Gene: MYLK

4638
AAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MSTP083|MYLK1|smMLCK
myosin light chain kinase
protein-coding
3q21.1
Ensembl:ENSG00000065534 MIM:600922 Vega:OTTHUMG00000141304 UniprotKB:Q15746
NG_029111.1
PubMed|SNP Mapped
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.838e-1 (AD)  3.436e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10511417chr3:123816489 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07638500chr3:123371420MYLK5.740e-8Maternal smoking in pregnancy27040690
cg07638500chr3:123371420MYLK2.380e-9Maternal smoking in pregnancy27040690
cg07638500chr3:123371420MYLK4.230e-10Maternal smoking in pregnancy27040690
cg19534753chr3:123340306MYLK3.620e-8Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EFCAB140.813
GM2A0.807
MYO60.79
SNX180.783
SYPL10.78
KAT2B0.771
C1orf1980.767
QKI0.767
CPQ0.766
HEATR5A0.765

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.415
OR4F5-0.409
CACNA1F-0.4
ABCC12-0.381
KCNB2-0.376
RTP1-0.375
KCNK9-0.367
CALHM1-0.366
CLEC4G-0.364
GRM2-0.36

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MYLK mRNA"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MYLK mRNA]"22698814
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of MYLK mRNA"19095052
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MYLK protein10733514
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of MYLK protein18710790
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of MYLK mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of MYLK mRNA]28655636
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of MYLK mRNA24140754
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of MYLK mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MYLK mRNA21420995|2223033
C109238acylineacyline results in decreased expression of MYLK mRNA17510436
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MYLK protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MYLK mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MYLK gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MYLK mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of MYLK mRNA26238599
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of MYLK mRNA"25351596
C547126AZM551248AZM551248 results in decreased expression of MYLK mRNA22323515
C487081belinostatbelinostat results in decreased expression of MYLK mRNA26272509
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of MYLK mRNA21635667
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYLK mRNA20106945|2163298
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of MYLK mRNA25566086
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MYLK mRNA20823114
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of MYLK mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of MYLK mRNA17404688
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of MYLK mRNA19687787
D004958EstradiolEstradiol results in decreased expression of MYLK mRNA19687787
D004958EstradiolEstradiol inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK mRNA]16977382
C006780bisphenol Abisphenol A affects the expression of MYLK mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of MYLK mRNA23410634
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MYLK mRNA12419474
C018475butyraldehydebutyraldehyde results in decreased expression of MYLK mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MYLK mRNA23741332
D002118CalciumCalcium deficiency results in increased activity of MYLK protein11054866
D002118CalciumCalcium results in increased activity of MYLK protein10640419
D002118CalciumML 7 inhibits the reaction [Calcium deficiency results in increased activity of MYLK protein]11054866
D002118Calcium[[Calcium results in increased activity of MYLK protein] which results in increased phosphorylation of MYL9 protein] which results in decreased secretion of REN protein9618396
D002118Calcium[ML 7 results in decreased activity of MYLK protein] which results in decreased uptake of Calcium9506478
D002118Calcium[ML 9 results in decreased activity of MYLK protein] which results in decreased uptake of Calcium9506478
D002118CalciumMYLK protein affects the uptake of Calcium9506478
D002217CarbacholCarbachol results in increased phosphorylation of MYLK protein15939040
D002217CarbacholML 7 inhibits the reaction [Carbachol results in increased phosphorylation of MYLK protein]15939040
D002217CarbacholMYLK protein affects the susceptibility to Carbachol17272850
D002220CarbamazepineCarbamazepine affects the expression of MYLK mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of MYLK mRNA26272509
D002772Cholera ToxinCholera Toxin results in decreased activity of MYLK protein9572834
D002784CholesterolCholesterol results in increased activity of MYLK protein21052790
D002784CholesterolCholesterol results in increased expression of MYLK protein21052790
D002784CholesterolML 7 inhibits the reaction [Cholesterol results in increased activity of MYLK protein]21052790
C031180chrysenechrysene results in increased expression of MYLK mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased expression of MYLK mRNA24386269
C018021cobaltous chloridecobaltous chloride results in decreased expression of MYLK protein24386269
