Gene: ATF1

466
EWS-ATF1|FUS/ATF-1|TREB36
activating transcription factor 1
protein-coding
12q13.12
Ensembl:ENSG00000123268 MIM:123803 Vega:OTTHUMG00000169482 UniprotKB:P18846
NG_027673.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.889e-1 (AD)  9.647e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
G3BP10.799
LYSMD30.795
PAPOLA0.788
C3orf380.77
MEX3C0.763
TMED50.763
CDKN2AIP0.761
RB10.758
TMX10.755
KIAA15510.755

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.507
OR4F29-0.474
C12orf54-0.209
FAM180B-0.203
CYP4A11-0.203
CFC1B-0.184
HES5-0.182
ZNRF4-0.173
OR8G1-0.167
SPRR2D-0.163

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00852PseudoephedrineSmall Molecule90-82-4ApprovedTarget
ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]12660819
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF1 protein]16424113
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ATF1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ATF1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ATF1 mRNA"21346803
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]"23452621
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATF1 mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein16671086
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneAtenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]16671086
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]16671086
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonetyrphostin AG 1478 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]16671086
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATF1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ATF1 mRNA21420995
D006710HomocysteineHomocysteine promotes the reaction [ATF1 protein binds to CCNA2 promoter]8550827
D003913DextroamphetamineDextroamphetamine results in decreased expression of ATF1 mRNA12205029
D003913DextroamphetamineSOD1 inhibits the reaction [Dextroamphetamine results in decreased expression of ATF1 mRNA]12205029
D000841AnisomycinAnisomycin results in increased phosphorylation of ATF1 protein12660819
D000841Anisomycin[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]12660819
D000841AnisomycinSB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]12660819
D016718Arachidonic AcidArachidonic Acid inhibits the reaction [Quercetin results in increased phosphorylation of ATF1 protein]20551291
D001262AtenololAtenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]16671086
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATF1 mRNA"19150397|2001819
C006780bisphenol Abisphenol A affects the methylation of ATF1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of ATF1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ATF1 gene28505145
C533207BIX 02189BIX 02189 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of ATF1 protein]22521884
D019256Cadmium ChlorideBIX 02189 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of ATF1 protein]22521884
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of ATF1 protein22521884|2788460
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATF1 mRNA20061341
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ATF1 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ATF1 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of ATF1 protein10559391
D003300CopperCopper promotes the reaction [Disulfiram results in decreased activity of ATF1 protein]15367699
D003300Copper[Disulfiram co-treated with Copper] results in decreased activity of ATF1 protein15367699
D019327Copper SulfateCopper Sulfate results in increased expression of ATF1 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of ATF1 mRNA22077320
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]23452621
D016572CyclosporineCyclosporine results in increased expression of ATF1 mRNA25562108
D003676DeferoxamineDeferoxamine results in increased activity of ATF1 protein10559391
C007262deoxynivalenoldeoxynivalenol results in increased expression of ATF1 mRNA22846391
C007262deoxynivalenol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF1 protein]16424113
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of ATF1 protein16424113
C007262deoxynivalenolDocosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF1 protein]16424113
C007262deoxynivalenolSB 203580 inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF1 protein]16424113
D003994BucladesineBucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]12164941
C000944dicrotophosdicrotophos results in decreased expression of ATF1 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of ATF1 mRNA23041725
D004147DioxinsDioxins affects the expression of ATF1 mRNA20463971
D004221DisulfiramCopper promotes the reaction [Disulfiram results in decreased activity of ATF1 protein]15367699
D004221Disulfiram[Disulfiram co-treated with Copper] results in decreased activity of ATF1 protein15367699
D004281Docosahexaenoic AcidsDocosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF1 protein]16424113
C413879EKB 569EKB 569 results in decreased expression of ATF1 mRNA22242139
D005485FlutamideFlutamide results in increased expression of ATF1 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased phosphorylation of ATF1 protein22138297
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]23452621
D005839GentamicinsGentamicins results in increased expression of ATF1 mRNA22061828
D006046GoldGold results in decreased expression of ATF1 mRNA25523186
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ATF1 mRNA18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of ATF1 protein20302854
D006861Hydrogen PeroxideMycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATF1 protein]20302854
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ATF1 mRNA23430699|2479639
D007654KetoconazoleBucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]12164941
D007654KetoconazoleKetoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]12164941
D007654KetoconazoleKetoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]12164941
D008345ManganeseManganese results in increased phosphorylation of ATF1 protein16787641
D008345ManganeseSB 203580 inhibits the reaction [Manganese results in increased phosphorylation of ATF1 protein]16787641
C025340manganese chloridemanganese chloride results in increased phosphorylation of ATF1 protein16787641
