Gene: ATF4

468
CREB-2|CREB2|TAXREB67|TXREB
activating transcription factor 4
protein-coding
22q13.1
Ensembl:ENSG00000128272 MIM:604064 Vega:OTTHUMG00000151099 UniprotKB:P18848
NC_000022.11
PubMed
CD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.913e-1 (AD)  2.289e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18405341chr22:39918625ATF44.400e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF2S20.907
EIF10.903
BUD310.901
EIF3G0.891
SRSF90.887
JTB0.884
SSR20.883
PCBP10.878
RALY0.877
NME1-NME20.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.796
OR4F5-0.794
FREM2-0.173
PPIAP10-0.161
SSPN-0.155
NPHS2-0.154
OR10J4-0.151
OR2A14-0.149
CCR8-0.147
MROH9-0.144

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00852PseudoephedrineSmall Molecule90-82-4ApprovedTarget
ID Drug Name Action PubMed
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of ATF4 protein"24515801|2603571
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of ATF4 protein]"24515801
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"NR4A1 protein inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of ATF4 protein]"24515801
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]"15509775
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]"23892647
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]"15509775
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of ATF4 mRNA]"22959925
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone affects the activity of ATF4 protein25596134
C5277421-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone"1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of ATF4 mRNA]"28962527
C0793931,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole"1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA]"21703327
C0793931,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole"1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in increased expression of ATF4 mRNA"21703327
C4928471-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea"1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea results in increased activity of ATF4 protein"19164757
C5602961,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one"1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one results in increased expression of ATF4 mRNA"21504179
C5602961,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one"1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one results in increased expression of ATF4 protein"21504179
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ATF4 mRNA28329830
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of ATF4 mRNA]25827057
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ATF4 protein"25639565
C5112952,2',4,4'-tetrabromodiphenyl ether"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ATF4 protein]]"25639565
C5112952,2',4,4'-tetrabromodiphenyl ether"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ATF4 protein]"25639565
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ATF4 mRNA"23962555
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [nefazodone results in increased expression of ATF4 protein]"27613715
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATF4 protein"25950987
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"salubrinal inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATF4 protein]"25950987
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ATF4 mRNA"21703327
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]24057571
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneCycloheximide inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]24057571
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneSB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]24057571
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ATF4 mRNA"20702593
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ATF4 protein]25870318
C1065923,9-bis((ethylthio)methyl)-K-252a"3,9-bis((ethylthio)methyl)-K-252a results in increased expression of ATF4 mRNA"15294995
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ATF4 mRNA"18648102
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ATF4 protein"19561079
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of ATF4 mRNA24291486
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of ATF4 protein24291486
C0275764-hydroxy-2-nonenalAcetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]24291486
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]27634458
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [leflunomide results in increased expression of ATF4 protein]28988120
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]28063906
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 mRNA]27470132
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 protein]27470132
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 mRNA]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 protein]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]28063906
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]27484784
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]28844859
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of ATF4 protein27484784|2884485
C1052604-tert-octylphenol4-tert-octylphenol results in decreased expression of ATF4 mRNA17011747
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of ATF4 mRNA17011747
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of ATF4 mRNA"27709270
D000082AcetaminophenAcetaminophen results in increased expression of ATF4 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of ATF4 mRNA15606129|1756273
D000082AcetaminophenAcetaminophen results in decreased expression of ATF4 mRNA17585979
D000082AcetaminophenAcetaminophen results in increased expression of ATF4 mRNA11264010
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ATF4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ATF4 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]27634458
D000111AcetylcysteineAcetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein]28754437
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]15788408
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein]25568320
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF4 protein]"27816613
D000111AcetylcysteineAcetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein]21266191
D000111AcetylcysteineAcetylcysteine results in increased expression of ATF4 protein19722195
D000111AcetylcysteineAcetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein]25451595
D000111AcetylcysteineAcetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]24291486
D000111AcetylcysteineAcetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]27484784
D000111AcetylcysteineAcetylcysteine results in decreased expression of ATF4 protein27484784
D000171AcroleinAcrolein results in increased expression of and affects the localization of ATF4 protein18951912
D000171AcroleinAcrolein results in increased expression of ATF4 mRNA28119953
D000171AcroleinAcrolein results in increased expression of ATF4 protein28119953
D020106Acrylamide4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]27634458
D020106AcrylamideAcetylcysteine inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]27634458
D020106AcrylamideAcrylamide results in increased expression of ATF4 protein27634458
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ATF4 protein23405127
D000638AmiodaroneAmiodarone results in increased expression of ATF4 protein21292685
D000638Amiodarone"1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of ATF4 mRNA]"28962527
D000638AmiodaroneAmiodarone results in increased expression of ATF4 mRNA28962527
