Gene info: ID 4585

Gene: MUC4

GENE ID: 4585

Synonyms: ASGP|HSA276359|MUC-4

Description: mucin 4, cell surface associated

Gene type: protein-coding

Location: 3q29

dbXrefs: Ensembl:ENSG00000145113 MIM:158372 Vega:OTTHUMG00000151827 UniprotKB:Q99102

RefSeq: NG_053117.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 10

Sherlock p-value : 8.923e-1 (AD) 8.147e-1 (ND) (Frontal_Cortex)

Pascal p-value : 5.422e-1 (AD) 6.481e-2 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg12869262	chr3:195528619	MUC4	Gene body	3.339e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MC1R	0.586
PASK	0.543
PRSS53	0.541
DNAH2	0.532
LPAR2	0.524
CACNA1C	0.517
RGL4	0.515
CCDC62	0.513
CSMD2	0.51
B4GALNT3	0.508

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CENPM	-0.294
SOX3	-0.294
PDE11A	-0.29
LRRCC1	-0.278
EPM2A	-0.271
STRA8	-0.258
ZFHX4-AS1	-0.254
AAMDC	-0.252
CA14	-0.245
ENDOU	-0.244

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
D020106	Acrylamide	Acrylamide results in decreased expression of MUC4 mRNA	28959563
C499366	Active Hexose Correlated Compound	Active Hexose Correlated Compound inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA]	17449585
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of MUC4 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MUC4 mRNA	16483693
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of MUC4 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MUC4 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of MUC4 gene	25435355
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of MUC4 mRNA	17404688
D004958	Estradiol	Estradiol results in increased expression of MUC4 mRNA	17010207
C006780	bisphenol A	bisphenol A results in decreased expression of MUC4 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of MUC4 mRNA	26079696
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MUC4 mRNA	20938992
D005576	Colforsin	Colforsin results in increased expression of MUC4 protein	28049186
C014347	decitabine	[decitabine co-treated with trichostatin A] results in increased expression of MUC4 mRNA	19127263
C014347	decitabine	decitabine results in increased expression of MUC4 mRNA	19127263
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of MUC4 mRNA	17010207
C118739	entinostat	entinostat results in increased expression of MUC4 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MUC4 mRNA	15834898\|1755790
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of MUC4 mRNA	27776689
D015025	Zearalenone	Zearalenone results in increased expression of MUC4 mRNA	17557909
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MUC4 mRNA	20938992
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of MUC4 mRNA	20846436
C069837	fullerene C60	fullerene C60 affects the expression of MUC4 mRNA	19167457
C020251	kappa-casein glycomacropeptide	kappa-casein glycomacropeptide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA]	15867298
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MUC4 mRNA	20938992
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MUC4 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MUC4 mRNA"	25554681
C028007	nickel monoxide	nickel monoxide results in decreased expression of MUC4 mRNA	19167457
C474055	octylphenol	octylphenol results in increased expression of MUC4 mRNA	17010207
D010100	Oxygen	Oxygen deficiency results in decreased expression of MUC4 mRNA	24205000
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of MUC4 mRNA	26272509
D052638	Particulate Matter	Particulate Matter results in increased expression of MUC4 mRNA	28049186
D052638	Particulate Matter	Particulate Matter results in increased expression of MUC4 protein	28049186
D052638	Particulate Matter	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of MUC4 mRNA]	28049186
D052638	Particulate Matter	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of MUC4 protein]	28049186
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of MUC4 mRNA	23892564
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of MUC4 mRNA	18692542
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of MUC4 mRNA	27153767
C014153	pirimiphos methyl	pirimiphos methyl results in increased expression of MUC4 mRNA	27845199
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of MUC4 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of MUC4 mRNA	22238285
C084904	Ro 41-5253	Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]	16007204
C084904	Ro 41-5253	Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]	16007204
C084904	Ro 41-5253	Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of MUC4 protein]	16007204
C093642	SB 203580	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of MUC4 mRNA]	28049186
C093642	SB 203580	SB 203580 inhibits the reaction [Particulate Matter results in increased expression of MUC4 protein]	28049186
C093642	SB 203580	SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of MUC4 mRNA]	28049186
C093642	SB 203580	SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of MUC4 protein]	28049186
D012643	Selenium	Selenium results in increased expression of MUC4 mRNA	19244175
D053260	Soot	Soot results in increased expression of MUC4 mRNA	22461453\|2655175
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA]	17449585
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MUC4 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MUC4 promoter]	19654925
C009495	titanium dioxide	titanium dioxide results in increased expression of MUC4 mRNA	19695317
C009495	titanium dioxide	titanium dioxide affects the expression of MUC4 mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of MUC4 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MUC4 mRNA	25788831
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MUC4 mRNA	20133372
D014212	Tretinoin	IFNG protein inhibits the reaction [Tretinoin results in increased expression of MUC4 mRNA]	16007204
D014212	Tretinoin	IFNG protein inhibits the reaction [Tretinoin results in increased expression of MUC4 protein]	16007204
D014212	Tretinoin	Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]	16007204
D014212	Tretinoin	Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of MUC4 protein]	16007204
D014212	Tretinoin	Tretinoin results in increased expression of MUC4 mRNA	16007204
D014212	Tretinoin	Tretinoin results in increased expression of MUC4 protein	16007204
C012589	trichostatin A	[decitabine co-treated with trichostatin A] results in increased expression of MUC4 mRNA	19127263
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of MUC4 mRNA	19127263\|2493525
D014302	Trinitrobenzenesulfonic Acid	Active Hexose Correlated Compound inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA]	17449585
D014302	Trinitrobenzenesulfonic Acid	kappa-casein glycomacropeptide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA]	15867298
D014302	Trinitrobenzenesulfonic Acid	Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA]	17449585
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA	15867298\|1744958
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MUC4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MUC4 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of MUC4 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased methylation of MUC4 gene	29154799
D001335	Vehicle Emissions	SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of MUC4 mRNA]	28049186
D001335	Vehicle Emissions	SB 203580 inhibits the reaction [Vehicle Emissions results in increased expression of MUC4 protein]	28049186
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of MUC4 mRNA	28049186
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of MUC4 protein	28049186

