Gene: MYBL2

4605
B-MYB|BMYB
MYB proto-oncogene like 2
protein-coding
20q13.12
Ensembl:ENSG00000101057 MIM:601415 Vega:OTTHUMG00000033062 UniprotKB:P10244
NC_000020.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.664e-1 (AD)  9.050e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs285171chr20:43709235 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF20A0.744
RRM20.716
GATA10.712
TOP2A0.71
FAM83A0.692
MKI670.692
AURKB0.688
PBK0.679
RHAG0.673
CCNB20.672

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.307
ARSF-0.297
VWC2-0.284
DLX1-0.282
KIT-0.281
PAH-0.281
PVALB-0.278
NPPC-0.277
GAD2-0.273
MYADML2-0.27

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of MYBL2 mRNA"22101062
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYBL2 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MYBL2 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYBL2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYBL2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYBL2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYBL2 mRNA"25510870
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of MYBL2 mRNA12419474
D000082AcetaminophenAcetaminophen affects the expression of MYBL2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of MYBL2 mRNA17942131
D020106AcrylamideAcrylamide results in increased expression of MYBL2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MYBL2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MYBL2 mRNA22484513|2254567
D016604Aflatoxin B1[sulforafan co-treated with Aflatoxin B1] affects the expression of MYBL2 mRNA25450479
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of MYBL2 mRNA17254854
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of MYBL2 mRNA17639512
C547126AZM551248AZM551248 results in increased expression of MYBL2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYBL2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of MYBL2 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYBL2 mRNA17942131
D004958EstradiolEstradiol results in decreased expression of MYBL2 mRNA23373633
D004958EstradiolEstradiol results in increased expression of MYBL2 mRNA16474171|1831028
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of MYBL2 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of MYBL2 mRNA25210133
C006780bisphenol Abisphenol A affects the expression of MYBL2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MYBL2 mRNA27685785|2927551
C006780bisphenol Abisphenol A results in increased expression of MYBL2 mRNA16474171
C006780bisphenol Abisphenol A affects the methylation of MYBL2 promoter27334623
C006780bisphenol Abisphenol A affects the expression of MYBL2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MYBL2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MYBL2 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of MYBL2 mRNA17942131|2527062
C059041calyculin Acalyculin A results in decreased expression of MYBL2 mRNA25270620
D002330CarmustineCarmustine results in increased expression of MYBL2 mRNA16005536
D002746ChlorpromazineChlorpromazine analog results in decreased expression of MYBL2 mRNA15924885
C018021cobaltous chloridecobaltous chloride results in decreased expression of MYBL2 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of MYBL2 mRNA24386269
D003300CopperCopper deficiency results in increased expression of MYBL2 mRNA26033743
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MYBL2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of MYBL2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of MYBL2 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of MYBL2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of MYBL2 mRNA19159671|2010694
D016572CyclosporineCyclosporine results in decreased expression of MYBL2 mRNA17942131
D000069439DasatinibDasatinib results in decreased expression of MYBL2 mRNA20579391
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MYBL2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MYBL2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MYBL2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of MYBL2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of MYBL2 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of MYBL2 mRNA28302478
D019422Dietary SucroseDietary Sucrose results in increased expression of MYBL2 mRNA26033743
C014476diethyl maleatediethyl maleate results in increased expression of MYBL2 mRNA21161181
D002117CalcitriolCalcitriol results in decreased expression of MYBL2 mRNA12875902|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of MYBL2 mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MYBL2 mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYBL2 mRNA17942748
C056516exemestaneexemestane results in increased expression of MYBL2 mRNA17254854
C082360fipronilfipronil results in decreased expression of MYBL2 mRNA23962444
D005472FluorouracilFluorouracil results in increased expression of MYBL2 mRNA16557594
D005472FluorouracilMYBL2 protein affects the susceptibility to Fluorouracil15548681
C039281furanfuran results in decreased expression of MYBL2 mRNA27387713
C039281furanfuran results in increased expression of MYBL2 mRNA25539665
D019833GenisteinGenistein results in increased expression of MYBL2 mRNA16474171
D005839GentamicinsGentamicins results in decreased expression of MYBL2 mRNA22061828
C004312glycidolglycidol results in increased expression of MYBL2 mRNA24915197
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MYBL2 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of MYBL2 mRNA12419474
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MYBL2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYBL2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MYBL2 mRNA28628672
C544151jinfukangjinfukang results in increased expression of MYBL2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MYBL2 mRNA24796395|2596192
