Gene info: ID 4627

Gene: MYH9

GENE ID: 4627

Description: myosin heavy chain 9

Gene type: protein-coding

Location: 22q12.3

dbXrefs: Ensembl:ENSG00000100345 MIM:160775 Vega:OTTHUMG00000030429 UniprotKB:P35579

RefSeq: NG_011884.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.015e-1 (AD) 1.669e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg04077141	chr22:36782143	MYH9		5.300e-14	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM109	0.838
COLGALT1	0.835
VCL	0.826
MGAT1	0.823
PACSIN2	0.819
NFKB1	0.812
HNRNPH1	0.81
CDC42SE1	0.809
ARF6	0.807
PTPN1	0.806

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.601
OR4F5	-0.592
DIAPH3	-0.218
REN	-0.215
HES5	-0.196
HPDL	-0.178
SOX3	-0.175
FTH1P18	-0.162
KLRC2	-0.16
GSDMC	-0.149

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB11638	Artenimol	Small Molecule	71939-50-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of MYH9 mRNA"	21346803
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of MYH9 mRNA"	18648102
C011421	5-chloro-2-methyl-4-isothiazolin-3-one	5-chloro-2-methyl-4-isothiazolin-3-one results in increased metabolism of MYH9 protein	29267982
D000082	Acetaminophen	Acetaminophen results in increased expression of MYH9 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of MYH9 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of MYH9 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MYH9 mRNA	19770486
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of MYH9 protein	25258189
D001280	Atrazine	Atrazine results in decreased expression of MYH9 mRNA	25929836
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of MYH9 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MYH9 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MYH9 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MYH9 mRNA	19770486\|2590861
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MYH9 mRNA	22228805\|2261060
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MYH9 mRNA"	19150397
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MYH9 mRNA	20823114
D004958	Estradiol	Estradiol results in increased expression of MYH9 mRNA	20106945\|2301914
C044887	beta-methylcholine	beta-methylcholine affects the expression of MYH9 mRNA	21179406
C551172	bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)	"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of MYH9 mRNA"	20162321
C006780	bisphenol A	bisphenol A results in decreased expression of MYH9 mRNA	25181051
C006780	bisphenol A	[Fructose co-treated with bisphenol A] results in increased expression of MYH9 protein	26930160
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of MYH9 protein	19552622
C472645	blebbistatin	blebbistatin results in decreased activity of MYH9 protein	21216307
C472645	blebbistatin	[blebbistatin results in decreased activity of MYH9 protein] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]	21216307
C013418	bromfenacoum	bromfenacoum results in increased expression of MYH9 protein	28903499
D002065	Buspirone	Buspirone results in decreased expression of MYH9 mRNA	24136188
C018475	butyraldehyde	butyraldehyde results in increased expression of MYH9 mRNA	26079696
D002104	Cadmium	Cadmium results in increased oxidation of MYH9 protein	24077948
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MYH9 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MYH9 mRNA	27339419
C100187	chloropicrin	chloropicrin results in decreased expression of MYH9 mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MYH9 gene	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of MYH9 protein	28596144
D002922	Ciguatoxins	Ciguatoxins affects the expression of MYH9 mRNA	18353800
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of MYH9 mRNA	20008804
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of MYH9 mRNA	19320972
D003042	Cocaine	Cocaine affects the expression of MYH9 mRNA	20187946
C030973	cupric oxide	cupric oxide results in decreased expression of MYH9 mRNA	22077320
D016572	Cyclosporine	Cyclosporine results in increased expression of MYH9 mRNA	20106945\|2556210
C007262	deoxynivalenol	deoxynivalenol affects the phosphorylation of MYH9 protein	23811945
C007262	deoxynivalenol	deoxynivalenol results in increased phosphorylation of MYH9 protein	23352502
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of MYH9 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of MYH9 mRNA	21266533
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MYH9 mRNA	20823114
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of MYH9 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of MYH9 mRNA	27392435
C000944	dicrotophos	dicrotophos results in increased expression of MYH9 mRNA	28302478
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of MYH9 protein"	22248470
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MYH9 protein"	22248470
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased metabolism of MYH9 protein	29267982
D004317	Doxorubicin	Doxorubicin affects the expression of MYH9 protein	29385562
C118739	entinostat	entinostat results in increased expression of MYH9 mRNA	27188386
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MYH9 protein	23301498
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased methylation of MYH9 promoter	27415467
C540355	fenamidone	fenamidone results in increased expression of MYH9 mRNA	27029645
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MYH9 gene	20938992
D005632	Fructose	[Fructose co-treated with bisphenol A] results in increased expression of MYH9 protein	26930160
D005632	Fructose	Fructose results in decreased expression of MYH9 protein	26930160
C056933	fumonisin B1	fumonisin B1 results in increased expression of MYH9 mRNA	16221962
D019833	Genistein	ESR1 promotes the reaction [Genistein results in increased expression of MYH9 protein]	20884965
D019833	Genistein	Genistein results in increased expression of MYH9 protein	20884965
D005897	Glafenine	Glafenine results in increased expression of MYH9 mRNA	24136188
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of MYH9 mRNA	19376150
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYH9 mRNA	25613284
D007529	Isoflavones	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of MYH9 protein"	22248470
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of MYH9 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of MYH9 mRNA	23430699
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MYH9 mRNA	20823114
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MYH9 gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MYH9 mRNA	28001369
C028577	monobutyl phthalate	monobutyl phthalate affects the expression of MYH9 mRNA	20864626
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MYH9 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MYH9 mRNA"	25620056
C051752	nefazodone	nefazodone results in decreased expression of MYH9 mRNA	24136188
C012655	nimesulide	nimesulide results in decreased expression of MYH9 mRNA	24136188
C025256	nonylphenol	nonylphenol results in decreased expression of MYH9 mRNA	22982499
C018620	oleoresins	oleoresins results in decreased expression of MYH9 mRNA	20008804
C006253	pirinixic acid	pirinixic acid results in decreased expression of MYH9 mRNA	16221962\|1742611
C045950	propiconazole	propiconazole results in increased expression of MYH9 mRNA	21278054
C005556	propionaldehyde	propionaldehyde results in increased expression of MYH9 mRNA	26079696
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of MYH9 mRNA	27029645
D011794	Quercetin	Quercetin results in increased expression of MYH9 protein	14750173
C089730	rosiglitazone	rosiglitazone affects the expression of MYH9 protein	19556978
D012643	Selenium	Selenium results in increased expression of MYH9 mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide analog affects the secretion of MYH9 protein	25895662
D012999	Soman	Soman results in increased expression of MYH9 mRNA	19281266
D013501	Surface-Active Agents	Surface-Active Agents results in increased expression of MYH9 mRNA	22467014
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in decreased expression of MYH9 mRNA"	26680231
D013749	Tetrachlorodibenzodioxin	[blebbistatin results in decreased activity of MYH9 protein] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]	21216307
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MYH9 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MYH9 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MYH9 mRNA	16054898
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MYH9 protein	16548065
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYH9 mRNA	25613284
D013876	Thiophenes	Thiophenes analog promotes the reaction [Tretinoin results in increased expression of MYH9 mRNA]	16140955
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MYH9 mRNA	28111298
D014212	Tretinoin	Thiophenes analog promotes the reaction [Tretinoin results in increased expression of MYH9 mRNA]	16140955
D014212	Tretinoin	Tretinoin results in increased expression of MYH9 mRNA	16140955
C012589	trichostatin A	trichostatin A results in increased expression of MYH9 mRNA	26238599
C057693	troglitazone	troglitazone results in decreased expression of MYH9 mRNA	28973697
D014520	Urethane	Urethane results in increased expression of MYH9 mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of MYH9 mRNA	15885361
D014635	Valproic Acid	Valproic Acid affects the expression of MYH9 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of MYH9 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of MYH9 mRNA	23179753\|2623859
D014640	Vancomycin	Vancomycin results in decreased expression of MYH9 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of MYH9 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of MYH9 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of MYH9 mRNA	18042343
C029297	vinylidene chloride	vinylidene chloride results in increased expression of MYH9 mRNA	26682919
C111237	vorinostat	vorinostat results in increased expression of MYH9 mRNA	26238599
D015032	Zinc	Zinc deficiency results in increased expression of MYH9 mRNA	22171008

