Gene: SERPINC1

462
AT3|AT3D|ATIII|ATIII-R2|THPH7
serpin family C member 1
protein-coding
1q25.1
Ensembl:ENSG00000117601 MIM:107300 Vega:OTTHUMG00000037276 UniprotKB:P01008
NG_012462.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.149e-3 (AD)  4.250e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BNIPL0.626
CELSR10.613
C7orf610.613
REP150.605
CYP39A10.601
IFNA20.582
PRAMEF80.566
MICB0.548
JMJD60.547
TMEM790.54

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MPO-0.4
DCAF16-0.374
PDK1-0.366
SLC35E3-0.361
WDR31-0.357
MAP10-0.346
SCGB2B2-0.343
PCYOX1L-0.327
FAM122C-0.325
SLC16A6-0.325

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00407ArdeparinSmall Molecule9005-49-6Approved|Investigational|WithdrawnTarget
DB00569Fondaparinux sodiumSmall Molecule114870-03-0Approved|InvestigationalTarget
DB01109HeparinSmall Molecule9005-49-6Approved|InvestigationalTarget
DB01225EnoxaparinSmall Molecule9005-49-6ApprovedTarget
DB04464N-FormylmethionineSmall MoleculeExperimentalTarget
DB05361SR-123781ASmall Molecule-InvestigationalTarget
DB06271SulodexideBiotechDrug57821-29-1Approved|InvestigationalTarget
DB06779DalteparinSmall Molecule9005-49-6ApprovedTarget
DB06822TinzaparinSmall Molecule9041-08-1ApprovedTarget
DB08813NadroparinSmall Molecule9041-08-1Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB09258BemiparinSmall Molecule91449-79-5Approved|InvestigationalTarget
DB11598Antithrombin III humanBiotechDrug9000-94-6ApprovedTarget
ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of SERPINC1 mRNA"20566314
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SERPINC1 mRNA"17547211
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SERPINC1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SERPINC1 mRNA"21346803
C0415944-nonylphenol4-nonylphenol affects the expression of SERPINC1 mRNA15792627
D000082AcetaminophenAcetaminophen results in decreased expression of SERPINC1 mRNA26690555|2906747
D000082AcetaminophenAcetaminophen results in decreased expression of SERPINC1 protein16687475
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of SERPINC1 mRNA"20566314
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SERPINC1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SERPINC1 mRNA21632981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SERPINC1 mRNA19770486
D015119Aminocaproic AcidAminocaproic Acid results in increased expression of SERPINC1 protein11304663
D000965AntimonyAntimony results in decreased expression of SERPINC1 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of SERPINC1 mRNA17547211
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SERPINC1 mRNA24449571
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of SERPINC1 mRNA22120849
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SERPINC1 mRNA22316170
D004958EstradiolEstradiol results in increased expression of SERPINC1 mRNA23557687
D004958Estradiol[Estradiol co-treated with norethindrone acetate] results in decreased expression of SERPINC1 protein17393018
D001629BezafibrateBezafibrate results in increased expression of SERPINC111461176
C006780bisphenol Abisphenol A results in increased expression of SERPINC1 mRNA23557687
C006780bisphenol Abisphenol A results in increased expression of SERPINC1 mRNA26364221
C006780bisphenol Abisphenol A affects the expression of SERPINC1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SERPINC1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SERPINC1 gene28505145
D002066BusulfanBusulfan affects the expression of SERPINC1 protein15580502
D002104CadmiumCadmium results in decreased expression of SERPINC1 mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SERPINC1 mRNA17547211
C006871calcium heparincalcium heparin results in increased activity of SERPINC1 protein55783
D002741ChlorotrianiseneChlorotrianisene results in decreased expression of SERPINC1453287
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of [F2 protein binds to SERPINC1 protein]"16961586
D002857ChromiumChromium results in decreased expression of SERPINC1 mRNA17547211
C041167chromium nitratechromium nitrate results in decreased expression of SERPINC1 protein23618972
C012255clobazam[clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein]16376047
D002994ClofibrateClofibrate results in decreased expression of SERPINC1 protein73932
D002994ClofibrateClofibrate results in decreased expression of SERPINC1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of SERPINC1 mRNA17553155
D003276Contraceptives, Oral"Contraceptives, Oral results in decreased activity of SERPINC1 protein"6514354
D003276Contraceptives, Oral"SERPINC1 protein affects the susceptibility to Contraceptives, Oral"8967151
D003277Contraceptives, Oral, Combined"Contraceptives, Oral, Combined results in decreased expression of SERPINC1 protein"4688259
