Gene info: ID 4615

Gene: MYD88

GENE ID: 4615

Synonyms: MYD88D

Description: myeloid differentiation primary response 88

Gene type: protein-coding

Location: 3p22.2

dbXrefs: Ensembl:ENSG00000172936 MIM:602170 Vega:OTTHUMG00000131083 UniprotKB:Q99836

RefSeq: NG_016964.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND

# Publications: 9

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.046e-1 (AD) 8.919e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DTX3L	0.926
DRAM1	0.918
LTBR	0.917
PARP9	0.916
S100A11	0.907
APOL6	0.906
PLSCR1	0.904
PSMB8	0.904
IFI30	0.902
SP110	0.9

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABCC12	-0.58
SLC7A4	-0.58
MARCH4	-0.558
NEUROD6	-0.554
CALHM1	-0.552
ADRA1D	-0.546
KCNB2	-0.545
MYADML2	-0.536
PPEF1	-0.536
TMEM179	-0.534

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MYD88 mRNA"	25614096
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of MYD88 mRNA"	21346803
C003898	2-anisidine	2-anisidine results in decreased expression of MYD88 mRNA	28089782
C577942	2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide	"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of MYD88 mRNA]"	26644586
C577942	2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide	"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of MYD88 mRNA"	26644586
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of MYD88 protein	26194647
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]"	23452621
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[A 769662 co-treated with Lipopolysaccharides] results in increased expression of MYD88 protein]"	28096963
C550091	9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol	"9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of MYD88 mRNA]"	20590609
C550091	9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol	"9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of MYD88 protein]"	20590609
C512408	A 769662	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[A 769662 co-treated with Lipopolysaccharides] results in increased expression of MYD88 protein]"	28096963
C512408	A 769662	[A 769662 co-treated with Lipopolysaccharides] results in increased expression of MYD88 protein	28096963
D000082	Acetaminophen	Acetaminophen results in decreased expression of MYD88 mRNA	21420995\|2223033
D000082	Acetaminophen	MYD88 gene polymorphism affects the susceptibility to Acetaminophen	26104854
D000082	Acetaminophen	Acetaminophen results in increased expression of MYD88 protein	26079055
D000082	Acetaminophen	Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MYD88 protein]	26079055
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [benzanthrone results in increased expression of MYD88 protein]	28495615
D000119	Acetylmuramyl-Alanyl-Isoglutamine	MYD88 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analog	15905553
C499366	Active Hexose Correlated Compound	MYD88 protein affects the reaction [Active Hexose Correlated Compound results in increased secretion of CXCL8 protein]	23194525
C499366	Active Hexose Correlated Compound	MYD88 protein affects the reaction [Active Hexose Correlated Compound results in increased secretion of CCL2 protein]	23194525
C499366	Active Hexose Correlated Compound	MYD88 protein affects the reaction [Active Hexose Correlated Compound results in increased secretion of CXCL1 protein]	23194525
D000276	Adjuvants, Immunologic	"MYD88 protein affects the reaction [Adjuvants, Immunologic inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]]"	17404311
D000276	Adjuvants, Immunologic	"MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Adjuvants, Immunologic] results in increased secretion of IL1B protein modified form]"	17404311
D000276	Adjuvants, Immunologic	"MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Adjuvants, Immunologic] results in increased secretion of IL6 protein]"	17404311
D000276	Adjuvants, Immunologic	"MYD88 protein affects the reaction [[TNF protein co-treated with Adjuvants, Immunologic] results in increased secretion of IL6 protein]"	17404311
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MYD88 mRNA	28789997
C545596	alternaramide	alternaramide inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	26620692
C545596	alternaramide	alternaramide inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]	26620692
D000534	Alum Compounds	MYD88 protein affects the reaction [Alum Compounds inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]]	17404311
D000534	Alum Compounds	MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Alum Compounds] results in increased secretion of IL1B protein modified form]	17404311
D000534	Alum Compounds	MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Alum Compounds] results in increased secretion of IL6 protein]	17404311
D000534	Alum Compounds	MYD88 protein affects the reaction [Alum Compounds inhibits the reaction [TNF protein results in increased secretion of CXCL10 protein]]	17404311
D000534	Alum Compounds	MYD88 protein affects the reaction [[TNF protein co-treated with Alum Compounds] results in increased secretion of IL6 protein]	17404311
C012714	aluminum phosphate	MYD88 protein affects the reaction [aluminum phosphate inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]]	17404311
C012714	aluminum phosphate	MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with aluminum phosphate] results in increased secretion of IL1B protein modified form]	17404311
C012714	aluminum phosphate	MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with aluminum phosphate] results in increased secretion of IL6 protein]	17404311
C012714	aluminum phosphate	MYD88 protein affects the reaction [[TNF protein co-treated with aluminum phosphate] results in increased secretion of IL6 protein]	17404311
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of MYD88 mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of MYD88 mRNA	19654921
D001151	Arsenic	Arsenic results in decreased expression of MYD88 protein	19654921
C006632	arsenic trioxide	arsenic trioxide results in increased expression of MYD88 mRNA	17530438
C015001	arsenite	arsenite results in decreased expression of MYD88 mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of MYD88 mRNA]	18929588
C038044	baicalin	baicalin results in decreased expression of MYD88 protein	22019745
C012768	benzanthrone	Acetylcysteine inhibits the reaction [benzanthrone results in increased expression of MYD88 protein]	28495615
C012768	benzanthrone	benzanthrone results in increased expression of MYD88 protein	28495615
C012768	benzanthrone	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [benzanthrone results in increased expression of MYD88 protein]	28495615
D001554	Benzene	Benzene results in increased expression of MYD88 mRNA	19162166