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000146	microfilament motor activity	-	IDA	12237319 15845534
GO:0003723	RNA binding	-	HDA	22681889
GO:0003774	motor activity	-	NAS	12421915
GO:0003777	microtubule motor activity	-	IEA	-
GO:0003779	actin binding	-	IDA	15065866
GO:0005515	protein binding	-	IPI	10822899 12202484 12421915 12577067 14508515 14640694 15479433 16186248 16403913 17925381 18504258 20421509 20603131 20936779 22229724 22483112 23100250 24189400 28228547
GO:0005516	calmodulin binding	-	IEA	-
GO:0005524	ATP binding	-	IDA	15065866 15845534
GO:0008017	microtubule binding	-	IEA	-
GO:0016887	ATPase activity	-	IDA	12237319 24072716
GO:0019904	protein domain specific binding	-	IPI	23325791
GO:0030898	actin-dependent ATPase activity	-	IDA	15065866 15845534
GO:0030898	actin-dependent ATPase activity	contributes_to	IDA	24072716
GO:0042803	protein homodimerization activity	-	IDA	12237319
GO:0043495	protein membrane anchor	-	IMP	16403913
GO:0043531	ADP binding	-	IDA	15065866
GO:0045296	cadherin binding	-	HDA	25468996
GO:0051015	actin filament binding	-	IDA	12237319 14508515 15845534
GO:0051015	actin filament binding	contributes_to	IDA	24072716
GO:0051015	actin filament binding	-	NAS	16403913

