Gene: MYL2

4633
CMH10|MLC-2s/v|MLC2
myosin light chain 2
protein-coding
12q24.11
Ensembl:ENSG00000111245 MIM:160781 Vega:OTTHUMG00000169535 UniprotKB:P10916
NG_007554.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.789e-1 (AD)  5.299e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNNC10.899
MB0.873
CKM0.851
ACTA10.824
MYH70.804
LMOD20.783
TNNI10.78
DES0.736
MYL10.728
CSRP30.718

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
APOA4-0.292
DEFA6-0.29
FTCD-0.26
KCNK7-0.259
C19orf81-0.253
ZAR1-0.249
ZNF575-0.249
TMEM53-0.243
SAC3D1-0.243
LENG1-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1079462,7-dihydroxynaphthalene"2,7-dihydroxynaphthalene results in decreased expression of MYL2 mRNA"28940058
D000082AcetaminophenAcetaminophen results in increased expression of MYL2 mRNA26690555
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MYL2 mRNA21298039
D004999AmifostineAmifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL2 protein]19010997
D004999AmifostineAmifostine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MYL2 protein]19010997
D004999AmifostineAmifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein]19010997
D001205Ascorbic AcidAscorbic Acid results in increased expression of MYL2 mRNA21570463
D001374AzacitidineAzacitidine results in increased expression of MYL2 mRNA17105402
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MYL2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYL2 mRNA22228805
D004958EstradiolEstradiol affects the expression of MYL2 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of MYL2 mRNA18180321|2518105
C006780bisphenol Abisphenol A results in increased expression of MYL2 mRNA18180321
C006780bisphenol Abisphenol A results in increased methylation of MYL2 gene28505145
C086539BQ 788BQ 788 inhibits the reaction [AGT protein results in increased expression of MYL2 mRNA]15007106
C086539BQ 788BQ 788 inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]15007106
D002104CadmiumCadmium results in decreased expression of MYL2 mRNA17327700
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MYL2 mRNA17327700
D002994ClofibrateClofibrate results in decreased expression of MYL2 mRNA22300585
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [AGT protein results in increased expression of MYL2 protein]15007106
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]15007106
D003907Dexamethasone[Dexamethasone co-treated with Doxorubicin] results in increased expression of MYL2 mRNA19596060
D003907DexamethasoneDexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]19596060
D003907DexamethasoneDexamethasone results in decreased expression of MYL2 mRNA22733784
D003907DexamethasoneDexamethasone results in increased expression of MYL2 mRNA19596060
D003907DexamethasoneMifepristone inhibits the reaction [[Dexamethasone co-treated with Doxorubicin] results in increased expression of MYL2 mRNA]19596060
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]]19596060
D004041Dietary FatsDietary Fats results in increased expression of MYL2 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of MYL2 mRNA20920545
D004147DioxinsDioxins affects the expression of MYL2 mRNA20463971
D004317DoxorubicinDoxorubicin affects the expression of MYL2 protein29385562
D004317DoxorubicinDoxorubicin results in decreased expression of MYL2 mRNA28940058
D004317Doxorubicin[Dexamethasone co-treated with Doxorubicin] results in increased expression of MYL2 mRNA19596060
D004317DoxorubicinDexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]19596060
D004317DoxorubicinDoxorubicin results in increased expression of MYL2 protein21251210
D004317DoxorubicinMifepristone inhibits the reaction [[Dexamethasone co-treated with Doxorubicin] results in increased expression of MYL2 mRNA]19596060
D004317DoxorubicinMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]]19596060
D004317Doxorubicin[sodium nitrate co-treated with Doxorubicin] results in decreased expression of MYL2 protein21251210
D004317Doxorubicinsodium nitrate inhibits the reaction [Doxorubicin results in increased expression of MYL2 protein]21251210
D004317Doxorubicin[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA19596060
D004837EpinephrineEpinephrine affects the expression of MYL2 protein19464573
D004837Epinephrine[Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein19464573
D000431EthanolEthanol results in decreased expression of MYL2 mRNA17920746
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYL2 mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of MYL2 mRNA18035473
D006861Hydrogen PeroxideAmifostine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MYL2 protein]19010997
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of MYL2 protein19010997
C056599icariinicariin results in increased expression of MYL2 mRNA15780198|1649016
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MYL2 mRNA25613284
D008070LipopolysaccharidesAmifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL2 protein]19010997
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of MYL2 protein19010997
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of MYL2 mRNA12634122
D052998MicrocystinsMicrocystins results in increased expression of MYL2 protein22430071
