Gene: MXI1

4601
MAD2|MXD2|MXI|bHLHc11
MAX interactor 1, dimerization protein
protein-coding
10q25.2
Ensembl:ENSG00000119950 MIM:600020 Vega:OTTHUMG00000019033 UniprotKB:P50539
NG_012103.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.693e-1 (AD)  6.586e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LSM14A0.9
KTN10.885
RNF1140.872
KDSR0.868
RBM170.867
STAG20.859
EMC20.857
FMNL20.857
GOLGA70.857
EFCAB140.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.731
OR4F5-0.696
ADRA1D-0.286
FREM3-0.274
FBLN7-0.265
ST8SIA2-0.257
RTP1-0.257
ABCC12-0.256
PRSS12-0.254
HCRTR1-0.253

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of MXI1 mRNA"19162173
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of MXI1 mRNA"22101062
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of MXI1 mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MXI1 mRNA"19114083
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of MXI1 mRNA19643169
D020106AcrylamideAcrylamide results in decreased expression of MXI1 mRNA28959563
C106812adefovir dipivoxiladefovir dipivoxil results in decreased expression of MXI1 mRNA25596134
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MXI1 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MXI1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MXI1 mRNA"20018196
C006780bisphenol Abisphenol A results in increased expression of MXI1 mRNA25047013|2927551
C006780bisphenol Abisphenol A affects the expression of MXI1 mRNA25181051
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MXI1 mRNA20360939
C004656chloroacetaldehydechloroacetaldehyde affects the expression of MXI1 mRNA25596134
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MXI1 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MXI1 mRNA28472532
C059262cidofovircidofovir results in decreased expression of MXI1 mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of MXI1 mRNA25596134
D002994ClofibrateClofibrate results in decreased expression of MXI1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in increased expression of MXI1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of MXI1 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of MXI1 mRNA19167446
C030973cupric oxidecupric oxide results in increased expression of MXI1 mRNA22077320
D003520CyclophosphamideMXI1 protein affects the susceptibility to Cyclophosphamide16217747
D016572CyclosporineCyclosporine results in decreased expression of MXI1 mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of MXI1 mRNA23300844
D003703DemecolcineDemecolcine results in increased expression of MXI1 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of MXI1 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MXI1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MXI1 mRNA21266533
D002945CisplatinCisplatin affects the expression of MXI1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MXI1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MXI1 mRNA25596134
D002945CisplatinCisplatin results in increased expression of MXI1 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of MXI1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MXI1 mRNA20360939
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MXI1 mRNA20360939
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MXI1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MXI1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MXI1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MXI1 mRNA17351261
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MXI1 mRNA23649840
D005047EtoposideMXI1 protein affects the susceptibility to Etoposide16217747
D005472FluorouracilMXI1 protein affects the susceptibility to Fluorouracil16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MXI1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of MXI1 mRNA23649840
C056507gemcitabinegemcitabine results in increased expression of MXI1 mRNA17039268
D005839GentamicinsGentamicins results in decreased expression of MXI1 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of MXI1 mRNA24136188
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of MXI1 mRNA24680724
D007069IfosfamideIfosfamide results in decreased expression of MXI1 mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MXI1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MXI1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of MXI1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of MXI1 mRNA16835149
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MXI1 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MXI1 gene20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of MXI1 mRNA19643169
C008493methylselenic acidmethylselenic acid results in increased expression of MXI1 mRNA18548127
D008942MitoxantroneMXI1 protein affects the susceptibility to Mitoxantrone16217747
C022838nickel chloridenickel chloride results in increased expression of MXI1 mRNA17312168|2145529
D005996NitroglycerinNitroglycerin results in increased expression of MXI1 mRNA12102619
C507134ON 01910ON 01910 results in increased expression of MXI1 mRNA22351695
D010100OxygenOxygen deficiency results in increased expression of MXI1 mRNA25596134|2651600
D010100OxygenOxygen deficiency affects the expression of MXI1 mRNA17193925
D010100OxygenOxygen deficiency results in increased expression of MXI1 mRNA20880076
D000073878Palm OilPalm Oil results in increased expression of MXI1 mRNA18042831
D011374ProgesteroneProgesterone results in increased expression of MXI1 mRNA23012394
D011794QuercetinQuercetin results in decreased expression of MXI1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog affects the expression of MXI1 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of MXI1 mRNA19822182
D013629TamoxifenTamoxifen affects the expression of MXI1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MXI1 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MXI1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MXI1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MXI1 mRNA25613284
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of MXI1 mRNA"17951470
D014212TretinoinTretinoin affects the expression of MXI1 mRNA16054129
C012589trichostatin Atrichostatin A affects the expression of MXI1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of MXI1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MXI1 mRNA"26179874
D014520UrethaneUrethane results in increased expression of MXI1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MXI1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MXI1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of MXI1 mRNA22083351|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MXI1 gene25560391
C025643vinclozolinvinclozolin affects the expression of MXI1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingcontributes_toIDA8425219  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA bindingcontributes_toIC-  
GO:0003677DNA binding-TAS8425219  
GO:0003714transcription corepressor activity-TAS8425219  
GO:0005515protein binding-IPI16189514  25416956  25609649  27705803  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA11875718  
GO:0006351transcription, DNA-templated-IEA-  
GO:0008285negative regulation of cell proliferation-TAS9624006  
GO:0042994cytoplasmic sequestering of transcription factor-TAS8425219  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
GO:0090575RNA polymerase II transcription factor complex-IDA8425219  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16885739Pilot study of mucosal genetic differences in early smokers and nonsmokers. (2006 Aug)Smith RVLaryngoscope