C025340manganese chlorideSB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of ATF1 protein]16787641
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of ATF1 mRNA25270620
D008898MimosineMimosine results in increased activity of ATF1 protein10559391
D009173Mycophenolic AcidMycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATF1 protein]20302854
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]16671086
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein]22188298
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]12164941
C051752nefazodonenefazodone results in increased expression of ATF1 mRNA24136188
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of ATF1 mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]23452621
D010100OxygenATF1 protein promotes the reaction [Oxygen deficiency results in increased expression of UCP3 protein]18579531
D010100OxygenOxygen deficiency promotes the reaction [[ATF1 protein binds to UCP3 promoter] which results in increased expression of UCP3 mRNA]18579531
D010100OxygenOxygen deficiency results in increased expression of ATF1 mRNA18579531
D010100OxygenOxygen deficiency results in increased expression of ATF1 protein18579531
D010100OxygenOxygen deficiency results in increased phosphorylation of ATF1 protein18579531
D010100OxygenSB 203580 inhibits the reaction [Oxygen deficiency results in increased phosphorylation of ATF1 protein]18579531
D015232DinoprostoneBucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]12164941
D015232Dinoprostone[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein22188298
D015232DinoprostoneDinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]12164941
D015232DinoprostoneDinoprostone results in increased phosphorylation of ATF1 protein12164941
D015232DinoprostoneKetoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]12164941
D015232DinoprostoneKetoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]12164941
D015232DinoprostoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein]22188298
D015232DinoprostoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]12164941
C018637phoronephorone affects the expression of ATF1 mRNA18198479
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]23452621
D044945ProanthocyanidinsProanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of ATF1 mRNA]26802905
D011441PropylthiouracilPropylthiouracil results in increased expression of ATF1 mRNA24780913
D011794QuercetinArachidonic Acid inhibits the reaction [Quercetin results in increased phosphorylation of ATF1 protein]20551291
D011794QuercetinQuercetin results in increased phosphorylation of ATF1 protein20551291
C502851quinocetoneProanthocyanidins inhibits the reaction [quinocetone metabolite results in decreased expression of ATF1 mRNA]26802905
C502851quinocetonequinocetone metabolite results in decreased expression of ATF1 mRNA26802905
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]23452621
C059514resveratrolresveratrol results in increased phosphorylation of ATF1 protein20080969
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ATF1 mRNA21427059
C093642SB 203580[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]12660819
C093642SB 203580SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]12660819
C093642SB 203580SB 203580 inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF1 protein]16424113
C093642SB 203580SB 203580 inhibits the reaction [Oxygen deficiency results in increased phosphorylation of ATF1 protein]18579531
C093642SB 203580SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of ATF1 protein]16787641
C093642SB 203580SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of ATF1 protein]16787641
C017947sodium arsenitesodium arsenite affects the methylation of ATF1 gene28589171
C017947sodium arsenitesodium arsenite results in increased phosphorylation of ATF1 protein12660819|1452399
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATF1 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ATF1 mRNA19465110
D014118Toxins, Biological"Toxins, Biological affects the expression of ATF1 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of ATF1 mRNA20530235
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ATF1 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATF1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ATF1 mRNA24935251|2627250
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]16671086
D014635Valproic AcidValproic Acid affects the expression of ATF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ATF1 mRNA22083351|2317975
D014635Valproic AcidValproic Acid results in decreased expression of ATF1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ATF1 gene25560391
C111237vorinostatvorinostat results in decreased expression of ATF1 mRNA22083351
D017307XamoterolXamoterol results in increased phosphorylation of ATF1 protein16671086

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA1655749  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA1655749  
GO:0003700DNA-binding transcription factor activity-TAS2196176  8401579  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0005515protein binding-IPI10722738  20102225  25609649  
GO:0042802identical protein binding-IPI20102225  21045134  
GO:0044877protein-containing complex binding-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0010976positive regulation of neuron projection development-IEA-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0032025response to cobalt ion-IEA-  
GO:0034622cellular protein-containing complex assembly-IEA-  
GO:0045740positive regulation of DNA replication-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA1655749  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA8798441  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:1990590ATF1-ATF4 transcription factor complex-IDA12871976  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-198725Nuclear Events (kinase and transcription factor activation)TAS
R-HSA-199920CREB phosphorylationTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinasesTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29434341Hyalinizing clear cell carcinoma of the bronchial glands: presentation of three cases and pathological comparisons with salivary gland counterparts and bronchial mucoepidermoid carcinomas. (2018 Feb 12)Takamatsu MMod Pathol