D003300CopperSERPINC1 protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of SERPINC1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SERPINC1 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of SERPINC1 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of SERPINC1 protein2859508
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of SERPINC1 mRNA"20566314
D017985DalteparinDalteparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]11869846
D003973DiatrizoateDiatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein]2020943
D004026DieldrinDieldrin results in decreased expression of SERPINC1 mRNA23041725
D004026DieldrinDieldrin results in increased expression of SERPINC1 mRNA23041725
C023635dienogest[Ethinyl Estradiol co-treated with dienogest] results in decreased activity of SERPINC1 protein15288212
D004041Dietary FatsDietary Fats results in decreased expression of SERPINC1 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SERPINC1 mRNA21527772
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SERPINC1 mRNA28943392
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of SERPINC1 mRNA27638505
C418365estradiol, norethindrone drug combination"estradiol, norethindrone drug combination results in decreased expression of SERPINC1 protein"14561536
C454300estradiol valerate-dienogest[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased activity of SERPINC1 protein15288212
D004967EstrogensEstrogens results in decreased activity of SERPINC1 protein55783
D004967EstrogensEstrogens results in decreased expression of SERPINC1 protein4688259
D004967EstrogensEstrogens results in decreased expression of SERPINC111461176
D004997Ethinyl Estradiol[Ethinyl Estradiol binds to Norethindrone] which results in decreased expression of SERPINC1 protein14561536
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with dienogest] results in decreased activity of SERPINC1 protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased activity of SERPINC1 protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of SERPINC1 protein11994571
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of SERPINC1 protein12618251
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased activity of SERPINC1 protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of SERPINC1 protein12618251|1498137
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of SERPINC1 protein12618251
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased activity of SERPINC1 protein17374706
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SERPINC1 protein18298783|6889048
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in decreased activity of SERPINC1 protein11994571|8908527
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in decreased expression of SERPINC1 protein10928463|1261825
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of SERPINC1 protein15318540|8237574
C072593ethinyl estradiol, levonorgestrel drug combination"ethinyl estradiol, levonorgestrel drug combination results in decreased expression of SERPINC1 protein"18238963
C039281furanfuran results in decreased expression of SERPINC1 mRNA26194646
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of SERPINC1 protein11994571
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of SERPINC1 protein12618251
D006493HeparinHeparin deficiency results in decreased expression of SERPINC1 protein7895349
D006493HeparinHeparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]11869846
D006493HeparinHeparin results in decreased expression of SERPINC1 protein73932|8122184
D006493HeparinHeparin results in increased expression of [F2 protein binds to SERPINC1 protein]16961586
D006493HeparinHeparin binds to SERPINC1 protein21138266
D006493Heparin[Heparin binds to SERPINC1 protein] which results in decreased activity of F10 protein21138266
D006493Heparin[Heparin binds to SERPINC1 protein] which results in decreased activity of F2 protein21138266
D006493HeparinHeparin results in increased activity of SERPINC1 protein3698718
D006493Heparin[Heparin results in increased activity of SERPINC1 protein] which results in decreased activity of F2 protein3698718
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of SERPINC1 mRNA"20566314
D006854HydrocortisoneHydrocortisone results in increased expression of SERPINC1 protein12682474
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SERPINC1 mRNA20044591
D007485Ioxaglic AcidIoxaglic Acid inhibits the reaction [F2 protein binds to SERPINC1 protein]2020943
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of SERPINC1 mRNA"20566314
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of SERPINC11828463
D008628MercuryMercury results in decreased expression of SERPINC1 mRNA17547211
