Gene: MUSK

4593
CMS9|FADS
muscle associated receptor tyrosine kinase
protein-coding
9q31.3
Ensembl:ENSG00000030304 MIM:601296 Vega:OTTHUMG00000020485 UniprotKB:O15146
NG_016016.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.863e-1 (AD)  5.767e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYB5R20.686
LAYN0.677
SLC22A160.648
RBP70.637
OR5D140.605
HOXD120.594
RASGRP30.594
PPFIBP20.588
HOXD110.583
C11orf880.582

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.444
CDH22-0.435
DLGAP3-0.433
KCNQ4-0.432
SCRT1-0.431
PAK6-0.428
SHANK2-0.428
MMP24-0.424
RIMS4-0.419
ST6GALNAC5-0.417

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MUSK mRNA"18648102
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MUSK mRNA16483693
D001194AsbestosAsbestos affects the expression of MUSK mRNA17297452
C006780bisphenol Abisphenol A results in increased expression of MUSK mRNA27685785
C006780bisphenol Abisphenol A affects the expression of MUSK mRNA25181051
D002211CapsaicinCapsaicin results in increased expression of MUSK protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MUSK protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of MUSK protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of MUSK protein]22150557
D002994ClofibrateClofibrate results in increased expression of MUSK mRNA22300585
D003042CocaineCocaine affects the expression of MUSK mRNA20187946
D004041Dietary FatsDietary Fats results in increased expression of MUSK mRNA18042831
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of MUSK mRNA24680724
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MUSK mRNA"20188158
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of MUSK mRNA12832660
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MUSK protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of MUSK protein]22150557
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MUSK mRNA27935865
D000073878Palm OilPalm Oil results in increased expression of MUSK mRNA18042831
D012524SarinSarin results in increased expression of MUSK mRNA19522546
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MUSK protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of MUSK protein]22150557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MUSK mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MUSK mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MUSK gene27618143
D014635Valproic AcidValproic Acid results in decreased methylation of MUSK gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MUSK gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MUSK mRNA27935865
C088658zoledronic acidzoledronic acid results in decreased expression of MUSK mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-ISS-  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IEA-  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005515protein binding-IPI22939624  
GO:0005524ATP binding-IEA-  
GO:0017147Wnt-protein binding-IBA21873635  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IBA21873635  
GO:0001934positive regulation of protein phosphorylation-IMP25537362  
GO:0001934positive regulation of protein phosphorylation-ISS-  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-TAS7546737  
GO:0007275multicellular organism development-IBA21873635  
GO:0007275multicellular organism development-IEA-  
GO:0007528neuromuscular junction development-IDA25537362  
GO:0007528neuromuscular junction development-ISS-  
GO:0007613memory-ISS-  
GO:0008582regulation of synaptic growth at neuromuscular junction-ISS-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010628positive regulation of gene expression-ISS-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030154cell differentiation-IEA-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0046777protein autophosphorylation-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071340skeletal muscle acetylcholine-gated channel clustering-ISS-  
GO:2000541positive regulation of protein geranylgeranylation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-ISS-  
GO:0030054cell junction-IEA-  
GO:0031594neuromuscular junction-ISS-  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA23382219  
GO:0045211postsynaptic membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-3000178ECM proteoglycansIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9200520Gas chromatographic method using electron-capture detection for the determination of musk xylene in human blood samples. Biological monitoring of the general population. (1997 May 23)Angerer JJ Chromatogr B Biomed Sci Appl