D047071	beta-Glucans	MYD88 gene mutant form inhibits the reaction [beta-Glucans results in increased secretion of IL6 protein]	17572156
D047071	beta-Glucans	MYD88 gene mutant form inhibits the reaction [beta-Glucans results in increased secretion of TNF protein]	17572156
C006780	bisphenol A	bisphenol A results in decreased expression of MYD88 mRNA	28806546
C006780	bisphenol A	bisphenol A results in increased expression of MYD88 mRNA	23606268
C006780	bisphenol A	[nonylphenol co-treated with bisphenol A] results in increased expression of MYD88 mRNA	23606268
C006780	bisphenol A	[Pam(3)CSK(4) peptide co-treated with bisphenol A] results in decreased expression of MYD88 mRNA	28806546
C006780	bisphenol A	[Poly I-C co-treated with bisphenol A] results in decreased expression of MYD88 mRNA	28806546
C006780	bisphenol A	bisphenol A results in increased expression of MYD88 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of MYD88 gene	28505145
C000611646	bisphenol F	[Pam(3)CSK(4) peptide co-treated with bisphenol F] results in decreased expression of MYD88 mRNA	28806546
C000611646	bisphenol F	[Poly I-C co-treated with bisphenol F] results in decreased expression of MYD88 mRNA	28806546
D000069286	Bortezomib	Bortezomib results in decreased expression of MYD88 mRNA	20471514
D002065	Buspirone	Buspirone results in increased expression of MYD88 mRNA	24136188
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of MYD88 mRNA	23741332
C058667	cadmium selenide	[cadmium selenide co-treated with zinc sulfide] results in increased expression of MYD88 mRNA	22342292
D002220	Carbamazepine	Carbamazepine affects the expression of MYD88 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MYD88 mRNA	23146752
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MYD88 protein	23146752
D002251	Carbon Tetrachloride	Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 mRNA]	23146752
D002251	Carbon Tetrachloride	Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein]	23146752
D002330	Carmustine	Carmustine results in decreased expression of MYD88 mRNA	15980968
C054133	casticin	casticin results in increased expression of MYD88 mRNA	27862857
D002726	Chlorogenic Acid	Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MYD88 protein]	26079055
D002726	Chlorogenic Acid	Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 mRNA]	23146752
D002726	Chlorogenic Acid	Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein]	23146752
D008076	Cholesterol, HDL	"Cholesterol, HDL inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]"	20972769
C012843	cinnamic aldehyde	cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	18306459
C012843	cinnamic aldehyde	cinnamic aldehyde inhibits the reaction [Poly I-C results in increased expression of MYD88 mRNA]	18306459
D002994	Clofibrate	Clofibrate results in decreased expression of MYD88 mRNA	17585979
D002995	Clofibric Acid	Clofibric Acid affects the expression of MYD88 mRNA	17602206
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [IRAK1 protein binds to MYD88 protein]	25780291
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [TLR2 protein binds to MYD88 protein]	25780291
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [TLR4 protein binds to MYD88 protein]	25780291
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [TRAF6 protein binds to MYD88 protein]	25780291
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of MYD88 mRNA	19549813
C408982	CPG-oligonucleotide	CPG-oligonucleotide promotes the reaction [[TLR9 co-treated with MYD88] results in increased expression of HSPA1B protein]	17046822
C029892	cupric chloride	cupric chloride results in increased expression of MYD88 mRNA	24650576
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]	23452621
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein]	19002562
D016572	Cyclosporine	Cyclosporine results in decreased expression of MYD88 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased methylation of MYD88 promoter	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of MYD88 mRNA	19770486\|2758566
D016572	Cyclosporine	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of MYD88 mRNA]	27585667
C007262	deoxynivalenol	"deoxynivalenol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MYD88 protein]"	26961612
C042577	diallyl trisulfide	diallyl trisulfide inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]	25500681
D003976	Diazinon	Diazinon results in increased methylation of MYD88 gene	22964155
D002945	Cisplatin	[Cisplatin co-treated with CDKN1A protein] results in increased expression of MYD88 mRNA	18483502
D002945	Cisplatin	Cisplatin results in increased expression of MYD88 mRNA	26546572
D004008	Diclofenac	Diclofenac results in increased expression of MYD88 mRNA	26934552
D004026	Dieldrin	Dieldrin results in increased expression of MYD88 mRNA	28385952
D004041	Dietary Fats	[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA	27769711
D004041	Dietary Fats	esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA]	27769711
D004052	Diethylnitrosamine	MYD88 protein affects the reaction [Diethylnitrosamine results in increased expression of IL6 protein]	17615358
D004052	Diethylnitrosamine	MYD88 protein promotes the reaction [Diethylnitrosamine results in increased expression of IL6 protein]	18093689\|1869155
D004052	Diethylnitrosamine	MYD88 protein results in increased susceptibility to Diethylnitrosamine	18093689
D004147	Dioxins	Dioxins affects the expression of MYD88 mRNA	20463971
D004221	Disulfiram	Disulfiram results in increased expression of MYD88 mRNA	20530235
D004317	Doxorubicin	[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of MYD88 mRNA	27181935
D004391	Dust	MYD88 gene mutant form inhibits the reaction [Dust results in increased expression of CCL2 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [Dust results in increased expression of CCL3 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [Dust results in increased expression of [IL12A protein binds to IL12B protein]]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [Dust results in increased expression of IL6 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [Dust results in increased expression of TNF protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL2 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL5 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL7 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CXCL1 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL4 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL5 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL6 protein]	26882889
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of TNF protein]	26882889
D004391	Dust	MYD88 gene mutant form promotes the reaction [Dust results in increased expression of CCL3 protein]	26882889
