Gene: MTTP

4547
ABL|MTP
microsomal triglyceride transfer protein
protein-coding
4q23
Ensembl:ENSG00000138823 MIM:157147 Vega:OTTHUMG00000131023 UniprotKB:P55157
NG_011469.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.486e-1 (AD)  4.556e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LYPLAL10.631
FAM227B0.62
LACTB20.617
APH1B0.614
NEK10.607
PEX70.605
ZMYND120.604
DUS4L0.6
ATP5S0.593
RMI10.593

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPPIN-0.324
MTRNR2L6-0.321
RNF223-0.319
MTRNR2L9-0.311
MTRNR2L10-0.303
CETP-0.294
MTRNR2L2-0.281
FCER2-0.267
RERGL-0.263
TG-0.263

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01094HesperetinSmall Molecule520-33-2ApprovedTarget
DB04852ImplitapideSmall Molecule177469-96-4InvestigationalTarget
DB08827LomitapideSmall Molecule182431-12-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4901661-(4-methoxyphenyl)piperazine1-(4-methoxyphenyl)piperazine results in decreased expression of MTTP mRNA26821219
C11912918alpha-glycyrrhetinic acid18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA]28549656
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MTTP mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of MTTP mRNA"28973532
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MTTP mRNA"18648102
C0415944-nonylphenol4-nonylphenol results in decreased expression of MTTP mRNA17912697
D000082AcetaminophenAcetaminophen results in decreased expression of MTTP mRNA21420995|2223033
D020106AcrylamideAcrylamide results in decreased expression of MTTP mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MTTP protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MTTP mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MTTP gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MTTP mRNA19770486
C103303alitretinoinalitretinoin results in increased expression of MTTP mRNA15537571
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MTTP mRNA21298039
D000638AmiodaroneAmiodarone results in decreased expression of MTTP mRNA27089845
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MTTP mRNA24449571
D001241AspirinAspirin results in decreased expression of MTTP mRNA27089845
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of MTTP mRNA10357840
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of MTTP mRNA12056585
D000069059Atorvastatin CalciumMevalonic Acid inhibits the reaction [Atorvastatin Calcium results in increased expression of MTTP mRNA]12056585
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MTTP mRNA21632981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of MTTP mRNA"26238291
D001599BerberineBerberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein]25455889
D004958EstradiolEstradiol results in decreased expression of MTTP mRNA20106945
D001629BezafibrateBezafibrate results in decreased expression of MTTP mRNA19124612
D001629BezafibrateBezafibrate results in increased expression of MTTP mRNA19124612
D001629BezafibratePPARA protein affects the susceptibility to [Bezafibrate results in increased expression of MTTP mRNA]19124612
C006780bisphenol Abisphenol A results in decreased expression of MTTP mRNA17912697
C006780bisphenol Abisphenol A results in increased expression of MTTP mRNA28483554
C006780bisphenol Abisphenol A results in decreased expression of MTTP mRNA28500084
C006780bisphenol Abisphenol A results in increased expression of MTTP mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of MTTP mRNA25181051
D002065BuspironeBuspirone results in decreased expression of MTTP mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MTTP mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MTTP mRNA26352046
D000074262Canola OilCanola Oil results in increased expression of MTTP mRNA16631440
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased activity of MTTP protein17405876
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased degradation of MTTP protein17405876
D002331CarnitineCarnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA]18299183
D002791Cholesterol, Dietary"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of MTTP mRNA"19509184
D002794Choline"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of MTTP mRNA"28973532
D002794Choline[Choline deficiency co-treated with Methionine deficiency] results in decreased expression of MTTP mRNA25178843
D002794CholineCholine deficiency results in decreased expression of MTTP mRNA25178843
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MTTP mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of MTTP mRNA28973532
D002994ClofibrateClofibrate results in decreased expression of MTTP mRNA27089845
D002994ClofibrateClofibrate results in increased expression of MTTP mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of MTTP mRNA24386269
D003300Copper[Fructose co-treated with Copper deficiency] results in decreased expression of MTTP mRNA25813056
D019327Copper SulfateCopper Sulfate results in decreased expression of MTTP mRNA19549813
C057862cyanoginosin LRcyanoginosin LR affects the expression of MTTP protein26984711
D016572CyclosporineCyclosporine affects the expression of MTTP mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of MTTP mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of MTTP mRNA21163907
D016572CyclosporineCyclosporine results in decreased expression of MTTP mRNA19770486
C089595cylindrospermopsincylindrospermopsin results in decreased expression of MTTP mRNA24921660
D003609DactinomycinDactinomycin inhibits the reaction [pirinixic acid results in increased expression of MTTP mRNA]15537571
