Gene: NCAM1

4684
CD56|MSK39|NCAM
neural cell adhesion molecule 1
protein-coding
11q23.2
Ensembl:ENSG00000149294 MIM:116930 Vega:OTTHUMG00000167196 UniprotKB:P13591
NG_032036.1
PubMed|SNP Mapped
2   ANCO-SNPs
CD|OD|ND|AD
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.035e-2 (AD)  8.086e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2288158chr11:113262954 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs28463004chr11:113156036 (GRCh38.p7)A>Gcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20857767chr11:113147175NCAM13'UTR6.604e-4Alcohol use disorders26763658
cg20268522chr11:112832152NCAM12.700e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNAO10.931
FAM171A10.929
GRID10.916
TRPC4AP0.915
POMGNT10.915
BSDC10.913
ATG130.911
CKAP50.909
ARL8A0.907
CORO2B0.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.711
OR4F29-0.673
SIX1-0.421
TFPI2-0.406
TBX21-0.382
KLRB1-0.381
C2orf83-0.379
SLAMF6-0.378
FMO1-0.378
FOXL1-0.374

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0365351,6-bis(cyclohexyloximinocarbonyl)hexane"1,6-bis(cyclohexyloximinocarbonyl)hexane inhibits the reaction [NCAM1 protein results in increased phosphorylation of GAP43 protein]"9852580
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of NCAM1 protein"21673325
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in increased expression of NCAM1 mRNA"21436126
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in increased expression of NCAM1 protein"21436126
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NCAM1 mRNA"21436126
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of NCAM1 protein"21436126
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of NCAM1 mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NCAM1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCAM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCAM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCAM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCAM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCAM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCAM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCAM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCAM1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of NCAM1 mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of NCAM1 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of NCAM1 mRNA20708675
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid affects the localization of NCAM1 protein modified form17845906
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in decreased expression of NCAM1 protein modified form17845906
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NCAM1 mRNA16483693
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of NCAM1 mRNA18585445
D001151ArsenicArsenic affects the expression of NCAM1 mRNA18414638
D001151ArsenicArsenic affects the expression of NCAM1 protein24675094
C030693AshwagandhaAshwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 mRNA]24987671
C030693AshwagandhaAshwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 protein]24987671
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of NCAM1 mRNA18585445
D001374AzacitidineAzacitidine results in increased expression of NCAM1 mRNA18037191
C547126AZM551248AZM551248 results in decreased expression of NCAM1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NCAM1 mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NCAM1 mRNA22228805
D004958EstradiolEstradiol results in increased expression of NCAM1 mRNA22411564
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased expression of NCAM1 mRNA]22411564
D004958EstradiolEstradiol results in decreased expression of NCAM1 mRNA14664709
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of NCAM1 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of NCAM1 mRNA21179406
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of NCAM1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of NCAM1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NCAM1 gene28505145
C053342brevetoxinbrevetoxin analog results in increased expression of NCAM1 mRNA14529743
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NCAM1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of NCAM1 mRNA26079696
D002104CadmiumCadmium results in decreased expression of NCAM1 mRNA21694771
D002104CadmiumCadmium results in increased expression of NCAM1 mRNA22666406
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NCAM1 mRNA18308070
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NCAM1 mRNA20360939
D002166CamptothecinNCAM1 mRNA results in decreased susceptibility to Camptothecin25269479
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NCAM1 mRNA17484886
C084597chlorcyclizinechlorcyclizine results in decreased expression of NCAM1 mRNA21058326
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCAM1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of NCAM1 mRNA26272509
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NCAM1 mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of NCAM120938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NCAM1 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NCAM1 mRNA20938992
