Gene: MTR

4548
HMAG|MS|cblG
5-methyltetrahydrofolate-homocysteine methyltransferase
protein-coding
1q43
Ensembl:ENSG00000116984 MIM:156570 Vega:OTTHUMG00000040060 UniprotKB:Q99707
NG_008959.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
25   
2.960e-1 (AD)  2.448e-1 (ND)   (Frontal_Cortex)
5.239e-1 (AD)  1.920e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7526063chr1:236808698 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MED140.903
PEX10.897
TARBP10.874
DOPEY10.868
RBM250.859
ATG140.858
NKTR0.856
RCOR30.856
MTF20.851
NHLRC30.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102A-0.399
OR4F5-0.393
OR4F29-0.389
FOXJ1-0.373
MTRNR2L9-0.342
MTRNR2L6-0.341
MGARP-0.33
EPPIN-0.329
C7orf61-0.319
CELSR1-0.316

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00115CyanocobalaminSmall Molecule68-19-9Approved|NutraceuticalTarget
DB00116Tetrahydrofolic acidSmall Molecule135-16-0NutraceuticalTarget
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalTarget
DB00200HydroxocobalaminSmall Molecule13422-51-0ApprovedTarget
DB11590ThimerosalSmall Molecule54-64-8ApprovedTarget
DB11256Levomefolic acidSmall Molecule31690-09-2Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein]14745455
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MTR mRNA"19114083
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein]14745455
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MTR mRNA"21346803
C0303715,6,7,8-tetrahydrofolic acid"5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in decreased expression of MTR protein]"16598758
C0303715,6,7,8-tetrahydrofolic acid"[Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]"16598758
C0059845-methyltetrahydrofolate5-methyltetrahydrofolate binds to MTR protein17477549
D000082AcetaminophenAcetaminophen results in decreased expression of MTR mRNA21420995
D012436S-AdenosylmethionineAluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D012436S-AdenosylmethionineArsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D012436S-AdenosylmethionineButhionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D012436S-AdenosylmethionineGlutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D012436S-AdenosylmethionineGlutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D012436S-AdenosylmethionineGlutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D012436S-Adenosylmethionine[glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form26989453
D012436S-Adenosylmethionine[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form26989453
D012436S-AdenosylmethionineLead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D012436S-Adenosylmethioninemecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D012436S-AdenosylmethionineMercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D012436S-AdenosylmethionineS-Adenosylmethionine binds to MTR protein17477549
D012436S-AdenosylmethionineThimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D000535AluminumAluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D000535AluminumAluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D000535AluminumAluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
D006710HomocysteineHomocysteine binds to MTR protein17477549
D006710HomocysteineMTR gene polymorphism affects the metabolism of Homocysteine20532609
D006710HomocysteineMTR protein results in increased methylation of Homocysteine23665415
D006710Homocysteine[MTR protein results in increased methylation of Homocysteine] which results in increased chemical synthesis of Methionine23665415
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MTR mRNA16483693
D018501Antirheumatic AgentsMTR gene polymorphism affects the susceptibility to Antirheumatic Agents18322994
D018501Antirheumatic AgentsMTR protein affects the susceptibility to Antirheumatic Agents18322994
D001151ArsenicArsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D001151ArsenicArsenic inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
C006632arsenic trioxidearsenic trioxide results in decreased expression of MTR protein15894607
C044946benazeprilMTR gene SNP affects the susceptibility to benazepril20445573
C044946benazeprilMTR protein polymorphism affects the susceptibility to benazepril15148588
D001562BenzimidazolesBenzimidazoles results in decreased activity of MTR protein17222188
C015700benzo-1,2,3-thiadiazole"benzo-1,2,3-thiadiazole analog results in decreased activity of MTR protein"17222188
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MTR mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of MTR gene25435355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MTR mRNA"26238291
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MTR mRNA20823114
C006780bisphenol Abisphenol A affects the expression of MTR mRNA21786754
C006780bisphenol Abisphenol A affects the expression of MTR mRNA21786754
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
D019328Buthionine SulfoximineGlutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D019328Buthionine Sulfoximinemecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MTR mRNA27509014
C018475butyraldehydebutyraldehyde results in decreased expression of MTR mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of MTR mRNA19320972
D003300CopperCopper affects the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D019327Copper SulfateCopper Sulfate results in decreased expression of MTR mRNA19549813
D003520CyclophosphamideCyclophosphamide results in decreased expression of MTR mRNA27281708
D016572CyclosporineCyclosporine results in decreased expression of MTR mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MTR mRNA]27941970
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MTR mRNA20823114