D003840Deoxycholic AcidDeoxycholic Acid results in decreased expression of MTTP mRNA27089845
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MTTP mRNA16835292
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MTTP mRNA17361019
D002945CisplatinCisplatin results in increased expression of MTTP protein22023808
C000944dicrotophosdicrotophos results in decreased expression of MTTP mRNA28302478
D018119StavudineCarnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA]18299183
D018119StavudineStavudine results in decreased expression of MTTP mRNA18299183
D004041Dietary Fats"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of MTTP mRNA"19509184
D004041Dietary Fats[Dietary Fats co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MTTP mRNA27713108
D004041Dietary FatsDietary Fats results in decreased expression of MTTP mRNA28673684
D004041Dietary FatsDietary Fats results in increased expression of MTTP mRNA16357043
D004041Dietary Fats[Dietary Fats co-treated with Ethanol] results in decreased expression of MTTP mRNA24275070
D004041Dietary FatsDietary Fats results in decreased expression of MTTP mRNA24275070
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of MTTP mRNA21354252
C118739entinostatentinostat results in decreased expression of MTTP mRNA27188386
D004917Erythromycin[Penicillin G co-treated with Erythromycin] results in increased expression of MTTP mRNA27503388
D000431EthanolBerberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein]25455889
D000431Ethanol[Ethanol co-treated with Zinc] results in increased expression of MTTP mRNA19637192
D000431EthanolEthanol results in decreased expression of MTTP protein25455889
D000431Ethanol[Zinc deficiency co-treated with Ethanol] affects the expression of MTTP mRNA24155903
D000431Ethanol[Dietary Fats co-treated with Ethanol] results in decreased expression of MTTP mRNA24275070
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated results in increased expression of MTTP mRNA"18356535
D005485FlutamideFlutamide results in decreased expression of MTTP mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MTTP mRNA20938992
D005632Fructose"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of MTTP mRNA"19509184
D005632FructoseFGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of MTTP mRNA]28123933
D005632FructoseFructose results in increased expression of MTTP mRNA28123933
D005632Fructose[Fructose co-treated with Copper deficiency] results in decreased expression of MTTP mRNA25813056
C039281furanfuran results in increased methylation of MTTP gene22079235
D019695Glycyrrhizic AcidGlycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA]28549656
C010974glyphosateglyphosate results in decreased expression of MTTP mRNA16532367
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of MTTP mRNA28433809
D017313FenretinideFenretinide results in increased expression of MTTP mRNA28973697
C410337K 7174K 7174 results in decreased expression of MTTP mRNA24086573
D048628KetolidesKetolides analog results in decreased expression of MTTP mRNA24967691
C067713lactacystinlactacystin results in increased ubiquitination of MTTP protein17405876
D007854LeadLead affects the expression of MTTP mRNA28903495
C013592mangiferinmangiferin results in decreased expression of MTTP mRNA22038976
D008713MethimazoleMethimazole results in increased expression of MTTP mRNA22504374
D008715Methionine"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of MTTP mRNA"28973532
D008715Methionine[Choline deficiency co-treated with Methionine deficiency] results in decreased expression of MTTP mRNA25178843
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MTTP mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of MTTP mRNA28973532
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MTTP mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MTTP mRNA"20188158
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Atorvastatin Calcium results in increased expression of MTTP mRNA]12056585
C500085muraglitazarmuraglitazar results in increased expression of MTTP mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MTTP mRNA"25448806
D0150581-Naphthylisothiocyanate18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA]28549656
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of MTTP mRNA28549656
D0150581-NaphthylisothiocyanateGlycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA]28549656
D009532NickelNickel affects the expression of MTTP mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of MTTP mRNA]14575637
C022838nickel chloridenickel chloride affects the expression of MTTP mRNA22110744
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MTTP protein"19637192
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MTTP protein]"19637192
D010126OzoneOzone results in decreased expression of MTTP mRNA16183385
D010400Penicillin G[Penicillin G co-treated with Erythromycin] results in increased expression of MTTP mRNA27503388
D010400Penicillin GPenicillin G results in increased expression of MTTP mRNA27503388
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of MTTP mRNA21705711
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of MTTP mRNA21705711
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of MTTP mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MTTP mRNA17681415
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MTTP mRNA19710929
C006253pirinixic acidpirinixic acid results in increased activity of MTTP protein15537571