D004391	Dust	MYD88 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL3 protein]	26882889
D015777	Eicosanoids	MYD88 protein promotes the reaction [Pam(3)CSK(4) peptide results in increased metabolism of Eicosanoids]	17369491
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of MYD88 protein]	27890776
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of MYD88 protein]	27890776
D000069347	Erlotinib Hydrochloride	[Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of MYD88 mRNA	27738319
C007628	esculetin	esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA]	27769711
D000431	Ethanol	Ethanol results in increased expression of MYD88 mRNA	26858005
D000431	Ethanol	Fructose promotes the reaction [Ethanol results in increased expression of MYD88 mRNA]	26858005
D000431	Ethanol	Ethanol results in increased expression of MYD88 mRNA	26115886
D000431	Ethanol	Ethanol results in increased expression of MYD88 protein	22525864
D000431	Ethanol	Plant Extracts inhibits the reaction [Ethanol results in increased expression of MYD88 protein]	22525864
D000431	Ethanol	Scopoletin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA]	26115886
D000431	Ethanol	Silymarin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA]	26115886
C507035	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [benzanthrone results in increased expression of MYD88 protein]	28495615
C507035	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of MYD88 mRNA]	27585667
C100807	ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate	ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]	20023007
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of MYD88 exon	16300676
D015025	Zearalenone	Zearalenone results in increased expression of MYD88 mRNA	27757495
D005485	Flutamide	Flutamide results in decreased expression of MYD88 mRNA	24136188
D005492	Folic Acid	Folic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88]	24177262
D005632	Fructose	Fructose promotes the reaction [Ethanol results in increased expression of MYD88 mRNA]	26858005
C460864	FSL-1 lipoprotein, synthetic	"MYD88 protein affects the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]"	25200491
C460864	FSL-1 lipoprotein, synthetic	"MYD88 protein affects the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]"	25200491
D037741	Fullerenes	Fullerenes analog results in increased expression of MYD88 mRNA	22342292
D062610	Fungal Polysaccharides	[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of MYD88 mRNA	27181935
D005690	Galactose	"[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein"	23535186
D005690	Galactose	"scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein]"	23535186
C007834	genipin	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	22687549
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]	23452621
D005839	Gentamicins	Gentamicins results in increased expression of MYD88 mRNA	22061828
C568713	GSK1210151A	GSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of MYD88 mRNA]	26644586
C568713	GSK1210151A	GSK1210151A results in decreased expression of MYD88 mRNA	26644586
D017313	Fenretinide	Fenretinide results in increased expression of MYD88 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [TRAF6 protein binds to [IL1R1 protein binds to MYD88 protein]]	16354686
C082585	iberin	iberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to MYD88 protein]]	25294874
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYD88 mRNA	25613284
D007545	Isoproterenol	Isoproterenol results in increased expression of MYD88 mRNA	24842192
D007545	Isoproterenol	Metformin inhibits the reaction [Isoproterenol results in increased expression of MYD88 mRNA]	24842192
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of MYD88 mRNA]	26644586
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MYD88 mRNA	23086925\|2664458
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of MYD88 mRNA	24332044
C114999	K-12 lipopolysaccharide	"MYD88 protein affects the reaction [Adjuvants, Immunologic inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]]"	17404311
C114999	K-12 lipopolysaccharide	MYD88 protein affects the reaction [Alum Compounds inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]]	17404311
C114999	K-12 lipopolysaccharide	MYD88 protein affects the reaction [aluminum phosphate inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]]	17404311
C114999	K-12 lipopolysaccharide	"MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Adjuvants, Immunologic] results in increased secretion of IL1B protein modified form]"	17404311
C114999	K-12 lipopolysaccharide	"MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Adjuvants, Immunologic] results in increased secretion of IL6 protein]"	17404311
C114999	K-12 lipopolysaccharide	MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Alum Compounds] results in increased secretion of IL1B protein modified form]	17404311
C114999	K-12 lipopolysaccharide	MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Alum Compounds] results in increased secretion of IL6 protein]	17404311
C114999	K-12 lipopolysaccharide	MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with aluminum phosphate] results in increased secretion of IL1B protein modified form]	17404311
C114999	K-12 lipopolysaccharide	MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with aluminum phosphate] results in increased secretion of IL6 protein]	17404311
C114999	K-12 lipopolysaccharide	MYD88 protein affects the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]	17404311
D007854	Lead	Lead affects the expression of MYD88 mRNA	28903495
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of MYD88 mRNA"	23090859
C482199	lipopolysaccharide, E coli O55-B5	"9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of MYD88 mRNA]"	20590609
C482199	lipopolysaccharide, E coli O55-B5	"9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of MYD88 protein]"	20590609
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of MYD88 mRNA"	20590609
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of MYD88 protein"	20590609
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MYD88 mRNA"	18930950
C440499	lipopolysaccharide, Escherichia coli O111 B4	"deoxynivalenol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MYD88 protein]"	26961612
C440499	lipopolysaccharide, Escherichia coli O111 B4	"[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein"	23535186
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MYD88 protein"	26961612\|2928948
C440499	lipopolysaccharide, Escherichia coli O111 B4	"MYD88 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]"	21430222
C440499	lipopolysaccharide, Escherichia coli O111 B4	"MYD88 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PARK2 mRNA]"	21858193
