Gene: MYCN

4613
MODED|N-myc|NMYC|ODED|bHLHe37
MYCN proto-oncogene, bHLH transcription factor
protein-coding
2p24.3
Ensembl:ENSG00000134323 MIM:164840 Vega:OTTHUMG00000039579 UniprotKB:P04198
NG_007457.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.878e-1 (AD)  3.058e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MEX3B0.665
MYLIP0.663
EEPD10.657
IPO130.619
CDR2L0.613
FAM222A0.608
DPYSL50.605
AATK0.597
BCAR10.596
FOXO60.596

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYSLTR2-0.382
SLC4A1-0.38
ALAS2-0.38
FCGR3B-0.352
CEACAM4-0.351
PCK1-0.351
VNN2-0.35
CXCR2-0.343
CA1-0.343
OR4F5-0.338

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of MYCN mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MYCN mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYCN mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of MYCN mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MYCN mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYCN mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYCN mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYCN mRNA"25510870
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]12569580
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYCN mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of MYCN mRNA"23829299
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MYCN mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C5585299-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one"9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of MYCN protein"22789543
D000082AcetaminophenAcetaminophen results in decreased expression of MYCN mRNA17585979
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MYCN mRNA16483693
D000966Antimony Potassium Tartrate[MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Antimony Potassium Tartrate10348353
D000966Antimony Potassium TartrateMYCN protein results in decreased susceptibility to Antimony Potassium Tartrate10348353
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MYCN mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of MYCN mRNA12478894|2468527
C006632arsenic trioxidearsenic trioxide results in increased expression of MYCN mRNA20458559
C015001arsenitearsenite results in decreased expression of MYCN mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of MYCN mRNA]18929588
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of MYCN mRNA17404688
C044887beta-methylcholinebeta-methylcholine affects the expression of MYCN mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MYCN mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of MYCN mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of MYCN promoter27334623
C006780bisphenol Abisphenol A affects the expression of MYCN mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of MYCN mRNA25270620
C018475butyraldehydebutyraldehyde results in increased expression of MYCN mRNA26079696
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MYCN mRNA12634122
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MYCN mRNA25270620
D002737ChloropreneChloroprene results in decreased expression of MYCN mRNA23125180
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of MYCN mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MYCN mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MYCN gene20938992
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MYCN mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MYCN mRNA12634122
D002994ClofibrateClofibrate results in decreased expression of MYCN mRNA25270620
D003033Coal TarCoal Tar results in increased expression of MYCN mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of MYCN mRNA24386269
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of MYCN mRNA21356183
D003300CopperCopper results in increased expression of MYCN mRNA21356183
C551994crizotinibcrizotinib inhibits the reaction [ALK protein results in increased expression of MYCN mRNA]22286764
C551994crizotinibcrizotinib inhibits the reaction [ALK protein results in increased expression of MYCN protein]22286764
D003471CuprizoneCuprizone results in increased expression of MYCN mRNA26577399
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of MYCN protein23352502
D003976DiazinonDiazinon affects the expression of MYCN mRNA22546817
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of MYCN mRNA28962523
D004026DieldrinDieldrin affects the expression of MYCN mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of MYCN mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of MYCN mRNA]21852083
C014476diethyl maleatediethyl maleate results in decreased expression of MYCN mRNA25270620
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MYCN mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MYCN mRNA24535843
D004317Doxorubicin[MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Doxorubicin10348353
D004317DoxorubicinMYCN protein results in decreased susceptibility to Doxorubicin10348353
C118739entinostatentinostat results in increased expression of MYCN mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MYCN mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MYCN mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MYCN mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MYCN mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MYCN mRNA15576828
C024565ethylene dichlorideethylene dichloride results in decreased expression of MYCN mRNA28189721
D005047Etoposide[MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Etoposide10348353
D005047EtoposideMYCN protein results in decreased susceptibility to Etoposide10348353
D005472FluorouracilFluorouracil results in decreased expression of MYCN mRNA19272435
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MYCN mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MYCN gene20938992
D004397FonofosFonofos results in increased methylation of MYCN promoter22847954
C039281furanfuran results in increased methylation of MYCN gene22079235
D019833GenisteinGenistein affects the expression of MYCN mRNA26865667
C568713GSK1210151AGSK1210151A results in decreased expression of MYCN mRNA24952595
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of MYCN mRNA25270620
C538724HhAntag691MYCN protein results in decreased susceptibility to HhAntag69124973920
D007545IsoproterenolIsoproterenol results in decreased expression of MYCN mRNA20003209
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with panobinostat] results in decreased expression of MYCN mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to MYCN promoter]23430699
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat results in decreased expression of MYCN protein]26733615
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MYCN mRNA23430699|2495259
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MYCN protein23430699|2673361
C561695(+)-JQ1 compoundMYCN protein affects the susceptibility to (+)-JQ1 compound25535366
C561695(+)-JQ1 compoundMYCN protein results in increased susceptibility to (+)-JQ1 compound23430699
C561695(+)-JQ1 compoundpanobinostat inhibits the reaction [(+)-JQ1 compound results in decreased expression of MYCN protein]26733615
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound results in decreased expression of MYCN protein]26733615
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MYCN mRNA24297863|2497392
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MYCN protein24297863
C561695(+)-JQ1 compoundMYCN protein results in increased susceptibility to (+)-JQ1 compound24297863
D007649KetamineKetamine results in decreased expression of MYCN mRNA20080153
C561435LDE225MYCN protein results in decreased susceptibility to LDE22524973920
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MYCN mRNA12634122
C045463leflunomideleflunomide results in increased expression of MYCN mRNA19751817
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MYCN mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MYCN gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MYCN mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MYCN mRNA"20188158
C550258MLN 8237MLN 8237 results in decreased expression of MYCN protein25174395
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of MYCN mRNA16809437
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of MYCN mRNA16809437
C523799MRK 003MRK 003 results in increased expression of MYCN mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MYCN mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of MYCN mRNA22546817
C516714NVP-TAE684NVP-TAE684 inhibits the reaction [ALK protein results in increased expression of MYCN mRNA]22286764
C516714NVP-TAE684NVP-TAE684 inhibits the reaction [ALK protein results in increased expression of MYCN protein]22286764
D010100OxygenOxygen deficiency results in decreased expression of MYCN mRNA26516004
C496932panobinostat[(+)-JQ1 compound co-treated with panobinostat] results in decreased expression of MYCN mRNA26733615
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat results in decreased expression of MYCN protein]26733615
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C496932panobinostatpanobinostat inhibits the reaction [(+)-JQ1 compound results in decreased expression of MYCN protein]26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound results in decreased expression of MYCN protein]26733615
C496932panobinostatpanobinostat results in decreased expression of MYCN protein26733615
C496932panobinostatpanobinostat results in increased expression of MYCN mRNA26272509
D010278ParathionParathion results in increased methylation of MYCN promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MYCN mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of MYCN mRNA23602845
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MYCN mRNA24535843
D010634PhenobarbitalPhenobarbital results in decreased expression of MYCN mRNA23091169
D059808PolyphenolsPolyphenols results in increased expression of MYCN mRNA16293270
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MYCN mRNA28903501
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of MYCN mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of MYCN mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of MYCN mRNA24780913
C450682R116010R116010 promotes the reaction [Isotretinoin results in decreased expression of MYCN mRNA]17486130
C450682R116010R116010 promotes the reaction [Tretinoin results in decreased expression of MYCN mRNA]17486130
C450682R116010R116010 results in increased expression of MYCN mRNA17486130
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of MYCN mRNA]21852083
D015474IsotretinoinIsotretinoin results in decreased expression of MYCN mRNA17486130
D015474IsotretinoinR116010 promotes the reaction [Isotretinoin results in decreased expression of MYCN mRNA]17486130
C009166retinol acetateretinol acetate results in increased expression of MYCN mRNA16772331
D012834SilverSilver results in decreased expression of MYCN mRNA27131904
C009277sodium arsenate[MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to sodium arsenate10348353
C009277sodium arsenateMYCN protein results in decreased susceptibility to sodium arsenate10348353
C017947sodium arsenitesodium arsenite affects the methylation of MYCN gene28589171
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MYCN mRNA12634122
C017947sodium arsenitesodium arsenite results in increased expression of MYCN mRNA12016162
C017947sodium arsenitesodium arsenite results in decreased expression of MYCN mRNA11241755
D053260SootSoot results in decreased expression of MYCN mRNA26551751
C012568terbufosterbufos results in increased methylation of MYCN promoter22847954
D043343Testosterone PropionateTestosterone Propionate results in decreased expression of MYCN mRNA15601916
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MYCN mRNA17035482|1993321
D019284ThapsigarginThapsigargin results in decreased expression of MYCN mRNA22378314
D014212TretinoinTretinoin results in decreased expression of MYCN mRNA18230668
D014212TretinoinR116010 promotes the reaction [Tretinoin results in decreased expression of MYCN mRNA]17486130
D014212TretinoinTretinoin results in decreased expression of MYCN17283129
D014212TretinoinTretinoin results in decreased expression of MYCN mRNA17229153|1748613
D014212TretinoinTretinoin results in decreased expression of MYCN mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of MYCN mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of MYCN mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of MYCN mRNA19042947
C046243tryptanthrinetryptanthrine results in decreased expression of MYCN mRNA23500671
C046243tryptanthrinetryptanthrine results in decreased expression of MYCN protein23500671
D014415TunicamycinTunicamycin results in decreased expression of MYCN mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of MYCN mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of MYCN mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of MYCN gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of MYCN mRNA19136453|2054688
D014750Vincristine[MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Vincristine10348353
D014750VincristineMYCN protein results in decreased susceptibility to Vincristine10348353
D010205Pantothenic AcidPantothenic Acid results in increased expression of MYCN mRNA19397697
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYCN mRNA"27188386
C111237vorinostatvorinostat results in increased expression of MYCN mRNA26272509
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]12569580

