Gene: MX1

4599
IFI-78K|IFI78|MX|MxA
MX dynamin like GTPase 1
protein-coding
21q22.3
Ensembl:ENSG00000157601 MIM:147150 Vega:OTTHUMG00000086755 UniprotKB:P20591
NG_027788.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.506e-1 (AD)  1.605e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs758342chr21:41418414 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12359279chr21:42797953MX1Promoter9.560e-4Alcohol use disorders26763658
cg26312951chr21:42797847MX14.260e-11Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RSAD20.898
CMPK20.888
USP180.844
STAT10.834
IFIT30.822
IFI60.817
DDX580.813
ISG150.812
OAS30.802
OAS10.798

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.36
OR4F5-0.349
HPSE2-0.254
HPR-0.239
SLC25A48-0.23
MTRNR2L6-0.226
DIAPH3-0.224
KCNJ16-0.221
MTRNR2L9-0.214
PLA2G5-0.209

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of MX1 mRNA"19095052
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MX1 mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of MX1 mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MX1 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MX1 mRNA"18648102
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of MX1 mRNA19191707
C0413987,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester"7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester results in increased expression of MX1 mRNA"16756086
D000082AcetaminophenAcetaminophen results in decreased expression of MX1 mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of MX1 mRNA28959563
C077990alvocidibalvocidib inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]]23589332
C077990alvocidibalvocidib inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]]23589332
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MX1 mRNA16483693
D001151Arsenic[Arsenic results in increased abundance of monomethylarsonic acid] which affects the expression of MX1 mRNA28793237
C006632arsenic trioxidearsenic trioxide results in increased expression of MX1 protein19364129
D001241AspirinAspirin results in decreased expression of MX1 mRNA15928584
D001379AzathioprineAzathioprine results in decreased expression of MX1 mRNA19192274
D001554BenzeneBenzene results in decreased expression of MX1 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MX1 mRNA19152381
D001564Benzo(a)pyrenechlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of MX1 mRNA]19152381
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MX1 mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MX1 mRNA11356909|2373587
D004958EstradiolEstradiol results in decreased expression of MX1 mRNA23373633
D004958EstradiolEstradiol affects the expression of MX1 mRNA15598610
C006780bisphenol Abisphenol A results in increased expression of MX1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MX1 mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MX1 mRNA14729362|1500399
C584509C646 compoundC646 compound results in increased expression of MX1 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MX1 mRNA25993096
C007020chlorophyllinchlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of MX1 mRNA]19152381
D004390ChlorpyrifosChlorpyrifos results in decreased expression of MX1 mRNA18691654
D004390ChlorpyrifosChlorpyrifos results in increased expression of MX1 mRNA15178118
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of MX1 mRNA19524605
D003300Copper[Disulfiram binds to Copper] which results in increased expression of MX1 mRNA24690739
D003471CuprizoneCuprizone results in increased expression of MX1 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of MX1 mRNA20106945|2214713
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of MX1 mRNA17330099
C014347decitabinedecitabine results in increased expression of MX1 mRNA16367923|2185625
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of MX1 mRNA28962523
D002945CisplatinCisplatin results in increased expression of MX1 mRNA21151649
D004004DichlororibofuranosylbenzimidazoleDichlororibofuranosylbenzimidazole inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]]23589332
D004008DiclofenacDiclofenac results in decreased expression of MX1 mRNA19192274
D004041Dietary FatsDietary Fats results in decreased expression of MX1 mRNA21852083
C014476diethyl maleatediethyl maleate results in decreased expression of MX1 mRNA21161181
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of MX1 mRNA23876855
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of MX1 mRNA24690739
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MX1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MX1 mRNA15834898|1735126
C017690fenvaleratefenvalerate results in decreased expression of MX1 mRNA18691654
D005557FormaldehydeFormaldehyde results in decreased expression of MX1 mRNA28937961
C007834genipingenipin inhibits the reaction [Lipopolysaccharides results in increased expression of MX1 mRNA]22687549
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of MX1 protein]20884965
D019833GenisteinGenistein results in decreased expression of MX1 protein20884965
D005839GentamicinsGentamicins results in increased expression of MX1 mRNA22061828
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of MX1 mRNA19192274
C412815GW 4064GW 4064 results in decreased expression of MX1 mRNA26655953
C492448ICG 001ICG 001 results in increased expression of MX1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MX1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MX1 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein promotes the reaction [BRD4 protein binds to MX1 promoter]]23589332
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein promotes the reaction [CDK9 protein binds to MX1 promoter]]23589332
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein promotes the reaction [NELFA protein binds to MX1 promoter]]23589332
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to MX1 gene]]23589332
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein binds to MX1 promoter]]23589332
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein promotes the reaction [POLR2A protein modified form binds to MX1 gene]]23589332
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein promotes the reaction [SUPT5H protein binds to MX1 promoter]]23589332
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein results in increased expression of MX1 mRNA]23589332
D007840LatexLatex analog results in increased expression of MX1 mRNA24768652
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MX1 mRNA"25673294
D008070LipopolysaccharidesLipopolysaccharides affects the expression of MX1 mRNA28070326
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MX1 mRNA15860229
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of MX1 mRNA]28070326
D008070Lipopolysaccharidesgenipin inhibits the reaction [Lipopolysaccharides results in increased expression of MX1 mRNA]22687549