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ATF4 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of ATF4 mRNA18305237
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ATF4 mRNA24449571
C006632arsenic trioxide"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]"23892647
C006632arsenic trioxide"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]"27638049
C006632arsenic trioxide[arsenic trioxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of ATF4 protein23892647
C006632arsenic trioxidearsenic trioxide results in increased expression of and affects the localization of ATF4 protein27461142
C006632arsenic trioxidearsenic trioxide results in increased expression of ATF4 mRNA23892647
C006632arsenic trioxidearsenic trioxide results in increased expression of ATF4 protein23892647|2763804
C006632arsenic trioxideATF4 protein affects the reaction [arsenic trioxide results in decreased expression of IL1B mRNA]27461142
C006632arsenic trioxideATF4 protein affects the reaction [arsenic trioxide results in decreased expression of ITGAM protein]27461142
C006632arsenic trioxideATF4 protein affects the reaction [arsenic trioxide results in increased cleavage of CASP3 protein]27461142
C006632arsenic trioxideATF4 protein affects the reaction [arsenic trioxide results in increased expression of IL10 mRNA]27461142
C006632arsenic trioxideATF4 protein affects the reaction [arsenic trioxide results in increased expression of TGFB1 mRNA]27461142
C006632arsenic trioxideATF4 protein affects the reaction [arsenic trioxide results in increased expression of TNF mRNA]27461142
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide affects the expression of DRP1 protein modified form]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of and affects the localization of BAX protein]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of and affects the localization of CYCS protein]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of and affects the localization of RAC1 protein]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of CAPN1 protein]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of CASP12 protein modified form]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of CASP3 protein modified form]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of DDIT3 protein]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of EIF2AK3 protein modified form]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of HSP90B1 protein]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of HSPA5 protein]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of HSPA9 protein]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of ITPR1 protein modified form]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of NCF1 protein]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of NCF2 protein]27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of TP53 protein]27638049
C006632arsenic trioxideThioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]23892647
C006632arsenic trioxideThioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]23892647
C015001arsenitearsenite results in increased expression of ATF4 protein14604972
C015001arsenitearsenite results in increased phosphorylation of ATF4 protein22959463
C015001arseniteATF4 mutant form inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA]22215663
C015001arseniteATF4 mutant form inhibits the reaction [arsenite results in increased expression of SLC38A2 protein]22215663
C015001arsenitearsenite results in increased expression of ATF4 protein20589738
C015001arsenitearsenite results in increased expression of ATF4 mRNA22425709
C015001arsenitearsenite results in increased expression of ATF4 protein18226606
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of ATF4 mRNA"17331233
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ATF4 mRNA"25757056
D001241AspirinAspirin results in decreased expression of ATF4 mRNA15928584
D001280AtrazineAtrazine results in decreased expression of ATF4 mRNA22378314
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATF4 mRNA]15477007
D001554BenzeneBenzene affects the expression of ATF4 mRNA15878777
D001564Benzo(a)pyreneBenzo(a)pyrene affects the activity of ATF4 protein20624995
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATF4 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATF4 mRNA21569818|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ATF4 mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF4 protein14604972|1791264
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF4 protein23593480
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeCycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF4 protein]23593480
D015764BepridilBepridil results in increased expression of ATF4 protein21292685
D004958EstradiolEstradiol affects the expression of ATF4 mRNA15598610
D004958EstradiolEstradiol results in increased expression of ATF4 mRNA25210133
C516541BI D1870BI D1870 inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]24057571
C006780bisphenol Abisphenol A results in decreased expression of ATF4 mRNA20678512
C006780bisphenol Abisphenol A affects the methylation of ATF4 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of ATF4 mRNA12233820|2891097
C006780bisphenol Abisphenol A results in increased expression of ATF4 mRNA25181051|2698221
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ATF4 mRNA21601586|2243402
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ATF4 mRNA17553608|2160158
C032688boric acidboric acid results in increased expression of ATF4 mRNA25425213|2758702
C032688boric acidboric acid results in increased expression of ATF4 protein25425213|2758702
D000069286Bortezomib"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]"15509775
D000069286BortezomibATF4 mutant form inhibits the reaction [Bortezomib results in increased expression of PMAIP1 mRNA]20022965
D000069286BortezomibATF4 mutant form inhibits the reaction [Bortezomib results in increased expression of PMAIP1 protein]20022965
D000069286BortezomibATF4 results in decreased susceptibility to Bortezomib20022965
D000069286BortezomibBortezomib promotes the reaction [ATF4 protein binds to PMAIP1 promoter]20022965
D000069286BortezomibBortezomib results in increased expression of ATF4 mRNA15509775|2002296
D000069286BortezomibBortezomib results in increased expression of ATF4 protein15509775|1692868
D000069286BortezomibDactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 mRNA]20022965
D000069286BortezomibDactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]20022965
D000069286BortezomibNUPR1 mutant form promotes the reaction [Bortezomib results in increased expression of ATF4 mRNA]20022965
D000069286Bortezomib"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]"15509775
D000069286BortezomibBortezomib results in increased expression of ATF4 protein15509775
D000069286BortezomibBortezomib results in increased activity of ATF4 protein19164757
D020126Brefeldin ABrefeldin A results in increased expression of ATF4 protein24865413|2735823
D002101Cacodylic AcidCacodylic Acid results in increased expression of ATF4 mRNA23221991
D002101Cacodylic AcidCacodylic Acid results in increased expression of ATF4 mRNA16122865
D002104CadmiumCadmium results in increased expression of ATF425805271
D002104CadmiumSelenium inhibits the reaction [Cadmium results in increased expression of ATF4]25805271
D002104CadmiumCadmium results in increased expression of ATF4 mRNA16759985
D002104CadmiumCadmium results in increased expression of ATF4 protein16759985
D002104CadmiumCycloheximide inhibits the reaction [Cadmium results in increased expression of ATF4 protein]16759985
D019256Cadmium Chloride2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]24057571
