Gene info: ID 4544

Gene: MTNR1B

GENE ID: 4544

Synonyms: FGQTL2|MEL-1B-R|MT2

Description: melatonin receptor 1B

Gene type: protein-coding

Location: 11q14.3

dbXrefs: Ensembl:ENSG00000134640 MIM:600804 Vega:OTTHUMG00000167364 UniprotKB:P49286

RefSeq: NG_028160.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.376e-1 (AD) 3.080e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C6orf141	0.607
ANKRD63	0.585
RGS8	0.564
HTR4	0.546
MCOLN3	0.535
GPR88	0.52
FAT2	0.518
CACNA1H	0.518
MAN1A1	0.515
STAC	0.513

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASCL1	-0.313
CDKN2C	-0.31
RNF182	-0.306
ALDH1A1	-0.294
LPAR3	-0.28
GLI1	-0.279
PADI2	-0.265
ARHGEF16	-0.262
ACSS3	-0.259
NFIA	-0.259

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00980	Ramelteon	Small Molecule	196597-26-9	Approved\|Investigational	Target
DB01065	Melatonin	Small Molecule	73-31-4	Approved\|Nutraceutical	Target
DB02709	Resveratrol	Small Molecule	501-36-0	Approved\|Experimental\|Investigational	Target
DB06594	Agomelatine	Small Molecule	138112-76-2	Approved\|Investigational	Target
DB09071	Tasimelteon	Small Molecule	609799-22-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of MTNR1B mRNA"	18648102
C114459	4-phenyl-2-propionamidotetraline	4-phenyl-2-propionamidotetraline binds to MTNR1B protein	22047556
C114459	4-phenyl-2-propionamidotetraline	4-phenyl-2-propionamidotetraline binds to and results in decreased activity of MTNR1B protein	21473625
C114459	4-phenyl-2-propionamidotetraline	4-phenyl-2-propionamidotetraline binds to and results in decreased activity of MTNR1B protein	14521627
D000073	Acenaphthenes	Acenaphthenes analog binds to MTNR1B protein	11063602
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MTNR1B mRNA	16483693
D001786	Blood Glucose	MTNR1B gene mutant form affects the abundance of Blood Glucose	26824606
D012721	Carbaryl	Carbaryl binds to MTNR1B protein	28027439
D012721	Carbaryl	Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]	28027439
D012721	Carbaryl	Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]	28027439
D002235	Carbofuran	Carbofuran binds to MTNR1B protein	28027439
D002235	Carbofuran	Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]	28027439
D002235	Carbofuran	Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]]	28027439
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MTNR1B mRNA	12734012
C007054	chrysoeriol	chrysoeriol binds to MTNR1B protein	20399199
D016572	Cyclosporine	Cyclosporine results in decreased methylation of MTNR1B promoter	27989131
D005419	Flavonoids	Flavonoids results in increased expression of MTNR1B mRNA	18035473
D006160	Guanosine Triphosphate	Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]	28027439
D006160	Guanosine Triphosphate	Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]]	28027439
C057154	luzindole	luzindole binds to and results in decreased activity of MTNR1B protein	11270484\|2147362
C057154	luzindole	[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin	11270484
C057154	luzindole	luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]	28238930
D008550	Melatonin	Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]	28027439
D008550	Melatonin	Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]	28027439
D008550	Melatonin	Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]	28027439
D008550	Melatonin	Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]]	28027439
D008550	Melatonin	Melatonin analog binds to MTNR1B protein	17645693
D008550	Melatonin	Melatonin binds to MTNR1B protein	11063602\|1764569
D008550	Melatonin	MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]	26283214
D008550	Melatonin	[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin	11270484
D008550	Melatonin	Melatonin binds to MTNR1B protein	16030176
D008550	Melatonin	luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]	28238930
D008550	Melatonin	Melatonin results in increased expression of MTNR1B protein	28238930
D008550	Melatonin	Melatonin binds to MTNR1B protein	17762829\|2682460
D008694	Methamphetamine	MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]	26283214
D008727	Methotrexate	Methotrexate results in increased expression of MTNR1B mRNA	24449571
C561057	N-(2-(2-ethyl-8,9-dihydrofuro(3,2-c)pyrazolo(1,5-a)pyridin-1-yl)ethyl)acetamide	"N-(2-(2-ethyl-8,9-dihydrofuro(3,2-c)pyrazolo(1,5-a)pyridin-1-yl)ethyl)acetamide binds to MTNR1B protein"	21568291
C550454	N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide	"N-(2-(2-methoxy-6H-dipyrido(2,3-a-3,2-e)pyrrolizin-11-yl)ethyl)-2-furamide binds to MTNR1B protein"	20399199
C559869	N-(2-(7-(cyclohexylmethyl)-1,6-dihydro-2H-indeno(5,4-b)furan-8-yl)ethyl)acetamide	"N-(2-(7-(cyclohexylmethyl)-1,6-dihydro-2H-indeno(5,4-b)furan-8-yl)ethyl)acetamide binds to and results in increased activity of MTNR1B protein"	21473625
D010575	Pesticides	Pesticides results in decreased methylation of MTNR1B gene	28396702
D043803	Phenalenes	Phenalenes analog binds to MTNR1B protein	11063602
C495910	ramelteon	ramelteon binds to MTNR1B protein	21473625\|2156829
C059514	resveratrol	resveratrol binds to MTNR1B protein	20399199
C084711	S 20098	S 20098 analog binds to and results in increased activity of MTNR1B protein	22301214
C084711	S 20098	S 20098 binds to MTNR1B protein	11063602\|2230121
D013739	Testosterone	MTNR1B gene polymorphism affects the abundance of Testosterone	20207350
D014635	Valproic Acid	Valproic Acid results in decreased methylation of MTNR1B gene	29154799

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004930	G-protein coupled receptor activity	-	TAS	7568007
GO:0005515	protein binding	-	IPI	20859254 26514267 28827538
GO:0008502	melatonin receptor activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	TAS	7568007
GO:0007268	chemical synaptic transmission	-	TAS	7568007
GO:0042593	glucose homeostasis	-	IMP	20668700
GO:0050796	regulation of insulin secretion	-	IMP	20668700

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	7568007

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29452776	Women-specific risk factors for heart failure: A genetic approach. (2018 Mar)	van der Kemp J	Maturitas
22820272	Diurnal variation in nicotine sensitivity in mice: role of genetic background and melatonin. (2012 Nov)	Mexal S	Neuropharmacology
26927145	Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China. (2016 Feb 26)	Gao K	Int J Environ Res Public Health