C440499	lipopolysaccharide, Escherichia coli O111 B4	"MYD88 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PARK2 protein]"	21858193
C440499	lipopolysaccharide, Escherichia coli O111 B4	"MYD88 affects the susceptibility to lipopolysaccharide, Escherichia coli O111 B4"	21858193
C440499	lipopolysaccharide, Escherichia coli O111 B4	"scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein]"	23535186
C442865	lipopolysaccharide, Helicobacter pylori	"MYD88 protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CXCL8 mRNA]"	21220698
D008070	Lipopolysaccharides	MYD88 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]	22053092
D008070	Lipopolysaccharides	MYD88 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]	22053092
D008070	Lipopolysaccharides	MYD88 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]	22053092
D008070	Lipopolysaccharides	MYD88 mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]	22053092
D008070	Lipopolysaccharides	APOA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	20972769
D008070	Lipopolysaccharides	"Cholesterol, HDL inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]"	20972769
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MYD88 mRNA	20972769
D008070	Lipopolysaccharides	MYD88 affects the reaction [Lipopolysaccharides results in increased expression of MIR146A mRNA]	24863965
D008070	Lipopolysaccharides	MYD88 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein]	21112663
D008070	Lipopolysaccharides	"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[A 769662 co-treated with Lipopolysaccharides] results in increased expression of MYD88 protein]"	28096963
D008070	Lipopolysaccharides	[A 769662 co-treated with Lipopolysaccharides] results in increased expression of MYD88 protein	28096963
D008070	Lipopolysaccharides	alternaramide inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	26620692
D008070	Lipopolysaccharides	alternaramide inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]	26620692
D008070	Lipopolysaccharides	APOA1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	20972769
D008070	Lipopolysaccharides	cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	18306459
D008070	Lipopolysaccharides	diallyl trisulfide inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]	25500681
D008070	Lipopolysaccharides	ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]	20023007
D008070	Lipopolysaccharides	Folic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88]	24177262
D008070	Lipopolysaccharides	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	22687549
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of and results in increased phosphorylation of MYD88 protein	23735482
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of MYD88 mRNA	25896969
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MYD88	24177262
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MYD88 mRNA	18306459\|2097276
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MYD88 protein	15593098\|2002300
D008070	Lipopolysaccharides	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	24056979
D008070	Lipopolysaccharides	MYD88 affects the reaction [Lipopolysaccharides affects the localization of and results in increased activity of GATA2 protein]	23940812
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [Lipopolysaccharides results in increased expression of SLC30A4 protein]	16892068
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [Lipopolysaccharides results in increased expression of SLC30A6 protein]	16892068
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 mRNA]	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2L1 protein]	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2 mRNA]	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL13 protein]	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL6 protein]	24453940
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of TNF protein]	24453940
D008070	Lipopolysaccharides	Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in increased phosphorylation of MYD88 protein]	23735482
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of MYD88 mRNA	25613284
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Titanium] results in decreased expression of MYD88 mRNA	21308757
D008070	Lipopolysaccharides	MYD88 protein results in increased susceptibility to Lipopolysaccharides	20865294
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MYD88 mRNA	28528741
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MYD88 protein	28528741
D008070	Lipopolysaccharides	ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	28528741
D008070	Lipopolysaccharides	ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]	28528741
D008070	Lipopolysaccharides	iberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to MYD88 protein]]	25294874
D008070	Lipopolysaccharides	Lipopolysaccharides promotes the reaction [TLR4 protein binds to MYD88 protein]	25294874
D008550	Melatonin	Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 mRNA]	28238930
D008550	Melatonin	Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 protein]	28238930
D008550	Melatonin	Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]]	28238930
D008687	Metformin	Metformin inhibits the reaction [Isoproterenol results in increased expression of MYD88 mRNA]	24842192
D008727	Methotrexate	[Methotrexate co-treated with CDKN1A protein] results in decreased expression of MYD88 mRNA	18483502
D008727	Methotrexate	Methotrexate results in increased expression of MYD88 mRNA	21678067
C008435	methyldithiocarbamate	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	24056979
C437683	motexafin gadolinium	motexafin gadolinium results in decreased expression of MYD88 mRNA	16357179
C437683	motexafin gadolinium	[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of MYD88 mRNA	16357179
D009151	Mustard Gas	Mustard Gas results in increased expression of MYD88 mRNA	18955075
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of MYD88 mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MYD88 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MYD88 mRNA"	22293422\|2555468
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of MYD88 mRNA	19812364
D009532	Nickel	Nickel results in increased expression of MYD88 mRNA	24768652\|2558310
C022838	nickel chloride	MYD88 mutant form inhibits the reaction [nickel chloride results in increased expression of CXCL8 protein]	24080332
C022838	nickel chloride	MYD88 mutant form inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]	24080332
C022838	nickel chloride	nickel chloride results in increased expression of MYD88 protein	21473897
D009573	Nitrites	MYD88 protein affects the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]	10967106
D009573	Nitrites	MYD88 protein mutant form inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]	10967106