D019256Cadmium ChlorideATF4 protein results in decreased susceptibility to Cadmium Chloride24057571
D019256Cadmium ChlorideATF4 results in decreased susceptibility to Cadmium Chloride21809093
D019256Cadmium ChlorideBI D1870 inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]24057571
D019256Cadmium ChlorideCadmium Chloride affects the activity of ATF4 protein25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATF424057571
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATF4 protein21809093
D019256Cadmium ChlorideCycloheximide inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]24057571
D019256Cadmium ChlorideEGF protein promotes the reaction [Cadmium Chloride results in increased expression of ATF4]24057571
D019256Cadmium ChlorideMK 2206 inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]24057571
D019256Cadmium ChlorideSB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]24057571
D019256Cadmium ChlorideSirolimus inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]24057571
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATF420600546
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATF4 mRNA16759985
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ATF4 protein16759985
D019256Cadmium ChlorideCycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of ATF4 protein]16759985
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of ATF4 mRNA18654764
D002185CannabidiolCannabidiol results in increased expression of ATF4 mRNA21542829
D002211CapsaicinCapsaicin affects the localization of ATF4 protein20925121
D002211CapsaicinCapsaicin results in increased expression of ATF4 protein18533110|1913926
D002211CapsaicinCycloheximide inhibits the reaction [Capsaicin results in increased expression of ATF4 protein]18533110
D002220CarbamazepineCarbamazepine affects the expression of ATF4 mRNA24752500
D002220CarbamazepineCarbamazepine results in increased expression of ATF4 mRNA24752500
D002251Carbon Tetrachloride1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of ATF4 mRNA]25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ATF4 mRNA25827057
D002392CatechinCatechin results in increased expression of ATF4 mRNA15465739
C469298CEP-11004CEP-11004 results in increased expression of ATF4 mRNA15294995
C004656chloroacetaldehydechloroacetaldehyde affects the activity of ATF4 protein25596134
C006972chloroacetic acidAcetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein]25451595
C006972chloroacetic acidchloroacetic acid results in increased expression of ATF4 protein25451595
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ATF4 mRNA23650126
C100187chloropicrinchloropicrin affects the expression of ATF4 mRNA26352163
D002746Chlorpromazine[Chlorpromazine co-treated with Cholic Acids] affects the expression of ATF4 mRNA27344345
D002746ChlorpromazineChlorpromazine affects the activity of ATF4 protein25596134
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ATF4 mRNA27344345
D002793Cholic Acids[Chlorpromazine co-treated with Cholic Acids] affects the expression of ATF4 mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of ATF4 mRNA27344345
C031180chrysenechrysene results in increased expression of ATF4 mRNA26377693
C059262cidofovircidofovir affects the activity of ATF4 protein25596134
C032151cifenlinecifenline results in increased expression of ATF4 protein21292685
D002953CitrininCitrinin results in increased expression of ATF4 mRNA21844328
D004002Clodronic AcidClodronic Acid affects the activity of ATF4 protein25596134
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ATF4 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of ATF4 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ATF4 mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATF4 mRNA17602206
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of ATF4 mRNA18654764
D003042CocaineCocaine results in increased expression of ATF418593214
D003042CocaineCocaine results in increased expression of ATF4 mRNA23644055
D003300CopperCopper results in increased expression of ATF425159668
D019327Copper SulfateCopper Sulfate results in increased expression of ATF4 mRNA19549813
C029892cupric chloride[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of ATF4 mRNA20920558
C029892cupric chloridepyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of ATF4 mRNA]20920558
D003513CycloheximideCycloheximide inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]24057571
D003513CycloheximideCycloheximide inhibits the reaction [Capsaicin results in increased expression of ATF4 protein]18533110
D003513CycloheximideCycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF4 protein]23593480
D003513CycloheximideCycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of ATF4 protein]16759985
D003513CycloheximideCycloheximide inhibits the reaction [Cadmium results in increased expression of ATF4 protein]16759985
D016572CyclosporineCyclosporine affects the activity of ATF4 protein25596134
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of ATF4 mRNA27344345
D016572CyclosporineCyclosporine results in increased expression of ATF4 mRNA24973091
D016572CyclosporineCyclosporine results in increased expression of ATF4 mRNA23958496
D016572CyclosporineCyclosporine affects the activity of ATF4 protein25596134
C089595cylindrospermopsincylindrospermopsin results in increased expression of ATF4 mRNA24921660
D003603CytotoxinsCytotoxins results in increased expression of ATF4 mRNA21147958
D003609DactinomycinDactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 mRNA]20022965
D003609DactinomycinDactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]20022965
D003609DactinomycinDactinomycin inhibits the reaction [Fenretinide results in increased expression of ATF4 mRNA]20022965
D003609DactinomycinDactinomycin inhibits the reaction [Fenretinide results in increased expression of ATF4 protein]20022965
D003609DactinomycinDactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]20022965
D003609DactinomycinDactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]20022965
D003620DantroleneDantrolene results in decreased expression of ATF4 protein15921666
C515055darinaparsindarinaparsin results in increased expression of ATF4 protein22535156
D013759DronabinolATF4 results in increased susceptibility to Dronabinol16818650
D013759DronabinolDronabinol results in increased expression of ATF4 mRNA16616335|1681865
D013759DronabinolNUPR1 affects the reaction [Dronabinol results in increased expression of ATF4 mRNA]16616335
D013759DronabinolDronabinol results in increased expression of ATF4 mRNA16616335|2154282
D013759DronabinolNUPR1 affects the reaction [Dronabinol results in increased expression of ATF4 mRNA]16616335
D013759DronabinolDronabinol results in increased expression of ATF4 mRNA16616335
D003907DexamethasoneDexamethasone results in decreased expression of ATF4 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ATF4 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ATF4 mRNA17379624|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ATF4 mRNA21266533
D002945CisplatinCisplatin affects the activity of ATF4 protein25596134
D002945CisplatinCisplatin results in decreased expression of ATF4 mRNA25270620
D002945CisplatinCisplatin results in increased expression of ATF4 protein21616140
D002945Cisplatinsalubrinal promotes the reaction [Cisplatin results in increased expression of ATF4 protein]21616140
D004008DiclofenacDiclofenac affects the expression of ATF4 mRNA24752500
D004008DiclofenacDiclofenac results in increased expression of ATF4 mRNA24752500|2731309
D004041Dietary Fats[APOE protein affects the susceptibility to [Dietary Fats co-treated with Particulate Matter]] which affects the expression of ATF4 mRNA17655762
