Gene info: ID 463

Gene: ZFHX3

GENE ID: 463

Synonyms: ATBF1|ATBT|ZNF927

Description: zinc finger homeobox 3

Gene type: protein-coding

Location: 16q22.2-q22.3

dbXrefs: Ensembl:ENSG00000140836 MIM:104155 Vega:OTTHUMG00000137599 UniprotKB:Q15911

RefSeq: NG_013211.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.483e-1 (AD) 3.624e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg05764102	chr16:72991344	ZFHX3	Promoter	1.837e-6	Alcohol use disorders	26763658
cg05969150	chr16:72882495	ZFHX3		3.100e-12	Smoking	27651444
cg27262054	chr16:73067525	ZFHX3		6.400e-10	Smoking	27651444
cg05915866	chr16:73090838	ZFHX3		2.000e-8	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNF217	0.842
ANO6	0.829
TEP1	0.825
CFLAR	0.824
BNIP2	0.808
LPP	0.807
RREB1	0.806
ATP10D	0.804
CREB3L2	0.803
NEDD4	0.799

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABCC12	-0.514
NEUROD6	-0.493
GSG1	-0.488
ADRA1D	-0.487
RTN4R	-0.47
BHLHA9	-0.469
FBLN7	-0.468
PPEF1	-0.468
CRH	-0.466
DLK2	-0.464

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ZFHX3 mRNA"	19114083
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of ZFHX3 mRNA"	20406850
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ZFHX3 mRNA"	28973690
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of ZFHX3 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZFHX3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFHX3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFHX3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFHX3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZFHX3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFHX3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFHX3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFHX3 mRNA"	27188386
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of ZFHX3 mRNA"	28073004
D000082	Acetaminophen	Acetaminophen results in decreased expression of ZFHX3 mRNA	25704631
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of ZFHX3 gene	27153756
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of ZFHX3 mRNA	17023530
C015001	arsenite	arsenite results in increased methylation of ZFHX3 promoter	23974009
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ZFHX3 mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ZFHX3 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ZFHX3 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZFHX3 mRNA"	19150397
C044887	beta-methylcholine	beta-methylcholine affects the expression of ZFHX3 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the methylation of ZFHX3 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased methylation of ZFHX3 promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of ZFHX3 mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of ZFHX3 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of ZFHX3 mRNA	26079696
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ZFHX3 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of ZFHX3 mRNA	26577399
D003474	Curcumin	Curcumin results in decreased expression of ZFHX3 mRNA	17198877
D013759	Dronabinol	Dronabinol results in decreased expression of ZFHX3 mRNA	16616335
D002945	Cisplatin	Cisplatin results in decreased expression of ZFHX3 mRNA	27392435
C000944	dicrotophos	dicrotophos results in increased expression of ZFHX3 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of ZFHX3 mRNA	18042831
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of ZFHX3 mRNA	25242112
D004237	Diuron	Diuron results in decreased expression of ZFHX3 mRNA	21551480
C118739	entinostat	entinostat results in decreased expression of ZFHX3 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZFHX3 mRNA"	27188386
D004397	Fonofos	Fonofos results in increased methylation of ZFHX3 promoter	22847954
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ZFHX3 mRNA	21179406
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZFHX3 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ZFHX3 mRNA	25307878\|2625444
C017461	lead nitrate	lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]	11891201
C017461	lead nitrate	lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA]	11891201
C045463	leflunomide	leflunomide results in increased expression of ZFHX3 mRNA	28988120
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of ZFHX3 mRNA	10975854
D008777	Methyltestosterone	Methyltestosterone results in increased expression of ZFHX3 mRNA	29191790
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ZFHX3 mRNA"	25554681
C028007	nickel monoxide	nickel monoxide results in increased expression of ZFHX3 mRNA	19167457
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of ZFHX3 mRNA	25729387
D000073878	Palm Oil	Palm Oil results in decreased expression of ZFHX3 mRNA	18042831
D010278	Parathion	Parathion results in increased methylation of ZFHX3 promoter	22847954
D010634	Phenobarbital	Phenobarbital affects the expression of ZFHX3 mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFHX3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of ZFHX3 mRNA	26272509
D011205	Povidone	[Silver analog co-treated with Povidone] results in increased expression of ZFHX3 mRNA	25194297
C045950	propiconazole	propiconazole results in decreased expression of ZFHX3 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of ZFHX3 mRNA	24780913
D011794	Quercetin	Quercetin results in increased expression of ZFHX3 protein	19207037
D012834	Silver	[Silver analog co-treated with Povidone] results in increased expression of ZFHX3 mRNA	25194297
D010042	Ouabain	Ouabain results in decreased expression of ZFHX3 mRNA	16412265
C012568	terbufos	terbufos results in increased methylation of ZFHX3 promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ZFHX3 mRNA	21570461\|2405805
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ZFHX3 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ZFHX3 mRNA	19465110\|1977048
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZFHX3 mRNA	25613284
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of ZFHX3 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of ZFHX3 mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of ZFHX3 mRNA	16604517
D014212	Tretinoin	Tretinoin results in increased expression of ZFHX3 mRNA	20488242
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFHX3 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of ZFHX3 mRNA	24935251\|2627250
C057693	troglitazone	troglitazone results in increased expression of ZFHX3 mRNA	19140230
C057693	troglitazone	troglitazone results in decreased expression of ZFHX3 mRNA	28973697
D014415	Tunicamycin	Tunicamycin results in decreased expression of ZFHX3 mRNA	22378314
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZFHX3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ZFHX3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ZFHX3 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ZFHX3 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of ZFHX3 mRNA	23179753\|2438349
D014638	Vanadates	Vanadates results in increased expression of ZFHX3 mRNA	22714537
C025643	vinclozolin	vinclozolin results in decreased expression of ZFHX3 mRNA	23034163
D024483	Vitamin K 3	Vitamin K 3 affects the expression of ZFHX3 mRNA	20044591
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of ZFHX3 mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	7507206
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IC	-
GO:0003700	DNA-binding transcription factor activity	-	NAS	1719379
GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	-	TAS	1719379
GO:0005515	protein binding	-	IPI	20599712 22452784
GO:0008270	zinc ion binding	-	IEA	-
GO:0019899	enzyme binding	-	IPI	14715251
GO:0044212	transcription regulatory region DNA binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	11314020
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IGI	10318867
GO:0006355	regulation of transcription, DNA-templated	-	TAS	1719379
GO:0006366	transcription by RNA polymerase II	-	TAS	1719379
GO:0007420	brain development	-	IBA	21873635
GO:0007517	muscle organ development	-	IEA	-
GO:0032922	circadian regulation of gene expression	-	ISS	-
GO:0045664	regulation of neuron differentiation	-	IBA	21873635
GO:0045893	positive regulation of transcription, DNA-templated	-	IBA	21873635
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	20599712
GO:0071559	response to transforming growth factor beta	-	IDA	20599712
GO:1904059	regulation of locomotor rhythm	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	20599712 24651376
GO:0005634	nucleus	-	TAS	1719379
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IDA	10318867
GO:0005737	cytoplasm	-	IDA	20599712
GO:0016604	nuclear body	-	IDA	24651376

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8941855	RUNX3 regulates CDKN1A transcription	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22776031	Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke. (2012 Jul 9)	Hacke W	BMC Med
23132824	Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study. (2013 Mar)	Smith JG	Eur J Heart Fail