Gene info: ID 4543

Gene: MTNR1A

GENE ID: 4543

Synonyms: MEL-1A-R|MT1

Description: melatonin receptor 1A

Gene type: protein-coding

Location: 4q35.2

dbXrefs: Ensembl:ENSG00000168412 MIM:600665 Vega:OTTHUMG00000185575 UniprotKB:P48039

RefSeq: NC_000004.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.500e-1 (AD) 1.365e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CXorf51A	0.6
MRGPRX4	0.545
NEK8	0.466
ARSG	0.445
SP6	0.421
GOLGA8T	0.404
KLLN	0.395
INHBC	0.384
SLC16A6	0.378
PLK4	0.375

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HOMER3	-0.228
SLC22A6	-0.228
RLBP1	-0.21
RERGL	-0.21
KLRK1	-0.209
FOXD1	-0.207
NR0B1	-0.203
C1QTNF1	-0.199
EIF5AL1	-0.197
GVQW1	-0.196

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00980	Ramelteon	Small Molecule	196597-26-9	Approved\|Investigational	Target
DB01065	Melatonin	Small Molecule	73-31-4	Approved\|Nutraceutical	Target
DB02709	Resveratrol	Small Molecule	501-36-0	Approved\|Experimental\|Investigational	Target
DB06594	Agomelatine	Small Molecule	138112-76-2	Approved\|Investigational	Target
DB09071	Tasimelteon	Small Molecule	609799-22-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of MTNR1A mRNA"	26377693
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of MTNR1A mRNA	25088246
C114459	4-phenyl-2-propionamidotetraline	4-phenyl-2-propionamidotetraline binds to MTNR1A protein	22047556
D000073	Acenaphthenes	Acenaphthenes analog binds to MTNR1A protein	11063602
D000082	Acetaminophen	Acetaminophen affects the expression of MTNR1A mRNA	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MTNR1A mRNA	16483693
C006780	bisphenol A	bisphenol A results in decreased expression of MTNR1A mRNA	25181051
D001786	Blood Glucose	MTNR1A gene mutant form affects the abundance of Blood Glucose	26824606
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MTNR1A mRNA	12160620
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MTNR1A mRNA	23741332
D012721	Carbaryl	Carbaryl binds to MTNR1A protein	28027439
D012721	Carbaryl	Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]	28027439
D002235	Carbofuran	Carbofuran binds to MTNR1A protein	28027439
D002235	Carbofuran	Carbofuran inhibits the reaction [Melatonin binds to MTNR1A protein]	28027439
D002713	Chlorine	Chlorine results in decreased expression of MTNR1A mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] results in increased expression of MTNR1A mRNA	18636392
C007054	chrysoeriol	chrysoeriol binds to MTNR1A protein	20399199
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of MTNR1A mRNA	28962523
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of MTNR1A mRNA	26924002
D000431	Ethanol	[Ethanol co-treated with Melatonin] results in increased expression of MTNR1A protein	23591044
D004397	Fonofos	Fonofos results in increased methylation of MTNR1A promoter	22847954
C039281	furan	furan results in increased expression of MTNR1A mRNA	24183702
C000625835	HFPO2 compound	HFPO2 compound results in increased expression of MTNR1A mRNA	27553808
C000625836	HFPO4 compound	HFPO4 compound results in increased expression of MTNR1A mRNA	27553808
C057154	luzindole	luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein]	28238930
D008550	Melatonin	Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]	28027439
D008550	Melatonin	Carbofuran inhibits the reaction [Melatonin binds to MTNR1A protein]	28027439
D008550	Melatonin	Melatonin analog binds to MTNR1A protein	17645693
D008550	Melatonin	Melatonin binds to MTNR1A protein	11063602\|1764569
D008550	Melatonin	[Ethanol co-treated with Melatonin] results in increased expression of MTNR1A protein	23591044
D008550	Melatonin	luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein]	28238930
D008550	Melatonin	Melatonin results in increased expression of MTNR1A protein	23591044\|2823893
D008550	Melatonin	Melatonin binds to MTNR1A protein	17762829\|2682460
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of MTNR1A mRNA	26924002
C561057	N-(2-(2-ethyl-8,9-dihydrofuro(3,2-c)pyrazolo(1,5-a)pyridin-1-yl)ethyl)acetamide	"N-(2-(2-ethyl-8,9-dihydrofuro(3,2-c)pyrazolo(1,5-a)pyridin-1-yl)ethyl)acetamide binds to MTNR1A protein"	21568291
C550454	N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide	"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide binds to MTNR1A protein"	20399199
D010126	Ozone	[Ozone co-treated with Chlorine] results in increased expression of MTNR1A mRNA	18636392
D010278	Parathion	Parathion results in increased methylation of MTNR1A promoter	22847954
D043803	Phenalenes	Phenalenes analog binds to MTNR1A protein	11063602
D010634	Phenobarbital	Phenobarbital affects the expression of MTNR1A mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of MTNR1A mRNA	19270015
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MTNR1A mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of MTNR1A mRNA	18301758
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of MTNR1A mRNA	24780913
C495910	ramelteon	ramelteon binds to MTNR1A protein	21473625\|2156829
C059514	resveratrol	resveratrol binds to MTNR1A protein	20399199
C084711	S 20098	S 20098 analog binds to and results in increased activity of MTNR1A protein	22301214
C084711	S 20098	S 20098 binds to MTNR1A protein	11063602\|2230121
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of MTNR1A mRNA	18175754
C012568	terbufos	terbufos results in increased methylation of MTNR1A promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MTNR1A mRNA	28922406
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of MTNR1A mRNA	25975270
D014241	Trichloroethylene	Trichloroethylene results in increased expression of MTNR1A mRNA	25549359
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of MTNR1A gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	20859254
GO:0042562	hormone binding	-	IPI	10531408
GO:0097159	organic cyclic compound binding	-	IPI	10531408

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	TAS	9645677
GO:0007617	mating behavior	-	TAS	7946354
GO:0007623	circadian rhythm	-	IBA	21873635
GO:0007623	circadian rhythm	-	TAS	9645677

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IDA	10531408
GO:0043235	receptor complex	-	IDA	10531408

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22820272	Diurnal variation in nicotine sensitivity in mice: role of genetic background and melatonin. (2012 Nov)	Mexal S	Neuropharmacology
25806809	Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development. (2015)	Lin FY	PLoS One