Gene: NCF2

4688
NCF-2|NOXA2|P67-PHOX|P67PHOX
neutrophil cytosolic factor 2
protein-coding
1q25.3
Ensembl:ENSG00000116701 MIM:608515 Vega:OTTHUMG00000035329 UniprotKB:P19878
NG_007267.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.263e-2 (AD)  1.244e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LCP10.908
CCR10.905
CYTH40.896
SASH30.892
SPI10.89
LILRA20.889
ALOX5AP0.888
PTPN60.887
SAMSN10.886
PTPRC0.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.47
MAGIX-0.463
DLK2-0.453
TMEM179-0.45
WNT7A-0.443
ZNF835-0.439
EXTL1-0.433
RTN4R-0.433
NEUROD6-0.431
SLC7A4-0.429

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00514DextromethorphanSmall Molecule125-71-3ApprovedTarget
ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of NCF2 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of NCF2 mRNA]"27071940
C5214061-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA]20723002
C5214061-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein]20723002
C0261142-xylene2-xylene results in increased expression of NCF2 mRNA20359517
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of NCF2 protein]]"26054749
D000082AcetaminophenAcetaminophen results in increased expression of NCF2 mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of NCF2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NCF2 mRNA]17585979
C056165acetovanilloneacetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein]16380530
C056165acetovanilloneacetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NCF2 mRNA]24080574
C056165acetovanilloneacetovanillone inhibits the reaction [IL1B protein affects the localization of NCF2 protein]19375465
C056165acetovanilloneacetovanillone inhibits the reaction [NCF1 protein binds to NCF2 protein]22431579
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein]21195169
D000111AcetylcysteineAcetylcysteine results in decreased expression of NCF2 protein21195169
D000171AcroleinAcrolein inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NCF2 protein]11246141
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NCF2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NCF2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NCF2 mRNA23630614
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein]21195169
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of NCF2 mRNA"23195993
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of NCF2 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NCF2 mRNA24449571
D016718Arachidonic AcidArachidonic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein]12101222
C050510arsenic trichloridearsenic trichloride results in increased expression of NCF2 protein21854796
C006632arsenic trioxidearsenic trioxide affects the localization of NCF2 protein18424721|2253202
C006632arsenic trioxidearsenic trioxide results in increased expression of NCF2 mRNA22532027
C006632arsenic trioxidearsenic trioxide results in increased expression of NCF2 protein15070760|2253202
C006632arsenic trioxideNCF2 mutant form inhibits the reaction [arsenic trioxide results in increased abundance of Reactive Oxygen Species]22532027
C006632arsenic trioxideNCF2 mutant form inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]22532027
C006632arsenic trioxideNCF2 mutant form inhibits the reaction [arsenic trioxide results in increased phosphorylation of EGFR protein]22532027
C006632arsenic trioxidearsenic trioxide results in increased expression of NCF2 protein27638049
C006632arsenic trioxideATF4 protein promotes the reaction [arsenic trioxide results in increased expression of NCF2 protein]27638049
C015001arsenitearsenite results in increased expression of NCF2 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in increased expression of NCF2 mRNA]18929588
D001241AspirinAspirin inhibits the reaction [AGT protein modified form results in increased expression of NCF2 mRNA]22306536
D001280AtrazineAtrazine results in decreased expression of NCF2 mRNA22982499
D001379AzathioprineAzathioprine results in increased expression of NCF2 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of NCF2 mRNA22323515
D001554BenzeneBenzene results in increased expression of NCF2 mRNA20359517
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NCF2 mRNA20106945|2163298
D004958EstradiolEstradiol affects the expression of NCF2 mRNA14699072
D004958EstradiolEstradiol results in increased expression of NCF2 mRNA20106945
D004958EstradiolEstradiol affects the expression of NCF2 mRNA16195479
D004958EstradiolEstradiol inhibits the reaction [Progesterone results in increased expression of NCF2 mRNA]16195479
D004958Estradiol[Medroxyprogesterone Acetate co-treated with Estradiol] results in increased expression of NCF2 protein21670166
C006780bisphenol Abisphenol A affects the expression of NCF2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of NCF2 mRNA14555285
C006780bisphenol Abisphenol A results in decreased expression of NCF2 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of NCF2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NCF2 mRNA25181051
C086539BQ 788BQ 788 inhibits the reaction [LEP protein results in increased expression of NCF2 protein]16380530
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of NCF2 mRNA16997883
C025191bromodichloromethane[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein23438451
C025191bromodichloromethaneLEP protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]23438451
