Gene info: ID 4691

Gene: NCL

GENE ID: 4691

Synonyms: C23|Nsr1

Description: nucleolin

Gene type: protein-coding

Location: 2q37.1

dbXrefs: Ensembl:ENSG00000115053 MIM:164035 Vega:OTTHUMG00000153866 UniprotKB:P19338

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.818e-1 (AD) 2.746e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg06846495	chr2:232326668	NCL		1.860e-9	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HTATSF1	0.95
SET	0.949
CSDE1	0.94
RAC1	0.939
MRFAP1	0.936
SETD3	0.932
IK	0.928
TCEAL4	0.926
YWHAE	0.926
HNRNPA3	0.924

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.855
OR4F5	-0.825
MTRNR2L6	-0.204
MTRNR2L9	-0.191
MTRNR2L10	-0.18
MOGAT2	-0.177
MTRNR2L3	-0.156
TTLL10	-0.152
RNF223	-0.15
OR4F16	-0.148

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone affects the phosphorylation of NCL protein"	27026707
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of NCL mRNA"	20702594
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of NCL mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of NCL mRNA"	21346803
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of NCL mRNA"	18648102
C065250	4-hydroxy-equilenin	4-hydroxy-equilenin results in decreased expression of NCL mRNA	15135645
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of NCL mRNA	20829426
D000082	Acetaminophen	Acetaminophen results in decreased expression of NCL mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in increased expression of NCL protein	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of NCL mRNA	17562736
C016601	afimoxifene	afimoxifene results in decreased expression of NCL mRNA	16514628
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of NCL gene	28458013
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in increased expression of NCL mRNA	17785943
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NCL mRNA	16483693
D000677	Amsacrine	NCL protein affects the susceptibility to Amsacrine	16600179
D001151	Arsenic	Arsenic affects the methylation of NCL gene	25304211
D001151	Arsenic	Arsenic results in increased expression of NCL protein	19818359
C050510	arsenic trichloride	arsenic trichloride affects the localization of NCL protein	16421274
C050510	arsenic trichloride	arsenic trichloride promotes the reaction [NCL protein binds to GADD45A mRNA]	16421274
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of NCL mRNA	15894607
D001280	Atrazine	Atrazine results in increased expression of NCL mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of NCL mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NCL mRNA	22228805
D004958	Estradiol	Estradiol affects the phosphorylation of NCL protein	27026707
D004958	Estradiol	Estradiol results in increased expression of NCL mRNA	16514628
C006780	bisphenol A	bisphenol A affects the expression of NCL mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of NCL mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of NCL mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased phosphorylation of NCL protein	22174045
C013418	bromfenacoum	bromfenacoum results in decreased expression of NCL protein	28903499
C515564	bromovanin	bromovanin results in increased expression of NCL protein	21419150
C026105	butylidenephthalide	butylidenephthalide results in decreased expression of NCL protein	23770345
C018475	butyraldehyde	butyraldehyde results in decreased expression of NCL mRNA	26079696
C584509	C646 compound	C646 compound results in decreased expression of NCL mRNA	26191083
C028031	cadmium acetate	cadmium acetate results in decreased expression of NCL mRNA	18155341
D002220	Carbamazepine	Carbamazepine results in decreased expression of NCL mRNA	17381134
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of NCL mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of NCL mRNA	27339419
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of NCL mRNA	23650126
C100187	chloropicrin	chloropicrin results in increased expression of NCL mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NCL gene	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of NCL mRNA	28472532
D002994	Clofibrate	Clofibrate results in decreased expression of NCL mRNA	16081524
D002995	Clofibric Acid	Clofibric Acid affects the expression of NCL mRNA	17602206
D003024	Clozapine	Clozapine results in increased expression of NCL mRNA	14647396
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of NCL mRNA	19320972\|1937684
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of NCL mRNA	19789285
D019327	Copper Sulfate	Copper Sulfate results in increased expression of NCL mRNA	19789285
C030973	cupric oxide	cupric oxide results in increased expression of NCL protein	25470785
D016572	Cyclosporine	Cyclosporine results in decreased expression of NCL mRNA	22147139
D016572	Cyclosporine	Cyclosporine results in decreased expression of NCL mRNA	19770486
C007262	deoxynivalenol	deoxynivalenol affects the phosphorylation of NCL protein	23352502
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NCL mRNA]	27941970
D002945	Cisplatin	Cisplatin results in decreased expression of NCL mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased phosphorylation of NCL protein	22006019
D002945	Cisplatin	Cisplatin results in decreased expression of NCL protein	22023808
D004041	Dietary Fats	Dietary Fats results in increased expression of NCL mRNA	19030233
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of NCL mRNA]	19030233
D004298	Dopamine	Dopamine results in increased expression of NCL protein	24675778
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NCL protein	23301498
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of NCL mRNA	17347304
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of NCL mRNA	15576828\|1755790