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MTR mRNA27392435
D004298Dopamine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein]14745455
D004298Dopamine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein]14745455
D004298DopamineDopamine results in increased activity of MTR protein14745455
D004298DopamineEthanol promotes the reaction [Dopamine results in increased activity of MTR protein]14745455
D004298Dopaminewortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein]14745455
D004317DoxorubicinMTR mRNA results in decreased susceptibility to Doxorubicin16322897
D000431EthanolEthanol inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D000431EthanolEthanol promotes the reaction [Dopamine results in increased activity of MTR protein]14745455
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MTR mRNA17606305
D005492Folic AcidFolic Acid affects the expression of MTR mRNA17311948
D005557FormaldehydeFormaldehyde results in decreased expression of MTR mRNA23649840
D005978GlutathioneGlutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D005978GlutathioneGlutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D005978GlutathioneGlutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
C064617glutathionylcobalamin[glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form26989453
D006879HydroxocobalaminAluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D006879HydroxocobalaminArsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D006879HydroxocobalaminButhionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D006879HydroxocobalaminGlutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D006879HydroxocobalaminGlutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D006879HydroxocobalaminGlutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D006879Hydroxocobalamin[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form26989453
D006879HydroxocobalaminLead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D006879Hydroxocobalaminmecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D006879HydroxocobalaminMercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D006879HydroxocobalaminThimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D019271Hypoxanthine"[Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]"16598758
D019271Hypoxanthine[Thymidine co-treated with Hypoxanthine] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]16598758
D007213IndomethacinIndomethacin results in decreased expression of MTR mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MTR mRNA27392435
D007854LeadLead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D007854LeadLead inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D007854LeadLead inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
C019476mecobalaminAluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
C019476mecobalaminArsenic inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
C019476mecobalaminButhionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
C019476mecobalaminLead inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
C019476mecobalaminmecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
C019476mecobalaminmecobalamin results in increased activity of MTR protein alternative form26989453
C019476mecobalaminMercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
C019476mecobalaminThimerosal inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MTR mRNA20823114
D008627Mercuric ChlorideMercuric Chloride affects the expression of MTR mRNA20353558
D008628MercuryMercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D008628MercuryMercury inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D008628MercuryMercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
D008715Methionine[MTR protein results in increased methylation of Homocysteine] which results in increased chemical synthesis of Methionine23665415
D008727Methotrexate"5,6,7,8-tetrahydrofolic acid inhibits the reaction [Methotrexate results in decreased expression of MTR protein]"16598758
D008727MethotrexateMethotrexate affects the localization of MTR protein22484375
D008727MethotrexateMethotrexate results in decreased expression of MTR protein16598758
D008727MethotrexateMTR gene polymorphism affects the metabolism of Methotrexate15753437
D008727MethotrexateMTR mRNA results in decreased susceptibility to Methotrexate19426680
D008727Methotrexate"[Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]"16598758
D008727Methotrexate[Thymidine co-treated with Hypoxanthine] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]16598758
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MTR mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MTR mRNA"26251327
C059539midostaurinmidostaurin results in decreased expression of MTR mRNA20980353
D009609Nitrous OxideNitrous Oxide results in decreased activity of MTR protein18472229
D009609Nitrous OxideNitrous Oxide results in decreased activity of MTR protein18472229
D010396PenicillaminePenicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MTR mRNA19710929
D011374ProgesteroneProgesterone results in increased expression of MTR mRNA20864642
D011794QuercetinQuercetin results in decreased expression of MTR mRNA21632981
C017947sodium arsenitesodium arsenite results in increased expression of MTR mRNA25697676
D013311StreptozocinStreptozocin results in decreased activity of MTR protein16835399
D013849ThimerosalGlutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]26989453
D013849ThimerosalThimerosal affects the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D013849ThimerosalThimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]26989453
D013849ThimerosalThimerosal inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]26989453
