Gene: MUC7

4589
MG2
mucin 7, secreted
protein-coding
4q13.3
Ensembl:ENSG00000171195 MIM:158375 Vega:OTTHUMG00000129916 UniprotKB:Q8TAX7
NG_012348.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.702e-1 (AD)  2.308e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1109501chr4:70463773 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZG16B0.939
PIP0.874
BPIFB20.743
C6orf580.594
STATH0.544
TNP10.503
PRM10.495
PIGR0.493
CRISP30.487
PRM20.467

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOG-0.267
UCP3-0.256
KIF4A-0.244
UTP20-0.232
CLDN20-0.23
CYP2C8-0.229
SFTPC-0.227
CCDC73-0.225
CPO-0.223
SMN1-0.222

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D002104CadmiumCadmium results in decreased expression of MUC7 mRNA24376830
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MUC7 mRNA17183730
D009532NickelNickel results in decreased expression of MUC7 mRNA24768652|2558310
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MUC7 mRNA17183730

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16203048  
GO ID GO Term Qualifier Evidence PubMed
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0016266O-glycan processing-TAS-  
GO:0031640killing of cells of other organism-IDA12543672  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IDA12543672  
GO ID GO Term Qualifier Evidence PubMed
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0044218other organism cell membrane-IDA12543672  
GO:0070062extracellular exosome-HDA19199708  
GO:0097679other organism cytoplasm-IDA12543672  
KEGG ID KEGG Term
hsa04970Salivary secretion
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083625Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)TAS
R-HSA-5083632Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)TAS
R-HSA-5083636Defective GALNT12 causes colorectal cancer 1 (CRCS1)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5621480Dectin-2 familyTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-913709O-linked glycosylation of mucinsTAS
R-HSA-977068Termination of O-glycan biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28620964Does gene expression in laryngeal subsites differ between patients with laryngopharyngeal reflux and controls? (2018 Feb)Wood JMClin Otolaryngol