Gene info: ID 4586

Gene: MUC5AC

GENE ID: 4586

Synonyms: MUC5|TBM|leB|mucin

Description: mucin 5AC, oligomeric mucus/gel-forming

Gene type: protein-coding

Location: 11p15.5

dbXrefs: Ensembl:ENSG00000215182 MIM:158373 Vega:OTTHUMG00000154270 UniprotKB:P98088

RefSeq: NC_000011.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 40

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GIF	0.835
TFF2	0.826
TFF1	0.803
PGA4	0.774
AGR2	0.73
OR4D9	0.724
LIPF	0.692
PGC	0.679
PGA3	0.675
ATP4B	0.657

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C1orf134	-0.202
AGAP4	-0.19
NKAIN4	-0.189
SMN2	-0.189
TNNT1	-0.185
THNSL2	-0.185
LHFPL1	-0.181
CATSPER3	-0.179
SHBG	-0.173
KCNN3	-0.169

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea inhibits the reaction [ELANE protein results in increased expression of MUC5AC mRNA]"	10843967\|1191908
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea inhibits the reaction [ELANE protein results in increased expression of MUC5AC protein]"	17456367
C038983	1,3-dimethylthiourea	"1,3-dimethylthiourea inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]"	10640773
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide results in decreased expression of MUC5AC mRNA"	19458046
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	15531749
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]	15531749
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]	22766066
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC mRNA]	10640773
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]	10640773
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]	20971882
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]	25177032
C091768	3'-methoxy-4'-nitroflavone	3'-methoxy-4'-nitroflavone inhibits the reaction [Particulate Matter results in increased expression of MUC5AC mRNA]	19372248
C091768	3'-methoxy-4'-nitroflavone	3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]	19372248
C064545	4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid	"4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of MUC5AC mRNA"	10953040
C019429	4-hydroxyretinoic acid	4-hydroxyretinoic acid results in increased expression of MUC5AC mRNA	10953040
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of MUC5AC mRNA	17034753
C041819	4-oxoretinol	4-oxoretinol results in increased expression of MUC5AC mRNA	17034753
D000082	Acetaminophen	Acetaminophen affects the expression of MUC5AC mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]	20709182
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]	10640773
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]	25177032
D000171	Acrolein	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	15531749
D000171	Acrolein	Acrolein results in increased expression of MUC5AC mRNA	15531749\|1966124
D000171	Acrolein	Acrolein results in increased expression of MUC5AC protein	20359552
D000171	Acrolein	ADAM17 protein promotes the reaction [Acrolein results in increased expression of MUC5AC mRNA]	15531749
D000171	Acrolein	EGFR protein affects the reaction [Acrolein results in increased expression of MUC5AC mRNA]	15531749
D000171	Acrolein	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]]	20359552
D000171	Acrolein	MMP14 protein affects the reaction [Acrolein results in increased expression of MUC5AC mRNA]	19661247
D000171	Acrolein	MMP9 protein promotes the reaction [Acrolein results in increased expression of MUC5AC mRNA]	15531749
D000171	Acrolein	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	15531749
D000171	Acrolein	Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]	20359552
D000171	Acrolein	TIMP3 protein inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	15531749
D000171	Acrolein	Acrolein results in increased expression of MUC5AC mRNA	18006877\|1966124
D000171	Acrolein	Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	18006877\|1966124
D000171	Acrolein	MMP9 gene mutant form inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	18006877
D000171	Acrolein	Acrolein results in increased expression of MUC5AC mRNA	19464576\|2035955
D000171	Acrolein	Acrolein results in increased expression of MUC5AC protein	19464576\|2035955
D000171	Acrolein	rosiglitazone inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	19464576
D000171	Acrolein	rosiglitazone inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]	19464576
D000171	Acrolein	Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	20359552
D000171	Acrolein	Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]	20359552
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MUC5AC mRNA	21641981
D000393	Air Pollutants	Air Pollutants results in increased expression of MUC5AC mRNA	23159501
C103303	alitretinoin	alitretinoin results in increased expression of MUC5AC mRNA	17034753
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]	24333275
D000640	Amitrole	Amitrole results in decreased expression of MUC5AC mRNA	17512462
C004984	apocarotenal	apocarotenal results in increased expression of MUC5AC mRNA	17034753
D001564	Benzo(a)pyrene	Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]	20709182
D001564	Benzo(a)pyrene	AHR mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]	20709182
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MUC5AC mRNA	20709182
D001564	Benzo(a)pyrene	resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]	20709182
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]	22766066
D019207	beta Carotene	beta Carotene results in increased expression of MUC5AC mRNA	17034753
C006780	bisphenol A	bisphenol A affects the expression of MUC5AC mRNA	23757601
D001761	Bleomycin	Bleomycin results in increased expression of MUC5AC mRNA	18684396
D001761	Bleomycin	Bleomycin results in increased expression of MUC5AC mRNA	26093215
D001761	Bleomycin	Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA]	26093215
D001761	Bleomycin	Phytochemicals inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA]	26093215
C018475	butyraldehyde	butyraldehyde results in decreased expression of MUC5AC mRNA	26079696
D002211	Capsaicin	Capsaicin promotes the reaction [Citric Acid results in increased secretion of MUC5AC protein]	22566028
D002211	Capsaicin	Capsaicin results in increased secretion of MUC5AC protein	22566028