D015735MifepristoneMifepristone inhibits the reaction [[Dexamethasone co-treated with Doxorubicin] results in increased expression of MYL2 mRNA]19596060
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]]19596060
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MYL2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MYL2 mRNA"25554681|2562005
C017557nickel subsulfidenickel subsulfide results in increased expression of MYL2 mRNA24952340
C029938nickel sulfatenickel sulfate results in increased expression of MYL2 mRNA16166746
D010126OzoneOzone results in decreased expression of MYL2 mRNA12763052
D000073878Palm OilPalm Oil results in increased expression of MYL2 mRNA18042831
D010656PhenylephrineADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]11470465
D010656PhenylephrineBQ 788 inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]15007106
D010656Phenylephrinecyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]15007106
D010656PhenylephrineMAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]11513749
D010656PhenylephrineMYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]14676212
D010656PhenylephrinePhenylephrine results in increased expression of MYL2 mRNA11470465
D010656PhenylephrinePhenylephrine results in increased phosphorylation of MYL2 protein18202317
D010656PhenylephrineUridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]14676212
C006253pirinixic acidpirinixic acid results in increased expression of MYL2 mRNA17951219
C012526quercitrinquercitrin affects the expression of MYL2 mRNA25193878
C059514resveratrolresveratrol results in decreased expression of MYL2 mRNA22610192
C059514resveratrolresveratrol results in decreased expression of MYL2 mRNA17588540
D012906SmokeSmoke results in increased expression of MYL2 mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of MYL2 mRNA22058191
C017947sodium arsenitesodium arsenite affects the methylation of MYL2 gene28589171
C031618sodium nitrate[sodium nitrate co-treated with Doxorubicin] results in decreased expression of MYL2 protein21251210
C031618sodium nitratesodium nitrate inhibits the reaction [Doxorubicin results in increased expression of MYL2 protein]21251210
D053260SootSoot results in increased expression of MYL2 mRNA26551751
D014284TriiodothyronineTriiodothyronine results in increased expression of MYL2 mRNA22281776
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MYL2 mRNA15716485
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYL2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MYL2 mRNA26139165
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MYL2 mRNA25613284
D014260TriclosanTriclosan results in decreased expression of MYL2 mRNA28940058
D014544Uridine TriphosphateUridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]14676212
D014544Uridine TriphosphateUridine Triphosphate inhibits the reaction [MYOCD protein results in increased expression of MYL2 protein]14676212
D014700VerapamilDexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]19596060
D014700VerapamilMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]]19596060
D014700Verapamil[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA19596060
D014700VerapamilVerapamil results in decreased expression of MYL2 mRNA19596060
D019820Xanthine[Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein19464573
D019820Xanthine[Xanthine co-treated with XDH protein] affects the expression of MYL2 protein19464573
C104536xanthohumolxanthohumol results in decreased phosphorylation of and results in decreased activity of MYL2 protein23503627
C016837zinc chloridezinc chloride results in decreased expression of MYL2 mRNA19683351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003785actin monomer binding-IDA9180271  
GO:0005509calcium ion binding-IDA11102452  
GO:0005515protein binding-IPI11773029  16555005  
GO:0008307structural constituent of muscle-NAS17885681  
GO:0032036myosin heavy chain binding-NAS8287067  
GO ID GO Term Qualifier Evidence PubMed
GO:0002026regulation of the force of heart contraction-ISS-  
GO:0006942regulation of striated muscle contraction-TAS8673105  
GO:0007507heart development-ISS-  
GO:0009791post-embryonic development-IEA-  
GO:0030049muscle filament sliding-TAS-  
GO:0030308negative regulation of cell growth-IMP15824735  
GO:0042694muscle cell fate specification-IEA-  
GO:0048747muscle fiber development-IEA-  
GO:0055003cardiac myofibril assembly-ISS-  
GO:0055010ventricular cardiac muscle tissue morphogenesis-IMP8673105  
GO:0060047heart contraction-ISS-  
GO:0060048cardiac muscle contraction-IEA-  
GO:0098735positive regulation of the force of heart contraction-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IDA17043135  
GO:0015629actin cytoskeletoncolocalizes_withIDA17043135  
GO:0016459myosin complex-TAS11102452  
GO:0030016myofibril-NAS8287067  
GO:0030017sarcomere-TAS16754800  
GO:0031672A band-IEA-  
GO:0097512cardiac myofibril-IDA25771144  
KEGG ID KEGG Term
hsa04260Cardiac muscle contraction
hsa04510Focal adhesion
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-390522Striated Muscle ContractionTAS
R-HSA-397014Muscle contractionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24142389Male-specific genetic effect on hypertension and metabolic disorders. (2014 Mar)Heo SGHum Genet
21270382Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (2011 Apr)Baik IAm J Clin Nutr