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 protein]"	24223152
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]"	24223152
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MYD88 mRNA"	17622302
C025256	nonylphenol	[nonylphenol co-treated with bisphenol A] results in increased expression of MYD88 mRNA	23606268
C025256	nonylphenol	nonylphenol results in increased expression of MYD88 mRNA	23606268
C025589	ochratoxin A	ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]	28528741
C025589	ochratoxin A	ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]	28528741
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL2 protein]	26882889
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL5 protein]	26882889
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL7 protein]	26882889
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CXCL1 protein]	26882889
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]	26882889
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL4 protein]	26882889
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL5 protein]	26882889
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL6 protein]	26882889
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of TNF protein]	26882889
D010047	Ovalbumin	MYD88 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL3 protein]	26882889
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]"	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]	23452621
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of MYD88 mRNA	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]	23452621
D010100	Oxygen	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 protein]"	24223152
D010100	Oxygen	Oxygen deficiency results in increased expression of MYD88 protein	24223152
D010100	Oxygen	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]"	24223152
D010100	Oxygen	Oxygen deficiency results in increased expression of MYD88 mRNA	24223152
D010126	Ozone	MYD88 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]	17626835
D010126	Ozone	MYD88 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 mRNA]	17626835
D010126	Ozone	MYD88 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 protein]	17626835
D010126	Ozone	MYD88 gene mutant form results in decreased susceptibility to Ozone	17626835
D010126	Ozone	Ozone results in increased expression of MYD88 mRNA	17626835\|2154328
C508075	Pam(3)CSK(4) peptide	[Pam(3)CSK(4) peptide co-treated with bisphenol A] results in decreased expression of MYD88 mRNA	28806546
C508075	Pam(3)CSK(4) peptide	[Pam(3)CSK(4) peptide co-treated with bisphenol F] results in decreased expression of MYD88 mRNA	28806546
C508075	Pam(3)CSK(4) peptide	MYD88 protein promotes the reaction [Pam(3)CSK(4) peptide results in increased metabolism of Eicosanoids]	17369491
C016030	pantogab	pantogab results in increased expression of MYD88 mRNA	17379144
D010269	Paraquat	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of MYD88 protein]	27890776
D010269	Paraquat	Paraquat results in increased expression of MYD88 protein	27890776
D010269	Paraquat	epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of MYD88 protein]	27890776
D010269	Paraquat	MYD88 protein affects the reaction [Paraquat results in increased expression of IL1B mRNA]	28131803
D010269	Paraquat	MYD88 protein affects the reaction [Paraquat results in increased expression of IL1B protein]	28131803
D010269	Paraquat	MYD88 protein affects the reaction [Paraquat results in increased expression of TNF mRNA]	28131803
D010269	Paraquat	MYD88 protein affects the reaction [Paraquat results in increased expression of TNF protein]	28131803
D010269	Paraquat	MYD88 protein affects the reaction [Paraquat results in increased phosphorylation of RELA protein]	28131803
D010269	Paraquat	MYD88 protein results in increased susceptibility to Paraquat	28131803
D010269	Paraquat	Paraquat results in increased expression of MYD88 mRNA	28131803
D010269	Paraquat	Paraquat results in increased expression of MYD88 protein	27890776\|2813180
D010269	Paraquat	Phosphorothioate Oligonucleotides inhibits the reaction [Paraquat results in increased expression of MYD88 protein]	28363843
D052638	Particulate Matter	MYD88 gene mutant form inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]	23896513
D052638	Particulate Matter	MYD88 gene mutant form inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]	23896513
D052638	Particulate Matter	MYD88 gene mutant form inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]	23896513
D052638	Particulate Matter	MYD88 gene mutant form inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]	23896513
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of MYD88 mRNA	23892564
D010424	Pentobarbital	Pentobarbital results in increased expression of MYD88 mRNA	16978161
D010457	Peptidoglycan	MYD88 gene mutant form inhibits the reaction [Peptidoglycan results in increased expression of IL10 protein]	17238832
D010457	Peptidoglycan	Peptidoglycan results in increased expression of MYD88 protein	15593098
D054735	Phosphorothioate Oligonucleotides	Phosphorothioate Oligonucleotides inhibits the reaction [Paraquat results in increased expression of MYD88 protein]	28363843
D010862	Pilocarpine	Pilocarpine results in increased expression of MYD88 mRNA	17971868
C006253	pirinixic acid	pirinixic acid results in increased expression of MYD88 mRNA	18301758\|2381119
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]	23452621
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Ethanol results in increased expression of MYD88 protein]	22525864
D011070	Poly I-C	[Poly I-C co-treated with bisphenol A] results in decreased expression of MYD88 mRNA	28806546
D011070	Poly I-C	[Poly I-C co-treated with bisphenol F] results in decreased expression of MYD88 mRNA	28806546
D011070	Poly I-C	cinnamic aldehyde inhibits the reaction [Poly I-C results in increased expression of MYD88 mRNA]	18306459
D011070	Poly I-C	Poly I-C results in increased expression of MYD88 mRNA	18306459
D011374	Progesterone	Progesterone results in increased expression of MYD88 mRNA	21549006
D011794	Quercetin	Quercetin results in decreased expression of MYD88 mRNA	19729006\|2163298
D011794	Quercetin	Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in increased phosphorylation of MYD88 protein]	23735482
C402365	resiquimod	MYD88 gene mutant form inhibits the reaction [resiquimod results in increased expression of IL10 protein]	17238832
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]	23452621
C059514	resveratrol	resveratrol results in decreased activity of MYD88 protein	24617573
C059514	resveratrol	resveratrol results in decreased expression of MYD88 protein	24818579
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of MYD88 mRNA]	24758933
