ID GO Term Qualifier Evidence PubMed
GO:0005747mitochondrial respiratory chain complex I-IBA21873635  
GO:0005747mitochondrial respiratory chain complex I-NAS3921850  
GO:0016021integral component of membrane-IEA-  
GO:0030964NADH dehydrogenase complex-IBA21873635  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19494790Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. (2009 Jul)Sapag APharmacogenet Genomics