Gene info: ID 4602

Gene: MYB

GENE ID: 4602

Synonyms: Cmyb|c-myb|c-myb_CDS|efg

Description: MYB proto-oncogene, transcription factor

Gene type: protein-coding

Location: 6q23.3

dbXrefs: Ensembl:ENSG00000118513 MIM:189990 Vega:OTTHUMG00000015629 UniprotKB:P10242

RefSeq: NG_012330.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.829e-1 (AD) 6.985e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GPR1	0.849
DRD3	0.848
C6orf141	0.844
GPR101	0.84
SAG	0.838
ENTHD1	0.835
TMPRSS6	0.833
OTOF	0.832
CHAT	0.826
MYO3A	0.82

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NTNG2	-0.31
ALDH1A1	-0.306
SYTL2	-0.306
CDKN2C	-0.294
RNF182	-0.272
MYL3	-0.256
OTOS	-0.233
SLC17A7	-0.23
PSTPIP1	-0.229
FEZF2	-0.229

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C477819	15-deoxyprostaglandin J2	15-deoxyprostaglandin J2 results in decreased expression of MYB mRNA	12649303
C477819	15-deoxyprostaglandin J2	15-deoxyprostaglandin J2 results in decreased expression of MYB protein	12649303
C031903	1-UFT protocol	MYB protein results in increased susceptibility to 1-UFT protocol	16734730
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MYB mRNA"	19167446
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane analog results in decreased expression of MYB mRNA"	26593444
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of MYB mRNA"	28591870
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYB mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYB mRNA"	27188386
C013813	4-anisidine	4-anisidine results in decreased expression of MYB mRNA	12929121
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYB mRNA"	27188386
C496492	abrine	abrine results in decreased expression of MYB mRNA	22595364
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in increased expression of MYB mRNA]	21233418
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MYB mRNA	22100608
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MYB protein	7593635
D001280	Atrazine	Atrazine results in decreased expression of MYB mRNA	22378314
D001280	Atrazine	Atrazine results in increased expression of MYB mRNA	18585445
D001554	Benzene	Benzene results in decreased activity of MYB protein	15541759
D001554	Benzene	Benzene results in decreased expression of MYB mRNA	21382456
D001554	Benzene	Benzene results in increased expression of MYB protein	18281070\|1991352
D001554	Benzene	catalase-polyethylene glycol inhibits the reaction [Benzene results in increased expression of MYB protein]	18281070
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of MYB mRNA	23117580
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MYB mRNA	21569818
D004958	Estradiol	Estradiol affects the expression of MYB mRNA	21826169
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of MYB mRNA	20404318
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MYB mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of MYB mRNA	15223131\|1602987
D004958	Estradiol	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of MYB mRNA]	21185374
D004958	Estradiol	Estradiol results in increased expression of MYB mRNA	15289156
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of MYB mRNA	28591870
C006780	bisphenol A	bisphenol A affects the expression of MYB mRNA	21826169
C006780	bisphenol A	bisphenol A results in increased expression of MYB mRNA	15223131\|1602987
C006780	bisphenol A	bisphenol A results in decreased expression of MYB mRNA	25181051
C492482	bisphenol B	bisphenol B results in increased expression of MYB mRNA	28591870
C000611646	bisphenol F	bisphenol F results in increased expression of MYB mRNA	28591870
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of MYB mRNA	18958704
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of MYB mRNA	22079614
C059041	calyculin A	calyculin A results in increased expression of MYB mRNA	25270620
D000069287	Capecitabine	MYB protein results in increased susceptibility to Capecitabine	16734730
C070295	catalase-polyethylene glycol	catalase-polyethylene glycol inhibits the reaction [Benzene results in increased expression of MYB protein]	18281070
C034221	catechol	catechol results in increased activity of MYB protein	15541759\|1593581
C034221	catechol	catechol results in increased phosphorylation of MYB protein	15541759\|1593581
C034221	catechol	AHR gene mutant form inhibits the reaction [catechol results in decreased expression of MYB protein]	15935814
C034221	catechol	catechol results in decreased expression of MYB protein	15935814
C019304	ciprofibrate	ciprofibrate results in decreased expression of MYB mRNA	12649303
C019304	ciprofibrate	ciprofibrate results in decreased expression of MYB protein	12649303
D002994	Clofibrate	Clofibrate results in decreased expression of MYB mRNA	12649303
D002994	Clofibrate	Clofibrate results in decreased expression of MYB protein	12649303
D002996	Clomiphene	Clomiphene results in decreased expression of MYB mRNA	26865669
D060729	Coal Ash	Coal Ash results in increased activity of MYB protein	19000753
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of MYB mRNA	22941251
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of MYB mRNA	20971185
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MYB mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with ESR1 protein] results in increased expression of MYB mRNA	18310284
D003375	Coumestrol	Coumestrol results in increased expression of MYB mRNA	19167446
D003375	Coumestrol	ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of MYB mRNA]	18310284
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MYB mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in increased expression of MYB mRNA	16144937
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of MYB mRNA	26924002
D004026	Dieldrin	Dieldrin results in increased expression of MYB mRNA	28385952
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of MYB mRNA	26865669
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of MYB mRNA	15289156
D002117	Calcitriol	Calcitriol results in decreased expression of MYB mRNA	12875902\|1600243
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of MYB mRNA	21592394
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of MYB mRNA	26924002
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in decreased expression of MYB mRNA	17374397
C025034	doxifluridine	MYB protein results in increased susceptibility to doxifluridine	16734730
C118739	entinostat	entinostat results in decreased expression of MYB mRNA	27188386
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in increased expression of MYB mRNA]	21233418
D004967	Estrogens	Estrogens results in increased expression of MYB mRNA	21233418
D004970	Estrone	Estrone results in increased expression of MYB mRNA	26865669
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of MYB mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MYB mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYB mRNA	17942748
D008656	Mestranol	Mestranol results in increased expression of MYB mRNA	26865669
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of MYB gene	16724327
D005054	Eugenol	Eugenol results in decreased expression of MYB mRNA	17374397
C020748	ferrous sulfate	[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MYB protein	7593635
D005472	Fluorouracil	Fluorouracil results in decreased expression of MYB mRNA	16557594
D005472	Fluorouracil	MYB protein affects the susceptibility to Fluorouracil	15548681
D005472	Fluorouracil	MYB protein affects the susceptibility to Fluorouracil	15235111
D005492	Folic Acid	Folic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein]	16112698
C070081	fulvestrant	fulvestrant results in decreased expression of MYB mRNA	26865669
C056507	gemcitabine	gemcitabine results in increased expression of MYB mRNA	17039268
D019833	Genistein	Genistein results in increased expression of MYB mRNA	16474171\|2686566
D019833	Genistein	Genistein results in increased expression of MYB mRNA	15289156
C010974	glyphosate	glyphosate results in decreased expression of MYB mRNA	28711546
C010974	glyphosate	glyphosate results in increased expression of MYB mRNA	28711546