C025191bromodichloromethaneLEPR protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]23438451
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NCF2 protein21195169
D019256Cadmium ChlorideCadmium Chloride affects the expression of NCF2 mRNA18804290
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein]21195169
D019256Cadmium ChlorideAICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein]21195169
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NCF2 protein21195169
D019256Cadmium ChloridePTEN inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein]21195169
D019256Cadmium ChlorideSirolimus inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein]21195169
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of NCF2 mRNA17854599
C026690cerous chloridecerous chloride affects the expression of NCF2 mRNA28954213
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of NCF2 mRNA28954213
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NCF2 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of and results in increased activity of and affects the localization of NCF2 protein21742780
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of NCF2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NCF2 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of NCF2 protein16507596
D003042CocaineCocaine results in increased expression of NCF2 protein18952886
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of NCF2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of NCF2 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of NCF2 mRNA17211630
C029892cupric chloridecupric chloride results in decreased expression of NCF2 mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of NCF2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of NCF2 mRNA20106945|2163298
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased expression of NCF2 protein]16380530
C017160cypermethrincypermethrin results in increased expression of NCF2 mRNA21142847
D003630DaunorubicinDaunorubicin results in increased expression of NCF2 protein21054405
D003630Daunorubicintelmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF2 protein]21054405
D003703DemecolcineDemecolcine results in increased expression of NCF2 mRNA23649840
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of NCF2 mRNA16997883
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of NCF2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of NCF2 mRNA27392435
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of NCF2 mRNA25386960
D004041Dietary Fats[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein23438451
D004041Dietary FatsLEP protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]23438451
D004041Dietary FatsLEPR protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]23438451
C067311docetaxeldocetaxel results in increased localization of and results in increased activity of NCF2 protein25634538
C063533dofetilidedofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA]20723002
C063533dofetilidedofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein]20723002
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of NCF2 mRNA26159488
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of NCF2 mRNA24534155
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [IL1B protein affects the localization of NCF2 protein]19375465
D000431EthanolEthanol results in increased expression of NCF2 protein22872060
D000431Ethanol[sodium arsenite co-treated with Ethanol] results in increased expression of NCF2 protein22872060
D000431EthanolEthanol results in increased expression of NCF2 mRNA20026259
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NCF2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NCF2 mRNA17942748
C004912ethylbenzeneethylbenzene results in increased expression of NCF2 mRNA20359517
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NCF2 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of NCF2 mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of NCF2 mRNA23649840|2766457
D005947Glucose"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of NCF2 protein]]"26054749
D005947GlucoseGlucose results in increased expression of NCF2 protein26054749
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of NCF2 protein]26054749
D017313FenretinideFenretinide results in increased expression of NCF2 protein15059897|1607792
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NCF2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of NCF2 mRNA16997883
D007545Isoproterenol1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA]20723002
D007545Isoproterenol1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein]20723002
D007545Isoproterenoldofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA]20723002
D007545Isoproterenoldofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein]20723002
D007545IsoproterenolIsoproterenol results in increased expression of NCF2 mRNA20723002
D007545IsoproterenolIsoproterenol results in increased expression of NCF2 protein20723002
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of NCF2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NCF2 mRNA22904298|2308692
D007612KanamycinKanamycin promotes the reaction [RAC1 binds to NCF2]16521128
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of NCF2 mRNA28954213
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NCF2 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NCF2 mRNA27339419