C047360	felbamate	felbamate results in decreased expression of NCL mRNA	17381134
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of NCL mRNA	17347304
D005472	Fluorouracil	Fluorouracil affects the splicing of NCL mRNA	17169984
D005485	Flutamide	Flutamide results in decreased expression of NCL mRNA	21126777
D005485	Flutamide	Flutamide results in increased expression of NCL mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NCL gene	20938992
C070081	fulvestrant	fulvestrant results in decreased expression of NCL mRNA	16514628
C040029	gabapentin	gabapentin results in increased expression of NCL mRNA	17381134
D005839	Gentamicins	Gentamicins results in increased expression of NCL mRNA	22061828
D006220	Haloperidol	Haloperidol results in increased expression of NCL mRNA	14647396
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of NCL mRNA	20044591
C492448	ICG 001	ICG 001 results in decreased expression of NCL mRNA	26191083
D007213	Indomethacin	Indomethacin results in decreased expression of NCL mRNA	28201806
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NCL mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of NCL mRNA	22904298
D008070	Lipopolysaccharides	NCL protein inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]	21309717
D008070	Lipopolysaccharides	NCL protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]	21309717
D008070	Lipopolysaccharides	NCL protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]	21309717
D008070	Lipopolysaccharides	NCL protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]	21309717
D008070	Lipopolysaccharides	NCL protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]	21309717
D008070	Lipopolysaccharides	NCL protein inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of NFKB1 protein]	21309717
D008070	Lipopolysaccharides	Lipopolysaccharides binds to NCL protein	21309751
D008070	Lipopolysaccharides	NCL protein results in increased uptake of Lipopolysaccharides	21309751
D008070	Lipopolysaccharides	[NCL protein results in increased uptake of Lipopolysaccharides] which results in increased expression of IL6 protein	21309751
D008070	Lipopolysaccharides	[NCL protein results in increased uptake of Lipopolysaccharides] which results in increased expression of TNF protein	21309751
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NCL mRNA	21641980
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NCL gene	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of NCL mRNA	24449571
D008731	Methoxychlor	Methoxychlor affects the expression of NCL mRNA	20829426
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of NCL mRNA	27544571
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of NCL mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of NCL mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of NCL protein	24675778
D015741	Metribolone	Metribolone promotes the reaction [NDRG1 protein binds to NCL protein]	17220478
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of NCL mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of NCL mRNA"	25554681\|2562005
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of NCL mRNA	19162173
D010578	Petroleum	Petroleum affects the expression of NCL mRNA	25208076
D010634	Phenobarbital	Phenobarbital affects the expression of NCL mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of NCL mRNA	17381134
D010672	Phenytoin	Phenytoin results in decreased expression of NCL mRNA	17381134
C006253	pirinixic acid	pirinixic acid results in increased expression of NCL mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of NCL mRNA	19162173
D010936	Plant Extracts	Plant Extracts results in decreased expression of NCL mRNA	25056133
D010936	Plant Extracts	Plant Extracts results in increased expression of NCL mRNA	23557933
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of NCL mRNA	16514628
C059514	resveratrol	resveratrol results in decreased expression of NCL protein	25505154
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of NCL mRNA]	19030233
C016104	sodium bichromate	sodium bichromate results in increased expression of NCL mRNA	25993096
D018038	Sodium Selenite	Sodium Selenite results in increased expression of NCL mRNA	18175754
D012999	Soman	Soman results in increased expression of NCL mRNA	19281266
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of NCL mRNA	16214533
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NCL mRNA	21641980
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NCL mRNA	16962184\|2070259
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of NCL protein	16548065
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NCL mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of NCL mRNA	27760801
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of NCL mRNA	15894607
D014212	Tretinoin	Tretinoin results in increased expression of NCL mRNA	20488242
C012589	trichostatin A	trichostatin A results in decreased expression of NCL mRNA	15901671
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of NCL mRNA	19042947
C057693	troglitazone	troglitazone results in decreased expression of NCL mRNA	28973697
C000602704	UF010 compound	UF010 compound results in increased acetylation of NCL protein	25699604
D014635	Valproic Acid	Valproic Acid results in decreased expression of NCL mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in decreased methylation of NCL gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of NCL mRNA	17381134
D014635	Valproic Acid	Valproic Acid results in decreased expression of NCL mRNA	15901671
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of NCL gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of NCL mRNA	22570695
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of NCL mRNA"	25208076