D013849ThimerosalThimerosal results in decreased expression of MTR mRNA27188386
D013936Thymidine"[Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]"16598758
D013936Thymidine[Thymidine co-treated with Hypoxanthine] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]16598758
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MTR mRNA28065790
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of MTR mRNA]27469509
D014241TrichloroethyleneTrichloroethylene metabolite results in decreased activity of MTR protein24923549
D014241TrichloroethyleneTrichloroethylene results in decreased activity of MTR protein24923549
C012589trichostatin Atrichostatin A results in increased expression of MTR mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MTR mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MTR mRNA"26179874
D014520UrethaneUrethane results in decreased expression of MTR mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MTR mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MTR mRNA24935251
D014805Vitamin B 12Vitamin B 12 binds to MTR protein17477549
D014805Vitamin B 12Vitamin B 12 results in increased activity of MTR protein17982279
D014805Vitamin B 12Vitamin B 12 results in increased activity of MTR protein18472229
C009687wortmanninwortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein]14745455
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17288554  23825108  
GO:0008270zinc ion binding-IEA-  
GO:0008705methionine synthase activity-IBA21873635  
GO:0008705methionine synthase activity-IDA16769880  
GO:0008705methionine synthase activity-IMP23825108  
GO:0031419cobalamin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007399nervous system development-TAS8968737  
GO:0009086methionine biosynthetic process-IMP23825108  
GO:0009235cobalamin metabolic process-IMP23825108  
GO:0009235cobalamin metabolic process-TAS-  
GO:0031103axon regeneration-ISS-  
GO:0032259methylation-IEA-  
GO:0042558pteridine-containing compound metabolic process-IEA-  
GO:0048678response to axon injury-ISS-  
GO:0071732cellular response to nitric oxide-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa00450Selenocompound metabolism
hsa00670One carbon pool by folate
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156581MethylationTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-3296469Defects in cobalamin (B12) metabolismTAS
R-HSA-3296482Defects in vitamin and cofactor metabolismTAS
R-HSA-3359467Defective MTRR causes methylmalonic aciduria and homocystinuria type cblETAS
R-HSA-3359469Defective MTR causes methylmalonic aciduria and homocystinuria type cblGTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24278388One-carbon metabolism pathway gene variants and risk of clear cell renal cell carcinoma in a Chinese population. (2013)Zhang LPLoS One
24368279Dietary folate and related micronutrients, folate-metabolising genes, and ovarian cancer survival. (2014 Mar)Dixon SCGynecol Oncol
20223888The impact of sex and vascular risk factors on brain tissue changes with aging: magnetization transfer imaging results of the Austrian stroke prevention study. (2010 Aug)Ropele SAJNR Am J Neuroradiol
12716294Methionine Synthase Reductase Gene A66G Polymorphism is Associated with Risk of Colorectal Cancer. (2002)Matsuo KAsian Pac J Cancer Prev
23593229Methionine synthase A2756G polymorphism and risk of colorectal adenoma and cancer: evidence based on 27 studies. (2013)Ding WPLoS One
15790587Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan. (2005 Jul)Yang CXCarcinogenesis
19588544Combined effect of NAT2, MTR and MTHFR genotypes and tobacco on bladder cancer susceptibility in Tunisian population. (2009)Ouerhani SCancer Detect Prev
21339095Smoking and polymorphisms in folate metabolizing genes and their effects on the histological stage and grade for bladder tumors. (2011 Feb)Rouissi KBull Cancer
21254359Folate pathway and nonsyndromic cleft lip and palate. (2011 Jan)Blanton SHBirth Defects Res A Clin Mol Teratol
25102261Maternal folate, alcohol and energy metabolism-related gene polymorphisms and the risk of recurrent pregnancy loss. (2012 Oct)Sata FJ Dev Orig Health Dis
17468511Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study. (2007 Aug)Suzuki TCarcinogenesis
27473058Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects. (2016 Jul 29)Nakao HBMC Gastroenterol
25219684Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development. (2015 Apr)Bezerra JFOral Dis
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet
27803768Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma. (2016 Oct 18)Peres NPWorld J Hepatol
16580699A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers. (2006 Jul 25)Ishikawa HMutat Res
21597034The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. (2011 Jun)Ye XPsychosom Med
19837268Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population. (2009 Nov)Rouissi KCancer Genet Cytogenet
17596206One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study. (2007 Sep)Suzuki TCancer Sci
25702197Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: results from the German Investigation on Neurobiology in Alcoholism (GINA). (2015 Mar)Semmler AAlcohol
23372658Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer. (2013)Swartz MDPLoS One
19394322Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians. (2009 Jul)Vinukonda GClin Chim Acta
21338559Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population. (2011 Oct)Huang TPublic Health Nutr
20544798Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. (2010 Aug)Summers CMBirth Defects Res A Clin Mol Teratol
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