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of NCF2 protein17448908
D008070LipopolysaccharidesNCF2 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides]17448908
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NCF2 mRNA21645290
D019808LosartanLosartan inhibits the reaction [AGT protein modified form results in increased expression of NCF2 mRNA]22306536
D017258Medroxyprogesterone Acetate[Medroxyprogesterone Acetate co-treated with Estradiol] results in increased expression of NCF2 protein21670166
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NCF2 mRNA20938992
D008752Methylene ChlorideMethylene Chloride results in increased expression of NCF2 mRNA20359517
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of NCF2 mRNA23876855
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NCF2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NCF2 mRNA"25554681
C046170naphthenic acidnaphthenic acid results in decreased expression of NCF2 mRNA21396992
D000068577NebivololNebivolol inhibits the reaction [AGT protein affects the localization of NCF2 protein]16940222
D000068577NebivololNebivolol inhibits the reaction [AGT protein results in increased expression of NCF2 protein]16940222
D009532NickelNickel results in decreased expression of NCF2 mRNA23195993
D009532NickelNickel results in increased expression of NCF2 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of NCF2 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of NCF2 mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of NCF2 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of NCF2 mRNA20971185
D019787Linoleic AcidLinoleic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein]12101222
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of NCF2 mRNA24888373
D010100Oxygen[Semaxinib co-treated with Oxygen deficiency] results in decreased expression of NCF2 mRNA24947524
D019308Palmitic Acidacetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NCF2 mRNA]24080574
D019308Palmitic AcidPalmitic Acid results in increased expression of NCF2 mRNA24080574
D019308Palmitic AcidU 0126 inhibits the reaction [Palmitic Acid results in increased expression of NCF2 mRNA]24080574
D010269ParaquatParaquat affects the localization of NCF2 protein17662968
D010269Paraquatrottlerin inhibits the reaction [Paraquat affects the localization of NCF2 protein]17662968
D052638Particulate MatterNCF2 protein affects the reaction [Particulate Matter results in increased expression of IL6 mRNA]19371610
D052638Particulate MatterNCF2 protein affects the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]19371610
D052638Particulate MatterNCF2 protein affects the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]19371610
D052638Particulate MatterNCF2 protein affects the susceptibility to Particulate Matter19371610
D052638Particulate MatterParticulate Matter affects the localization of NCF2 protein19371610
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of NCF2 mRNA23948077
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of NCF2 mRNA18804290
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of NCF2 mRNA24888373
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NCF2 mRNA22714537
D011374ProgesteroneEstradiol inhibits the reaction [Progesterone results in increased expression of NCF2 mRNA]16195479
D011374ProgesteroneProgesterone results in increased expression of NCF2 mRNA16195479
D011794QuercetinQuercetin results in increased expression of NCF2 mRNA21632981
D020849Raloxifene HydrochlorideESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of NCF2 mRNA]14699072
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of NCF2 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCF2 mRNA19059307
D017382Reactive Oxygen SpeciesNCF2 mutant form inhibits the reaction [arsenic trioxide results in increased abundance of Reactive Oxygen Species]22532027
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of NCF2 protein]]"26054749
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of NCF2 protein]26054749
C059514resveratrolresveratrol inhibits the reaction [IL1B protein affects the localization of NCF2 protein]19375465
C089730rosiglitazonerosiglitazone results in decreased expression of NCF2 mRNA17255338
C089730rosiglitazonerosiglitazone results in decreased expression of NCF2 protein17255338
C085746rottlerinrottlerin inhibits the reaction [Paraquat affects the localization of NCF2 protein]17662968
C116890Semaxinib[Semaxinib co-treated with Oxygen deficiency] results in decreased expression of NCF2 mRNA24947524
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of NCF2 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide results in increased expression of NCF2 mRNA21602193
D012834SilverSilver results in increased expression of NCF2 mRNA26014281
D012834SilverSilver results in increased expression of NCF2 mRNA22576574
D020123SirolimusSirolimus inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein]21195169
D020123SirolimusSirolimus results in decreased expression of NCF2 protein21195169
C017947sodium arsenite[sodium arsenite co-treated with Ethanol] results in increased expression of NCF2 protein22872060
C017947sodium arsenitesodium arsenite results in increased expression of NCF2 mRNA23876855|2822993
C017947sodium arsenitesodium arsenite results in increased phosphorylation of NCF2 protein19414066