C071423	capsazepine	capsazepine inhibits the reaction [Citric Acid results in increased secretion of MUC5AC protein]	22566028
D002744	Chlorpheniramine	Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]	17622767
D002744	Chlorpheniramine	Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein]	17622767
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of MUC5AC mRNA	28472532
D019343	Citric Acid	Capsaicin promotes the reaction [Citric Acid results in increased secretion of MUC5AC protein]	22566028
D019343	Citric Acid	capsazepine inhibits the reaction [Citric Acid results in increased secretion of MUC5AC protein]	22566028
D019343	Citric Acid	Citric Acid results in increased secretion of MUC5AC protein	22566028
D060729	Coal Ash	Coal Ash results in increased expression of MUC5AC mRNA	10637131
D003676	Deferoxamine	Deferoxamine inhibits the reaction [ELANE protein results in increased expression of MUC5AC mRNA]	11919081
C007262	deoxynivalenol	deoxynivalenol results in increased expression of and results in increased secretion of MUC5AC protein	24496642
C007262	deoxynivalenol	deoxynivalenol results in increased expression of MUC5AC mRNA	24496642
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of MUC5AC mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in increased expression of MUC5AC mRNA	25016146
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of MUC5AC mRNA	26924002
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]	10640773
D004642	Emodin	Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]	22484343
D000069347	Erlotinib Hydrochloride	Erlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	18006877\|1966124
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of MUC5AC mRNA	23649840
D015025	Zearalenone	Zearalenone results in increased expression of and results in increased secretion of MUC5AC protein	24496642
D015025	Zearalenone	Zearalenone results in increased expression of MUC5AC mRNA	24496642
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]	21203431
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]	21203431
D005419	Flavonoids	Flavonoids results in decreased expression of MUC5AC mRNA	18035473
D005557	Formaldehyde	Formaldehyde results in increased expression of MUC5AC mRNA	23649840
C056933	fumonisin B1	fumonisin B1 results in increased expression of and results in increased secretion of MUC5AC protein	24496642
C056933	fumonisin B1	fumonisin B1 results in increased expression of MUC5AC mRNA	24496642
D024504	gamma-Tocopherol	gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA]	19389874
D007975	Leukotriene B4	Leukotriene B4 results in increased expression of MUC5AC protein	12654629
D006632	Histamine	Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]	17622767
D006632	Histamine	Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein]	17622767
D006632	Histamine	Histamine results in increased expression of MUC5AC mRNA	17622767
D006632	Histamine	Histamine results in increased expression of MUC5AC protein	17622767
D006632	Histamine	Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]	17622767
D006632	Histamine	Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC protein]	17622767
D006861	Hydrogen Peroxide	"1,3-dimethylthiourea inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]"	10640773
D006861	Hydrogen Peroxide	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC mRNA]	10640773
D006861	Hydrogen Peroxide	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]	10640773
D006861	Hydrogen Peroxide	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]	10640773
D006861	Hydrogen Peroxide	Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]	10640773
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of MUC5AC mRNA	10640773
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of MUC5AC protein	10640773
D006861	Hydrogen Peroxide	tyrphostin AG 1478 inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC mRNA]	10640773
D006861	Hydrogen Peroxide	tyrphostin AG 1478 inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]	10640773
C006552	kaempferol	kaempferol inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]	19367675
C006552	kaempferol	kaempferol inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]	25177032
C008261	lead acetate	lead acetate results in increased expression of MUC5AC mRNA	22609695
D017999	Leukotriene E4	Leukotriene E4 results in increased expression of MUC5AC protein	12654629
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MUC5AC mRNA	18684396\|2141431
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MUC5AC protein	21419012
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased secretion of MUC5AC protein	21414310
D008070	Lipopolysaccharides	PI3 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]	21419012
D008070	Lipopolysaccharides	PI3 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]	21419012
D008070	Lipopolysaccharides	Tobramycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]	21414310
D008070	Lipopolysaccharides	Tobramycin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein]	21414310
D008070	Lipopolysaccharides	alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]	24333275
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MUC5AC mRNA	18197913\|1902409
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MUC5AC protein	18197913
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased secretion of MUC5AC protein	19024099
D008070	Lipopolysaccharides	Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]	18197913
D008070	Lipopolysaccharides	Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]	18197913
D008070	Lipopolysaccharides	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]	19024099
D008070	Lipopolysaccharides	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein]	19024099
D017997	Leukotriene C4	[IL13 protein results in increased abundance of Leukotriene C4] which results in increased secretion of MUC5AC protein	12654629
D017997	Leukotriene C4	Leukotriene C4 results in increased expression of MUC5AC mRNA	12654629
D017997	Leukotriene C4	Leukotriene C4 results in increased expression of MUC5AC protein	12654629
D017998	Leukotriene D4	[IL13 protein results in increased abundance of Leukotriene D4] which results in increased secretion of MUC5AC protein	12654629