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATF4 mRNA28433925
D004041Dietary FatsDietary Fats results in increased expression of ATF4 protein26055348
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of ATF4 protein]26055348
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATF4 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ATF4 mRNA19245819
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ATF4 mRNA25280772
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATF4 mRNA17602206
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ATF4 mRNA17011747
C012906dihydrocapsaicindihydrocapsaicin results in increased expression of ATF4 protein19139269
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]"27638049
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of ATF4 mRNA27638505
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of ATF4 mRNA22425709
D004229DithiothreitolDithiothreitol results in increased expression of ATF4 mRNA27226639
D004229DithiothreitolDithiothreitol results in increased expression of ATF4 mRNA27226639
D004317DoxorubicinDoxorubicin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]16298333
D004317DoxorubicinDoxorubicin results in decreased expression of ATF4 mRNA16298333
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ATF4 mRNA22079256
C078846epoxomicin"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ATF4 protein]]"25639565
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of ATF4 protein24768708
D000431EthanolEthanol results in increased expression of ATF4 protein24224909
D000431Ethanolresveratrol inhibits the reaction [Ethanol results in increased expression of ATF4 protein]24224909
D000431EthanolEthanol results in increased expression of ATF4 mRNA28119953
D000431EthanolEthanol results in increased expression of ATF4 protein28119953
D000431EthanolHydralazine inhibits the reaction [Ethanol results in increased expression of ATF4 mRNA]28119953
D000431EthanolEthanol results in increased expression of ATF4 mRNA28119953
D000431EthanolEthanol results in increased expression of ATF4 protein28119953
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ATF4 mRNA16174780|1646718
D004997Ethinyl Estradiolfulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ATF4 mRNA]16467188
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATF4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ATF4 mRNA16174780|1940095
D005047EtoposideEtoposide results in decreased expression of ATF4 mRNA25270620
C060802fangchinolineAcetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein]28754437
C060802fangchinolinefangchinoline results in increased expression of ATF4 protein28754437
D011345FenofibrateFenofibrate affects the activity of ATF4 protein25596134
D011345FenofibrateFenofibrate affects the activity of ATF4 protein25596134
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ATF4 mRNA28329830
D005459FluoridesFluorides affects the expression of ATF4 mRNA20709135
D005485FlutamideFlutamide results in increased expression of ATF4 mRNA24136188
D005632FructoseFructose results in increased expression of ATF4 mRNA15150374
C070081fulvestrantfulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ATF4 mRNA]16467188
C070081fulvestrantfulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ATF4 mRNA]16467188
C039281furanfuran results in increased expression of ATF4 mRNA24183702
C038958gadolinium chloridegadolinium chloride affects the expression of ATF4 mRNA21198628
D005688Galactosamine4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 mRNA]28844859
D005688Galactosamine4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 protein]28844859
D005688Galactosamine[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 mRNA28844859
D005688Galactosamine[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 protein28844859
D005839GentamicinsGentamicins results in increased expression of ATF4 mRNA22061828
D005897GlafenineGlafenine results in increased expression of ATF4 mRNA24136188
D005947GlucoseGlucose deficiency results in increased expression of ATF4 mRNA27226639
D005978Glutathione"Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of ATF4 protein]"24515801
D005978GlutathioneGlutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein]24515801
D006046Gold[Polyethyleneimine binds to Gold] which results in decreased expression of ATF4 mRNA28433809
C001329helenalinhelenalin results in increased expression of ATF4 protein23123298
D017313FenretinideATF4 mutant form inhibits the reaction [Fenretinide results in increased expression of PMAIP1 mRNA]20022965
D017313FenretinideATF4 mutant form inhibits the reaction [Fenretinide results in increased expression of PMAIP1 protein]20022965
D017313FenretinideATF4 results in decreased susceptibility to Fenretinide20022965
D017313FenretinideDactinomycin inhibits the reaction [Fenretinide results in increased expression of ATF4 mRNA]20022965
D017313FenretinideDactinomycin inhibits the reaction [Fenretinide results in increased expression of ATF4 protein]20022965
D017313FenretinideFenretinide affects the expression of ATF4 mRNA20022965
D017313FenretinideFenretinide affects the expression of ATF4 protein20022965
D017313FenretinideFenretinide promotes the reaction [ATF4 protein binds to PMAIP1 promoter]20022965
D017313FenretinideFenretinide results in increased expression of ATF4 mRNA16671099|1735392
D017313FenretinideNUPR1 mutant form promotes the reaction [Fenretinide affects the expression of ATF4 mRNA]20022965
D006830HydralazineHydralazine inhibits the reaction [Ethanol results in increased expression of ATF4 mRNA]28119953
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ATF4 mRNA12419474
C031927hydroquinonehydroquinone results in increased expression of ATF4 mRNA15452088
D007052IbuprofenIbuprofen affects the activity of ATF4 protein25596134
C492448ICG 001ICG 001 results in increased expression of ATF4 mRNA26191083
D007069IfosfamideIfosfamide affects the activity of ATF4 protein25596134
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATF4 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATF4 mRNA15477007
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ATF4 mRNA23086925
C410337K 7174K 7174 results in increased expression of ATF4 mRNA24086573
C008261lead acetatelead acetate results in decreased expression of ATF4 mRNA24260418
C008261lead acetatelead acetate results in increased expression of ATF4 protein22811615
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] affects the expression of ATF4 mRNA18654764
C045463leflunomide4-phenylbutyric acid inhibits the reaction [leflunomide results in increased expression of ATF4 protein]28988120
C045463leflunomideleflunomide results in increased expression of ATF4 protein28988120
C045463leflunomideMAPK1 protein affects the reaction [leflunomide results in increased expression of ATF4 protein]28988120
C045463leflunomideMAPK3 protein affects the reaction [leflunomide results in increased expression of ATF4 protein]28988120
C045463leflunomideleflunomide results in increased expression of ATF4 mRNA24136188
C052901lemongrass oillemongrass oil results in increased expression of ATF4 mRNA25458622
C002385linsidominelinsidomine results in increased expression of ATF4 mRNA21703327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ATF4 protein19675143
D008070Lipopolysaccharides4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 mRNA]28844859
D008070Lipopolysaccharides4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 protein]28844859
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 mRNA28844859
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of ATF4 protein28844859
D018021Lithium ChlorideLithium Chloride results in increased expression of ATF4 mRNA15711924
