Gene: MVK

4598
LRBP|MK|MVLK|POROK3
mevalonate kinase
protein-coding
12q24.11
Ensembl:ENSG00000110921 MIM:251170 Vega:OTTHUMG00000169256 UniprotKB:Q03426
NG_007702.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.796e-1 (AD)  5.721e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PEX160.873
RAB4B0.869
NMRAL10.861
MMAB0.86
MRPL550.847
MVD0.839
ASPSCR10.834
RNF1260.83
PHLDA30.825
ZFPL10.824

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.589
OR4F29-0.556
MTRNR2L9-0.449
MTRNR2L6-0.423
CCDC36-0.422
MTRNR2L10-0.391
MTRNR2L2-0.377
PABPC4L-0.372
MTRNR2L8-0.367
TTLL10-0.347

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04695FARNESYL THIOPYROPHOSPHATESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MVK mRNA"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MVK mRNA]"22698814
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of MVK mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MVK mRNA"25614096
C00358522-hydroxycholesterol22-hydroxycholesterol results in decreased expression of MVK mRNA19426978
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of MVK mRNA"20638727
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of MVK mRNA"28433925
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MVK mRNA"18648102
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in decreased expression of MVK mRNA15135645
D000082AcetaminophenAcetaminophen results in decreased expression of MVK mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MVK mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of MVK mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MVK protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MVK mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MVK gene27153756
C519728archazolid Barchazolid B results in increased expression of MVK mRNA25218289
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of MVK mRNA"19446018
C406592azaspiracidazaspiracid results in increased expression of MVK mRNA28939011
C547126AZM551248AZM551248 results in increased expression of MVK mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MVK mRNA21871943|2623829
D004958EstradiolEstradiol results in increased expression of MVK mRNA19167446
C006780bisphenol Abisphenol A results in decreased methylation of MVK promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of MVK promoter27312807
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of MVK mRNA"28433925
C006780bisphenol Abisphenol A results in increased methylation of MVK gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MVK mRNA22079614
D002110CaffeineCaffeine results in increased expression of MVK mRNA25868845
C084597chlorcyclizinechlorcyclizine results in increased expression of MVK mRNA21058326
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of MVK mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MVK mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of MVK mRNA19549813
D003474CurcuminCurcumin affects the expression of MVK mRNA27208389
D003474CurcuminCurcumin results in decreased expression of MVK mRNA27208389
D016572CyclosporineCyclosporine results in decreased expression of MVK mRNA20106945
C093628cyproconazolecyproconazole results in decreased expression of MVK mRNA22045034
D003907DexamethasoneDexamethasone results in increased expression of MVK mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MVK mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of MVK mRNA28962523
D002945CisplatinCisplatin results in increased expression of MVK mRNA27594783
D004041Dietary FatsDietary Fats affects the expression of MVK mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of MVK mRNA28433925
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of MVK mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of MVK mRNA"28433925
C521792DMU-212DMU-212 affects the expression of MVK mRNA26428916
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of MVK mRNA16988119
D000431EthanolEthanol results in increased expression of MVK mRNA19167417
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in decreased expression of MVK mRNA22711419
D005419FlavonoidsFlavonoids results in decreased expression of MVK mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of MVK mRNA28329830
C061365flusilazoleflusilazole affects the expression of MVK mRNA22634333
D005557FormaldehydeFormaldehyde results in decreased expression of MVK mRNA23649840
D005897GlafenineGlafenine results in increased expression of MVK mRNA24136188
D017313FenretinideFenretinide results in decreased expression of MVK mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of MVK mRNA26191083
C544151jinfukangjinfukang results in increased expression of MVK mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of MVK protein17337753
C410337K 7174K 7174 results in decreased expression of MVK mRNA24086573
D008694MethamphetamineMethamphetamine results in increased expression of MVK mRNA25290377
