Gene: MUTYH

4595
MYH
mutY DNA glycosylase
protein-coding
1p34.1
Ensembl:ENSG00000132781 MIM:604933 Vega:OTTHUMG00000007682 UniprotKB:Q9UIF7
NG_008189.1
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.697e-1 (AD)  8.350e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNPEPL10.841
CCDC1590.823
ASCC20.804
RBCK10.797
SLC12A90.791
GUSB0.79
CAPS0.789
PRR140.787
USP400.786
ARHGEF10.784

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.511
OR4F29-0.491
HS6ST3-0.394
KCNH7-0.36
GRM5-0.35
CDH7-0.35
TRPC5-0.345
KCNH5-0.344
CDKL5-0.34
PPM1E-0.329

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MUTYH mRNA"15215175
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MUTYH mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MUTYH mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of MUTYH mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MUTYH mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MUTYH mRNA16483693
D001151ArsenicArsenic affects the methylation of MUTYH gene25304211
C006632arsenic trioxideMUTYH protein affects the activity of arsenic trioxide17101720
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MUTYH mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of MUTYH mRNA21179406
C006780bisphenol Abisphenol A results in decreased methylation of MUTYH promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of MUTYH promoter27312807
C006780bisphenol Abisphenol A affects the expression of MUTYH mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of MUTYH mRNA17659339
D002110CaffeineCaffeine results in increased expression of MUTYH mRNA20864626
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of MUTYH mRNA11566570
C018021cobaltous chloridecobaltous chloride results in decreased expression of MUTYH mRNA19376846
D016572CyclosporineCyclosporine results in increased methylation of MUTYH promoter27989131
D013759Dronabinol[Dronabinol co-treated with Ethanol] results in increased expression of MUTYH mRNA17618662
D013759DronabinolDronabinol results in increased expression of MUTYH mRNA17618662
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MUTYH mRNA27392435
D000431EthanolEthanol results in decreased expression of MUTYH mRNA11566570
D000431Ethanol[Dronabinol co-treated with Ethanol] results in increased expression of MUTYH mRNA17618662
D000431EthanolEthanol results in increased expression of MUTYH mRNA17618662
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MUTYH mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MUTYH mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MUTYH mRNA17942748
C039281furanfuran results in increased expression of MUTYH mRNA22079235
D017313FenretinideFenretinide results in decreased expression of MUTYH mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of MUTYH mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MUTYH mRNA27392435
C544151jinfukangjinfukang results in increased expression of MUTYH mRNA27392435
D007854LeadMUTYH gene polymorphism affects the susceptibility to Lead22466227
C008261lead acetatelead acetate results in increased expression of MUTYH mRNA21335049
C031895lead chromatelead chromate results in increased expression of MUTYH mRNA23584427
D008694MethamphetamineMethamphetamine results in decreased expression of MUTYH mRNA19564919
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of MUTYH mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MUTYH mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MUTYH mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MUTYH mRNA23649840
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of MUTYH mRNA20864626
C005246myristicinmyristicin results in decreased expression of MUTYH mRNA24792648
D010100OxygenOxygen deficiency results in decreased expression of MUTYH protein25030372
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MUTYH mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MUTYH mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MUTYH mRNA19710929
C019536potassium bromatepotassium bromate results in decreased expression of MUTYH mRNA22539617
D011192Potassium DichromatePotassium Dichromate results in increased expression of MUTYH mRNA23608068
D011794QuercetinQuercetin results in increased expression of MUTYH mRNA18095365
C017947sodium arsenitesodium arsenite results in decreased expression of MUTYH mRNA17558810
D013629TamoxifenTamoxifen affects the expression of MUTYH mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MUTYH mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MUTYH mRNA22808131
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of MUTYH mRNA25613284
D014520UrethaneUrethane results in decreased expression of MUTYH mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MUTYH gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000701purine-specific mismatch base pair DNA N-glycosylase activity-IBA21873635  
GO:0000701purine-specific mismatch base pair DNA N-glycosylase activity-IMP20848659  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI11801590  
GO:0019104DNA N-glycosylase activity-TAS-  
GO:0032357oxidized purine DNA binding-IBA21873635  
GO:0032405MutLalpha complex bindingNOTIDA11801590  
GO:0032406MutLbeta complex bindingNOTIDA11801590  
GO:0032407MutSalpha complex binding-IDA11801590  
GO:0032408MutSbeta complex bindingNOTIDA11801590  
GO:00340398-oxo-7,8-dihydroguanine DNA N-glycosylase activity-IBA21873635  
GO:0035485adenine/guanine mispair binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:00515394 iron, 4 sulfur cluster binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-IBA21873635  
GO:0006281DNA repair-TAS8682794  
GO:0006284base-excision repair-IBA21873635  
GO:0006298mismatch repair-IBA21873635  
GO:0006298mismatch repair-TAS7823963  
GO:0045007depurination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005739mitochondrion-IEA-  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110330Recognition and association of DNA glycosylase with site containing an affected purineTAS
R-HSA-110331Cleavage of the damaged purineTAS
R-HSA-110357Displacement of DNA glycosylase by APEX1TAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73927DepurinationTAS
R-HSA-73929Base-Excision Repair, AP Site FormationTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19300419Polymorphisms of the DNA base excision repair gene MUTYH in head and neck cancer. (2009 Mar)Sliwinski TExp Oncol
17220334High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. (2007 Jan)Huang MCancer Epidemiol Biomarkers Prev
21195504Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. (2011 Aug)Qian BLung Cancer
19902366Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. (2010 Feb)Agalliu ICancer Causes Control
18155253OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study. (2008 Mar 1)Hatt LMutat Res
26159902DNA Repair Gene Polymorphisms in Relation to Non-Small Cell Lung Cancer Survival. (2015)Su YCell Physiol Biochem
17203305Genetic variation in the base excision repair pathway and bladder cancer risk. (2007 Apr)Figueroa JDHum Genet
23951112Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk. (2013)Corral RPLoS One
18374480DNA repair of oxidative DNA damage in human carcinogenesis: potential application for cancer risk assessment and prevention. (2008 Jul 18)Paz-Elizur TCancer Lett
20571908MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study. (2011 Feb)Sliwinski TMol Biol Rep