C025340manganese chloridemanganese chloride promotes the reaction [EIF2AK3 protein results in increased expression of ATF4 mRNA]23948121
C025340manganese chloridemanganese chloride results in increased expression of ATF4 mRNA23934647
C025340manganese chloridemanganese chloride results in increased expression of ATF4 protein23934647
C025340manganese chlorideSNCA protein promotes the reaction [manganese chloride results in increased expression of ATF4 mRNA]23934647
C520507manganese tetrakis-(N-methyl-2 pyridyl) porphyrinmanganese tetrakis-(N-methyl-2 pyridyl) porphyrin inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA]21703327
D008550MelatoninMelatonin inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]17645694
D008627Mercuric ChlorideMercuric Chloride results in increased expression of ATF4 protein16759985
D008628MercuryMercury results in increased expression of ATF4 protein16759985
D008687MetforminMetformin affects the activity of ATF4 protein25596134
D008694MethamphetamineATF4 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]27323860
D008694MethamphetamineATF4 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]27323860
D008694MethamphetamineATF4 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]27323860
D008694MethamphetamineATF4 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]27323860
D008694MethamphetamineEIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of ATF4 protein]27323860
D008694MethamphetamineMethamphetamine results in increased expression of ATF4 protein27323860
D008694MethamphetamineMethamphetamine results in increased expression of ATF4 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of ATF4 protein19564919
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF4 mRNA]19564919
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF4 protein]19564919
D008701MethapyrileneMethapyrilene results in increased expression of ATF4 mRNA17450226
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ATF4 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of ATF4 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of ATF4 mRNA21664453
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ATF4 mRNA24810058|2523447
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ATF4 protein24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ATF4 protein12486162
D016685MitomycinMitomycin results in increased expression of ATF4 mRNA12760830
D016685MitomycinMitomycin results in decreased expression of ATF4 mRNA25270620
C548887MK 2206MK 2206 inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]24057571
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of ATF4 mRNA22425709
D009151Mustard GasMustard Gas results in increased expression of ATF4 mRNA15674843
D009151Mustard GasMustard Gas affects the expression of ATF4 mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of ATF4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ATF4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ATF4 mRNA"25554681
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ATF4 mRNA27344345
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ATF4 mRNA20551477
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ATF4 mRNA19812364
C051752nefazodone"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [nefazodone results in increased expression of ATF4 protein]"27613715
C051752nefazodonenefazodone results in increased expression of ATF4 protein27613715
D019888NelfinavirNelfinavir results in increased expression of ATF4 protein22935518
D009534NiclosamideNiclosamide results in increased expression of ATF4 mRNA26917416
D009534NiclosamideNiclosamide results in increased expression of ATF4 protein26917416
C012655nimesulidenimesulide results in increased expression of ATF4 mRNA24136188
C041747nitazoxanidenitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]19664635
C041747nitazoxanidenitazoxanide results in increased expression of ATF4 protein19664635
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of ATF4 mRNA17616710
C063998nodularinnodularin results in increased expression of ATF4 mRNA27061667
C010615Nonidet P-40Nonidet P-40 results in increased expression of ATF4 mRNA26552463
C097760N-palmitoylsphingosineN-palmitoylsphingosine results in increased expression of ATF4 mRNA28223344
C097760N-palmitoylsphingosinetauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA]28223344
C570896NSC305787NSC305787 results in increased expression of ATF4 mRNA27137931
C570897NSC668394EZR protein affects the reaction [NSC668394 results in increased expression of ATF4 mRNA]27137931
C570897NSC668394NSC668394 results in increased expression of ATF4 mRNA27137931
C570897NSC668394NSC668394 results in increased expression of ATF4 mRNA27137931
D016627OxidopamineOxidopamine results in increased expression of ATF4 mRNA12486162
D016627OxidopamineOxidopamine results in increased expression of ATF4 protein12486162
C016340o,p'-DDT"o,p'-DDT results in increased expression of ATF4 mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in increased expression of ATF4 mRNA"24096037
C055122orlistatorlistat results in increased expression of ATF4 mRNA17283163
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ATF4 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of ATF4 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of ATF4 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ATF4 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ATF4 mRNA]17655762
D010098OxycodoneOxycodone results in increased expression of ATF4 protein26377394
D010098OxycodoneOxycodone results in increased expression of ATF4 protein26377394
D010100OxygenOxygen deficiency affects the activity of ATF4 protein25596134
D010100OxygenOxygen deficiency affects the stability of ATF4 protein14604972
D010100OxygenOxygen deficiency results in increased expression of ATF4 protein14604972
D010100OxygenOxygen results in decreased expression of ATF4 protein14604972
D010100OxygenOxygen results in increased expression of ATF4 mRNA27103661
D010269ParaquatParaquat results in increased expression of ATF4 mRNA21371552
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of ATF4 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of ATF4 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ATF4 mRNA]17655762
D052638Particulate MatterParticulate Matter results in increased expression of ATF4 mRNA21703343
D052638Particulate MatterParticulate Matter results in increased expression of ATF4 protein17922515|1967514
D052638Particulate Matter[APOE protein affects the susceptibility to [Dietary Fats co-treated with Particulate Matter]] which affects the expression of ATF4 mRNA17655762
C000610380p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane"p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in increased expression of ATF4 protein"26035713
C410127PCB 180PCB 180 results in decreased expression of ATF4 mRNA23829299
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ATF4 mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ATF4 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ATF4 mRNA19429403
D010634PhenobarbitalPhenobarbital affects the expression of ATF4 mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of ATF4 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of ATF4 mRNA16985257
D010894PiroxicamPiroxicam results in decreased expression of ATF4 mRNA21858171
D011094Polyethyleneimine[Polyethyleneimine binds to Gold] which results in decreased expression of ATF4 mRNA28433809
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ATF4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ATF4 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of ATF4 mRNA18037150