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of MYD88 protein]	24758933
C041376	rosmarinic acid	rosmarinic acid results in decreased expression of MYD88 protein	28789951
C099445	S 28463	MYD88 protein affects the susceptibility to S 28463	16361354
C018145	scoparone	"scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of MYD88 protein]"	23535186
D012603	Scopoletin	Scopoletin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA]	26115886
D012822	Silicon Dioxide	[MYD88 protein co-treated with TICAM1 protein] affects the susceptibility to Silicon Dioxide	18604214
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of MYD88 mRNA	21602193
D012834	Silver	Silver affects the expression of MYD88 mRNA	22342292
D012838	Silymarin	Silymarin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA]	26115886
D012999	Soman	Soman results in increased expression of MYD88 mRNA	19281266
D053260	Soot	Soot results in increased expression of MYD88 mRNA	22461453
D013311	Streptozocin	[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA	27769711
D013311	Streptozocin	esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of MYD88 mRNA]	27769711
C061133	tamibarotene	tamibarotene results in increased expression of MYD88 mRNA	15498508
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of MYD88 mRNA	27413111
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of MYD88 protein	27413111
C000591600	tetrachlorobenzoquinone	TLR4 gene mutant form inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 mRNA]	27413111
C000591600	tetrachlorobenzoquinone	HMGB1 affects the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 protein]	27413111
C000591600	tetrachlorobenzoquinone	Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 mRNA]	28238930
C000591600	tetrachlorobenzoquinone	Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 protein]	28238930
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of MYD88 mRNA	28238930
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of MYD88 protein	27413111\|2823893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MYD88 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of MYD88 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MYD88 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MYD88 mRNA	14718646
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MYD88 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	MYD88 mutant form inhibits the reaction [[Vitallium analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CXCL8 mRNA]	23680697
D013755	Tetradecanoylphorbol Acetate	MYD88 mutant form inhibits the reaction [[Vitallium analog co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CXCL8 protein]	23680697
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYD88 mRNA	25613284
D013792	Thalidomide	Thalidomide results in decreased expression of MYD88 mRNA	26006729\|2621778
D013893	Thiram	Thiram results in increased expression of MYD88 mRNA	20530235
D014025	Titanium	[Lipopolysaccharides co-treated with Titanium] results in decreased expression of MYD88 mRNA	21308757
C009495	titanium dioxide	titanium dioxide results in increased expression of MYD88 mRNA	22342292
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MYD88 mRNA	28111298
D014118	Toxins, Biological	"Toxins, Biological affects the expression of MYD88 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of MYD88 mRNA	15498508
C012589	trichostatin A	trichostatin A affects the expression of MYD88 mRNA	28542535
C046488	trimethyltin	trimethyltin results in increased expression of MYD88 mRNA	21435392
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein]	19002562
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of MYD88	16891783
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein	19002562
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MYD88 mRNA"	26179874
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MYD88 mRNA"	18930950
D014520	Urethane	Urethane results in decreased expression of MYD88 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of MYD88 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of MYD88 mRNA	23179753\|2800136
D014640	Vancomycin	Vancomycin results in decreased expression of MYD88 mRNA	18930951
D014800	Vitallium	MYD88 mutant form inhibits the reaction [[Vitallium analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CXCL8 mRNA]	23680697
D014800	Vitallium	MYD88 mutant form inhibits the reaction [[Vitallium analog co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CXCL8 protein]	23680697
D019345	Zinc Acetate	MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of CXCL8 protein]	24080332
D019345	Zinc Acetate	MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]	24080332
D019345	Zinc Acetate	[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of MYD88 mRNA	16357179
D019345	Zinc Acetate	Zinc Acetate results in decreased expression of MYD88 mRNA	16357179
C042103	zinc nitrate	MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of CCL2 mRNA]	23352990
C042103	zinc nitrate	MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of CXCL1 mRNA]	23352990
C042103	zinc nitrate	MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of IL6 mRNA]	23352990
C042103	zinc nitrate	MYD88 mutant form inhibits the reaction [zinc nitrate results in increased expression of TNF mRNA]	23352990
D015034	Zinc Oxide	MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CCL2 mRNA]	23352990
D015034	Zinc Oxide	MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of CXCL1 mRNA]	23352990
D015034	Zinc Oxide	MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of IL6 mRNA]	23352990
D015034	Zinc Oxide	MYD88 mutant form inhibits the reaction [Zinc Oxide analog results in increased expression of TNF mRNA]	23352990
D015034	Zinc Oxide	Zinc Oxide analog promotes the reaction [OVAL protein results in increased expression of MYD88 protein]	25127755
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [IRAK1 protein binds to MYD88 protein]	25780291
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [TLR2 protein binds to MYD88 protein]	25780291
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [TLR4 protein binds to MYD88 protein]	25780291
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [TRAF6 protein binds to MYD88 protein]	25780291
C031238	zinc sulfide	[cadmium selenide co-treated with zinc sulfide] results in increased expression of MYD88 mRNA	22342292
D015054	Zymosan	MYD88 gene mutant form inhibits the reaction [Zymosan results in increased expression of IL10 protein]	17238832
D015054	Zymosan	MYD88 gene mutant form inhibits the reaction [Zymosan results in increased expression of IL12B protein]	15845454
D015054	Zymosan	MYD88 gene mutant form inhibits the reaction [Zymosan results in increased expression of IL2 protein]	15845454