D017998	Leukotriene D4	Leukotriene D4 results in increased expression of MUC5AC mRNA	12654629
D017998	Leukotriene D4	Leukotriene D4 results in increased expression of MUC5AC protein	12654629
D017998	Leukotriene D4	verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC mRNA]	12654629
D017998	Leukotriene D4	verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC protein]	12654629
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of MUC5AC mRNA	23649840
D008775	Methylprednisolone	Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA]	26093215
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]]	20359552
C066851	mithramycin A	mithramycin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]	20971882
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of MUC5AC mRNA	26924002
C092152	N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide	"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [ELANE protein results in increased expression of MUC5AC mRNA]"	17456367
C092152	N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide	"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [ELANE protein results in increased expression of MUC5AC protein]"	17456367
C078131	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	15531749
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MUC5AC mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MUC5AC mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MUC5AC mRNA"	27106021
D009285	Naphthoquinones	[Naphthoquinones co-treated with OVAL protein] results in increased expression of MUC5AC mRNA	17318628
C005274	naringin	naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]	22766066
C005274	naringin	naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]	22766066
D009532	Nickel	CCL2 protein affects the reaction [[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of MUC5AC mRNA]	24499286
D009532	Nickel	[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of MUC5AC mRNA	24499286
D009544	Niflumic Acid	Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]	17622767
D009544	Niflumic Acid	Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC protein]	17622767
C038405	nivalenol	nivalenol results in increased expression of and results in increased secretion of MUC5AC protein	24496642
C038405	nivalenol	nivalenol results in increased expression of MUC5AC mRNA	24496642
D010047	Ovalbumin	Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]	22484343
D010047	Ovalbumin	Ovalbumin results in increased expression of MUC5AC mRNA	12388339\|1279400
D010047	Ovalbumin	Ovalbumin results in increased expression of MUC5AC protein	12794006
D010047	Ovalbumin	PH 163 inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]	12794006
D010047	Ovalbumin	PH 163 inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]	12794006
D010047	Ovalbumin	verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]	12794006
D010047	Ovalbumin	verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]	12794006
D010047	Ovalbumin	zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]	12794006
D010047	Ovalbumin	zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]	12794006
D010126	Ozone	Ozone results in increased expression of MUC5AC mRNA	10496685
D010269	Paraquat	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]	25177032
D010269	Paraquat	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]	25177032
D010269	Paraquat	kaempferol inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]	25177032
D010269	Paraquat	MAPK8 protein affects the reaction [Paraquat results in increased expression of MUC5AC mRNA]	25177032
D010269	Paraquat	Paraquat results in increased expression of MUC5AC mRNA	25177032
D010269	Paraquat	pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]	25177032
D052638	Particulate Matter	3'-methoxy-4'-nitroflavone inhibits the reaction [Particulate Matter results in increased expression of MUC5AC mRNA]	19372248
D052638	Particulate Matter	Particulate Matter results in increased expression of MUC5AC mRNA	19372248\|2220925
D052638	Particulate Matter	Particulate Matter results in increased expression of MUC5AC protein	22209256\|2282075
D052638	Particulate Matter	TAPI-2 inhibits the reaction [Particulate Matter results in increased expression of MUC5AC mRNA]	22820758
D052638	Particulate Matter	tyrphostin AG 1478 inhibits the reaction [Particulate Matter results in increased expression of MUC5AC mRNA]	22820758
D052638	Particulate Matter	CCL2 protein affects the reaction [[TBX21 gene mutant form results in increased susceptibility to Particulate Matter] which results in increased expression of MUC5AC mRNA]	24499286
D052638	Particulate Matter	Particulate Matter promotes the reaction [OVAL protein results in increased expression of MUC5AC mRNA]	20562226
D052638	Particulate Matter	Particulate Matter results in increased expression of MUC5AC mRNA	20429853\|2282075
D052638	Particulate Matter	[TBX21 gene mutant form results in increased susceptibility to Particulate Matter] which results in increased expression of MUC5AC mRNA	24499286
C104857	PH 163	PH 163 inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]	12794006
C104857	PH 163	PH 163 inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]	12794006
C104857	PH 163	PH 163 inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]	12654629
D064209	Phytochemicals	Phytochemicals inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA]	26093215
D010936	Plant Extracts	Plant Extracts results in decreased secretion of MUC5AC protein	27369807
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of MUC5AC mRNA	23608068
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]	22766066
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]	25177032
D011794	Quercetin	Quercetin inhibits the reaction [IL1B protein results in increased expression of MUC5AC mRNA]	19367675
D017382	Reactive Oxygen Species	Reactive Oxygen Species affects the reaction [ELANE protein results in increased expression of MUC5AC mRNA]	10843967
D017382	Reactive Oxygen Species	Reactive Oxygen Species promotes the reaction [ELANE protein results in increased expression of MUC5AC mRNA]	11919081
C059514	resveratrol	resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]	20709182
C059514	resveratrol	resveratrol inhibits the reaction [OVAL protein results in increased expression of MUC5AC mRNA]	26549244