D011718Pyrazinamide4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]28063906
D011718PyrazinamidePyrazinamide results in increased expression of ATF4 mRNA28063906
D011718PyrazinamidePyrazinamide results in increased expression of ATF4 protein28063906
D011718Pyrazinamide4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased expression of ATF4 protein]28063906
D011718PyrazinamidePyrazinamide results in increased expression of ATF4 protein28063906
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of ATF4 mRNA]20920558
C031280pyrazolepyrazole results in increased expression of ATF4 mRNA17945193
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATF4 mRNA]15477007
C020972pyrrolidine dithiocarbamic acid[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of ATF4 mRNA20920558
C020972pyrrolidine dithiocarbamic acidpyrazolanthrone inhibits the reaction [[cupric chloride binds to pyrrolidine dithiocarbamic acid] which results in increased expression of ATF4 mRNA]20920558
D011794QuercetinQuercetin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]22115781
D011794QuercetinQuercetin results in increased expression of ATF4 protein25611565
D011794Quercetinsalubrinal promotes the reaction [Quercetin results in increased expression of ATF4 protein]25611565
D011794Quercetintauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased expression of ATF4 protein]25611565
D017382Reactive Oxygen Species[arsenic trioxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of ATF4 protein23892647
C059514resveratrolresveratrol inhibits the reaction [Ethanol results in increased expression of ATF4 protein]24224909
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of ATF4 protein]26055348
D012172RetinaldehydeRetinaldehyde results in increased expression of ATF4 mRNA25331497
D012293Rifampin4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 mRNA]27470132
D012293Rifampin4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of ATF4 protein]27470132
D012293RifampinRifampin results in increased expression of ATF4 mRNA27470132
D012293RifampinRifampin results in increased expression of ATF4 protein27470132
D012293RifampinATF4 mutant form inhibits the reaction [Rifampin results in increased expression of HSPA5 protein]24638036
D012293RifampinRifampin results in increased expression of ATF4 protein24638036
D012402RotenoneMIR384 mRNA promotes the reaction [Rotenone results in increased phosphorylation of ATF4 protein]26864693
D012402RotenoneRotenone results in increased expression of ATF4 mRNA19233273|2481005
D012402RotenoneRotenone results in increased expression of ATF4 protein19233273
D012402RotenoneRotenone results in increased phosphorylation of ATF4 protein26864693
D012402RotenoneRotenone results in increased expression of ATF4 mRNA23186747
D012402RotenoneRotenone results in increased expression of ATF4 protein12486162
C496827salubrinal[salubrinal co-treated with EPO protein] results in decreased expression of ATF4 protein23690448
C496827salubrinal"salubrinal inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATF4 protein]"25950987
C496827salubrinalsalubrinal promotes the reaction [Quercetin results in increased expression of ATF4 protein]25611565
C496827salubrinalsalubrinal results in increased expression of ATF4 protein21809093|2369044
C496827salubrinalsalubrinal promotes the reaction [Cisplatin results in increased expression of ATF4 protein]21616140
C496827salubrinalsalubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein]28844859
C496827salubrinalsalubrinal promotes the reaction [Tunicamycin results in increased expression of ATF4 protein]28844859
C417521SB 216763SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]24057571
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF4 mRNA]19564919
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF4 protein]19564919
D012643SeleniumSelenium inhibits the reaction [Cadmium results in increased expression of ATF4]25805271
D012643SeleniumSelenium results in increased expression of ATF4 mRNA19244175
D020280SertralineSertraline results in increased expression of ATF4 protein24865413
D020123SirolimusSirolimus inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]24057571
D012906SmokeSmoke results in increased expression of ATF4 protein18206657
C009277sodium arsenatesodium arsenate analog results in increased expression of ATF4 mRNA23221991
C017947sodium arseniteAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]15788408
C017947sodium arseniteAPEX1 inhibits the reaction [[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of HPRT1 gene]17938202
C017947sodium arseniteAPEX1 inhibits the reaction [[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of TK1 gene]17938202
C017947sodium arseniteATF4 mutant form inhibits the reaction [sodium arsenite results in increased expression of APEX1 protein]17938202
C017947sodium arseniteATF4 mutant form results in increased susceptibility to sodium arsenite17938202
C017947sodium arsenite[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of HPRT1 gene17938202
C017947sodium arsenite[ATF4 mutant form results in increased susceptibility to sodium arsenite] which results in increased mutagenesis of TK1 gene17938202
C017947sodium arseniteATF4 protein affects the reaction [sodium arsenite results in increased expression of VEGFA mRNA]15788408
C017947sodium arsenite[sodium arsenite co-treated with ATF4 protein] results in increased expression of VEGFA mRNA15788408
C017947sodium arsenitesodium arsenite promotes the reaction [ATF4 protein binds to VEGFA promoter]15788408
C017947sodium arsenitesodium arsenite results in increased expression of and results in increased activity of ATF4 protein15788408
C017947sodium arsenitesodium arsenite results in increased expression of ATF4 mRNA12760830
C017947sodium arseniteATF4 affects the susceptibility to sodium arsenite17938202
C017947sodium arseniteATF4 mutant form inhibits the reaction [sodium arsenite results in increased expression of APEX1 protein]17938202
C017947sodium arseniteEIF2S1 protein mutant form inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]16330322
C017947sodium arsenitesodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]17938202
C017947sodium arsenite[sodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]] which binds to APEX1 promoter17938202
C017947sodium arsenite[[sodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]] which binds to APEX1 promoter] which results in increased expression of APEX1 mRNA17938202
C017947sodium arsenite[sodium arsenite promotes the reaction [JUN protein binds to ATF4 protein]] which results in increased expression of APEX1 mRNA17938202
C017947sodium arsenitesodium arsenite results in increased expression of ATF4 mRNA16014739|2322199
C017947sodium arsenitesodium arsenite results in increased expression of ATF4 protein12606582|1633032
C017947sodium arseniteMelatonin inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]17645694
C017947sodium arsenitesodium arsenite results in increased expression of ATF4 protein17645694|1768157
C016104sodium bichromatesodium bichromate results in increased expression of ATF4 mRNA12760830
C016104sodium bichromatesodium bichromate results in increased expression of ATF4 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of ATF4 mRNA22561333
D012969Sodium FluorideSodium Fluoride results in decreased expression of ATF4 mRNA25132241
D012999SomanSoman results in increased expression of ATF4 mRNA19281266
C471405sorafenibsorafenib promotes the reaction [ATF4 protein results in increased expression of DDIT4 protein]21601561
C471405sorafenibsorafenib results in increased expression of ATF4 mRNA21601561
C471405sorafenibsorafenib results in increased expression of ATF4 protein21601561
