Gene: MTRR

4552
MSR|cblE
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
protein-coding
5p15.31
Ensembl:ENSG00000124275 MIM:602568 Vega:OTTHUMG00000090477 UniprotKB:Q9UBK8
NG_008856.1
PubMed
0   ANCO-SNPs
ND
25   
5.718e-1 (AD)  3.026e-1 (ND)   (Frontal_Cortex)
7.354e-1 (AD)  2.393e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP2R2A0.879
ITCH0.871
PDS5A0.869
DHX150.868
TLK20.866
MAP3K70.866
TBC1D150.861
RPS6KB10.861
FRMD50.86
TBC1D230.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
OR4F29-0.546
MTRNR2L10-0.289
MTRNR2L6-0.275
MTRNR2L9-0.269
OR4F16-0.259
HES5-0.256
MTRNR2L2-0.251
TTLL10-0.251
MTRNR2L8-0.248

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00115CyanocobalaminSmall Molecule68-19-9Approved|NutraceuticalTarget
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalTarget
DB00200HydroxocobalaminSmall Molecule13422-51-0ApprovedTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MTRR mRNA"22698814
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MTRR mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MTRR mRNA"18648102
C0059845-methyltetrahydrofolateMTRR protein affects the abundance of 5-methyltetrahydrofolate17369066
D000082AcetaminophenAcetaminophen results in decreased expression of MTRR mRNA25704631
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MTRR gene27153756
D000447AldehydesAldehydes results in decreased expression of MTRR mRNA25014914
D006710HomocysteineMTRR protein affects the abundance of Homocysteine17369066
D001151ArsenicMTRR protein affects the metabolism of Arsenic18682255
C006780bisphenol Abisphenol A affects the expression of MTRR mRNA21786754
C006780bisphenol Abisphenol A affects the expression of MTRR mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of MTRR protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of MTRR mRNA26079696
D002110CaffeineCaffeine results in decreased expression of MTRR mRNA20864626
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MTRR mRNA27339419
D002794Choline[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of MTRR mRNA23439872
D016572CyclosporineCyclosporine results in decreased expression of MTRR mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of MTRR mRNA19770486
D005492Folic AcidFolic Acid affects the expression of MTRR mRNA17311948
D005492Folic Acid[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of MTRR mRNA23439872
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MTRR mRNA20044591
D007213IndomethacinIndomethacin results in increased expression of MTRR mRNA28201806
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MTRR mRNA27339419
D008715MethionineMTRR protein affects the abundance of Methionine17369066
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of MTRR mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MTRR mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MTRR mRNA26011545
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of MTRR mRNA20864626
D009532NickelNickel results in increased expression of MTRR mRNA25583101
C046012pentanalpentanal results in decreased expression of MTRR mRNA26079696
D010634PhenobarbitalPhenobarbital results in increased expression of MTRR mRNA19270015
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MTRR mRNA22714537
D011192Potassium DichromatePotassium Dichromate affects the expression of MTRR mRNA23608068
D012402RotenoneRotenone results in increased expression of MTRR mRNA19013527
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MTRR mRNA25351596
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MTRR mRNA21215274
D014635Valproic AcidValproic Acid affects the expression of MTRR mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of MTRR mRNA17292431
D014638VanadatesVanadates results in decreased expression of MTRR mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MTRR gene25560391
C025643vinclozolinvinclozolin results in increased expression of MTRR mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003958NADPH-hemoprotein reductase activity-IBA21873635  
GO:0003958NADPH-hemoprotein reductase activity-IDA11466310  
GO:0005515protein binding-IPI17288554  25416956  
GO:0010181FMN binding-IBA21873635  
GO:0010181FMN binding-IDA11466310  
GO:0010181FMN binding-TAS9501215  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen-IBA21873635  
GO:0016723oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor-IDA17892308  
GO:0030586[methionine synthase] reductase activity-IBA21873635  
GO:0030586[methionine synthase] reductase activity-IDA11466310  
GO:0030586[methionine synthase] reductase activity-TAS9501215  17892308  