C059514	resveratrol	resveratrol inhibits the reaction [OVAL protein results in increased expression of MUC5AC protein]	26549244
C059514	resveratrol	resveratrol inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]	22213337
C059514	resveratrol	resveratrol inhibits the reaction [EGF protein results in increased expression of MUC5AC protein]	22213337
C059514	resveratrol	resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MUC5AC mRNA]	22213337
C059514	resveratrol	resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MUC5AC protein]	22213337
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of MUC5AC mRNA]	22213337
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of MUC5AC protein]	22213337
C059514	resveratrol	resveratrol results in decreased expression of MUC5AC	26549244
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	19464576
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]	19464576
D015575	Roxithromycin	Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]	18197913
D015575	Roxithromycin	Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]	18197913
C093642	SB 203580	SB 203580 inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]	22766066
C093642	SB 203580	SB 203580 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]	20971882
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased expression of MUC5AC protein	18357464
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased expression of MUC5AC protein	21161262
D012643	Selenium	Selenium results in decreased expression of MUC5AC mRNA	17512462
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]]	20359552
D019821	Simvastatin	Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]	20359552
D019821	Simvastatin	Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	20359552
D019821	Simvastatin	Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]	20359552
D019821	Simvastatin	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]	19024099
D019821	Simvastatin	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein]	19024099
C016104	sodium bichromate	sodium bichromate results in decreased expression of MUC5AC mRNA	22561333
D013458	Sulfur Dioxide	Sulfur Dioxide promotes the reaction [OVAL protein results in increased expression of MUC5AC mRNA]	29288730
C099410	TAPI-2	TAPI-2 inhibits the reaction [Particulate Matter results in increased expression of MUC5AC mRNA]	22820758
D013749	Tetrachlorodibenzodioxin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]	20971882
D013749	Tetrachlorodibenzodioxin	3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]	19372248
D013749	Tetrachlorodibenzodioxin	mithramycin A inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]	20971882
D013749	Tetrachlorodibenzodioxin	SB 203580 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]	20971882
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA	19372248\|2097188
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MUC5AC protein	20971882
D013749	Tetrachlorodibenzodioxin	tyrphostin AG 1478 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]	20971882
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MUC5AC mRNA	21570461
D013755	Tetradecanoylphorbol Acetate	resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MUC5AC mRNA]	22213337
D013755	Tetradecanoylphorbol Acetate	resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MUC5AC protein]	22213337
D014028	Tobacco Smoke Pollution	MIR218-2 mRNA inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased secretion of MUC5AC protein]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein inhibits the reaction [MIR218-2 mRNA inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased secretion of MUC5AC protein]]	28864214
D014028	Tobacco Smoke Pollution	TNFRSF1A protein promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased secretion of MUC5AC protein]	28864214
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of and results in increased secretion of MUC5AC protein	28864214
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA	18684396\|2578883
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA	27916735
D014028	Tobacco Smoke Pollution	Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]	27916735
D014031	Tobramycin	Tobramycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]	21414310
D014031	Tobramycin	Tobramycin inhibits the reaction [Lipopolysaccharides results in increased secretion of MUC5AC protein]	21414310
D014212	Tretinoin	Tretinoin results in increased expression of MUC5AC mRNA	17034753
D014222	Triamcinolone Acetonide	Triamcinolone Acetonide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]	27916735
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of MUC5AC mRNA	16141432
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC mRNA]	10640773
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]	10640773
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Particulate Matter results in increased expression of MUC5AC mRNA]	22820758
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA]	20971882
D014639	Vanadium	Vanadium results in increased expression of MUC5AC mRNA	10637131
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of MUC5AC mRNA	18684396\|2220925
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of MUC5AC protein	22209256
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of MUC5AC mRNA	20429853
C059141	verlukast	verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]	12794006
C059141	verlukast	verlukast inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]	12794006
C059141	verlukast	verlukast inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]	12654629
C059141	verlukast	verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC mRNA]	12654629
C059141	verlukast	verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC protein]	12654629
D014801	Vitamin A	Vitamin A results in increased expression of MUC5AC mRNA	17034753
C063449	zileuton	zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]	12794006
C063449	zileuton	zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]	12794006
C063449	zileuton	zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]	12654629
C063449	zileuton	zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]	12654629