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000212	meiotic spindle organization	-	IEA	-
GO:0001525	angiogenesis	-	IDA	16403913
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001768	establishment of T cell polarity	-	IEA	-
GO:0006509	membrane protein ectodomain proteolysis	-	IDA	16186248
GO:0006911	phagocytosis, engulfment	-	ISS	-
GO:0007018	microtubule-based movement	-	IEA	-
GO:0007229	integrin-mediated signaling pathway	-	NAS	10822899
GO:0007520	myoblast fusion	-	IEA	-
GO:0008360	regulation of cell shape	-	IMP	11029059
GO:0015031	protein transport	-	IMP	16403913
GO:0030048	actin filament-based movement	-	IDA	12237319 15845534
GO:0030220	platelet formation	-	IMP	12237319
GO:0030224	monocyte differentiation	-	IEP	1912569
GO:0031032	actomyosin structure organization	-	IDA	24072716
GO:0031532	actin cytoskeleton reorganization	-	IMP	15869600
GO:0032506	cytokinetic process	-	IMP	15774463
GO:0032796	uropod organization	-	IEA	-
GO:0043534	blood vessel endothelial cell migration	-	IMP	16403913
GO:0050900	leukocyte migration	-	NAS	12421915
GO:0051295	establishment of meiotic spindle localization	-	IEA	-
GO:0070527	platelet aggregation	-	HMP	23382103
GO:1903919	negative regulation of actin filament severing	-	IMP	23325791
GO:1903919	negative regulation of actin filament severing	-	ISS	-
GO:1903923	positive regulation of protein processing in phagocytic vesicle	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001725	stress fiber	-	IDA	7699007 14508515 14706930 15774463 16403913
GO:0001726	ruffle	-	IDA	16403913
GO:0001772	immunological synapse	colocalizes_with	IDA	15064761
GO:0001931	uropod	-	IDA	15064761
GO:0005634	nucleus	-	IDA	14508515
GO:0005737	cytoplasm	-	IDA	7699007
GO:0005819	spindle	-	IEA	-
GO:0005826	actomyosin contractile ring	-	IDA	11029059
GO:0005829	cytosol	-	IDA	14508515
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	16186248 16403913
GO:0005886	plasma membrane	colocalizes_with	IDA	15064761
GO:0005903	brush border	-	IEA	-
GO:0005913	cell-cell adherens junction	-	IEA	-
GO:0005925	focal adhesion	colocalizes_with	ISS	-
GO:0008180	COP9 signalosome	colocalizes_with	IDA	18850735
GO:0008305	integrin complex	colocalizes_with	IDA	10822899
GO:0015629	actin cytoskeleton	-	IDA	15869600
GO:0016020	membrane	-	HDA	19946888
GO:0016460	myosin II complex	-	IDA	24072716
GO:0031252	cell leading edge	-	IDA	12421915
GO:0031594	neuromuscular junction	-	IEA	-
GO:0032154	cleavage furrow	-	IDA	7699007 14508515
GO:0032991	protein-containing complex	-	IDA	12421915
GO:0042641	actomyosin	-	IDA	24072716
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 20458337 21362503 23533145
GO:0097513	myosin II filament	-	IDA	24072716

KEGG ID	KEGG Term
hsa04530	Tight junction
hsa04810	Regulation of actin cytoskeleton
hsa05416	Viral myocarditis

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-194315	Signaling by Rho GTPases	IEA
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	IEA
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-199991	Membrane Trafficking	IEA
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	TAS
R-HSA-2682334	EPH-Ephrin signaling	IEA
R-HSA-373755	Semaphorin interactions	IEA
R-HSA-3928663	EPHA-mediated growth cone collapse	IEA
R-HSA-400685	Sema4D in semaphorin signaling	IEA
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	IEA
R-HSA-422475	Axon guidance	IEA
R-HSA-5625740	RHO GTPases activate PKNs	IEA
R-HSA-5625900	RHO GTPases activate CIT	IEA
R-HSA-5627117	RHO GTPases Activate ROCKs	IEA
R-HSA-5627123	RHO GTPases activate PAKs	IEA
R-HSA-5627123	RHO GTPases activate PAKs	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19891592	Association among polymorphisms at MYH9, environmental factors, and nonsyndromic orofacial clefts in western China. (2010 Jan)	Jia ZL	DNA Cell Biol
20051853	Essential hypertension and risk of nephropathy: a reappraisal. (2010 May)	Murea M	Curr Opin Nephrol Hypertens
23974104	High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors. (2013 Sep 15)	Robinson TJ	Cell Cycle