GO:0050444aquacobalamin reductase (NADPH) activity-IDA16769880  
GO:0050660flavin adenine dinucleotide binding-IBA21873635  
GO:0050660flavin adenine dinucleotide binding-IDA17892308  
GO:0050660flavin adenine dinucleotide binding-TAS9501215  
GO:0050661NADP binding-TAS9501215  
GO:0070402NADPH binding-IDA11466310  
GO:0071949FAD binding-IDA11466310  
GO ID GO Term Qualifier Evidence PubMed
GO:0006306DNA methylation-ISS-  
GO:0006555methionine metabolic process-TAS9501215  
GO:0009086methionine biosynthetic process-IBA21873635  
GO:0009086methionine biosynthetic process-IDA11466310  
GO:0009235cobalamin metabolic process-TAS-  
GO:0033353S-adenosylmethionine cycle-ISS17369066  
GO:0043418homocysteine catabolic process-IDA11466310  
GO:0046655folic acid metabolic process-IDA11466310  
GO:0046655folic acid metabolic process-ISS-  
GO:0050667homocysteine metabolic process-IBA21873635  
GO:0055114oxidation-reduction process-TAS9501215  
GO:1904042negative regulation of cystathionine beta-synthase activity-IDA24416422  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS9501215  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156581MethylationTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-3296469Defects in cobalamin (B12) metabolismTAS
R-HSA-3296482Defects in vitamin and cofactor metabolismTAS
R-HSA-3359467Defective MTRR causes methylmalonic aciduria and homocystinuria type cblETAS
R-HSA-3359469Defective MTR causes methylmalonic aciduria and homocystinuria type cblGTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24278388One-carbon metabolism pathway gene variants and risk of clear cell renal cell carcinoma in a Chinese population. (2013)Zhang LPLoS One
23628113Unravelling the basis of variability in cobalamin levels in the general population. (2013 Nov 14)Andrew TBr J Nutr
24368279Dietary folate and related micronutrients, folate-metabolising genes, and ovarian cancer survival. (2014 Mar)Dixon SCGynecol Oncol
12716294Methionine Synthase Reductase Gene A66G Polymorphism is Associated with Risk of Colorectal Cancer. (2002)Matsuo KAsian Pac J Cancer Prev
16351505Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. (2005)Otani TNutr Cancer
21597397Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification. (2011 Jul)Nagele PPharmacogenet Genomics
22541966Incorporating single-nucleotide polymorphisms into the Lyman model to improve prediction of radiation pneumonitis. (2013 Jan 1)Tucker SLInt J Radiat Oncol Biol Phys
11806787Genetics University of Toronto Thrombophilia Study in Women (GUTTSI): genetic and other risk factors for venous thromboembolism in women. (2001)Ray JGCurr Control Trials Cardiovasc Med
29743634Replication study of polymorphisms associated with response to methotrexate in patients with rheumatoid arthritis. (2018 May 9)Lopez-Rodriguez RSci Rep
21339095Smoking and polymorphisms in folate metabolizing genes and their effects on the histological stage and grade for bladder tumors. (2011 Feb)Rouissi KBull Cancer
25102261Maternal folate, alcohol and energy metabolism-related gene polymorphisms and the risk of recurrent pregnancy loss. (2012 Oct)Sata FJ Dev Orig Health Dis
17468511Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study. (2007 Aug)Suzuki TCarcinogenesis
27473058Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects. (2016 Jul 29)Nakao HBMC Gastroenterol
15093278Cytogenetic biomarkers and genetic polymorphisms. (2004 Apr 1)Norppa HToxicol Lett
25219684Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development. (2015 Apr)Bezerra JFOral Dis
27803768Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma. (2016 Oct 18)Peres NPWorld J Hepatol
16580699A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers. (2006 Jul 25)Ishikawa HMutat Res
19837268Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population. (2009 Nov)Rouissi KCancer Genet Cytogenet
23188888Associations of MTHFR and MTRR polymorphisms with serum lipid levels in Chinese hypertensive patients. (2014 May)Jiang SClin Appl Thromb Hemost
17596206One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study. (2007 Sep)Suzuki TCancer Sci
23372658Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer. (2013)Swartz MDPLoS One
19394322Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians. (2009 Jul)Vinukonda GClin Chim Acta
22479380Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. (2012)McKay JAPLoS One
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet
20544798Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. (2010 Aug)Summers CMBirth Defects Res A Clin Mol Teratol