Gene: MUT

4594
MCM
methylmalonyl-CoA mutase
protein-coding
6p12.3
Ensembl:ENSG00000146085 MIM:609058 Vega:OTTHUMG00000014814 UniprotKB:P22033
NG_007100.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.402e-1 (AD)  2.310e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB100.901
MARCH50.896
PRDX30.893
PAICS0.891
DCTN40.888
ABI10.887
LMBRD10.886
ATPAF10.884
TSPAN30.882
ME10.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.731
OR4F29-0.682
CETP-0.303
KRTAP4-8-0.301
FCRL3-0.29
OR6C74-0.287
DPPA4-0.285
GADL1-0.281
EOMES-0.28
MTRNR2L6-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of MUT mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MUT mRNA17562736
C053001adefoviradefovir affects the expression of MUT mRNA mutant form19427250
C053001adefoviradefovir affects the expression of MUT protein mutant form19427250
C053001adefoviradefovir results in increased expression of MUT mRNA19199343
C053001adefoviradefovir results in increased expression of MUT protein19199343
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MUT mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MUT gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MUT mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of MUT mRNA21757418
D000638AmiodaroneAmiodarone affects the expression of MUT mRNA19483382
C010680antibiotic G 418antibiotic G 418 affects the expression of MUT mRNA mutant form19427250
C010680antibiotic G 418[antibiotic G 418 co-treated with Gentamicins] affects the activity of MUT protein mutant form19427250
C010680antibiotic G 418[antibiotic G 418 co-treated with Gentamicins] affects the expression of MUT mRNA mutant form19427250
C010680antibiotic G 418antibiotic G 418 promotes the reaction [Gentamicins affects the expression of MUT protein mutant form]19427250
C547126AZM551248AZM551248 results in decreased expression of MUT mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of MUT mRNA19483382
D004958EstradiolEstradiol results in decreased expression of MUT mRNA23019147
C044887beta-methylcholinebeta-methylcholine affects the expression of MUT mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MUT mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MUT mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of MUT mRNA28196854
C006780bisphenol Abisphenol A affects the expression of MUT mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of MUT protein28903499
D002104CadmiumCadmium results in increased oxidation of MUT protein24496640
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of MUT mRNA27339419
D002994ClofibrateClofibrate affects the expression of MUT mRNA19483382
C000913cobamamidecobamamide promotes the reaction [[MUT protein results in increased metabolism of methylmalonyl-coenzyme A] which results in increased chemical synthesis of succinyl-coenzyme A]16823967
D019327Copper SulfateCopper Sulfate results in decreased expression of MUT mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of MUT protein22699969
D016572CyclosporineCyclosporine results in decreased expression of MUT mRNA20106945
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of MUT mRNA26873546
D002945CisplatinCisplatin affects the expression of MUT mRNA mutant form19427250
D002945CisplatinCisplatin affects the expression of MUT protein mutant form19427250
D002945CisplatinCisplatin results in increased expression of MUT mRNA19199343|2759478
D002945CisplatinCisplatin results in increased expression of MUT protein19199343
C000944dicrotophosdicrotophos results in decreased expression of MUT mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of MUT mRNA19030233
D002117CalcitriolCalcitriol results in increased expression of MUT mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MUT mRNA"22485181
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of MUT mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of MUT mRNA26873546
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MUT mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MUT mRNA17942748
D005001EthionineEthionine affects the expression of MUT mRNA19483382
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MUT mRNA23649840
C039281furanfuran results in decreased expression of MUT mRNA26194646
D005839Gentamicins[antibiotic G 418 co-treated with Gentamicins] affects the activity of MUT protein mutant form19427250
D005839Gentamicins[antibiotic G 418 co-treated with Gentamicins] affects the expression of MUT mRNA mutant form19427250
D005839Gentamicinsantibiotic G 418 promotes the reaction [Gentamicins affects the expression of MUT protein mutant form]19427250
D005839GentamicinsGentamicins affects the expression of MUT protein mutant form19427250
D005897GlafenineGlafenine results in decreased expression of MUT mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MUT mRNA20044591
C071541hydroxycobalamin(c-lactam)hydroxycobalamin(c-lactam) results in decreased activity of MUT protein26219506
C071541hydroxycobalamin(c-lactam)hydroxycobalamin(c-lactam) results in decreased activity of MUT protein1432250|8229294
C071541hydroxycobalamin(c-lactam)hydroxycobalamin(c-lactam) results in decreased activity of MUT protein2327967
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MUT mRNA25613284
C015357methylmalonyl-coenzyme Acobamamide promotes the reaction [[MUT protein results in increased metabolism of methylmalonyl-coenzyme A] which results in increased chemical synthesis of succinyl-coenzyme A]16823967
