Gene: MVD

4597
FP17780|MDDase|MPD|POROK7
mevalonate diphosphate decarboxylase
protein-coding
16q24.2
Ensembl:ENSG00000167508 MIM:603236 Vega:OTTHUMG00000137865 UniprotKB:P53602
NG_052674.1
PubMed
CD|ND
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.894e-1 (AD)  8.802e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARFRP10.873
EBP0.863
E4F10.863
GPS10.855
NPDC10.851
ZFAND2B0.848
YIF1B0.842
TMEM1750.841
MVK0.839
WDR180.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.613
OR4F29-0.584
MTRNR2L9-0.445
MTRNR2L6-0.42
KCNJ15-0.416
FCGR3B-0.409
MTRNR2L10-0.397
CXCR2-0.385
CXCR1-0.375
PABPC4L-0.372

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of MVD mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of MVD mRNA28329830
C00358522-hydroxycholesterol22-hydroxycholesterol results in decreased expression of MVD mRNA19426978
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of MVD mRNA"28433925
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of MVD mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MVD mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MVD mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of MVD protein26194647
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MVD mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MVD mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of MVD mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of MVD mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of MVD mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MVD mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MVD mRNA]17585979
C014949acetylhydrazineacetylhydrazine results in increased expression of MVD mRNA15282401
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MVD protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MVD mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MVD mRNA19770486
C000188alachloralachlor results in increased expression of MVD mRNA12419858
D000452AldrinAldrin results in increased expression of MVD mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MVD mRNA16483693
D001104ArbutinArbutin results in decreased expression of MVD mRNA17103032
C519728archazolid Barchazolid B results in increased expression of MVD mRNA25218289
D001280AtrazineAtrazine results in decreased expression of MVD mRNA25929836
D019324beta-NaphthoflavoneAHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of MVD mRNA]22234961
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of MVD mRNA22234961
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MVD mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MVD mRNA21632981|2187194
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MVD mRNA19770486|2222880
C006780bisphenol Abisphenol A results in decreased methylation of MVD promoter27312807
C006780bisphenol Abisphenol A results in increased expression of MVD mRNA21932408|2516818
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of MVD mRNA"28433925
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MVD mRNA22079614
D002110CaffeineCaffeine results in decreased expression of MVD mRNA25868845
D002330CarmustineCarmustine results in decreased expression of MVD mRNA15980968
D000068579CelecoxibCelecoxib results in decreased expression of MVD17224647
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MVD mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of MVD mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MVD mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MVD mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of MVD mRNA24386269
D003300CopperCopper results in decreased expression of MVD mRNA17205981
D019327Copper SulfateCopper Sulfate results in decreased expression of MVD mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of MVD mRNA18579281
C030973cupric oxidecupric oxide results in increased expression of MVD mRNA22077320
D003474CurcuminCurcumin results in decreased expression of MVD mRNA17198877
D016572CyclosporineCyclosporine results in decreased expression of MVD mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of MVD mRNA25562108
C093628cyproconazolecyproconazole affects the expression of MVD mRNA22045034
D013759DronabinolDronabinol results in decreased expression of MVD mRNA16616335
D003976DiazinonDiazinon results in increased methylation of MVD gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MVD mRNA21266533
D002945CisplatinCisplatin affects the expression of MVD mRNA27594783
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MVD mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MVD mRNA24280081|2739243
D002945CisplatinCisplatin results in decreased expression of MVD mRNA24280081
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of MVD mRNA28433925
D004041Dietary Fats[Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA18367378
D004041Dietary FatsDietary Fats results in decreased expression of MVD mRNA19030233|2260994
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of MVD mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MVD mRNA19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of MVD mRNA"28433925
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MVD mRNA18164116
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of MVD mRNA28939011
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MVD protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MVD mRNA17351261
