Gene: CEACAM6

4680
CD66c|CEAL|NCA
carcinoembryonic antigen related cell adhesion molecule 6
protein-coding
19q13.2
Ensembl:ENSG00000086548 MIM:163980 Vega:OTTHUMG00000151064 UniprotKB:P40199
NC_000019.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.276e-1 (AD)  3.281e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2701chr19:41771194 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22676000chr19:42259081CEACAM6Promoter5.722e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BPI0.674
KRT730.66
SCNN1A0.64
CXCL170.628
DPPA40.625
SLAMF70.624
IL2RB0.623
CLEC12A0.617
UPK1B0.615
NCCRP10.614

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNC2-0.416
TMEM221-0.403
C16orf46-0.399
MAGIX-0.397
GNG13-0.397
GGH-0.39
RAC3-0.386
GALNT9-0.383
RHEBL1-0.382
C3orf80-0.376

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0415071-methylphenanthrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CEACAM6 mRNA17690111
D001151ArsenicArsenic affects the expression of CEACAM6 mRNA28793237
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of CEACAM6 mRNA28793237
C406592azaspiracidazaspiracid results in increased expression of CEACAM6 mRNA28939011
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of CEACAM6 mRNA17690111
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CEACAM6 mRNA"17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CEACAM6 mRNA18061397
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CEACAM6 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of CEACAM6 mRNA25321415
D004958EstradiolEstradiol results in increased expression of CEACAM6 mRNA19619570
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of CEACAM6 mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of CEACAM6 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEACAM6 mRNA16997883
C018475butyraldehydebutyraldehyde results in decreased expression of CEACAM6 mRNA26079696
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of CEACAM6 mRNA28793237
C018021cobaltous chloridecobaltous chloride results in decreased expression of CEACAM6 mRNA19376846
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of CEACAM6 mRNA26033743
D003300CopperCopper deficiency results in increased expression of CEACAM6 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of CEACAM6 mRNA27523638
C014347decitabinedecitabine results in increased expression of CEACAM6 mRNA18845559
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEACAM6 mRNA16997883
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of CEACAM6 mRNA"17690111
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of CEACAM6 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of CEACAM6 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of CEACAM6 mRNA14996990|2648566
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in increased expression of CEACAM6 mRNA"18061397
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEACAM6 mRNA16997883
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CEACAM6 mRNA26752646
D008727MethotrexateMethotrexate results in increased expression of CEACAM6 mRNA17400583
D009532NickelNickel results in decreased expression of CEACAM6 mRNA25583101
C558013NSC 689534NSC 689534 results in increased expression of CEACAM6 mRNA20971185
D010936Plant ExtractsPlant Extracts results in increased expression of CEACAM6 mRNA18061397
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of CEACAM6 mRNA17404688
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of CEACAM6 mRNA"21152443
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CEACAM6 mRNA25895662
C061133tamibaroteneCSF3 protein promotes the reaction [tamibarotene results in increased expression of CEACAM6 mRNA]27737899
C061133tamibarotenetamibarotene inhibits the reaction [CSF3 protein results in decreased expression of CEACAM6 mRNA]27737899
C061133tamibarotenetamibarotene promotes the reaction [CSF3 protein results in increased expression of CEACAM6 mRNA]27737899
C061133tamibarotenetamibarotene results in increased expression of CEACAM6 mRNA27737899
C021751tanshinonetanshinone results in decreased expression of CEACAM6 mRNA15849732
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CEACAM6 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CEACAM6 mRNA18061397|1961957
D014212TretinoinTretinoin results in increased expression of CEACAM6 mRNA23830798
C025643vinclozolinvinclozolin results in increased expression of CEACAM6 mRNA23034163
C016837zinc chloridezinc chloride results in increased expression of CEACAM6 mRNA18947441
C088658zoledronic acidzoledronic acid results in increased expression of CEACAM6 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21982860  
GO:0042802identical protein binding-IDA26483485  
GO:0042802identical protein binding-IPI21982860  
GO:0046982protein heterodimerization activity-IDA26483485  
GO ID GO Term Qualifier Evidence PubMed
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IMP2803308  11590190  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IMP2803308  8776764  11590190  
GO:0007165signal transduction-IMP14724575  
GO:0008284positive regulation of cell proliferation-IMP25171863  
GO:0030335positive regulation of cell migration-IMP16204051  25171863  
GO:0034116positive regulation of heterotypic cell-cell adhesion-IMP16204051  
GO:0043312neutrophil degranulation-TAS-  
GO:0050900leukocyte migration-TAS-  
GO:1904906positive regulation of endothelial cell-matrix adhesion via fibronectin-IMP16204051  
GO:2000811negative regulation of anoikis-IMP10910050  14724575  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA25645918  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IC2803308  
GO:0009986cell surface-IDA2317824  8776764  16204051  
GO:0016324apical plasma membrane-IDA10436421  
GO:0031225anchored component of membrane-IDA2317824  
GO:0035577azurophil granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1566977Fibronectin matrix formationTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (2011 May)Kendler KSAlcohol Clin Exp Res
23941132Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons. (2013 Aug 14)Klaile ERespir Res