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17327229  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17327229  
GO:0003677DNA binding-TAS10597290  
GO:0003700DNA-binding transcription factor activity-TAS3796607  
GO:0005515protein binding-IPI10597290  11593398  17289033  18003922  19111882  21698133  
23792191  25175806  25533335  26766587  27728805  27837025  
GO:0019900kinase binding-IPI27837025  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001502cartilage condensation-IEA-  
GO:0002053positive regulation of mesenchymal cell proliferation-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS3796607  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0010628positive regulation of gene expression-IDA23308108  
GO:0010629negative regulation of gene expression-IDA21796614  
GO:0010942positive regulation of cell death-IEA-  
GO:0030324lung development-IEA-  
GO:0042733embryonic digit morphogenesis-IEA-  
GO:0045607regulation of inner ear auditory receptor cell differentiation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IMP24391509  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17327229  
GO:0048704embryonic skeletal system morphogenesis-IEA-  
GO:0048712negative regulation of astrocyte differentiation-IEA-  
GO:0048754branching morphogenesis of an epithelial tube-IEA-  
GO:1903800positive regulation of production of miRNAs involved in gene silencing by miRNA-IC21796614  
GO:2000378negative regulation of reactive oxygen species metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-TAS3796607  
GO:0005634nucleus-IDA10597290  
GO:0005730nucleolus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics
11008916Parental smoking and alcohol consumption and risk of neuroblastoma. (2000 Sep)Yang QCancer Epidemiol Biomarkers Prev