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005176	ErbB-2 class receptor binding	-	TAS	10024507
GO:0030197	extracellular matrix constituent, lubricant activity	-	NAS	10920259

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	-
GO:0007160	cell-matrix adhesion	-	IEA	-
GO:0016266	O-glycan processing	-	TAS	-
GO:0030277	maintenance of gastrointestinal epithelium	-	IMP	17058067

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	HDA	16502470
GO:0005796	Golgi lumen	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	10024507
GO:0016020	membrane	-	NAS	10920259
GO:0031012	extracellular matrix	-	NAS	10920259
GO:0031982	vesicle	-	HDA	19190083
GO:0070062	extracellular exosome	-	HDA	19199708 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1643685	Disease	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-3781865	Diseases of glycosylation	TAS
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5083625	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	TAS
R-HSA-5083632	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	TAS
R-HSA-5083636	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	TAS
R-HSA-5173105	O-linked glycosylation	TAS
R-HSA-5621480	Dectin-2 family	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-913709	O-linked glycosylation of mucins	TAS
R-HSA-977068	Termination of O-glycan biosynthesis	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28065467	Lung Adenocarcinoma With MUC4 Expression Is Associated With Smoking Status, HER2 Protein Expression, and Poor Prognosis: Clinicopathologic Analysis of 338 Cases. (2017 Jul)	Rokutan-Kurata M	Clin Lung Cancer
22614008	Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through alpha7nAChR-mediated MUC4 upregulation. (2013 Mar 14)	Momi N	Oncogene
24204934	Genetic variants in MUC4 gene are associated with lung cancer risk in a Chinese population. (2013)	Zhang Z	PLoS One
28005264	Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis. (2017 Mar)	Lundmark A	J Clin Periodontol
27481516	Mucin-1 correlates with survival, smoking status, and growth patterns in lung adenocarcinoma. (2016 Oct)	Lappi-Blanco E	Tumour Biol
17079941	Cigarette smoke-induced differential expression of the genes involved in exocrine function of the rat pancreas. (2006 Nov)	Wittel UA	Pancreas
21526360	What role do mucins have in the development of laryngeal squamous cell carcinoma? A systematic review. (2011 Aug)	Sipaul F	Eur Arch Otorhinolaryngol
22537161	Nicotine, IFN-gamma and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. (2012 Apr 26)	Kunigal S	Mol Cancer
28620964	Does gene expression in laryngeal subsites differ between patients with laryngopharyngeal reflux and controls? (2018 Feb)	Wood JM	Clin Otolaryngol
26033517	Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut. (2016 May)	Allais L	Environ Microbiol