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MVD mRNA16174780|1755790
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in decreased expression of MVD mRNA22711419
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MVD mRNA23649840
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of MVD mRNA"23333450
D005419FlavonoidsFlavonoids results in increased expression of MVD mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of MVD mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of MVD mRNA28329830
C061365flusilazoleflusilazole affects the expression of MVD mRNA22634333
C061365flusilazoleflusilazole results in increased expression of MVD mRNA28263823
D005557FormaldehydeFormaldehyde results in decreased expression of MVD mRNA23649840
D019833GenisteinGenistein results in decreased expression of MVD mRNA16705744
D005944GlucosamineGlucosamine results in increased expression of MVD mRNA17178593
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of MVD mRNA22634610
C409722hexaconazolehexaconazole results in decreased expression of MVD mRNA22045034
D017313FenretinideFenretinide results in decreased expression of MVD mRNA28973697
C029424hydrazinehydrazine results in increased expression of MVD mRNA15282401
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of MVD mRNA19376150
D007501IronIron deficiency results in increased expression of MVD mRNA19821111
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MVD mRNA27392435
C544151jinfukangjinfukang results in increased expression of MVD mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of MVD protein17337753
C008261lead acetatelead acetate results in decreased expression of MVD mRNA22613225
C045463leflunomideleflunomide results in decreased expression of MVD mRNA19751817
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MVD mRNA21641980
D008694MethamphetamineMethamphetamine results in increased methylation of MVD promoter26307267
D008752Methylene ChlorideMethylene Chloride affects the expression of MVD mRNA28392392
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MVD mRNA23649840
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of MVD mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MVD mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MVD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MVD mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MVD mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of MVD mRNA18651567|2271453
C464660obeticholic acidobeticholic acid results in decreased expression of MVD mRNA27939613
D019319Okadaic AcidOkadaic Acid results in decreased expression of MVD mRNA28939011
D010126OzoneOzone results in decreased expression of MVD mRNA25838073
D010634PhenobarbitalPhenobarbital affects the expression of MVD mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of MVD mRNA19270015|1948288
D010634PhenobarbitalPhenobarbital results in increased expression of MVD mRNA19162173
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of MVD mRNA27756839
D010795Phthalic AcidsPhthalic Acids results in decreased expression of MVD mRNA15728792
C006253pirinixic acidpirinixic acid results in increased expression of MVD mRNA17950772|2081375
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of MVD mRNA]17950772
D059808PolyphenolsPolyphenols results in decreased expression of MVD mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in increased expression of MVD mRNA11678601
D011192Potassium DichromatePotassium Dichromate results in increased expression of MVD protein23718831
D017035PravastatinPravastatin results in increased expression of MVD mRNA27225895
D017035PravastatinPravastatin results in increased expression of MVD mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MVD mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of MVD mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of MVD mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of MVD mRNA27029645
D011794QuercetinQuercetin results in decreased expression of MVD mRNA21632981
C502851quinocetonequinocetone results in increased expression of MVD mRNA27046791
D015474IsotretinoinIsotretinoin results in decreased expression of MVD mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MVD mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of MVD mRNA19073995
D019821SimvastatinSimvastatin results in increased expression of MVD mRNA25055962
C017947sodium arsenitesodium arsenite results in increased expression of MVD mRNA25524072
D053260SootSoot results in increased expression of MVD mRNA22461453
C075117squalestatin 1squalestatin 1 results in increased expression of MVD mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of MVD mRNA27225895
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MVD mRNA21641980
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MVD mRNA"18579281
D013629TamoxifenTamoxifen affects the expression of MVD mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MVD mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MVD mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of MVD mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MVD mRNA18295293|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MVD mRNA16960034
D013853ThioacetamideThioacetamide results in increased expression of MVD mRNA23411599
D008063Thioctic Acid[Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA18367378