D003300Copper[Disulfiram binds to Copper] which results in increased expression of MYLK mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MYLK mRNA20971185
D003471CuprizoneCuprizone affects the expression of MYLK mRNA26577399
D003474CurcuminCurcumin results in increased expression of MYLK mRNA21594647
D003513CycloheximideCycloheximide inhibits the reaction [TNF protein results in increased expression of MYLK protein]15701621
D016572CyclosporineCyclosporine affects the expression of MYLK mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of MYLK mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of MYLK mRNA19770486
D003609DactinomycinDactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK mRNA]15701621
D003609DactinomycinDactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK protein]15701621
D000069439DasatinibDasatinib results in increased expression of MYLK mRNA20579391
C014347decitabinedecitabine affects the expression of MYLK mRNA17145863
D003907DexamethasoneDexamethasone results in increased expression of MYLK mRNA25047013
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MYLK mRNA20823114
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MYLK mRNA27392435
D002945CisplatinCisplatin results in increased expression of MYLK mRNA27392435
D004026DieldrinDieldrin results in increased expression of MYLK mRNA20438755
D004041Dietary FatsDietary Fats results in increased expression of MYLK mRNA18042831
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of MYLK mRNA21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of MYLK mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of MYLK mRNA]19850644
D004077Digoxin[ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]20510202
D002117CalcitriolCalcitriol results in increased expression of MYLK mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MYLK mRNA21592394
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of MYLK mRNA16507463
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of MYLK mRNA"27840820
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of MYLK mRNA24690739
D004237DiuronDiuron results in decreased expression of MYLK mRNA25152437
D004237DiuronDiuron results in increased expression of MYLK mRNA21551480
D004317DoxorubicinDoxorubicin results in decreased expression of MYLK protein12717111
D004642EmodinEmodin results in increased activity of MYLK protein15133857
C118739entinostatentinostat results in decreased expression of MYLK mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
D000431EthanolEthanol results in increased activity of MYLK protein10198341
D000431EthanolEthanol results in increased expression of MYLK mRNA25226407
D000431EthanolML 7 inhibits the reaction [Ethanol results in increased activity of MYLK protein]10198341
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MYLK mRNA17557909
D011345FenofibrateFenofibrate results in decreased expression of MYLK mRNA25572481
C039281furanfuran results in decreased expression of MYLK mRNA25539665
D019833GenisteinGenistein results in decreased expression of MYLK mRNA22228119
C049864ginsenoside Reginsenoside Re affects the expression of MYLK mRNA24658813
C049864ginsenoside Reginsenoside Re affects the expression of MYLK protein24658813
D005897GlafenineGlafenine results in decreased expression of MYLK mRNA24136188
D005947GlucoseML 7 inhibits the reaction [MYLK protein results in increased uptake of Glucose]18773891
D005947GlucoseML 9 inhibits the reaction [MYLK protein results in increased uptake of Glucose]18773891
D005947GlucoseMYLK protein results in increased uptake of Glucose18773891
D017313FenretinideFenretinide results in increased expression of MYLK mRNA28973697
D012701SerotoninMYLK protein affects the susceptibility to Serotonin14690016
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MYLK mRNA23410634
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of MYLK mRNA"21635667
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MYLK mRNA27392435
C544151jinfukangjinfukang results in increased expression of MYLK mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of MYLK mRNA15476862
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MYLK mRNA24796395
C063769KT 5926KT 5926 results in decreased activity of MYLK protein9572834
C063769KT 5926[KT 5926 results in decreased activity of MYLK protein] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]15526279
D008070LipopolysaccharidesEstradiol inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK mRNA]16977382
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MYLK mRNA16977382|1937478
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MYLK protein19374788
D008070LipopolysaccharidesML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK mRNA]19374788
D008070LipopolysaccharidesML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK protein]19374788
D008070LipopolysaccharidesMYLK protein affects the susceptibility to Lipopolysaccharides16192642
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of MYLK protein]18511912
C032881lysophosphatidic acidMYLK protein affects the susceptibility to lysophosphatidic acid10640419
C032881lysophosphatidic acidMYLK protein affects the susceptibility to lysophosphatidic acid11274070
C018091maduramicinmaduramicin results in decreased expression of MYLK mRNA29128925