D013148SpironolactoneSpironolactone results in decreased expression of NCF2 protein19114643
D013311StreptozocinStreptozocin results in increased expression of NCF2 protein21381899
D013311Streptozocintelmisartan inhibits the reaction [Streptozocin results in increased expression of NCF2 protein]21381899
C016766sulforafansulforafan results in increased expression of NCF2 mRNA26833863
D013481SuperoxidesNCF2 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides]17448908
D013629TamoxifenTamoxifen affects the expression of NCF2 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCF2 mRNA19059307
C084178telmisartantelmisartan inhibits the reaction [Streptozocin results in increased expression of NCF2 protein]21381899
C084178telmisartantelmisartan results in decreased expression of NCF2 mRNA16141465
C084178telmisartantelmisartan results in decreased expression of NCF2 protein16141465
C084178telmisartantelmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF2 protein]21054405
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of NCF2 protein27239688
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of NCF2 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NCF2 mRNA20106945
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NCF2 mRNA17942748
D013755Tetradecanoylphorbol AcetateAcrolein inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NCF2 protein]11246141
D013755Tetradecanoylphorbol AcetateNCF2 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein]21705328
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of NCF2 protein11246141
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NCF2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of NCF2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased activity of and affects the localization of NCF2 protein22442701
D014050TolueneToluene results in increased expression of NCF2 mRNA20359517
D014212TretinoinTretinoin results in increased expression of NCF2 mRNA16249480
D014241TrichloroethyleneTrichloroethylene results in increased expression of NCF2 mRNA20359517
C030665triphenyltintriphenyltin results in increased expression of NCF2 mRNA12788061
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NCF2 mRNA"26179874
C113580U 0126U 0126 inhibits the reaction [Palmitic Acid results in increased expression of NCF2 mRNA]24080574
D014520UrethaneUrethane results in decreased expression of NCF2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of NCF2 mRNA29154799
D014638VanadatesVanadates results in increased expression of NCF2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NCF2 gene25560391
D014750VincristineVincristine results in increased expression of NCF2 mRNA23649840
D024483Vitamin K 3Vitamin K 3 results in decreased expression of NCF2 protein21843500
D024483Vitamin K 3Vitamin K 3 results in increased expression of NCF2 protein16507596
D019287Zinc SulfateZinc Sulfate results in increased expression of NCF2 mRNA27504894
D015054ZymosanArachidonic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein]12101222
D015054ZymosanLinoleic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein]12101222
D015054ZymosanNCF1 protein promotes the reaction [Zymosan analog affects the localization of NCF2 protein]12101222
D015054ZymosanPLA2G4A protein promotes the reaction [Zymosan analog affects the localization of NCF2 protein]12101222
D015054ZymosanZymosan analog affects the localization of NCF2 protein12101222
D015054ZymosanZymosan analog promotes the reaction [NCF1 protein binds to NCF2 protein]12101222
D015054ZymosanZymosan analog results in increased phosphorylation of NCF2 protein12101222

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI7738010  7938008  8036496  11090627  11483497  11733522  
12169629  12887891  15591124  15657040  16297854  16782902  
19129478  21516116  22203994  25416956  25910212  26871637  
GO:0008022protein C-terminus binding-IPI9365277  
GO:0009055electron transfer activity-TAS1692159  
GO:0016175superoxide-generating NADPH oxidase activity-IEA-  
GO:0016176superoxide-generating NADPH oxidase activator activity-IEA-  
GO:0048365Rac GTPase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006801superoxide metabolic process-TAS7938008  
GO:0006909phagocytosis-IEA-  
GO:0006968cellular defense response-TAS1692159  
GO:0022900electron transport chain-IEA-  
GO:0042554superoxide anion generation-TAS7938008  
GO:0043085positive regulation of catalytic activity-IEA-  
GO:0045087innate immune response-TAS7938008  
GO:0045730respiratory burst-TAS7938008  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0032010phagolysosome-TAS-  
GO:0043020NADPH oxidase complex-TAS7938008  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04380Osteoclast differentiation
hsa04670Leukocyte transendothelial migration
hsa05140Leishmaniasis
Reactome ID Reactome Term Evidence
R-HSA-1222556ROS, RNS production in phagocytesTAS
R-HSA-1236973Cross-presentation of particulate exogenous antigens (phagosomes)TAS
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3299685Detoxification of Reactive Oxygen SpeciesTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-5668599RHO GTPases Activate NADPH OxidasesTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29574730Cigarette smoke modifies neutrophil chemotaxis, neutrophil extracellular trap formation and inflammatory response-related gene expression. (2018 Mar 25)White PCJ Periodontal Res