Gene: MUC2

4583
MLP|MUC-2|SMUC
mucin 2, oligomeric mucus/gel-forming
protein-coding
11p15.5
Ensembl:ENSG00000198788 MIM:158370 UniprotKB:Q02817
NG_051929.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.527e-1 (AD)  7.434e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC26A30.524
CLCA10.485
KRT200.482
ISX0.468
DEFA60.467
SPP20.427
MUC130.427
ZG160.419
GUCA2A0.414
KRT390.407

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNRNPCL1-0.219
PCDHA10-0.181
GLOD5-0.162
MEIG1-0.16
INS-IGF2-0.157
ADIG-0.155
KIF15-0.149
NMBR-0.145
OBP2B-0.143
C20orf173-0.14

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01411PranlukastSmall Molecule103177-37-3Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of MUC2 mRNA28329830
C0645454-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid"4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of MUC2 mRNA"10953040
C0194294-hydroxyretinoic acid4-hydroxyretinoic acid results in increased expression of MUC2 mRNA10953040
C499366Active Hexose Correlated CompoundActive Hexose Correlated Compound inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA]17449585
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of MUC2 mRNA21298039
D001280AtrazineAtrazine results in decreased expression of MUC2 mRNA25929836
D004958EstradiolEstradiol affects the expression of MUC2 mRNA23557687
D001647Bile Acids and SaltsBile Acids and Salts results in increased expression of MUC2 mRNA25973022
C006780bisphenol Abisphenol A results in decreased expression of MUC2 mRNA25181051
D002330CarmustineCarmustine results in decreased expression of MUC2 mRNA15980968
D004390ChlorpyrifosChlorpyrifos affects the metabolism of MUC2 protein25643018
D004002Clodronic AcidClodronic Acid results in decreased expression of MUC2 mRNA25187657
D060729Coal AshCoal Ash results in increased expression of MUC2 mRNA10702361
D016572CyclosporineCyclosporine results in increased expression of MUC2 mRNA25562108
D004052Diethylnitrosamine[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of MUC2 protein20935162
C017435enilconazoleenilconazole affects the expression of MUC2 mRNA29106682
D004917ErythromycinErythromycin results in decreased expression of MUC2 mRNA27503388
D004917Erythromycin[Penicillin G co-treated with Erythromycin] results in decreased expression of MUC2 mRNA27503388
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MUC2 mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of MUC2 mRNA28329830
D005557FormaldehydeFormaldehyde results in decreased expression of MUC2 mRNA28937961
C039281furanfuran results in decreased expression of MUC2 mRNA26194646
D007559IvermectinIvermectin results in decreased expression of MUC2 mRNA26443706
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MUC2 mRNA26752646
C076948lafutidinelafutidine inhibits the reaction [loxoprofen results in decreased expression of MUC2]20586851
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MUC2 mRNA"24972896
C040656loxoprofenlafutidine inhibits the reaction [loxoprofen results in decreased expression of MUC2]20586851
C040656loxoprofenloxoprofen results in decreased expression of MUC220586851
D008727MethotrexateMethotrexate results in decreased expression of MUC2 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MUC2 mRNA23649840
C500085muraglitazarmuraglitazar results in decreased expression of MUC2 mRNA21515302
C022838nickel chloridenickel chloride affects the expression of MUC2 mRNA21496282
D010047OvalbuminOvalbumin results in increased expression of MUC2 mRNA12388339
D010400Penicillin G[Penicillin G co-treated with Erythromycin] results in decreased expression of MUC2 mRNA27503388
D010634Phenobarbital[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of MUC2 protein20935162
C006253pirinixic acidpirinixic acid results in increased expression of MUC2 mRNA12832660
D011192Potassium DichromatePotassium Dichromate results in increased expression of MUC2 mRNA23608068
D011794QuercetinQuercetin results in increased expression of MUC2 mRNA15309432
C089730rosiglitazonerosiglitazone results in decreased expression of MUC2 mRNA21515302
D018038Sodium SeleniteN-TUTCA2 gene mutant form inhibits the reaction [Sodium Selenite results in increased expression of MUC2 mRNA]25187657
D018038Sodium SeleniteSodium Selenite results in decreased expression of MUC2 mRNA23274088
D018038Sodium SeleniteSodium Selenite results in increased expression of MUC2 mRNA25187657
D012460SulfasalazineSulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA]17449585
C501413tesaglitazartesaglitazar results in decreased expression of MUC2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MUC2 mRNA22574217
D014212TretinoinTretinoin results in increased expression of MUC2 mRNA10953040
C012589trichostatin Atrichostatin A results in decreased expression of MUC2 mRNA15901671
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of MUC2 mRNA25307695
D014302Trinitrobenzenesulfonic AcidActive Hexose Correlated Compound inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA]17449585
D014302Trinitrobenzenesulfonic AcidSulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA]17449585
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of MUC2 mRNA19998380
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA17449585
C057693troglitazonetroglitazone results in increased expression of MUC2 mRNA14634802
C057693troglitazonetroglitazone results in decreased expression of MUC2 mRNA21515302
D014635Valproic AcidValproic Acid results in increased methylation of MUC2 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of MUC2 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19359471  19432394  
GO ID GO Term Qualifier Evidence PubMed
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0016266O-glycan processing-TAS-  
GO:0030277maintenance of gastrointestinal epithelium-IMP17058067  
GO ID GO Term Qualifier Evidence PubMed
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0070702inner mucus layer-ISS-  
GO:0070703outer mucus layer-ISS-  
KEGG ID KEGG Term
hsa05110Vibrio cholerae infection
hsa05146Amoebiasis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15563701Expression of ErbB receptors and mucins in the airways of long term current smokers. (2004 Dec)O'Donnell RAThorax
24342438Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms. (2014 Feb)Elias KMGynecol Oncol
21526360What role do mucins have in the development of laryngeal squamous cell carcinoma? A systematic review. (2011 Aug)Sipaul FEur Arch Otorhinolaryngol
28620964Does gene expression in laryngeal subsites differ between patients with laryngopharyngeal reflux and controls? (2018 Feb)Wood JMClin Otolaryngol
26033517Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut. (2016 May)Allais LEnviron Microbiol