Gene: MUC6

4588
MUC-6
mucin 6, oligomeric mucus/gel-forming
protein-coding
11p15.5
Ensembl:ENSG00000184956 MIM:158374 Vega:OTTHUMG00000165140 UniprotKB:Q6W4X9
NG_052845.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.113e-1 (AD)  7.016e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL9A10.452
IGSF9B0.446
CACNG40.441
LINGO30.438
LAT0.432
TBC1D260.421
HDAC100.421
ADORA2A0.417
MYL70.414
CHRNA100.413

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARPBP-0.327
ZNF92-0.307
ITGBL1-0.303
TTC29-0.298
SLC36A4-0.295
ZNF429-0.289
LURAP1L-0.287
CENPN-0.282
ZNF277-0.282
GTDC1-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of MUC6 mRNA26690555
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MUC6 mRNA22129741
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MUC6 mRNA16483693
D001151ArsenicArsenic affects the methylation of MUC6 gene25304211
C006780bisphenol Abisphenol A results in decreased expression of MUC6 mRNA25181051
D003300CopperCopper deficiency results in increased expression of MUC6 mRNA26033743
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of MUC6 mRNA28962523
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MUC6 mRNA22129741
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of MUC6 mRNA27776689
C007738fluoranthenefluoranthene results in increased expression of MUC6 mRNA28329830
C069837fullerene C60fullerene C60 results in decreased expression of MUC6 mRNA19167457
C016517indole-3-carbinolindole-3-carbinol affects the expression of MUC6 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MUC6 mRNA22129741
C045463leflunomideleflunomide results in decreased expression of MUC6 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MUC6 mRNA"24972896
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of MUC6 mRNA22563483
D008727MethotrexateMethotrexate results in decreased expression of MUC6 mRNA17400583
C028007nickel monoxidenickel monoxide results in decreased expression of MUC6 mRNA19167457
D010100OxygenOxygen deficiency results in decreased expression of MUC6 mRNA24205000
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of MUC6 mRNA22563483
D010269ParaquatParaquat results in increased expression of MUC6 mRNA22563483
D010936Plant ExtractsPlant Extracts results in decreased expression of MUC6 mRNA23557933
C428725pyridabenpyridaben results in increased expression of MUC6 mRNA22563483
C031618sodium nitratesodium nitrate results in increased expression of MUC6 mRNA17275683
D014635Valproic AcidValproic Acid results in increased methylation of MUC6 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-NAS7680650  
GO ID GO Term Qualifier Evidence PubMed
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0016266O-glycan processing-TAS-  
GO:0030277maintenance of gastrointestinal epithelium-NAS7680650  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083625Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)TAS
R-HSA-5083632Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)TAS
R-HSA-5083636Defective GALNT12 causes colorectal cancer 1 (CRCS1)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5621480Dectin-2 familyTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-913709O-linked glycosylation of mucinsTAS
R-HSA-977068Termination of O-glycan biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29532581Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway. (2018 Mar 13)Hallfors JAddict Biol
28620964Does gene expression in laryngeal subsites differ between patients with laryngopharyngeal reflux and controls? (2018 Feb)Wood JMClin Otolaryngol