D003474CurcuminCurcumin results in increased expression of NCAM1 protein modified form19161989
C017160cypermethrincypermethrin results in decreased expression of NCAM1 mRNA22528246
D013759DronabinolDronabinol results in increased expression of NCAM1 mRNA11015613
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NCAM1 mRNA20360939
D004221DisulfiramDisulfiram results in decreased expression of NCAM1 mRNA20530235
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NCAM1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NCAM1 mRNA17942748
C004912ethylbenzeneethylbenzene results in decreased expression of NCAM1 mRNA20955722
D005419FlavonoidsFlavonoids results in decreased expression of NCAM1 mRNA18035473
D005473FluoxetineFluoxetine results in increased expression of NCAM1 mRNA21852994
D005492Folic AcidFolic Acid affects the expression of NCAM1 mRNA16361273
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of NCAM120938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NCAM1 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NCAM1 mRNA20938992
D004397FonofosFonofos results in increased methylation of NCAM1 promoter22847954
C039281furanfuran results in increased expression of NCAM1 mRNA27387713
D019833GenisteinGenistein results in decreased expression of NCAM1 mRNA21048042
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of NCAM1 mRNA22467014
D017313FenretinideFenretinide results in increased expression of NCAM1 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NCAM1 mRNA26644586
D007608Kainic AcidKainic Acid results in decreased expression of NCAM1 mRNA19700661
D007854LeadLead results in decreased expression of NCAM1 protein21182862
D007854LeadLead results in decreased expression of NCAM1 protein alternative form21182862
D007854LeadLead results in decreased expression of NCAM1 protein21182862
D007854LeadLead results in decreased expression of NCAM1 protein alternative form21182862
C008261lead acetatelead acetate results in increased expression of NCAM1 protein modified form10814846
C029891lead chloridelead chloride results in decreased expression of NCAM1 mRNA18499259
C029891lead chloridelead chloride results in decreased expression of NCAM1 protein18499259
C029891lead chloridelead chloride results in decreased expression of NCAM1 protein modified form18499259
C017461lead nitrateAshwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 mRNA]24987671
C017461lead nitrateAshwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 protein]24987671
C017461lead nitratelead nitrate results in decreased expression of NCAM1 mRNA24987671
C017461lead nitratelead nitrate results in decreased expression of NCAM1 protein24987671
C042720mercuric bromidemercuric bromide results in decreased expression of NCAM1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NCAM1 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of NCAM120938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NCAM1 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NCAM1 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of NCAM1 mRNA20713471
D008752Methylene ChlorideMethylene Chloride results in decreased expression of NCAM1 mRNA20955722
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NCAM1 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of NCAM1 mRNA19150642
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]"23933227
D009020MorphineMorphine results in decreased expression of NCAM1 protein modified form15673448
D009532NickelNickel results in decreased expression of NCAM1 mRNA24768652
C022838nickel chloridenickel chloride promotes the reaction [Tretinoin results in increased expression of NCAM1 mRNA]25614230
C022838nickel chloridenickel chloride promotes the reaction [Tretinoin results in increased expression of NCAM1 protein]25614230
D009538Nicotine"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]"23933227
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]"23933227
D005996NitroglycerinNitroglycerin results in increased expression of NCAM1 mRNA12102619
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of NCAM1 mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NCAM1 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NCAM1 mRNA]"21673326
D010100OxygenOxygen deficiency results in increased expression of NCAM1 mRNA20880076
D010278ParathionParathion results in increased methylation of NCAM1 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of NCAM1 mRNA27294297
C076994perfluorooctane sulfonic acid"[2,2',4,4'-tetrabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in increased expression of NCAM1 mRNA"21436126
C076994perfluorooctane sulfonic acid"[2,2',4,4'-tetrabromodiphenyl ether co-treated with perfluorooctane sulfonic acid] results in increased expression of NCAM1 protein"21436126
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NCAM1 protein25524167
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of NCAM1 mRNA21436126|2552416
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of NCAM1 protein21436126
D010643PhenoxybenzaminePhenoxybenzamine affects the localization of NCAM1 protein modified form17845906
D010643PhenoxybenzaminePhenoxybenzamine results in decreased expression of NCAM1 protein modified form17845906