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide results in decreased expression of MYB protein	10597302
D006589	Hexestrol	Hexestrol results in increased expression of MYB mRNA	26865669
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of MYB mRNA	20044591
C031927	hydroquinone	hydroquinone results in increased activity of MYB protein	15935814\|1761410
C031927	hydroquinone	hydroquinone results in increased phosphorylation of MYB protein	15935814\|1761410
D006918	Hydroxyurea	Hydroxyurea results in decreased expression of MYB mRNA	12929121
C051890	irinotecan	MYB protein results in increased susceptibility to irinotecan	16734730
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MYB mRNA	21889194\|2194939
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to BTK enhancer]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to BTK promoter]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to CCL4 enhancer]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to CCL4 promoter]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to FCGR2B enhancer]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to FCGR2B promoter]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to PECAM1 enhancer]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to PECAM1 promoter]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of BTK mRNA]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of CCL4 mRNA]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of FCGR2B mRNA]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of PECAM1 mRNA]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MYB mRNA	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MYB protein	25982114
C045463	leflunomide	leflunomide results in decreased expression of MYB mRNA	19751817
C533894	LG 100815	LG 100815 results in decreased expression of MYB mRNA	16951191
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MYB mRNA	26378955
D008315	Malondialdehyde	Malondialdehyde results in increased expression of MYB protein	7593635
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in decreased expression of MYB mRNA	18497975
D008727	Methotrexate	Methotrexate results in increased expression of MYB mRNA	24449571
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MYB mRNA	23179753\|2718838
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of MYB mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of MYB mRNA	23649840
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of MYB mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of MYB mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MYB mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of MYB mRNA	19812364
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of MYB mRNA	20971185
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in decreased expression of MYB mRNA"	16951191
C507134	ON 01910	ON 01910 affects the localization of MYB protein modified form	27150054
C507134	ON 01910	ON 01910 promotes the reaction [MYB protein binds to TRAF6 protein]	27150054
C507134	ON 01910	ON 01910 promotes the reaction [MYB protein binds to UBE2I protein]	27150054
C507134	ON 01910	ON 01910 results in decreased expression of and results in decreased sumoylation of MYB protein	27150054
D010081	Oxazolone	Oxazolone results in decreased expression of MYB mRNA	17374397
D010100	Oxygen	Oxygen deficiency results in decreased expression of MYB mRNA	26516004
D019800	Phenol	Phenol results in decreased activity of MYB protein	15541759
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYB mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of MYB mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of MYB mRNA	17426115
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in increased expression of MYB mRNA	16474171
D011374	Progesterone	Progesterone results in decreased expression of MYB mRNA	23018184
D011374	Progesterone	Progesterone results in decreased expression of MYB mRNA	18497975
D011374	Progesterone	Progesterone results in decreased expression of MYB mRNA	16966611\|2223828
D011794	Quercetin	Quercetin results in decreased expression of MYB mRNA	14715546
C004532	quinone	quinone results in increased activity of MYB protein	15935814\|1761410
C004532	quinone	quinone results in increased phosphorylation of MYB protein	15935814\|1761410
C004532	quinone	MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]	18778717
C004532	quinone	quinone results in increased activity of MYB protein	18778717
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of MYB mRNA]	21185374
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of MYB mRNA	26865669
C079198	S 1 (combination)	MYB protein results in increased susceptibility to S 1 (combination)	16734730
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of MYB mRNA	23806026
D012834	Silver	Silver results in decreased expression of MYB mRNA	27131904
D053260	Soot	Soot results in decreased expression of MYB mRNA	26551751
D020058	Styrene	Styrene affects the expression of MYB mRNA	28951217
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MYB mRNA	26378955
C061133	tamibarotene	tamibarotene affects the expression of MYB mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of MYB mRNA	17555576
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of MYB mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of MYB mRNA	21592394
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MYB mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MYB mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MYB mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYB mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MYB mRNA	16102516\|2405805
D013792	Thalidomide	CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein]	16616857
D013792	Thalidomide	Thalidomide results in decreased activity of MYB protein	16616857
D013792	Thalidomide	Thalidomide results in decreased phosphorylation of MYB protein	16616857
D019284	Thapsigargin	Thapsigargin results in decreased expression of MYB mRNA	22378314
C009495	titanium dioxide	titanium dioxide affects the expression of MYB mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MYB mRNA	22363418
D014118	Toxins, Biological	"Toxins, Biological affects the expression of MYB mRNA"	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of MYB mRNA	12875902\|1549850
D014212	Tretinoin	Tretinoin results in decreased expression of MYB mRNA	16604517
C012589	trichostatin A	trichostatin A results in decreased expression of MYB mRNA	15901671
C012589	trichostatin A	trichostatin A results in decreased expression of MYB mRNA	24935251
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of MYB mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MYB mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of MYB mRNA	12649303
C057693	troglitazone	troglitazone results in decreased expression of MYB protein	12649303
C057693	troglitazone	troglitazone results in decreased expression of MYB mRNA	17569031
D014415	Tunicamycin	Tunicamycin results in decreased expression of MYB mRNA	22378314
D014635	Valproic Acid	Valproic Acid results in decreased expression of MYB mRNA	15901671
D014635	Valproic Acid	Valproic Acid affects the expression of MYB mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of MYB mRNA	23179753\|2800136
D014635	Valproic Acid	Folic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein]	16112698
D014635	Valproic Acid	Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein]	16112698
D014635	Valproic Acid	Valproic Acid results in decreased expression of MYB protein	16112698
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of MYB gene	25560391
D010205	Pantothenic Acid	Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein]	16112698
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYB mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of MYB protein	10597302
C052518	WEB 2086	WEB 2086 results in decreased expression of MYB mRNA	11923217
C020174	WR 1065	WR 1065 results in increased expression of MYB mRNA	12007958
D015032	Zinc	Zinc deficiency results in increased activity of MYB protein	18356318