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SERPINC1 mRNA16966085
D009532NickelSERPINC1 protein binds to Nickel23896426
D009532NickelNickel results in decreased expression of SERPINC1 mRNA24084258
C022838nickel chloridenickel chloride results in decreased expression of SERPINC1 mRNA17547211
D009640Norethindrone[Ethinyl Estradiol binds to Norethindrone] which results in decreased expression of SERPINC1 protein14561536
C024262norethindrone acetate[Estradiol co-treated with norethindrone acetate] results in decreased expression of SERPINC1 protein17393018
C017576norgestimate[Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of SERPINC1 protein12618251
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased activity of SERPINC1 protein15288212
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of SERPINC1 protein12618251|1498137
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SERPINC1 mRNA20936131
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SERPINC1 mRNA17097637
D010634PhenobarbitalPhenobarbital results in increased expression of SERPINC1 protein19952496
D010672Phenytoin[clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein]16376047
D028321Plant PreparationsPlant Preparations results in decreased expression of SERPINC1 protein28284660
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SERPINC1 protein23618972
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SERPINC1 mRNA17547211
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SERPINC1 mRNA23608068
D011241PrednisonePrednisone results in increased expression of SERPINC1 protein11304663
C045362prochlorazprochloraz results in increased expression of SERPINC1 mRNA21470553
D011372ProgestinsProgestins results in decreased expression of SERPINC1 protein4688259
D011794QuercetinQuercetin results in decreased expression of SERPINC1 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of SERPINC1 protein25505154
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SERPINC1 mRNA23806026
C009277sodium arsenatesodium arsenate results in decreased expression of SERPINC1 mRNA16882884
C009277sodium arsenatesodium arsenate results in decreased expression of SERPINC1 mRNA21795629
C017947sodium arsenitesodium arsenite affects the expression of SERPINC1 mRNA17450228
C016104sodium bichromatesodium bichromate results in decreased expression of SERPINC1 mRNA24612858
D012460SulfasalazineSulfasalazine results in increased expression of SERPINC1 mRNA22016648
D013629TamoxifenTamoxifen results in decreased expression of SERPINC1 protein14692654
C004648testosterone enanthatetestosterone enanthate results in increased expression of SERPINC1 protein8585008
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of SERPINC1 mRNA28943392
C009495titanium dioxidetitanium dioxide affects the expression of SERPINC1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SERPINC1 protein19478969
D017312ToremifeneToremifene results in decreased expression of SERPINC1 protein14692654
D014118Toxins, Biological"Toxins, Biological affects the expression of SERPINC1 mRNA"19682533
C012589trichostatin Atrichostatin A results in decreased expression of SERPINC1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SERPINC1 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of SERPINC1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased expression of SERPINC1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SERPINC1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SERPINC1 mRNA26682919
D014859WarfarinWarfarin results in increased expression of SERPINC1 protein73932

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI15853774  
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-NAS12878203  
GO:0005515protein binding-IPI12878203  22582013  
GO:0008201heparin binding-IEA-  
GO:0042802identical protein binding-IPI18923394  
GO ID GO Term Qualifier Evidence PubMed
GO:0002438acute inflammatory response to antigenic stimulus-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0007595lactation-IEA-  
GO:0007596blood coagulation-TAS-  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:2000266regulation of blood coagulation, intrinsic pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA1695900  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0070062extracellular exosome-HDA23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140837Intrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28485404Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. (2017 Sep)Jorgenson EMol Psychiatry
26036284Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans. (2015 Jul)Xu KAlcohol Clin Exp Res
27161691PO-04 - A new genetic risk score for predicting venous thromboembolic events in cancer patients receiving chemotherapy. (2016 Apr)Martin AJThromb Res