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MX1 mRNA22687549|2405697
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MX1 mRNA]24056979
D008154LucanthoneLucanthone results in increased expression of MX1 mRNA21148553
D008727MethotrexateMethotrexate results in decreased expression of MX1 mRNA19192274
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MX1 mRNA]24056979
D008775MethylprednisoloneMethylprednisolone results in decreased expression of MX1 mRNA19192274
D016685MitomycinMX1 protein results in increased susceptibility to Mitomycin9389754
C020300monomethylarsonic acid[Arsenic results in increased abundance of monomethylarsonic acid] which affects the expression of MX1 mRNA28793237
D009151Mustard GasMustard Gas results in increased expression of MX1 mRNA25102026
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in decreased expression of MX1 mRNA"25487280
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MX1 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MX1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MX1 mRNA"25554681
D009532NickelNickel affects the expression of MX1 mRNA14575637
D009532NickelNickel results in increased expression of MX1 mRNA24768652|2558310
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of MX1 mRNA]14575637
C029938nickel sulfatenickel sulfate results in increased expression of MX1 mRNA25673294
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MX1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MX1 mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of MX1 mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of MX1 mRNA23892564
C046012pentanalpentanal results in increased expression of MX1 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of MX1 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of MX1 mRNA19162173
D010476PerfumePerfume results in increased expression of MX1 mRNA24768652
D010894PiroxicamPiroxicam results in decreased expression of MX1 mRNA19192274
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of MX1 mRNA]28070326
D010936Plant ExtractsPlant Extracts results in increased expression of MX1 mRNA21297082
D011070Poly I-CEHMT2 protein affects the reaction [Poly I-C results in increased expression of MX1 mRNA]26418342
D011070Poly I-CPoly I-C results in increased expression of MX1 mRNA26418342
D011070Poly I-CUNC 0638 promotes the reaction [Poly I-C results in increased expression of MX1 mRNA]26418342
D011070Poly I-CPoly I-C results in increased expression of MX1 mRNA17669408|2255818
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MX1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MX1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MX1 mRNA22714537
D011239PrednisolonePrednisolone results in decreased expression of MX1 mRNA19192274
D011374ProgesteroneProgesterone results in increased expression of MX1 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of MX1 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors results in decreased expression of MX1 mRNA28003376
C049705S-1,2-dichlorovinyl-N-acetylcysteine"S-1,2-dichlorovinyl-N-acetylcysteine results in increased expression of MX1 mRNA"16844155
D012643SeleniumSelenium results in increased expression of MX1 mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of MX1 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MX1 mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in increased expression of MX1 mRNA22300531|2535159
D012834SilverSilver results in decreased expression of MX1 mRNA27131904
D012906SmokeSmoke results in decreased expression of MX1 mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of MX1 mRNA17400579
C017947sodium arsenitesodium arsenite results in decreased expression of MX1 mRNA23876855
D012999SomanSoman results in increased expression of MX1 mRNA19281266
C025462sulindac sulfidesulindac sulfide results in decreased expression of MX1 mRNA16184548
D013629TamoxifenTamoxifen results in increased expression of MX1 mRNA19155303
C004648testosterone enanthatetestosterone enanthate affects the expression of MX1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MX1 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MX1 mRNA15644576
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of MX1 mRNA16010555
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MX1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of MX1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MX1 mRNA20133372
C479163tofacitinibtofacitinib results in decreased expression of MX1 mRNA25487280
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MX1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of MX1 mRNA25729387
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of MX1 mRNA]14575637
C561310UNC 0638UNC 0638 promotes the reaction [Poly I-C results in increased expression of MX1 mRNA]26418342
D014635Valproic AcidValproic Acid results in decreased expression of MX1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of MX1 mRNA23527032
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MX1 gene25560391
D014810Vitamin EVitamin E results in increased expression of MX1 mRNA19244175
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of MX1 mRNA17330099
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of MX1 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0005515protein binding-IPI15047845  15757897  21859714  25416956  27107014  
GO:0005525GTP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0042802identical protein binding-IPI20428112  25295396  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000266mitochondrial fission-IBA21873635  
GO:0003374dynamin family protein polymerization involved in mitochondrial fission-IBA21873635  
GO:0006915apoptotic process-TAS9389754  
GO:0006952defense response-TAS2154602  
GO:0007165signal transduction-TAS9389754  
GO:0009615response to virus-IMP15047845  
GO:0034340response to type I interferon-TAS21859714  
GO:0045071negative regulation of viral genome replication-IDA14687945  15047845  16202617  
GO:0045087innate immune response-IBA21873635  
GO:0045087innate immune response-TAS16202617  
GO:0048285organelle fission-IBA21873635  
GO:0051607defense response to virus-IBA21873635  
GO:0051607defense response to virus-IDA21478870  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0061025membrane fusion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA21859714  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-HDA16780588  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IBA21873635  
GO:0031965nuclear membrane-IDA-  
GO:0031966mitochondrial membrane-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IDA15047845  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26927796POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. (2016 Apr 1)Zhou HJ Immunol