Gene: MX2

4600
MXB
MX dynamin like GTPase 2
protein-coding
21q22.3
Ensembl:ENSG00000183486 MIM:147890 Vega:OTTHUMG00000086753 UniprotKB:P20592
NC_000021.9
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.461e-1 (AD)  9.150e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OAS20.919
EPSTI10.892
SAMD90.873
OAS10.872
DDX60L0.867
IFIH10.862
OAS30.86
TRIM220.845
OASL0.843
DDX580.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES6-0.294
ARSF-0.292
HPSE2-0.289
SLC29A4-0.288
SLC25A48-0.279
PYGM-0.278
ASPDH-0.275
ZNF835-0.274
C9orf24-0.273
GABRG1-0.271

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MX2 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of MX2 mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MX2 mRNA"23146750
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MX2 mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MX2 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of MX2 mRNA"23829299
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MX2 mRNA"23196670
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of MX2 mRNA19191707
D000082AcetaminophenAcetaminophen results in increased expression of MX2 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of MX2 mRNA17562736
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MX2 mRNA]18700144
D000082AcetaminophenAcetaminophen results in increased expression of MX2 mRNA17202762
D020106AcrylamideAcrylamide results in decreased expression of MX2 mRNA28959563
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of MX2 mRNA"23195993
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MX2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MX2 mRNA16483693
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of MX2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MX2 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MX2 mRNA20713471|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MX2 mRNA23735875
D004958EstradiolEstradiol results in increased expression of MX2 mRNA21185374
D004958EstradiolEstradiol results in increased expression of MX2 mRNA19484750
D004958EstradiolEstradiol results in decreased expression of MX2 mRNA20068009
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of MX2 mRNA26496021
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MX2 mRNA14729362|1500399
D019256Cadmium ChlorideCadmium Chloride affects the expression of MX2 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MX2 mRNA25993096
D000074262Canola OilCanola Oil metabolite results in decreased expression of MX2 mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MX2 mRNA15123359
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MX2 protein15123359
C018021cobaltous chloridecobaltous chloride results in decreased expression of MX2 mRNA24386269
D003314Corn OilCorn Oil affects the expression of MX2 mRNA16360708
D003520CyclophosphamideCyclophosphamide results in decreased expression of MX2 mRNA17403535
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of MX2 mRNA23640034
D003907DexamethasoneDexamethasone results in increased expression of MX2 mRNA25047013
D003976DiazinonDiazinon results in increased methylation of MX2 gene22964155
D004041Dietary FatsDietary Fats results in decreased expression of MX2 mRNA21852083
D004041Dietary FatsDietary Fats results in increased expression of MX2 mRNA21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of MX2 mRNA27405655
C014476diethyl maleatediethyl maleate results in decreased expression of MX2 mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of MX2 mRNA19638242
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of MX2 mRNA19647056
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MX2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MX2 mRNA17557909
D005557FormaldehydeFormaldehyde results in decreased expression of MX2 mRNA28937961
D005839GentamicinsGentamicins results in increased expression of MX2 mRNA22061828
C010974glyphosateglyphosate results in increased expression of MX2 mRNA25636363
C051890irinotecanirinotecan metabolite results in decreased expression of MX2 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of MX2 mRNA15956246
C029310lardlard results in decreased expression of MX2 mRNA26115784
C008261lead acetatelead acetate results in decreased expression of MX2 mRNA22613225
C008261lead acetatelead acetate results in decreased expression of MX2 mRNA22641619
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MX2 mRNA22235868
D008070LipopolysaccharidesLipopolysaccharides affects the expression of MX2 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of MX2 mRNA]28070326
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MX2 mRNA24056979|2658214
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MX2 mRNA]24056979
D008727MethotrexateMethotrexate results in decreased expression of MX2 mRNA24449571
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of MX2 mRNA20713471
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MX2 mRNA]24056979
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MX2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MX2 mRNA"20188158
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of MX2 mRNA23876855
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in decreased expression of MX2 mRNA"25487280
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MX2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MX2 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of MX2 mRNA23195993
D009532NickelNickel results in increased expression of MX2 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of MX2 mRNA19167457
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MX2 mRNA"19013360
D009966OrphenadrineOrphenadrine affects the expression of MX2 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MX2 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of MX2 mRNA19647056
C410127PCB 180PCB 180 results in decreased expression of MX2 mRNA23829299
D010416PentachlorophenolPentachlorophenol results in increased expression of MX2 mRNA23892564
D010634PhenobarbitalPhenobarbital results in decreased expression of MX2 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of MX2 mRNA23811191
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of MX2 mRNA]28070326
D010936Plant ExtractsPlant Extracts results in increased expression of MX2 mRNA21297082|2355793
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MX2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MX2 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MX2 mRNA19162173
D012822Silicon DioxideSilicon Dioxide results in increased expression of MX2 mRNA22300531
D012834SilverSilver results in decreased expression of MX2 mRNA27131904
D012835Silver NitrateSilver Nitrate results in increased expression of MX2 mRNA22727896
C017947sodium arsenitesodium arsenite results in decreased expression of MX2 mRNA23876855
D012999SomanSoman results in increased expression of MX2 mRNA19281266
C061133tamibarotenetamibarotene affects the expression of MX2 mRNA15498508
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of MX2 mRNA15885361
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of MX2 mRNA26496021
C004648testosterone enanthatetestosterone enanthate affects the expression of MX2 mRNA17440010
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of MX2 mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MX2 mRNA15644576
D013853ThioacetamideThioacetamide results in decreased expression of MX2 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of MX2 mRNA23557971|2776080
C479163tofacitinibtofacitinib results in decreased expression of MX2 mRNA25487280
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of MX2 mRNA"19647056
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MX2 mRNA25729387
D014212TretinoinTretinoin affects the expression of MX2 mRNA15498508
D014520UrethaneUrethane results in decreased expression of MX2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MX2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MX2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of MX2 gene29154799
C025643vinclozolinvinclozolin results in increased expression of MX2 mRNA23034163
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of MX2 mRNA20370541
D015032ZincZinc deficiency results in increased expression of MX2 mRNA19111725
D019287Zinc SulfateZinc Sulfate results in increased expression of MX2 mRNA19013360

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0005525GTP binding-IMP15184662  
GO:0008017microtubule binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000266mitochondrial fission-IBA21873635  
GO:0003374dynamin family protein polymerization involved in mitochondrial fission-IBA21873635  
GO:0006952defense response-TAS8798556  
GO:0009615response to virus-IDA24048477  
GO:0015031protein transport-IEA-  
GO:0035455response to interferon-alpha-IDA24121441  
GO:0045087innate immune response-IBA21873635  
GO:0046822regulation of nucleocytoplasmic transport-IMP15184662  
GO:0048285organelle fission-IBA21873635  
GO:0051028mRNA transport-IEA-  
GO:0051607defense response to virus-IBA21873635  
GO:0051607defense response to virus-IMP24121441  
GO:0051726regulation of cell cycle-IMP15184662  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0061025membrane fusion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS8798556  
GO:0005643nuclear pore-IDA15184662  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS8798556  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IBA21873635  
GO:0031966mitochondrial membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26455281Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. (2015 Dec)Stankiewicz AMPharmacol Biochem Behav