Gene: ND5

4540
MTND5
NADH dehydrogenase, subunit 5 (complex I)
protein-coding
-
Ensembl:ENSG00000198786 MIM:516005 UniprotKB:P03915
NC_011137.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB05382IodineSmall Molecule7553-56-2Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ND5 mRNA"21346803
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ND5 mRNA"19561079
C015001arsenitearsenite results in increased activity of ND5 protein28602540
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of ND5 mRNA"12909582
D001280AtrazineAtrazine results in decreased expression of ND5 mRNA22378314|2711463
D001280AtrazineAtrazine results in decreased expression of ND5 mRNA27114639
C004456beauvericinbeauvericin results in decreased expression of ND5 mRNA29203277
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of ND5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ND5 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ND5 mRNA28651000
D004958EstradiolEstradiol results in increased expression of ND5 mRNA28159858
C006780bisphenol Abisphenol A results in increased expression of ND5 mRNA28159858
C006780bisphenol Abisphenol A affects the expression of ND5 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ND5 mRNA28628672
D002235Carbofuran[Lindane co-treated with metolachlor co-treated with Carbofuran] affects the expression of ND5 mRNA21075942
C073341citraconic acidcitraconic acid results in increased expression of ND5 mRNA27277809
C073341citraconic acidNFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA]27277809
D003300CopperCopper affects the expression of ND5 mRNA23825565
D019327Copper SulfateCopper Sulfate results in increased expression of ND5 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of ND5 mRNA21072851
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ND5 mRNA28628672
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of ND5 mRNA17526437|1831399
D000069462Dimethyl FumarateDimethyl Fumarate results in increased expression of ND5 mRNA27277809
D000069462Dimethyl FumarateNFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA]27277809
D005054EugenolEugenol results in increased expression of ND5 mRNA21531020
D005485FlutamideFlutamide results in decreased expression of ND5 mRNA19442681
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ND5 mRNA28628672
C553340INX 08189INX 08189 results in decreased expression of ND5 mRNA27466212
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ND5 mRNA28628672
D001556Lindane[Lindane co-treated with metolachlor co-treated with Carbofuran] affects the expression of ND5 mRNA21075942
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ND5 mRNA24810058
C051786metolachlor[Lindane co-treated with metolachlor co-treated with Carbofuran] affects the expression of ND5 mRNA21075942
C051752nefazodonenefazodone results in decreased expression of ND5 mRNA27288927
D009532NickelNickel results in decreased expression of ND5 mRNA24084258
D009534NiclosamideNiclosamide results in increased expression of ND5 mRNA26452273
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ND5 mRNA28511854
D010634PhenobarbitalPhenobarbital results in decreased expression of ND5 mRNA21896655
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ND5 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ND5 mRNA15716485
D019284ThapsigarginThapsigargin results in decreased expression of ND5 mRNA22378314
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ND5 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of ND5 mRNA22378314
D015215ZidovudineZidovudine results in increased expression of ND5 mRNA16894629
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of ND5 mRNA17526437|1831399

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008137NADH dehydrogenase (ubiquinone) activity-NAS3921850  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0006120mitochondrial electron transport, NADH to ubiquinone-NAS3921850  
GO:0010243response to organonitrogen compound-IEA-  
GO:0032981mitochondrial respiratory chain complex I assembly-TAS-  
GO:0042542response to hydrogen peroxide-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005747mitochondrial respiratory chain complex I-IDA12611891  
GO:0005747mitochondrial respiratory chain complex I-NAS3921850  
GO:0016021integral component of membrane-IEA-  
GO:0043005neuron projection-IEA-  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05012Parkinson's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-6799198Complex I biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19494790Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. (2009 Jul)Sapag APharmacogenet Genomics