D008752Methylene ChlorideMethylene Chloride affects the expression of MVK mRNA28392392
C059539midostaurinmidostaurin results in decreased expression of MVK mRNA20980353
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MVK mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MVK mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of MVK mRNA24136188
D009532NickelNickel results in decreased expression of MVK mRNA24768652
C464660obeticholic acidobeticholic acid results in decreased expression of MVK mRNA27939613
D009840OligomycinsOligomycins results in increased expression of MVK mRNA23227865
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MVK mRNA25868421
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of MVK mRNA27756839
D010852PicrotoxinPicrotoxin results in increased expression of MVK mRNA15170462
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MVK mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in increased expression of MVK protein23718831
D011374ProgesteroneProgesterone results in increased expression of MVK mRNA18070364
D011441PropylthiouracilPropylthiouracil results in decreased expression of MVK mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of MVK mRNA27029645
C502851quinocetonequinocetone results in increased expression of MVK mRNA27046791
D015474IsotretinoinIsotretinoin results in decreased expression of MVK mRNA20436886
D012643SeleniumSelenium results in increased expression of MVK mRNA19244175
D019821SimvastatinSimvastatin results in increased expression of MVK mRNA25055962
D012969Sodium FluorideSodium Fluoride results in decreased expression of MVK protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of MVK mRNA18175754
D053260SootSoot results in increased expression of MVK mRNA22461453
C013698tallowtallow affects the expression of MVK mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MVK mRNA28922406
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of MVK mRNA"28433925
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of MVK mRNA28973375
D013893ThiramThiram results in increased expression of MVK mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of MVK mRNA27760801
C066340tolcaponetolcapone results in increased expression of MVK mRNA24136188
C032910triadimefontriadimefon results in increased expression of MVK mRNA19423681
D014241TrichloroethyleneTrichloroethylene results in decreased expression of MVK mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of MVK mRNA27188386
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MVK mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MVK mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of MVK mRNA25572481
C022884undecaneundecane results in decreased expression of MVK protein17337753
C406224valdecoxibvaldecoxib results in increased expression of MVK mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of MVK mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of MVK mRNA22045034
C088658zoledronic acidzoledronic acid results in increased expression of MVK mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-ISS-  
GO:0004496mevalonate kinase activity-IBA21873635  
GO:0004496mevalonate kinase activity-IDA1377680  9325256  14680974  14730012  18302342  
GO:0004496mevalonate kinase activity-IMP10369261  
GO:0004496mevalonate kinase activity-TAS-  
GO:0005515protein binding-IPI21044950  
GO:0005524ATP binding-ISS-  
GO:0042802identical protein binding-IDA9325256  
GO:0042802identical protein binding-IPI16189514  26871637  
GO ID GO Term Qualifier Evidence PubMed
GO:0006695cholesterol biosynthetic process-IBA21873635  
GO:0006695cholesterol biosynthetic process-IDA1377680  
GO:0006695cholesterol biosynthetic process-TAS-  
GO:0008299isoprenoid biosynthetic process-IDA14680974  14730012  
GO:0016125sterol metabolic process-IBA21873635  
GO:0016310phosphorylation-IEA-  
GO:0019287isopentenyl diphosphate biosynthetic process, mevalonate pathway-IBA21873635  
GO:0019287isopentenyl diphosphate biosynthetic process, mevalonate pathway-IEA-  
GO:0045540regulation of cholesterol biosynthetic process-TAS-  
GO:0050728negative regulation of inflammatory response-IMP16732551  
GO ID GO Term Qualifier Evidence PubMed
GO:0005777peroxisomeNOTIDA14730012  
GO:0005777peroxisome-ISS-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA14730012  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00900Terpenoid backbone biosynthesis
hsa01100Metabolic pathways
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-191273Cholesterol biosynthesisTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29069827The effect of MVK-MMAB variants, their haplotypes and GxE interactions on serum lipid levels and the risk of coronary heart disease and ischemic stroke. (2017 Sep 22)Miao LOncotarget
29618714Nicotine and methyl vinyl ketone, major components of cigarette smoke extracts, increase protective amyloid-beta peptides in cells harboring amyloid-beta precursor protein. (2018)Ohshima YJ Toxicol Sci