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MYLK mRNA26378955
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MYLK mRNA20823114
C042720mercuric bromidemercuric bromide results in decreased expression of MYLK mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of MYLK mRNA26307267
D008694MethamphetamineMethamphetamine affects the expression of MYLK mRNA19564919
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] affects the expression of MYLK mRNA19564919
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of MYLK protein11794376
C005219methyl cellosolvemethyl cellosolve metabolite results in increased expression of MYLK protein11794376
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MYLK mRNA23519560
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MYLK mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MYLK mRNA28001369
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of MYLK mRNA12634122
C070571ML 7ML 7 inhibits the reaction [Carbachol results in increased phosphorylation of MYLK protein]15939040
C070571ML 7ML 7 results in decreased activity of MYLK protein9572834
C070571ML 7[ML 7 results in decreased activity of MYLK protein] inhibits the reaction [TNF protein affects the localization of RELA protein]15526279
C070571ML 7[ML 7 results in decreased activity of MYLK protein] inhibits the reaction [TNF protein results in increased activity of RELA protein]15526279
C070571ML 7[ML 7 results in decreased activity of MYLK protein] inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]15526279
C070571ML 7[ML 7 results in decreased activity of MYLK protein] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]15526279
C070571ML 7[ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]20510202
C070571ML 7ML 7 results in decreased activity of MYLK protein17509155
C070571ML 7FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]16723733
C070571ML 7ML 7 inhibits the reaction [Calcium deficiency results in increased activity of MYLK protein]11054866
C070571ML 7ML 7 inhibits the reaction [Ethanol results in increased activity of MYLK protein]10198341
C070571ML 7ML 7 results in decreased activity of MYLK protein10733514|1253434
C070571ML 7[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein16675616
C070571ML 7[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein1643115
C070571ML 7[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein16723733
C070571ML 7ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK mRNA]19374788
C070571ML 7ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK protein]19374788
C070571ML 7ML 7 inhibits the reaction [MYLK protein results in increased uptake of Glucose]18773891
C070571ML 7ML 7 results in decreased activity of MYLK protein19943851
C070571ML 7ML 7 inhibits the reaction [Cholesterol results in increased activity of MYLK protein]21052790
C070571ML 7ML 7 results in decreased activity of MYLK protein17541957
C070571ML 7[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein18835913
C070571ML 7[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein9618396
C070571ML 7[ML 7 results in decreased activity of MYLK protein] which results in decreased uptake of Calcium9506478
C056218ML 9FADD protein affects the reaction [[ML 9 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]16723733
C056218ML 9ML 9 results in decreased activity of MYLK protein12534346
C056218ML 9[ML 9 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein16723733
C056218ML 9ML 9 inhibits the reaction [MYLK protein results in increased uptake of Glucose]18773891
C056218ML 9[ML 9 results in decreased activity of MYLK protein] which results in decreased uptake of Calcium9506478
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of MYLK mRNA16507463|2088654
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MYLK mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MYLK mRNA"25620056
D009532NickelNickel results in decreased expression of MYLK mRNA24768652|2558310
D009532NickelNickel results in increased expression of MYLK mRNA18922574
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYLK mRNA27935865
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MYLK mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MYLK mRNA25729387
D010100OxygenOxygen deficiency results in decreased phosphorylation of MYLK protein18375742
D000073878Palm OilPalm Oil results in increased expression of MYLK mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of MYLK mRNA26272509
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of MYLK mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of MYLK mRNA28341207|2865563
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of MYLK mRNA17097637
C076715pervanadateMYLK protein affects the susceptibility to pervanadate12020688
D010578PetroleumPetroleum affects the expression of MYLK mRNA25208076
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MYLK mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYLK mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MYLK mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of MYLK mRNA23811191
D011374ProgesteroneProgesterone results in decreased expression of MYLK mRNA23012394|2301818