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005123	death receptor binding	-	TAS	9374458
GO:0005515	protein binding	-	IPI	10383454 10880445 11544529 12860405 16189514 16365431 17126326 17258210 17567694 17583698 19948740 20676093 20696886 21334391 21988832 22155231 22581261 24316379 25416956 25910212 26592460 26871637 27107014
GO:0042802	identical protein binding	-	IPI	11544529 17258210 21516116 21988832 22155231 25416956 25910212 27107012
GO:0043621	protein self-association	-	IDA	22155231
GO:0070976	TIR domain binding	-	IPI	19509286

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	-	TAS	-
GO:0006915	apoptotic process	-	IMP	22155231
GO:0006954	inflammatory response	-	IEA	-
GO:0007165	signal transduction	-	NAS	9013863
GO:0007166	cell surface receptor signaling pathway	-	TAS	9374458
GO:0010628	positive regulation of gene expression	-	ISS	-
GO:0032481	positive regulation of type I interferon production	-	IMP	23633945
GO:0032481	positive regulation of type I interferon production	-	TAS	-
GO:0032740	positive regulation of interleukin-17 production	-	ISS	-
GO:0032747	positive regulation of interleukin-23 production	-	ISS	-
GO:0032755	positive regulation of interleukin-6 production	-	ISS	-
GO:0034162	toll-like receptor 9 signaling pathway	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	TAS	-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IEP	12761501
GO:0050727	regulation of inflammatory response	-	ISS	-
GO:0050830	defense response to Gram-positive bacterium	-	ISS	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	22155231
GO:0060337	type I interferon signaling pathway	-	IMP	23633945
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-
GO:0070555	response to interleukin-1	-	IMP	19281832
GO:0070935	3'-UTR-mediated mRNA stabilization	-	IDA	15294994
GO:0071260	cellular response to mechanical stimulus	-	IEP	19593445
GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	-	ISS	-
GO:1900017	positive regulation of cytokine production involved in inflammatory response	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	22155231
GO:0005737	cytoplasm	-	IDA	22155231
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0010008	endosome membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04210	Apoptosis
hsa04620	Toll-like receptor signaling pathway
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05143	African trypanosomiasis
hsa05144	Malaria
hsa05145	Toxoplasmosis

Reactome ID	Reactome Term	Evidence
R-HSA-1236974	ER-Phagosome pathway	TAS
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	TAS
R-HSA-193639	p75NTR signals via NF-kB	TAS
R-HSA-193639	p75NTR signals via NF-kB	IEA
R-HSA-193704	p75 NTR receptor-mediated signalling	TAS
R-HSA-193704	p75 NTR receptor-mediated signalling	IEA
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-209543	p75NTR recruits signalling complexes	TAS
R-HSA-209543	p75NTR recruits signalling complexes	IEA
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	TAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-5260271	Diseases of Immune System	TAS
R-HSA-5602358	Diseases associated with the TLR signaling cascade	TAS
R-HSA-5602498	MyD88 deficiency (TLR2/4)	TAS
R-HSA-5602680	MyD88 deficiency (TLR5)	TAS
R-HSA-5603037	IRAK4 deficiency (TLR5)	TAS
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-73887	Death Receptor Signalling	TAS
R-HSA-73887	Death Receptor Signalling	IEA
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-933541	TRAF6 mediated IRF7 activation	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28147216	An emerging role of Alu RNA in geographic atrophy pathogenesis: the implication for novel therapeutic strategies. (2016 Dec)	Mao X	Discov Med
25365203	Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness. (2014 Dec)	Wang Y	Lab Invest
26600481	Expression and significance of myeloid differentiation factor 88 in non-small cell lung carcinoma and normal paracancerous tissues. (2015 Nov 13)	Zhu J	Genet Mol Res
19635922	Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way. (2009 Aug 15)	Robays LJ	J Immunol
21444764	An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis. (2011 May 1)	Sheikh SZ	J Immunol
23803696	Innate immunity gene polymorphisms and the risk of colorectal neoplasia. (2013 Nov)	Chang CM	Carcinogenesis
26061394	Expression of Toll-like receptors in nasal epithelium in allergic rhinitis. (2015 Aug)	Renkonen J	APMIS
21447380	Naloxone-precipitated morphine withdrawal behavior and brain IL-1beta expression: comparison of different mouse strains. (2011 Aug)	Liu L	Brain Behav Immun
22882939	Expression and significance of myeloid differentiation factor 88 in marrow dendritic cells in asthmatic rats with cigarette smoke exposure. (2012 Jul)	Li Y	Chin Med J (Engl)