C471405sorafenib[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT3 mRNA21601561
C471405sorafenib[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT3 protein21601561
C471405sorafenib[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein21601561
C471405sorafenib[[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein21601561
C471405sorafenib[[[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein] which results in decreased expression of BIRC5 protein21601561
C559087SR 1078SR 1078 results in increased expression of ATF4 mRNA28698385
C559087SR 1078SR 1078 results in increased phosphorylation of ATF4 protein28698385
D013311StreptozocinStreptozocin results in increased expression of ATF4 protein24967692
D013311Streptozocinsulforafan inhibits the reaction [Streptozocin results in increased expression of ATF4 protein]24967692
C016766sulforafansulforafan inhibits the reaction [Streptozocin results in increased expression of ATF4 protein]24967692
D013467SulindacSulindac results in increased expression of ATF4 mRNA11906190
D016559TacrolimusTacrolimus results in increased expression of ATF4 mRNA23958496
D013629TamoxifenTamoxifen affects the expression of ATF4 mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of ATF4 mRNA19400957
D013629TamoxifenTamoxifen results in increased expression of ATF4 mRNA19400957
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased expression of ATF4 protein]25611565
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of ATF4 mRNA24312631
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA]28223344
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide results in increased expression of ATF4 mRNA19208803
C000591600tetrachlorobenzoquinone4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]27484784
C000591600tetrachlorobenzoquinoneAcetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]27484784
C000591600tetrachlorobenzoquinoneATF4 protein promotes the reaction [tetrachlorobenzoquinone results in increased expression of ATF3 protein]27484784
C000591600tetrachlorobenzoquinoneATF4 protein promotes the reaction [tetrachlorobenzoquinone results in increased expression of DDIT3 protein]27484784
C000591600tetrachlorobenzoquinoneATF4 protein promotes the reaction [tetrachlorobenzoquinone results in increased expression of TNFRSF10B protein]27484784
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of ATF4 mRNA28823167
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of ATF4 protein27484784
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATF4 mRNA22574217
D013749Tetrachlorodibenzodioxinfulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ATF4 mRNA]16467188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATF4 mRNA21570461|2405805
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATF4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ATF4 mRNA16467188|1794274
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATF4 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATF4 mRNA15477007
D019284ThapsigarginATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA]20022965
D019284ThapsigarginATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 protein]20022965
D019284ThapsigarginATF4 results in decreased susceptibility to Thapsigargin20022965
D019284ThapsigarginDactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]20022965
D019284ThapsigarginDactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]20022965
D019284ThapsigarginDoxorubicin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]16298333
D019284ThapsigarginNUPR1 mutant form promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]20022965
D019284ThapsigarginThapsigargin promotes the reaction [ATF4 protein binds to PMAIP1 promoter]20022965
D019284ThapsigarginThapsigargin results in increased activity of ATF4 protein23383089
D019284ThapsigarginThapsigargin results in increased expression of ATF4 mRNA16298333|1728316
D019284ThapsigarginThapsigargin results in increased expression of ATF4 protein16298333|2002296
D019284ThapsigarginATF4 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]24648495
D019284ThapsigarginThapsigargin results in increased expression of ATF4 mRNA24648495|2722663
D019284ThapsigarginThapsigargin results in increased expression of ATF4 protein20589738|2464849
D019284Thapsigargin4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]28844859
D019284Thapsigarginsalubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein]28844859
D019284ThapsigarginThapsigargin results in increased expression of ATF4 protein28844859
D008063Thioctic AcidThioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]23892647
D008063Thioctic AcidThioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]23892647
C009495titanium dioxidetitanium dioxide results in increased expression of ATF4 mRNA27760801
D014028Tobacco Smoke Pollution"1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA]"21703327
D014028Tobacco Smoke PollutionAcetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein]25568320
D014028Tobacco Smoke Pollutionmanganese tetrakis-(N-methyl-2 pyridyl) porphyrin inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA]21703327
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased expression of ATF4 mRNA21703327
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in increased expression of ATF4 protein25568320
D014028Tobacco Smoke Pollutiontrimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein]25568320
D014028Tobacco Smoke PollutionUric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA]21703327
D014212TretinoinTretinoin results in increased expression of ATF4 mRNA22498432
D014212TretinoinTretinoin results in increased expression of ATF4 protein22498432
C005855trimethyloxaminetrimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein]25568320
C001899triptolidetriptolide results in decreased expression of ATF4 mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF4 protein]"27816613
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF4 mRNA"26179874
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF4 protein"27816613
C057693troglitazonetroglitazone results in decreased expression of ATF4 mRNA28973697
C005865troxerutin"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ATF4 protein]]"25639565
C005865troxerutin"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ATF4 protein]"25639565
D014415TunicamycinATF4 protein affects the reaction [[Tunicamycin co-treated with APP protein modified form] results in increased expression of PSEN1 mRNA]22115781
D014415TunicamycinQuercetin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]22115781
D014415TunicamycinTunicamycin results in increased expression of ATF4 mRNA22378314|2431263
D014415TunicamycinTunicamycin results in increased expression of ATF4 protein14604972|2211578
D014415TunicamycinTunicamycin results in increased phosphorylation of ATF4 protein22959463
D014415Tunicamycin"1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of ATF4 mRNA]"22959925
D014415TunicamycinEIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of ATF4 mRNA]24648495
D014415TunicamycinEIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]24648495
D014415TunicamycinTunicamycin results in increased expression of ATF4 mRNA22001960|2295992
D014415TunicamycinTunicamycin results in increased expression of ATF4 protein24648495
D014415Tunicamycin4-phenylbutyric acid inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]28844859
D014415Tunicamycinsalubrinal promotes the reaction [Tunicamycin results in increased expression of ATF4 protein]28844859
D014415TunicamycinTunicamycin results in increased expression of ATF4 mRNA24291486|2489255