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of MYLK mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of MYLK mRNA17404688
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of MYLK mRNA19687787
C045950propiconazolepropiconazole results in decreased expression of MYLK mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of MYLK mRNA24780913
D011794QuercetinQuercetin results in decreased expression of MYLK mRNA21632981
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of MYLK mRNA21852083
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] affects the expression of MYLK mRNA19564919
C534628SCH 23390SCH 23390 results in decreased expression of MYLK mRNA19564919
D012715Sesame OilSesame Oil results in decreased expression of MYLK mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MYLK mRNA25351596
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of MYLK mRNA]21245298
C009277sodium arsenatesodium arsenate results in increased expression of MYLK mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of MYLK mRNA16507463
C016104sodium bichromatesodium bichromate affects the expression of MYLK mRNA22110744
D012969Sodium FluorideSodium Fluoride results in decreased expression of MYLK protein28918527
D010042OuabainOuabain results in decreased expression of MYLK mRNA28795476
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MYLK mRNA26378955
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MYLK mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MYLK mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYLK mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYLK mRNA22298810
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MYLK mRNA23519560
D013792ThalidomideThalidomide results in increased expression of MYLK mRNA26217789
D013853ThioacetamideThioacetamide results in decreased expression of MYLK mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of MYLK mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MYLK mRNA25729387
D019772TopotecanTopotecan results in increased expression of MYLK mRNA25729387
D014212TretinoinTretinoin results in decreased expression of MYLK mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of MYLK mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of MYLK mRNA24935251|2623859
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MYLK mRNA"26179874
C113580U 0126U 0126 inhibits the reaction [AGT protein results in increased expression of MYLK protein]18511912
D014520UrethaneUrethane results in decreased expression of MYLK mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYLK mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MYLK mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MYLK mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of MYLK mRNA23179753|2493525
D014667VasopressinsMYLK protein affects the susceptibility to Vasopressins15347643
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of MYLK mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of MYLK mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MYLK gene25487561
C025643vinclozolinvinclozolin affects the expression of MYLK mRNA19015723
D014800VitalliumVitallium analog results in increased expression of MYLK mRNA23825117
D024483Vitamin K 3Vitamin K 3 affects the expression of MYLK mRNA23410634
C111237vorinostatvorinostat results in increased expression of MYLK mRNA26238599
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of MYLK mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0004672protein kinase activity-IBA21873635  
GO:0004687myosin light chain kinase activity-IBA21873635  
GO:0004687myosin light chain kinase activity-IDA16284075  
GO:0005515protein binding-IPI17474147  25416956  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO:0006936muscle contraction-TAS-  
GO:0006939smooth muscle contraction-IBA21873635  
GO:0006939smooth muscle contraction-ISS-  
GO:0014820tonic smooth muscle contraction-IBA21873635  
GO:0014820tonic smooth muscle contraction-ISS-  
GO:0030335positive regulation of cell migration-IDA19826488  
GO:0032060bleb assembly-IMP20181817  
GO:0051928positive regulation of calcium ion transport-IDA16284075  
GO:0060414aorta smooth muscle tissue morphogenesis-IMP21055718  
GO:0071476cellular hypotonic response-IDA11976941  
GO:0072358cardiovascular system development-IBA21873635  
GO:0090303positive regulation of wound healing-IDA15825080  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IBA21873635  
GO:0001725stress fiber-IDA15020676  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA20053363  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0015629actin cytoskeleton-IDA-  
GO:0030027lamellipodium-IBA21873635  
GO:0030027lamellipodium-IDA20053363  
GO:0032154cleavage furrow-IBA21873635  
GO:0032154cleavage furrow-IDA15020676  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04510Focal adhesion
hsa04810Regulation of actin cytoskeleton
hsa04971Gastric acid secretion
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-397014Muscle contractionTAS
R-HSA-445355Smooth Muscle ContractionTAS
R-HSA-5627123RHO GTPases activate PAKsTAS
R-HSA-5627123RHO GTPases activate PAKsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19706030Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking. (2009 Nov)Horne BDAnn Hum Genet