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674 22681889
GO:0003723	RNA binding	-	IBA	21873635
GO:0003723	RNA binding	-	IDA	8321232
GO:0005515	protein binding	-	IPI	9512561 12427757 15064750 15161933 15674325 15848144 16213212 16403913 16648475 16777843 17615292 17620599 18292223 18457437 19174163 19393617 19515850 19877579 20195357 20221403 20858735 21081503 21242313 21281639 22103682 24515436 24658146 24965446
GO:0008022	protein C-terminus binding	-	IPI	16403913
GO:0042162	telomeric DNA binding	-	IDA	8321232
GO:0042802	identical protein binding	-	IPI	21575138
GO:0044547	DNA topoisomerase binding	-	IPI	8567649
GO:0048027	mRNA 5'-UTR binding	-	IDA	16213212

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	IDA	16403913
GO:0017148	negative regulation of translation	-	IMP	16213212
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0051252	regulation of RNA metabolic process	-	IBA	21873635
GO:0071364	cellular response to epidermal growth factor stimulus	-	IEA	-
GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	-	IMP	24071584
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	15121898 24071584
GO:0005654	nucleoplasm	-	IDA	23353999
GO:0005730	nucleolus	-	IBA	21873635
GO:0005730	nucleolus	-	IDA	12944467 19393617 24071584
GO:0005938	cell cortex	-	IDA	16403913
GO:0016020	membrane	-	HDA	19946888
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	15121898
GO:0070062	extracellular exosome	-	HDA	20458337
GO:1990904	ribonucleoprotein complex	-	IDA	17289661 18809582

KEGG ID	KEGG Term
hsa05130	Pathogenic Escherichia coli infection

Reactome ID	Reactome Term	Evidence
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	TAS
R-HSA-72312	rRNA processing	TAS
R-HSA-8868773	rRNA processing in the nucleus and cytosol	TAS
R-HSA-8953854	Metabolism of RNA	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26611246	High-Grade Neuroendocrine Carcinoma of the Larynx: The Mayo Clinic Experience. (2016 Jun)	Deep NL	Ann Otol Rhinol Laryngol
25531908	The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients. (2015 Feb)	Li X	Int J Oncol
27575817	Expression Profile of Six RNA-Binding Proteins in Pulmonary Sarcoidosis. (2016)	Navratilova Z	PLoS One
22342123	The relationship between reward-based learning and nicotine dependence in smokers with schizophrenia. (2012 Mar 30)	Ahnallen CG	Psychiatry Res