D014415TunicamycinTunicamycin results in increased expression of ATF4 protein24892553|2884485
D014520UrethaneUrethane results in increased expression of ATF4 mRNA28818685
D014527Uric AcidUric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA]21703327
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of ATF4 mRNA24312631
C073339usnic acid2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ATF4 protein]25870318
C073339usnic acidusnic acid results in increased expression of ATF4 protein25870318
D014635Valproic AcidValproic Acid results in decreased expression of ATF4 mRNA20546886
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of ATF4 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of ATF4 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of ATF4 mRNA25620054
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ATF4 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in increased expression of ATF4 protein17922515
C009684withaferin AAcetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein]21266191
C009684withaferin Awithaferin A results in increased expression of ATF4 protein21266191
C029659zearalenolzearalenol results in increased expression of ATF4 protein26584763
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ATF4 mRNA18593933
C016837zinc chloridezinc chloride results in decreased expression of ATF4 mRNA18947441
C088658zoledronic acidzoledronic acid results in decreased expression of ATF4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IC21113145  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA11478948  12871976  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001076transcription factor activity, RNA polymerase II transcription factor binding-IC12871976  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001085RNA polymerase II transcription factor binding-IPI11478948  
GO:0003677DNA binding-IDA15788408  18940792  
GO:0003677DNA binding-ISS-  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0003700DNA-binding transcription factor activity-TAS12689582  
GO:0005515protein binding-IPI9488481  11238952  12743605  12812986  12860379  15677469  
16169070  16189514  16343488  16682973  18330356  18940792  
19164757  19447967  20102225  20936779  21408167  21988832  
25241761  25416956  25910212  26700459  26871637  27107014  
GO:0008022protein C-terminus binding-IEA-  
GO:0019901protein kinase binding-IPI20873783  
GO:0043522leucine zipper domain binding-IDA11478948  
GO:0043565sequence-specific DNA binding-IDA22915762  
GO:0044212transcription regulatory region DNA binding-IDA21113145  
GO:0044212transcription regulatory region DNA bindingcontributes_toIDA12871976  
GO:0044212transcription regulatory region DNA binding-TAS23392669  
GO:0046982protein heterodimerization activity-NAS15775988  
GO ID GO Term Qualifier Evidence PubMed
GO:0006094gluconeogenesis-ISS-  
GO:0006355regulation of transcription, DNA-templated-ISS-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-ISS-  
GO:0006520cellular amino acid metabolic process-TAS12689582  
GO:0007214gamma-aminobutyric acid signaling pathway-IEA-  
GO:0009636response to toxic substance-IEA-  
GO:0010575positive regulation of vascular endothelial growth factor production-IMP22915762  
GO:0010628positive regulation of gene expression-IMP24136195  24939851  
GO:0030182neuron differentiation-IEA-  
GO:0032057negative regulation of translational initiation in response to stress-ISS-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0034198cellular response to amino acid starvation-ISS-  
GO:0034644cellular response to UV-ISS-  
GO:0034976response to endoplasmic reticulum stress-IDA19061639  
GO:0034976response to endoplasmic reticulum stress-IMP24939851  
GO:0036003positive regulation of transcription from RNA polymerase II promoter in response to stress-IC25681212  
GO:0036091positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress-IBA21873635  
GO:0036091positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress-IMP21113145  
GO:0036091positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress-ISS23392669  
GO:0036499PERK-mediated unfolded protein response-TAS22013210  22934019  
GO:0042149cellular response to glucose starvation-IMP22915762  
GO:0042789mRNA transcription by RNA polymerase II-ISS-  
GO:0043065positive regulation of apoptotic process-IBA21873635  
GO:0043065positive regulation of apoptotic process-TAS23392669  
GO:0043267negative regulation of potassium ion transport-IEA-  
GO:0043525positive regulation of neuron apoptotic process-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA15775988  18940792  
GO:0045893positive regulation of transcription, DNA-templated-IMP11960987  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-NAS9190894  
GO:0045943positive regulation of transcription by RNA polymerase I-IMP22915762  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA11478948  15775988  18940792  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP15788408  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0061395positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance-TAS14685163  
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-ISS-  
GO:0090650cellular response to oxygen-glucose deprivation-IEA-  
GO:1902237positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IEA-  
GO:1903204negative regulation of oxidative stress-induced neuron death-IGI23392669  
GO:1903351cellular response to dopamine-IMP24136195  
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress-IBA21873635  
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress-IDA12871976  
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress-IMP21113145  
GO:1990737response to manganese-induced endoplasmic reticulum stress-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11478948  16682973  23392669  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA23392669  
GO:0005737cytoplasm-ISS-  
GO:0005813centrosomecolocalizes_withIDA20873783  
GO:0032590dendrite membrane-IEA-  
GO:0032991protein-containing complex-IDA20873783  
GO:0034399nuclear periphery-IDA23392669  
GO:0043005neuron projection-IDA23392669  
GO:1990037Lewy body core-IDA23392669  
GO:1990589ATF4-CREB1 transcription factor complex-IDA12871976  
GO:1990590ATF1-ATF4 transcription factor complex-IDA12871976  
GO:1990617CHOP-ATF4 complex-IDA11478948  
GO:1990617CHOP-ATF4 complex-IPI18940792  
GO:1990617CHOP-ATF4 complex-NAS15775988  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04141Protein processing in endoplasmic reticulum
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04912GnRH signaling pathway
hsa05215Prostate cancer
Reactome ID Reactome Term Evidence
R-HSA-380994ATF4 activates genesTAS
R-HSA-381033ATF6 (ATF6-alpha) activates chaperonesTAS
R-HSA-381042PERK regulates gene expressionTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-381183ATF6 (ATF6-alpha) activates chaperone genesTAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28070146Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure. (2016)Geraghty PMediators Inflamm
29515441Autophagy Flux Contributes to Regulation of Components of Eclipta prostrata L. on Cigarette Smoking-Induced Injury of Bronchial Epithelial Cells. (2018)Ding SFront Pharmacol
21697995Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process. (2011)Geraghty PInt J Chron Obstruct Pulmon Dis
26860188Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis. (2016 Feb 9)Liao KJ Neuroinflammation
18079489Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach. (2008 May)Kelsen SGAm J Respir Cell Mol Biol
17056606Cigarette smoke-induced differential gene expression in blood cells from monozygotic twin pairs. (2007 Mar)van Leeuwen DMCarcinogenesis