C006253pirinixic acidpirinixic acid results in increased expression of MTTP mRNA15375163|1553757
C006253pirinixic acidpirinixic acid results in increased expression of MTTP protein15537571
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of MTTP mRNA]15537571
C006253pirinixic acidDactinomycin inhibits the reaction [pirinixic acid results in increased expression of MTTP mRNA]15537571
C006253pirinixic acidpirinixic acid results in increased activity of MTTP protein15537571
C006253pirinixic acidpirinixic acid results in increased expression of MTTP mRNA15537571
C006253pirinixic acidpirinixic acid results in increased expression of MTTP protein15537571
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of MTTP mRNA21334430
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of MTTP mRNA28433809
C045950propiconazolepropiconazole results in increased expression of MTTP mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of MTTP mRNA22504374
C496788PX-866PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA]25805502
D011794QuercetinQuercetin results in decreased expression of MTTP mRNA21632981|2587501
C089730rosiglitazonerosiglitazone results in increased expression of MTTP mRNA21515302
D012834SilverSilver results in increased expression of MTTP mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of MTTP mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of MTTP gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of MTTP mRNA26151952
D013024Soybean OilSoybean Oil results in increased expression of MTTP mRNA16631440
C003377taxifolintaxifolin results in decreased activity of MTTP protein15380446
D013713TeniposideTeniposide promotes the reaction [CETP protein results in decreased expression of MTTP mRNA]25914138
D013713TeniposideTeniposide results in decreased expression of MTTP mRNA25914138
C501413tesaglitazartesaglitazar results in increased expression of MTTP mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MTTP mRNA27618130
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MTTP mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Dietary Fats co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MTTP mRNA27713108
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTTP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MTTP mRNA28238261
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MTTP mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTTP mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MTTP mRNA21215274|2172422
D013752TetracyclineTetracycline results in decreased expression of MTTP mRNA27089845
D013752TetracyclineTetracycline results in decreased expression of MTTP mRNA24489787
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of MTTP mRNA]27469509
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of MTTP mRNA]14575637
C009564trilinoleintrilinolein results in increased expression of MTTP mRNA18356535
C101314trilinolenintrilinolenin results in increased expression of MTTP mRNA18356535
D014304TrioleinTriolein results in increased expression of MTTP mRNA18356535
C057693troglitazonetroglitazone results in increased expression of MTTP mRNA21515302
C080163trovafloxacintrovafloxacin results in decreased expression of MTTP mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of MTTP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MTTP mRNA23179753|2708984
D014635Valproic AcidValproic Acid affects the expression of MTTP mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of MTTP mRNA24489787
D014640VancomycinVancomycin results in increased expression of MTTP mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MTTP gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of MTTP mRNA26682919
D015032Zinc"Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MTTP protein]"19637192
D015032Zinc[Ethanol co-treated with Zinc] results in increased expression of MTTP mRNA19637192
D015032ZincZinc deficiency affects the expression of MTTP mRNA24155903
D015032Zinc[Zinc deficiency co-treated with Ethanol] affects the expression of MTTP mRNA24155903
D019287Zinc SulfateZinc Sulfate results in increased expression of MTTP mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005319lipid transporter activity-IDA22236406  25108285  
GO:0005319lipid transporter activity-TAS-  
GO:0005515protein binding-IPI23475612  25108285  26224785  
GO:0005548phospholipid transporter activity-IDA23475612  26224785  
GO:0008289lipid binding-IEA-  
GO:0046982protein heterodimerization activity-IDA23475612  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-TAS1439810  
GO:0009306protein secretion-IMP23749231  
GO:0015914phospholipid transport-IDA23475612  26224785  
GO:0034197triglyceride transport-IDA22236406  23475612  25108285  26224785  
GO:0034197triglyceride transport-IMP23749231  
GO:0034377plasma lipoprotein particle assembly-IDA23475612  26224785  
GO:0034378chylomicron assembly-TAS-  
GO:0034379very-low-density lipoprotein particle assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA22236406  23475612  26224785  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04975Fat digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-8866423VLDL assemblyTAS
R-HSA-8963888Chylomicron assemblyTAS
R-HSA-8963898Plasma lipoprotein assemblyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12205923[Comparative study of ventilatory functions of smokers with MTTp and F-V curve configuration]. (1999 Mar)Huang GHua Xi Yi Ke Da Xue Xue Bao
28101967Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. (2017 Jun)Bohn TMol Nutr Food Res