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MYBL2 mRNA12057914
D008154LucanthoneLucanthone results in decreased expression of MYBL2 mRNA21148553
D008713MethimazoleMethimazole results in decreased expression of MYBL2 mRNA17403546
D008727MethotrexateMethotrexate results in increased expression of MYBL2 mRNA16005536
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of MYBL2 mRNA24810058
C008493methylselenic acidmethylselenic acid results in decreased expression of MYBL2 mRNA12517777
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of MYBL2 mRNA28174063
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MYBL2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MYBL2 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of MYBL2 mRNA18978301
C022838nickel chloridenickel chloride affects the expression of MYBL2 mRNA22546817
D009538NicotineNicotine results in decreased expression of MYBL2 mRNA16949557
C572573N-nitroso-tris-chloroethylureaN-nitroso-tris-chloroethylurea results in increased expression of MYBL2 mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MYBL2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of MYBL2 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of MYBL2 mRNA26516004
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYBL2 mRNA"25510870
C494474perchlorateperchlorate results in decreased expression of MYBL2 mRNA17403546
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of MYBL2 mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of MYBL2 mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of MYBL2 mRNA25270620
D048789PhytoestrogensPhytoestrogens results in increased expression of MYBL2 mRNA18310284
C006253pirinixic acidpirinixic acid results in decreased expression of MYBL2 mRNA25270620
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of MYBL2 mRNA16474171
D011374ProgesteroneProgesterone results in decreased expression of MYBL2 mRNA16966611
D011441PropylthiouracilPropylthiouracil results in increased expression of MYBL2 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in decreased expression of MYBL2 mRNA17403546
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of MYBL2 mRNA17639512
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of MYBL2 mRNA19167446
C059514resveratrolresveratrol results in increased expression of MYBL2 mRNA19167446
D020123Sirolimus[TGFB1 protein co-treated with Sirolimus] results in decreased expression of MYBL2 protein12417722
C017947sodium arsenitesodium arsenite results in increased expression of MYBL2 mRNA12016162
C016104sodium bichromatesodium bichromate affects the expression of MYBL2 mRNA22110744
C075117squalestatin 1squalestatin 1 results in decreased expression of MYBL2 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of MYBL2 mRNA27225895
C016766sulforafan[sulforafan co-treated with Aflatoxin B1] affects the expression of MYBL2 mRNA25450479
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of MYBL2 mRNA"26680231
D014284TriiodothyronineTriiodothyronine results in decreased expression of MYBL2 mRNA17399805
D013629TamoxifenTamoxifen affects the expression of MYBL2 mRNA17555576
C021751tanshinonetanshinone results in increased expression of MYBL2 mRNA15849732
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of MYBL2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of MYBL2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MYBL2 mRNA21496263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYBL2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYBL2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MYBL2 mRNA16611356
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MYBL2 mRNA21496263
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYBL2 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of MYBL2 mRNA23411599
D013866ThioguanineThioguanine results in increased expression of MYBL2 mRNA16005536
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MYBL2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MYBL2 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of MYBL2 mRNA"19682533
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of MYBL2 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of MYBL2 mRNA18230668
D014212TretinoinTretinoin results in decreased expression of MYBL2 mRNA12875902|1731822
D014212TretinoinTretinoin results in decreased expression of MYBL2 mRNA16604517
C012589trichostatin Atrichostatin A results in decreased expression of MYBL2 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MYBL2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MYBL2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of MYBL2 mRNA11834241
D014635Valproic AcidValproic Acid results in decreased expression of MYBL2 mRNA15901671
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MYBL2 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased expression of MYBL2 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of MYBL2 gene29154799
C111237vorinostatvorinostat results in decreased expression of MYBL2 protein10597302

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10770937  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10770937  
GO:0003700DNA-binding transcription factor activity-TAS10770937  
GO:0005515protein binding-IPI17159899  17531812  19725879  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-TAS-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0043525positive regulation of neuron apoptotic process-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10770937  
GO:0051726regulation of cell cycle-TAS-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0031523Myb complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1IEA
R-HSA-1538133G0 and Early G1IEA
R-HSA-156711Polo-like kinase mediated eventsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453279Mitotic G1-G1/S phasesIEA
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8869496TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal