Gene: MYF6

4618
CNM3|MRF4|bHLHc4|myf-6
myogenic factor 6
protein-coding
12q21.31
Ensembl:ENSG00000111046 MIM:159991 Vega:OTTHUMG00000170165 UniprotKB:P23409
NG_021392.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.842e-1 (AD)  2.976e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZBED20.741
ENTHD10.721
C6orf1320.718
AMBN0.712
DRD30.708
GPR1010.697
TNFRSF80.69
DGKK0.69
GPR10.688
SAG0.688

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPH3-0.396
ANKRD9-0.39
GALNT9-0.37
NTNG2-0.367
NANOS3-0.36
NEUROD2-0.36
SOHLH1-0.345
EMX1-0.328
SDK2-0.32
TMEM221-0.316

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYF6 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of MYF6 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of MYF6 mRNA17585979
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MYF6 mRNA16483693
C015001arsenitearsenite results in increased methylation of MYF6 promoter23974009
C006780bisphenol Abisphenol A affects the methylation of MYF6 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of MYF6 mRNA25181051|2717856
D003907DexamethasoneDexamethasone results in increased expression of MYF6 mRNA22733784
D004147DioxinsDioxins affects the expression of MYF6 mRNA20463971
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MYF6 mRNA12057914
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MYF6 mRNA28001369
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MYF6 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of MYF6 mRNA15674843
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYF6 mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYF6 mRNA27935865
D053260SootSoot results in increased expression of MYF6 mRNA26551751
D013096SpermineSpermine results in increased expression of MYF6 mRNA18673383
D014212TretinoinMYF6 protein results in increased susceptibility to Tretinoin16236281
D014635Valproic AcidValproic Acid affects the expression of MYF6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MYF6 mRNA23179753
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYF6 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of MYF6 mRNA26272509
D015032ZincZinc deficiency results in decreased expression of MYF6 mRNA19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS2311584  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IBA21873635  
GO:0046982protein heterodimerization activity-ISS-  
GO:0070888E-box bindingcontributes_toISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001756somitogenesis-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS2311584  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007519skeletal muscle tissue development-TAS2311584  
GO:0035914skeletal muscle cell differentiation-IBA21873635  
GO:0042693muscle cell fate commitment-ISS-  
GO:0043403skeletal muscle tissue regeneration-IEA-  
GO:0045663positive regulation of myoblast differentiation-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0048743positive regulation of skeletal muscle fiber development-IBA21873635  
GO:0051149positive regulation of muscle cell differentiation-TAS-  
GO:0060415muscle tissue morphogenesis-IEA-  
GO:1901741positive regulation of myoblast fusion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS2311584  
GO:0005654nucleoplasm-TAS-  
GO:0090575RNA polymerase II transcription factor complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-375170CDO in myogenesisIEA
R-HSA-375170CDO in myogenesisTAS
R-HSA-525793MyogenesisIEA
R-HSA-525793MyogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23599765Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer. (2013 Apr)Zhao YOncol Lett