Gene: MYH1

4619
HEL71|MYHSA1|MYHa|MyHC-2X/D|MyHC-2x
myosin heavy chain 1
protein-coding
17p13.1
Ensembl:ENSG00000109061 MIM:160730 Vega:OTTHUMG00000130362 UniprotKB:P12882
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.762e-1 (AD)  8.436e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL10.835
XIRP20.823
MYLPF0.798
AMPD10.765
NEB0.763
MYH20.763
CKM0.763
TNNT30.755
TNNI20.754
TRIM630.726

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZBTB32-0.31
FEM1A-0.297
UFSP1-0.286
ANO8-0.281
AMH-0.277
TEX29-0.275
GMPPB-0.269
D2HGDH-0.269
C4orf48-0.268
TPGS1-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of MYH1 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of MYH1 mRNA28606764
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MYH1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of MYH1 mRNA"22863853
D001151ArsenicArsenic results in decreased expression of MYH1 protein22552367
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MYH1 protein"24431215
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"pyrrolidine dithiocarbamic acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MYH1 protein]"24431215
D004958EstradiolEstradiol affects the expression of MYH1 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of MYH1 mRNA27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of MYH1 mRNA]27082013
C006780bisphenol Abisphenol A results in decreased expression of MYH1 mRNA25181051
C032688boric acidboric acid affects the expression of MYH1 mRNA25637568
C034939cadmium sulfide[cadmium telluride co-treated with cadmium sulfide] results in decreased expression of MYH1 mRNA20596552
C028337cadmium telluride[cadmium telluride co-treated with cadmium sulfide] results in decreased expression of MYH1 mRNA20596552
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MYH1 mRNA15963578
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of MYH1 protein22552367
C031180chrysenechrysene results in increased expression of MYH1 mRNA26377693
D002922CiguatoxinsCiguatoxins affects the expression of MYH1 mRNA18353800
C019304ciprofibrateciprofibrate results in decreased expression of MYH1 mRNA12771043
D003471CuprizoneCuprizone affects the expression of MYH1 mRNA26577399
D003474CurcuminCurcumin results in decreased expression of MYH1 mRNA18299980
D003907DexamethasoneDexamethasone results in increased expression of MYH1 mRNA14618091
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MYH1 mRNA28085963
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of MYH1 mRNA12771043
C024629dimethyl phthalatedimethyl phthalate affects the expression of MYH1 mRNA26924002
C039281furanfuran results in increased expression of MYH1 mRNA27387713
C004312glycidolglycidol results in decreased expression of MYH1 mRNA24915197
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MYH1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MYH1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MYH1 mRNA"25620056
C029938nickel sulfatenickel sulfate results in increased expression of MYH1 mRNA16166746
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYH1 mRNA27935865
D010634PhenobarbitalPhenobarbital affects the expression of MYH1 mRNA23091169
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYH1 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of MYH1 mRNA20813756
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of MYH1 mRNA]27082013
D011374ProgesteroneProgesterone results in decreased expression of MYH1 mRNA18070364
D011374ProgesteroneProgesterone results in increased expression of MYH1 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of MYH1 mRNA24780913
C020972pyrrolidine dithiocarbamic acid"pyrrolidine dithiocarbamic acid inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MYH1 protein]"24431215
D011794QuercetinQuercetin results in increased expression of MYH1 mRNA23117658
D011794Quercetin[Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of MYH1 mRNA23117658
C017947sodium arsenitesodium arsenite results in increased expression of MYH1 mRNA20308225
D012969Sodium FluorideSodium Fluoride results in increased expression of MYH1 protein28918527
D053260SootSoot results in increased expression of MYH1 mRNA26551751
D013096SpermineSpermine results in increased expression of MYH1 mRNA18673383
D013739TestosteroneTestosterone affects the reaction [Testosterone deficiency affects the expression of MYH1 mRNA]21045173
D013739TestosteroneTestosterone deficiency affects the expression of MYH1 mRNA21045173
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MYH1 gene25560391
D014812Vitamin K[Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of MYH1 mRNA23117658
D014859Warfarin[Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of MYH1 mRNA23117658
D015032ZincZinc deficiency results in decreased expression of MYH1 mRNA20857495

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IEA-  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-IEA-  
GO:0007018microtubule-based movement-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005859muscle myosin complex-IDA18310078  
GO:0014704intercalated disc-IEA-  
GO:0031672A band-IEA-  
GO:0032982myosin filament-IEA-  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA15121898  
KEGG ID KEGG Term
hsa04530Tight junction
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28542447Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women. (2017)Wang XPLoS One