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005201	extracellular matrix structural constituent	-	TAS	7513696

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	-
GO:0016266	O-glycan processing	-	TAS	-
GO:0048015	phosphatidylinositol-mediated signaling	-	IDA	25591774

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IDA	25591774
GO:0005737	cytoplasm	-	IDA	25591774
GO:0005796	Golgi lumen	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19199708
GO:0070701	mucus layer	-	IDA	14749330

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1643685	Disease	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-3781865	Diseases of glycosylation	TAS
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5083625	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	TAS
R-HSA-5083632	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	TAS
R-HSA-5083636	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	TAS
R-HSA-5173105	O-linked glycosylation	TAS
R-HSA-5621480	Dectin-2 family	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-913709	O-linked glycosylation of mucins	TAS
R-HSA-977068	Termination of O-glycan biosynthesis	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26915146	Effect of Cadmium on Human Middle Ear Epithelial Cells. (2015 Dec)	Song JJ	J Int Adv Otol
23399768	Blocking of thromboxane A(2) receptor attenuates airway mucus hyperproduction induced by cigarette smoke. (2013 Mar 5)	An J	Eur J Pharmacol
29215731	Eucalyptol Protects Lungs against Bacterial Invasion through Attenuating Ciliated Cell Damage and Suppressing MUC5AC Expression. (2017 Dec 7)	Yu N	J Cell Physiol
19723147	MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. (2009 Sep)	Caramori G	Histopathology
22923641	The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium. (2012 Oct 15)	Fu XW	Am J Physiol Lung Cell Mol Physiol
21034448	Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium. (2010 Oct 29)	Wang G	Respir Res
19692129	Effects of cigarette smoking on mucin production in human middle ear epithelial cells. (2009 Oct)	Cho JG	Int J Pediatr Otorhinolaryngol
21456954	Anti-interleukin-17 antibodies attenuate airway inflammation in tobacco-smoke-exposed mice. (2011 Mar)	Shen N	Inhal Toxicol
17727719	Effect of active smoking on the human bronchial epithelium transcriptome. (2007 Aug 29)	Chari R	BMC Genomics
11133506	Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke. (2001 Jan)	Takeyama K	Am J Physiol Lung Cell Mol Physiol
17035444	Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. (2006 Oct)	Innes AL	Chest
21036164	Doxycycline attenuates acrolein-induced mucin production, in part by inhibiting MMP-9. (2011 Jan 10)	Ren S	Eur J Pharmacol
21078494	Nicotine suppresses inflammatory factors in HBE16 airway epithelial cells after exposure to cigarette smoke extract and lipopolysaccharide. (2010 Dec)	Li Q	Transl Res
22676183	Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers. (2012 Jun 7)	Wang G	BMC Med Genomics
28602698	Early growth response factor 1 is essential for cigarette smoke-induced MUC5AC expression in human bronchial epithelial cells. (2017 Aug 19)	Wang SB	Biochem Biophys Res Commun
21418399	Mixed squamous cell and glandular papilloma of the lung: a case study and literature review. (2011 Apr)	Inamura K	Pathol Int
24376700	Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. (2013)	Ning Y	PLoS One