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	7987850
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IC	-
GO:0005515	protein binding	-	IPI	18093978 18548008 20195357 20484083 20802522 25394790

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	20531406
GO:0000278	mitotic cell cycle	-	IBA	21873635
GO:0001666	response to hypoxia	-	IEA	-
GO:0006338	chromatin remodeling	-	IMP	20484083
GO:0006355	regulation of transcription, DNA-templated	-	NAS	2189102
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0032967	positive regulation of collagen biosynthetic process	-	IEA	-
GO:0043525	positive regulation of neuron apoptotic process	-	IEA	-
GO:0045624	positive regulation of T-helper cell differentiation	-	IMP	20484083
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	20531406
GO:0045893	positive regulation of transcription, DNA-templated	-	IBA	21873635
GO:0045893	positive regulation of transcription, DNA-templated	-	IMP	20484083 20531406
GO:0045893	positive regulation of transcription, DNA-templated	-	NAS	2189102
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	10233885 20484083
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	20531406
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	-
GO:0051571	positive regulation of histone H3-K4 methylation	-	IMP	20484083
GO:0051574	positive regulation of histone H3-K9 methylation	-	IMP	20484083
GO:0060252	positive regulation of glial cell proliferation	-	IEA	-
GO:0070301	cellular response to hydrogen peroxide	-	IEA	-
GO:0071300	cellular response to retinoic acid	-	IEA	-
GO:0071636	positive regulation of transforming growth factor beta production	-	IEA	-
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	-
GO:1904899	positive regulation of hepatic stellate cell proliferation	-	IEA	-
GO:2000491	positive regulation of hepatic stellate cell activation	-	IEA	-
GO:2000845	positive regulation of testosterone secretion	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	TAS	-
GO:0016363	nuclear matrix	-	NAS	3014652

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939211	ESR-mediated signaling	TAS
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	TAS
R-HSA-9006931	Signaling by Nuclear Receptors	TAS
R-HSA-9018519	Estrogen-dependent gene expression	TAS
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
2547647	The molecular genetics of human lung cancer. (1989 May)	Slebos RJ	Eur Respir J
15221349	The intron 6 G/T polymorphism of c-myb oncogene and the risk for coronary in-stent restenosis. (2004 Jul)	Gross CM	Basic Res Cardiol