C009495titanium dioxidetitanium dioxide results in increased expression of MVD mRNA23557971|2776080
C052342topiramatetopiramate results in increased expression of MVD mRNA16979414
C032910triadimefontriadimefon results in increased expression of MVD mRNA17178688
C032910triadimefontriadimefon results in increased expression of MVD mRNA17178689
D014241TrichloroethyleneTrichloroethylene results in decreased expression of MVD mRNA25549359
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MVD mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of MVD mRNA21346803
D014415TunicamycinTunicamycin results in increased expression of MVD mRNA17127020
D014635Valproic AcidValproic Acid results in decreased expression of MVD mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of MVD gene29154799
D014635Valproic AcidValproic Acid affects the expression of MVD mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of MVD mRNA22045034
D014635Valproic AcidValproic Acid results in increased expression of MVD mRNA24489787
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MVD gene25560391
C025643vinclozolinvinclozolin results in decreased expression of MVD mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of MVD mRNA22570695
D014752Vinyl ChlorideVinyl Chloride results in increased expression of MVD mRNA18579281
C029297vinylidene chloridevinylidene chloride results in decreased expression of MVD mRNA26682919
D014812Vitamin KVitamin K affects the expression of MVD mRNA16844298
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in decreased expression of MVD mRNA20370541
C088658zoledronic acidzoledronic acid results in increased expression of MVD mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004163diphosphomevalonate decarboxylase activity-IBA21873635  
GO:0004163diphosphomevalonate decarboxylase activity-IDA11792727  14680974  
GO:0004163diphosphomevalonate decarboxylase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0030544Hsp70 protein binding-IPI12646231  
GO:0042803protein homodimerization activity-IDA8626466  
GO ID GO Term Qualifier Evidence PubMed
GO:0006489dolichyl diphosphate biosynthetic process-TAS-  
GO:0006695cholesterol biosynthetic process-IEA-  
GO:0006695cholesterol biosynthetic process-NAS14680974  
GO:0006695cholesterol biosynthetic process-TAS-  
GO:0008284positive regulation of cell proliferation-IMP9270019  
GO:0008299isoprenoid biosynthetic process-IDA11792727  14680974  
GO:0019287isopentenyl diphosphate biosynthetic process, mevalonate pathway-IBA21873635  
GO:0045540regulation of cholesterol biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005777peroxisomeNOTIDA14972328  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA14972328  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00900Terpenoid backbone biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-191273Cholesterol biosynthesisTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446199Synthesis of Dolichyl-phosphateTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20955678[Detection of micro-vascular density(MVD) and its clinical significance in lung cancer]. (2000 Aug 20)Ge GZhongguo Fei Ai Za Zhi
7851067Cholesterol rich apo B containing lipoproteins and smoking are independently associated with macrovascular disease in normotensive NIDDM patients. (1994 Oct)Dean JDDiabet Med
26424214Plasma Chemokine signature correlates with lung goblet cell hyperplasia in smokers with and without chronic obstructive pulmonary disease. (2015 Sep 30)Kim VBMC Pulm Med
25081707Expression of hypoxia-inducible factor prolyl hydroxylase 3 HIFPH3 in human non-small cell lung cancer (NSCLC) and its correlation with prognosis. (2014)Chu XAsian Pac J Cancer Prev
15754996Intratumoral oxygenation of invasive squamous cell carcimoma of the vulva is not correlated with regional lymph node metastasis. (2005)Stone JEEur J Gynaecol Oncol
29376057High-Sensitivity C-Reactive Protein Is a Predictor of Coronary Microvascular Dysfunction in Patients with Ischemic Heart Disease. (2017)Tong DCFront Cardiovasc Med
18184464[Expression of erythropoietin receptor in esophageal carcinoma and its correlation to microvessel density]. (2008 Jan)Li MAi Zheng
21251407[Study of COX-2 expression and angiogenesis in non-small cell lung cancer]. (2004 Dec 20)Li CZhongguo Fei Ai Za Zhi
24417169[The expression of caspase-3, bFGF and MVD in laryngeal squamous cell carcinoma and the relationship among them]. (2013 Oct)Xu QLin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
16504835The association between metabolic control and prevalent macrovascular disease in Type 2 diabetes: the VA Cooperative Study in diabetes. (2006 Mar-Apr)Kirkman MSJ Diabetes Complications
25646735Chronic bronchitis and current smoking are associated with more goblet cells in moderate to severe COPD and smokers without airflow obstruction. (2015)Kim VPLoS One
20667409The 8-oxoguanine glycosylase I (hOGG1) Ser326Cys variant affects the susceptibility to multi-vessel disease in Taiwan coronary artery disease patients. (2010 Oct)Wang CLThromb Res
25158264Significance of the expression of integrin beta1, VEGF and MVD in hypopharyngeal squamous cell carcinoma. (2014 Aug 25)Hong YMGenet Mol Res
17849027Characterization of graft subsidence in anterior cervical discectomy and fusion with rigid anterior plate fixation. (2007 Aug)Samartzis DAm J Orthop (Belle Mead NJ)