C015357methylmalonyl-coenzyme AMUT protein results in increased metabolism of methylmalonyl-coenzyme A16823967
C015357methylmalonyl-coenzyme A[MUT protein results in increased metabolism of methylmalonyl-coenzyme A] which results in increased chemical synthesis of succinyl-coenzyme A16823967
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MUT mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MUT mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MUT mRNA"25554681
D009853OmeprazoleOmeprazole affects the expression of MUT mRNA19483382
D010695PhlorhizinPhlorhizin results in decreased expression of MUT mRNA22538082
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MUT mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of MUT mRNA19483382
D010936Plant ExtractsPlant Extracts results in increased expression of MUT mRNA23557933
C045362prochlorazprochloraz results in decreased expression of MUT mRNA21470553
C045950propiconazolepropiconazole results in decreased expression of MUT mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of MUT mRNA19483382
C059514resveratrolresveratrol results in increased expression of MUT protein18089832
C089730rosiglitazonerosiglitazone results in increased expression of MUT mRNA15520860
D012643SeleniumSelenium results in decreased expression of MUT mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of MUT mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MUT mRNA25895662
C012046succinyl-coenzyme Acobamamide promotes the reaction [[MUT protein results in increased metabolism of methylmalonyl-coenzyme A] which results in increased chemical synthesis of succinyl-coenzyme A]16823967
C012046succinyl-coenzyme A[MUT protein results in increased metabolism of methylmalonyl-coenzyme A] which results in increased chemical synthesis of succinyl-coenzyme A16823967
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MUT mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MUT mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of MUT mRNA19483382
D013893ThiramThiram results in decreased expression of MUT mRNA20530235
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of MUT mRNA12732648
D014635Valproic AcidValproic Acid affects the expression of MUT mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of MUT gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MUT mRNA19101580
D014635Valproic AcidValproic Acid affects the expression of MUT mRNA17292431
D014640VancomycinVancomycin results in increased expression of MUT mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of MUT mRNA21126777
C029297vinylidene chloridevinylidene chloride results in decreased expression of MUT mRNA26682919
D015215ZidovudineZidovudine affects the expression of MUT mRNA mutant form19427250
D015215ZidovudineZidovudine affects the expression of MUT protein mutant form19427250
D015215ZidovudineZidovudine results in increased expression of MUT mRNA19199343
D015215ZidovudineZidovudine results in increased expression of MUT protein19199343

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IDA20876572  
GO:0004494methylmalonyl-CoA mutase activity-IBA21873635  
GO:0004494methylmalonyl-CoA mutase activity-IMP27167370  28101778  
GO:0005515protein binding-IPI20876572  28497574  
GO:0031419cobalamin binding-IDA20876572  
GO:0042802identical protein binding-IDA20876572  
GO:0042803protein homodimerization activity-IDA20876572  
GO:0046872metal ion binding-IEA-  
GO:0072341modified amino acid binding-IDA20031578  
GO ID GO Term Qualifier Evidence PubMed
GO:0009235cobalamin metabolic process-TAS-  
GO:0009791post-embryonic development-IEA-  
GO:0043547positive regulation of GTPase activity-IDA20876572  28497574  
GO:0050667homocysteine metabolic process-IDA20031578  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-TAS2567699  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00280Valine, leucine and isoleucine degradation
hsa00630Glyoxylate and dicarboxylate metabolism
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-3296469Defects in cobalamin (B12) metabolismTAS
R-HSA-3296482Defects in vitamin and cofactor metabolismTAS
R-HSA-3359475Defective MMAA causes methylmalonic aciduria type cblATAS
R-HSA-3359478Defective MUT causes methylmalonic aciduria mut typeTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-71032Propionyl-CoA catabolismTAS
R-HSA-77289Mitochondrial Fatty Acid Beta-OxidationTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25350766Epidemiology of goblet cell and microvesicular hyperplastic polyps. (2014 Dec)Qazi TMAm J Gastroenterol
23628113Unravelling the basis of variability in cobalamin levels in the general population. (2013 Nov 14)Andrew TBr J Nutr
26081405[Association of cytochrome P450 2A6 gene polymorphisms with smoking behaviors:a Meta-analysis]. (2015 Feb)Pan LZhonghua Yu Fang Yi Xue Za Zhi
29383112Unique circulating microRNAs in relation to EGFR mutation status in Japanese smoker male with lung adenocarcinoma. (2017 Dec 29)Ito SOncotarget
15840612Cigarette smoking and colorectal cancer: APC mutations, hMLH1 expression, and GSTM1 and GSTT1 polymorphisms. (2005 May 1)Luchtenborg MAm J Epidemiol
23239997Functional characterization of TLR4 +3725 G/C polymorphism and association with protection against overweight. (2012)Penas-Steinhardt APLoS One