D010795Phthalic AcidsPhthalic Acids results in decreased expression of NCAM1 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of NCAM1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of NCAM1 mRNA20813756
C043435polylactic acid-polyglycolic acid copolymer"[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]"23933227
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased expression of NCAM1 mRNA]22411564
D011441PropylthiouracilPropylthiouracil results in increased expression of NCAM1 mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of NCAM1 mRNA23274088
C017947sodium arsenitesodium arsenite results in increased expression of NCAM1 mRNA25493608
C017947sodium arsenitesodium arsenite results in increased expression of NCAM1 mRNA23137061|2381114
C017947sodium arsenitesodium arsenite results in increased expression of NCAM1 protein23811142
C017947sodium arsenitesodium arsenite results in increased expression of NCAM1 protein modified form23811142
D018038Sodium SeleniteSodium Selenite results in decreased expression of NCAM1 mRNA23274088
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of NCAM1 mRNA22467014
D013629TamoxifenTamoxifen affects the expression of NCAM1 mRNA17555576
C012568terbufosterbufos results in increased methylation of NCAM1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NCAM1 mRNA16962184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NCAM1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NCAM1 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NCAM1 mRNA21167638
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of NCAM1 mRNA21602191
D013849ThimerosalThimerosal results in decreased expression of NCAM1 mRNA27188386
D014118Toxins, Biological"Toxins, Biological affects the expression of NCAM1 mRNA"19682533
D014212Tretinoinnickel chloride promotes the reaction [Tretinoin results in increased expression of NCAM1 mRNA]25614230
D014212Tretinoinnickel chloride promotes the reaction [Tretinoin results in increased expression of NCAM1 protein]25614230
D014212TretinoinTretinoin results in increased expression of NCAM1 mRNA25614230
D014212TretinoinTretinoin results in increased expression of NCAM1 protein25614230
D014241TrichloroethyleneTrichloroethylene results in decreased expression of NCAM1 mRNA20955722
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCAM1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of NCAM1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCAM1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NCAM1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NCAM1 mRNA19101580|2317975
D014638VanadatesVanadates results in decreased expression of NCAM1 mRNA22714537
C111237vorinostatvorinostat results in decreased expression of NCAM1 mRNA27188386
D015034Zinc OxideZinc Oxide analog results in decreased expression of NCAM1 mRNA27215404
D015034Zinc OxideZinc Oxide analog results in decreased expression of NCAM1 protein27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0007155cell adhesion-IEA-  
GO:0007411axon guidance-TAS-  
GO:0046718viral entry into host cell-IEA-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0071679commissural neuron axon guidance-ISS-  
GO:2001260regulation of semaphorin-plexin signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IDA17213291  
GO:0009986cell surface-IDA10766765  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
GO:0031225anchored component of membrane-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa05020Prion diseases
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-3000178ECM proteoglycansIEA
R-HSA-373760L1CAM interactionsTAS
R-HSA-375165NCAM signaling for neurite out-growthTAS
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-419037NCAM1 interactionsIEA
R-HSA-419037NCAM1 interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-445144Signal transduction by L1TAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18828801Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. (2008 Dec)Yang BZAlcohol Clin Exp Res
21663922Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium. (2011 Aug 15)McGuire VJ Neurol Sci
27023175Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. (2016 Mar 29)Stringer STransl Psychiatry
26410615An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans. (2015 Nov)Bidwell LCPharmacol Biochem Behav
22924764Array-based profiling of DNA methylation changes associated with alcohol dependence. (2013 Jan)Zhang HAlcohol Clin Exp Res
25273375NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. (2015 Apr)Bidwell LCPsychopharmacology (Berl)
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. (2012 Aug 1)Wang KSDrug Alcohol Depend
23303482ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. (2013 Mar)Nelson ECJAMA Psychiatry
19796663Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients. (2010 Feb 1)Lucht MProg Neuropsychopharmacol Biol Psychiatry
26423011Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015 Oct)Wain LVLancet Respir Med
17085484Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. (2006 Dec 15)Gelernter JHum Mol Genet
17761687Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. (2007 Dec 1)Yang BZHum Mol Genet