19661247	Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. (2009 Nov 1)	Deshmukh HS	Am J Respir Crit Care Med
21676518	A study of the effect of proinflammatory cytokines on the epithelial cells of smokers, with or without COPD. (2011 Sep)	Damia Ade D	Arch Bronconeumol
21930963	Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation. (2011 Nov 1)	Singh SP	J Immunol
18490768	Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. (2008 Jun 1)	Mishra NC	J Immunol
16242311	Cigarette smoke extract modulates respiratory defence mechanisms through effects on T-cells and airway epithelial cells. (2006 May)	Glader P	Respir Med
29053025	E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion. (2018 Feb 15)	Reidel B	Am J Respir Crit Care Med
17640479	Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease. (2007 Aug)	Wang K	Acta Pharmacol Sin
16261889	MUC5AC expression up-regulation goblet cell hyperplasia in the airway of patients with chronic obstructive pulmonary disease. (2005 Sep)	Ma R	Chin Med Sci J
24905583	beta2-Adrenoceptor involved in smoking-induced airway mucus hypersecretion through beta-arrestin-dependent signaling. (2014)	Zhou Y	PLoS One
27297822	Impact of Cigarette Smoking on Tear Function and Correlation between Conjunctival Goblet Cells and Tear MUC5AC Concentration in Office Workers. (2016 Jun 14)	Uchino Y	Sci Rep
15121636	Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. (2004 Aug)	Shao MX	Am J Physiol Lung Cell Mol Physiol
26704155	[Effects of simvastatin on airway inflammation and airway mucus hypersecretion in rats with chronic obstructive pulmonary disease]. (2015 Jun 9)	Wang S	Zhonghua Yi Xue Za Zhi
26797711	A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis. (2016 Apr)	Spanjer AI	Thorax
20060463	Cigarette smoke total particulate matter increases mucous secreting cell numbers in vitro: a potential model of goblet cell hyperplasia. (2010 Apr)	Haswell LE	Toxicol In Vitro
15498267	[Expression of epidermal growth factor receptor and MUC5AC on human airway with chronic obstructive pulmonary disease]. (2004 Sep)	Mao L	Zhonghua Jie He He Hu Xi Za Zhi
21544845	Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1alpha via epidermal growth factor receptor-mediated signaling pathways. (2012 Apr)	Yu H	J Appl Toxicol
26819423	[Effect of aminophylline and simvastatin on airway inflammation and mucus hypersecretion in rats with chronic obstructive pulmonary disease]. (2016 Jan)	Wang S	Zhong Nan Da Xue Xue Bao Yi Xue Ban
26485917	[Effect of Yifei Jianpi Recipe on Airway Inflammation and Airway Mucus Hypersecretion of Chronic Obstructive Pulmonary Disease Model Rats]. (2015 Aug)	Wang S	Zhongguo Zhong Xi Yi Jie He Za Zhi
28932196	(-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats. (2017)	Liang Y	Front Pharmacol
27916735	Laryngeal mucus hypersecretion is exacerbated after smoking cessation and ameliorated by glucocorticoid administration. (2017 Jan 4)	Ueha R	Toxicol Lett
22088530	Role of extracellular signal-regulated kinase 1/2 in cigarette smoke-induced mucus hypersecretion in a rat model. (2011 Oct)	Xiao J	Chin Med J (Engl)
25239867	Nuclear erythroid 2 p45-related factor-2 Nrf2 ameliorates cigarette smoking-induced mucus overproduction in airway epithelium and mouse lungs. (2014 Oct)	Ying YH	Microbes Infect
15563701	Expression of ErbB receptors and mucins in the airways of long term current smokers. (2004 Dec)	O'Donnell RA	Thorax