Gene: MYO5B

4645
-
myosin VB
protein-coding
18q21.1
Ensembl:ENSG00000167306 MIM:606540 Vega:OTTHUMG00000179843 UniprotKB:Q9ULV0
NG_012925.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.315e-2 (AD)  5.407e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF385D0.921
NXPH20.918
VWC20.889
LHX60.889
KIAA10240.871
MYO160.871
SIAH30.866
SLC32A10.864
KCNS30.864
GAD10.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.597
HEBP2-0.594
RAB13-0.583
TGIF1-0.563
AGTRAP-0.561
TRAF3IP2-0.551
HVCN1-0.547
ATOH8-0.546
STON2-0.544
AKR1C3-0.532

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of MYO5B mRNA"25768209
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MYO5B mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MYO5B mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of MYO5B mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYO5B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYO5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYO5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYO5B mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MYO5B mRNA21420995
D020106AcrylamideAcrylamide results in increased expression of MYO5B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MYO5B mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MYO5B gene28458013
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MYO5B mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MYO5B mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of MYO5B mRNA22521957
C547126AZM551248AZM551248 results in decreased expression of MYO5B mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYO5B mRNA20106945|2163298
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of MYO5B mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYO5B mRNA15034205
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MYO5B mRNA"26238291
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYO5B mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MYO5B mRNA]25566086
D004958EstradiolEstradiol results in decreased expression of MYO5B mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of MYO5B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MYO5B gene28505145
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of MYO5B mRNA24763279
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MYO5B mRNA"19167446
D016572CyclosporineCyclosporine results in decreased expression of MYO5B mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MYO5B mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MYO5B mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MYO5B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MYO5B mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of MYO5B mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MYO5B mRNA21592394
C024629dimethyl phthalatedimethyl phthalate affects the expression of MYO5B mRNA26924002
C118739entinostatentinostat results in increased expression of MYO5B mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MYO5B protein23301498
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of MYO5B mRNA17347304
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of MYO5B mRNA17347304
D005839GentamicinsGentamicins results in decreased expression of MYO5B mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of MYO5B mRNA24763279
D017313FenretinideFenretinide results in increased expression of MYO5B mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYO5B mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MYO5B mRNA27392435
C544151jinfukangjinfukang results in decreased expression of MYO5B mRNA27392435
D007608Kainic AcidKainic Acid results in decreased expression of MYO5B mRNA17997037
D008694MethamphetamineMYO5B gene SNP affects the susceptibility to Methamphetamine18316681
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MYO5B mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MYO5B mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MYO5B mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MYO5B mRNA"25620056
D009538NicotineNicotine results in decreased expression of MYO5B mRNA17997037
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of MYO5B mRNA17616710
C016340o,p'-DDT"o,p'-DDT results in increased expression of MYO5B mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in increased expression of MYO5B mRNA"24096037
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYO5B mRNA"27188386
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MYO5B mRNA16221955|1916217
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MYO5B mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of MYO5B mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MYO5B mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of MYO5B mRNA18301758|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of MYO5B mRNA]20059764
C006253pirinixic acidpirinixic acid results in increased expression of MYO5B mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of MYO5B mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of MYO5B mRNA27029645
C017947sodium arsenitesodium arsenite affects the expression of MYO5B mRNA29319823
D012999SomanSoman results in decreased expression of MYO5B mRNA19281266
D013629TamoxifenTamoxifen results in decreased expression of MYO5B mRNA25123088
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MYO5B mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MYO5B mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MYO5B mRNA15034205
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MYO5B mRNA25613284
D014212TretinoinTretinoin results in decreased expression of MYO5B mRNA23724009
D014212TretinoinTretinoin results in increased expression of MYO5B mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MYO5B gene27618143
C012589trichostatin Atrichostatin A results in increased expression of MYO5B mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of MYO5B mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MYO5B mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of MYO5B mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of MYO5B gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MYO5B gene25560391
C025643vinclozolinvinclozolin results in decreased expression of MYO5B mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000146microfilament motor activity-TAS-  
GO:0003777microtubule motor activity-IEA-  
GO:0005515protein binding-IPI19542231  25416956  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IEA-  
GO:0017137Rab GTPase binding-IPI17462998  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003091renal water homeostasis-TAS-  
GO:0007018microtubule-based movement-IEA-  
GO:0015031protein transport-IEA-  
GO:0016192vesicle-mediated transport-IMP17462998  
GO:0016197endosomal transport-IMP21206382  
GO ID GO Term Qualifier Evidence PubMed
GO:0016459myosin complex-IEA-  
GO:0030659cytoplasmic vesicle membrane-TAS-  
GO:0032991protein-containing complex-IDA17462998  
GO:0045179apical cortex-IDA21206382  
GO:0055037recycling endosomecolocalizes_withIC21206382  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-432040Vasopressin regulates renal water homeostasis via AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21546496Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children. (2011 Sep)Guerrero JAHaematologica