Gene: NAGA

4668
D22S674|GALB
alpha-N-acetylgalactosaminidase
protein-coding
22q13.2
Ensembl:ENSG00000198951 MIM:104170 Vega:OTTHUMG00000151276 UniprotKB:P17050
NG_009247.1
PubMed
0   ANCO-SNPs
ND
1   
4.801e-1 (AD)  5.383e-1 (ND)   (Frontal_Cortex)
5.238e-1 (AD)  1.329e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCL160.824
LOXL30.822
TEP10.821
MOB1A0.815
RIN30.803
CMTM60.803
TGFBR10.803
ARHGAP300.802
UNC93B10.802
STAT30.798

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.379
OR4F29-0.346
CPLX3-0.32
ABCC12-0.303
KCNB2-0.303
CRH-0.299
HAS1-0.297
NEUROD6-0.297
ADRA1D-0.294
MAGIX-0.293

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09462GlycerinSmall Molecule56-81-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of NAGA mRNA22230336
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NAGA mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NAGA mRNA]17585979
D000393Air PollutantsAir Pollutants analog results in decreased expression of NAGA mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of NAGA mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NAGA mRNA24449571
C547126AZM551248AZM551248 results in increased expression of NAGA mRNA22323515
C006780bisphenol Abisphenol A results in increased expression of NAGA mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of NAGA mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NAGA mRNA18804290
D000001CalcimycinCalcimycin affects the activity of NAGA protein18475545
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NAGA mRNA24763279
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of NAGA mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NAGA mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NAGA mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of NAGA mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of NAGA mRNA19549813
D003471CuprizoneCuprizone results in increased expression of NAGA mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of NAGA mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NAGA mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NAGA mRNA27392435
D002945CisplatinCisplatin results in increased expression of NAGA mRNA27594783
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of NAGA mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of NAGA mRNA25016146
C024629dimethyl phthalatedimethyl phthalate affects the expression of NAGA mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NAGA mRNA17942748
D005485FlutamideFlutamide results in decreased expression of NAGA mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of NAGA mRNA23649840
D005897GlafenineGlafenine results in decreased expression of NAGA mRNA24136188
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NAGA mRNA24763279
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of NAGA mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NAGA mRNA27392435
C544151jinfukangjinfukang results in increased expression of NAGA mRNA27392435
C008261lead acetatelead acetate results in increased expression of NAGA mRNA21829687
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NAGA mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NAGA mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of NAGA mRNA26924002
C051752nefazodonenefazodone results in decreased expression of NAGA mRNA24136188
D009532NickelNickel results in decreased expression of NAGA mRNA23195993
D009532NickelNickel results in increased expression of NAGA mRNA25583101
C025589ochratoxin Aochratoxin A results in decreased expression of NAGA mRNA19287073
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NAGA mRNA18804290
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NAGA mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of NAGA mRNA19162173
C017947sodium arsenitesodium arsenite affects the methylation of NAGA gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of NAGA mRNA17685462
D012969Sodium FluorideSodium Fluoride results in decreased expression of NAGA protein28918527
D012999SomanSoman results in increased expression of NAGA mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAGA mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of NAGA mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of NAGA mRNA23411599
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NAGA mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of NAGA mRNA25979313
C025643vinclozolinvinclozolin results in decreased expression of NAGA mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004557alpha-galactosidase activity-IBA21873635  
GO:0008456alpha-N-acetylgalactosaminidase activity-IDA19683538  
GO:0042803protein homodimerization activity-IPI19683538  
GO ID GO Term Qualifier Evidence PubMed
GO:0009311oligosaccharide metabolic process-IBA21873635  
GO:0016052carbohydrate catabolic process-IDA19683538  
GO:0016139glycoside catabolic process-IBA21873635  
GO:0019377glycolipid catabolic process-IMP9741689  
GO:0046477glycosylceramide catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005764lysosome-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00603Glycosphingolipid biosynthesis - globo series
hsa04142Lysosome
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27602338Analysis of Epstein Barr Virus Encoded RNA Expression in Nasopharyngeal Carcinoma in North-Eastern India: A Chromogenic in Situ Hybridization Based Study. (2016 Jul)Saikia AIran J Otorhinolaryngol